Research Topics
| B CryerSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Oral bisphosphonates and upper gastrointestinal tract problems: what is the evidence?Byron Cryer
Mayo Clin Proc 77:1031-43. 2002..To review and evaluate the evidence regarding possible associations of bisphosphonate use with upper gastrointestinal (GI) tract adverse events (AEs)...- A fixed-dose combination of naproxen and esomeprazole magnesium has comparable upper gastrointestinal tolerability to celecoxib in patients with osteoarthritis of the knee: results from two randomized, parallel-group, placebo-controlled trialsByron L Cryer
University of Texas Southwestern Medical Center, Dallas, USA
Ann Med 43:594-605. 2011..3%) was similar between treatment groups. UGI AEs resulted in few discontinuations (< 4%, either study). CONCLUSIONS. Naproxen/esomeprazole magnesium has comparable UGI tolerability to celecoxib in patients with osteoarthritis... - Upper gastrointestinal tolerability of once weekly alendronate 70 mg with concomitant non-steroidal anti-inflammatory drug useB Cryer
Department of Medicine, University of Texas Southwestern Medical School, Dallas, TX 75216, USA
Aliment Pharmacol Ther 21:599-607. 2005..Both oral bisphosphonates and non-steroidal anti-inflammatory drugs have the potential to irritate the upper gastrointestinal mucosa, and are frequently used by the same patient population... - A randomized, placebo-controlled, 6-month study of once-weekly alendronate oral solution for postmenopausal osteoporosisByron Cryer
Division of Digestive Diseases, Dallas Veterans Affairs Medical Center, Dallas, Texas 75216, USA
Am J Geriatr Pharmacother 3:127-36. 2005..This study evaluated the overall safety and tolerability of once-weekly (OW) alendronate 70 mg oral solution (OS) versus OW placebo OS... - Management of patients with high gastrointestinal risk on antiplatelet therapyByron Cryer
Department of Veterans Affairs Medical Center, Medical Service, Digestive Diseases, North Texas VA Medical Center, 4500 S Lancaster Road, Dallas, TX 75216, USA
Gastroenterol Clin North Am 38:289-303. 2009..Until more specific regulatory guidance is available, current recommendations are that patients taking both PPIs and clopidogrel concurrently should probably continue to do so until more data become available... - Low-dose aspirin-induced ulceration is attenuated by aspirin-phosphatidylcholine: a randomized clinical trialByron Cryer
University of Texas Southwestern and VA North Texas Health Care System, Dallas, Texas 75216 7167, USA
Am J Gastroenterol 106:272-7. 2011..We determined acute gastroduodenal erosion and ulceration following low-dose aspirin and aspirin-phosphatidylcholine complex (PL2200) in subjects at risk of aspirin ulcers... - The role of cyclooxygenase selective inhibitors in the gastrointestinal tractByron Cryer
Digestive Diseases 111B1, University of Texas Southwestern Medical School, Dallas VA Medical Center, 4500 South Lancaster Road, Dallas, TX 75216, USA
Curr Gastroenterol Rep 5:453-8. 2003..In the recently released studies of gastrointestinal outcomes (perforated, painful, or bleeding ulcers), incidence of clinically relevant ulceration with COX-2 NSAIDs is much lower than that of traditional NSAIDs... - Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humansM Feldman
Medical Service, Dallas Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA
Am J Physiol Gastrointest Liver Physiol 279:G1113-20. 2000..In conclusion, aspirin inhibits gastric COX activity for much longer than predicted from its pharmacokinetic profile, explaining why aspirin at widely spaced intervals is ulcerogenic... - Mucosal defense and repair. Role of prostaglandins in the stomach and duodenumB Cryer
Medical Service, Dallas Veterans Affairs Medical Center, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Gastroenterol Clin North Am 30:877-94, v-vi. 2001..This article reviews the role that mucosal prostaglandins play in defense of the gastric and duodenal mucosa against injury and ulceration... - Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humansB Cryer
Medical Service, Dallas VA Medical Center, and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Gastroenterology 117:17-25. 1999..Our objectives were to evaluate the long-term effects of very low daily aspirin doses in the gastrointestinal tract and effects on platelet-derived serum thromboxane levels in volunteers... - Assessment of upper gastrointestinal safety of etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparisonLoren Laine
Division of Gastrointestinal and Liver Diseases, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Lancet 369:465-73. 2007..Our aim was to assess the effects of these drugs on gastrointestinal outcomes in a population that includes patients taking gastrointestinal protective therapy... - The advent of highly selective inhibitors of cyclooxygenase--a reviewB Cryer
Medical Service, Dallas VA Medical Center, TX 75216, USA
Prostaglandins Other Lipid Mediat 56:341-61. 1998..This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors... - Aspirin absorption rates and platelet inhibition times with 325-mg buffered aspirin tablets (chewed or swallowed intact) and with buffered aspirin solutionM Feldman
Dallas Department of Veterans Affairs Medical Center and Department of Internal Medicine, University of Texas Southwestern Medical School, 75216, USA
Am J Cardiol 84:404-9. 1999..04 vs chewing a tablet; p = 0.13 vs swallowing a whole tablet). Chewing an aspirin tablet is the most effective way of accelerating absorption of aspirin into the blood and shortening the time required for an antiplatelet effect... - Role of Helicobacter pylori infection in gastroduodenal injury and gastric prostaglandin synthesis during long term/low dose aspirin therapy: a prospective placebo-controlled, double-blind randomized trialM Feldman
Department of Veterans Affairs Medical Center, Dallas, Texas 75216, USA
Am J Gastroenterol 96:1751-7. 2001..CONCLUSIONS: Long term/low dose aspirin therapy led to more gastric mucosal damage when H. pylori gastritis was present than when it was absent, despite similar degrees of gastric mucosal prostaglandin depletion... - Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cellsR F Souza
Department of Medicine, Dallas VA Medical Center, Texas 75216, USA
Cancer Res 60:5767-72. 2000..These observations suggest a potential role for selective COX-2 inhibitors in the prevention and treatment of esophageal adenocarcinoma for patients with Barrett's esophagus... - Risks of clinically significant upper gastrointestinal events with etodolac and naproxen: a historical cohort analysisRick A Weideman
Department of Pharmacy, Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
Gastroenterology 127:1322-8. 2004..However, concomitant use of low-dose aspirin negates the gastrointestinal safety advantages of etodolac... - A comparison of every-third-day versus daily low-dose aspirin therapy on serum thromboxane concentrations in healthy men and womenM Feldman
Medical Service, Dallas Department of Veterans Affairs Medical Center and University of Texas Southwestern Medical School, 75216, USA
Clin Appl Thromb Hemost 7:53-7. 2001..Every-third-day low-dose aspirin regimens (325 and 81 mg) deserve comparison with daily low-dose aspirin regimens in controlled clinical trials because the former regimens could prove to have equal efficacy with reduced toxicity... - The association of elevated HbA1c on the behavior of adenomatous polyps in patients with type-II diabetes mellitusAli A Siddiqui
Department of Internal Medicine, Dallas Veteran s Affairs Medical Center, 4500 S Lancaster Road 111B1, Dallas, TX 75216, USA
Dig Dis Sci 53:1042-7. 2008..The aim of our study was to determine whether poor control of diabetes mellitus (DM) is associated with increased prevalence of colonic adenomatous polyps (APs), especially those that are advanced ... - Elevated HbA1c is an independent predictor of aggressive clinical behavior in patients with colorectal cancer: a case-control studyAli A Siddiqui
Department of Internal Medicine, Dallas Veterans Affairs Medical Center, 4500 S Lancaster Road 111B1, Dallas, TX 75216, USA
Dig Dis Sci 53:2486-94. 2008..The aim of this study was to seek an association between the control of type 2 diabetes mellitus (T2DM), as determined by hemoglobin A1c (HbA1c) levels, and the outcome of colorectal cancer (CRC)... - The risk of acute myocardial infarction with etodolac is not increased compared to naproxen: a historical cohort analysis of a generic COX-2 selective inhibitorJohn J Warner
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
J Cardiovasc Pharmacol Ther 13:252-60. 2008..This study compares the risk of acute myocardial infarction among patients exposed to etodolac, naproxen, celecoxib, and rofecoxib... - Persistence with non-selective NSAIDs and celecoxib among patients with gastroesophageal reflux disease and osteoarthritis or rheumatoid arthritisB Cryer
Department of Medicine, Division of Gastroenterology, UT Southwestern Medical School, Dallas, TX 75390 9006, USA
Curr Med Res Opin 27:295-302. 2011..This study assessed nsNSAID and celecoxib prescription patterns, in particular persistence, in OA/RA patients with concomitant diagnosis of GERD... - Effects of low-dose aspirin on serum C-reactive protein and thromboxane B2 concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assayM Feldman
Medical Service, Dallas Department of Veterans Affairs Medical Center, Texas 75216, USA
J Am Coll Cardiol 37:2036-41. 2001..We performed a placebo-controlled study to evaluate the effect of low-dose aspirin on serum C-reactive protein (CRP) levels... - Double-blind, randomized, parallel, placebo-controlled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-treated healthy adult volunteersByron Cryer
Dallas Veterans Affairs Medical Center, Dallas, Texas, USA
Clin Ther 27:185-91. 2005..When using this regimen of OTC ibuprofen with immediate-release, low-dose aspirin, concerns about the loss of cardioprotective antiplatelet effects of aspirin are not supported by this study... - Gastrointestinal safety of low-dose aspirinByron Cryer
Department of Medicine, University of Texas Southwestern Medical School, Dallas VA Medical Center, USA
Am J Manag Care 8:S701-8. 2002..In contrast, because acetaminophen does not cause GI irritation, it should therefore be considered when an analgesic is needed... - Peptic ulcer diseaseD T Smoot
Gastroenterology Division, Department of Medicine, Howard University, Washington, DC 20060, USA
Prim Care 28:487-503, v. 2001..As a result of H pylori treatment and other unknown factors ulcer disease is declining and complications from ulcer disease have diminished significantly... - Effects of age on gastric alkaline and nonparietal fluid secretion in humansM Feldman
Department of Internal Medicine, Veterans Affairs Medical Center, Dallas, TX 75216, USA feldman
Gerontology 44:222-7. 1998..Thus, in healthy subjects with normal gastric histology, advancing age was associated with a significant decline in gastric HCO3-, Na+, and nonparietal fluid secretion, resulting in an increase in gastric acidity (H+ concentration)... - Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugsC Mel Wilcox
Department of Medicine, Division of Gastroenterology, University of Alabama at Birmingham, Alabama 35294 0007, USA
J Rheumatol 32:2218-24. 2005..To assess the frequency and indications for over-the-counter (OTC) nonsteroidal antiinflammatory drug (NSAID) use and to what degree the public is aware of their side effects... - Three-year oral pantoprazole administration is effective for patients with Zollinger-Ellison syndrome and other hypersecretory conditionsD C Metz
Department of Medicine, Division of Gastroenterology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Aliment Pharmacol Ther 23:437-44. 2006..CONCLUSIONS: Maintenance oral pantoprazole therapy up to 3 years at dosages of 40-120 mg b.d. was effective and well tolerated in patients with Zollinger-Ellison syndrome and other hypersecretory conditions... - Duration of the interval between the completion of bowel preparation and the start of colonoscopy predicts bowel-preparation qualityAli A Siddiqui
Department of Internal Medicine, Dallas Veteran s Affairs Medical Center, Dallas, Texas 75216, USA
Gastrointest Endosc 69:700-6. 2009..Recent studies suggest that colonoscopies done in the morning have better-quality bowel preparations than those done in the afternoon... - Tegaserod-induced myocardial infarction: case report and hypothesisAnthony J Busti
School of Pharmacy Dallas Ft Worth Regional Campus, Texas Tech University Health Sciences Center, Dallas, Texas 75216, USA
Pharmacotherapy 24:526-31. 2004..When considering prescribing a drug with 5-HT1 receptor agonist activity, clinicians should review the patient's medical history specifically for the presence of underlying cardiovascular risk factors... - Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trialJay L Goldstein
University of Illinois at Chicago, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 5:1167-74. 2007.... - Consensus development conference on the use of nonsteroidal anti-inflammatory agents, including cyclooxygenase-2 enzyme inhibitors and aspirinC Mel Wilcox
Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Clin Gastroenterol Hepatol 4:1082-9. 2006 - Evaluation and management of patients with recurrent peptic ulcer disease after acid-reducing operations: a systematic reviewRichard H Turnage
Department of Surgery, Louisiana State University Health Science Center Shreveport, Shreveport, LA 71130, USA
J Gastrointest Surg 7:606-26. 2003.... - COX-2-specific inhibitors: prescribing patterns in a large managed care health system and strategies to minimize costsRick A Weideman
Department of Veterans Affairs, North Texas Health Care System, Dallas 75216, USA
Am J Manag Care 8:869-77. 2002..To determine the relative costs associated with the exclusive use of celecoxib versus rofecoxib in a large managed care system... - COX-2-specific inhibitor or proton pump inhibitor plus traditional NSAID: is either approach sufficient for patients at highest risk of NSAID-induced ulcers?Byron Cryer
Gastroenterology 127:1256-8. 2004 - A randomized, controlled comparison of ibuprofen at the maximal over-the-counter dose compared with prescription-dose celecoxib on upper gastrointestinal mucosal injuryJames M Scheiman
Department of Internal Medicine, University of Michigan, Ann Arbor, 48109 0362, USA
Clin Gastroenterol Hepatol 2:290-5. 2004..We compared endoscopic injury related to nonprescription ibuprofen doses with celecoxib, also comparing prescription doses of naproxen with placebo as a positive control... - NSAID-associated deaths: the rise and fall of NSAID-associated GI mortalityByron Cryer
Am J Gastroenterol 100:1694-5. 2005..Another important contribution derived from this report is a more reliable estimate of NSAIDs' lower GI clinical consequences than previously available... - Reducing the risks of gastrointestinal bleeding with antiplatelet therapiesByron Cryer
N Engl J Med 352:287-9. 2005 - Maintenance oral pantoprazole therapy is effective for patients with Zollinger-Ellison syndrome and idiopathic hypersecretionDavid C Metz
University of Pennsylvania Medical Center, Division of Gastroenterology, Philadelphia 19104, USA
Am J Gastroenterol 98:301-7. 2003..CONCLUSIONS: Maintenance p.o. pantoprazole therapy at a dose of 80-240 mg/day in divided doses was both effective and generally well tolerated for patients with Zollinger-Ellison syndrome and idiopathic hypersecretion... - A COX-2-specific inhibitor plus a proton-pump inhibitor: is this a reasonable approach to reduction in NSAIDs' GI toxicity?Byron Cryer
Am J Gastroenterol 101:711-3. 2006..Thus, there continues to be no prospective data to support a GI benefit of COX-2 inhibitor plus a PPI over traditional NSAID plus a PPI in high-risk patients...