Research Topics
| Ruy J CruzSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Effects of ethyl pyruvate and other ?-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusionRuy J Cruz
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Surg Res 165:151-7. 2011..Herein, we tested the hypothesis that EP and other ?-keto carboxylic acid derivatives can modulate organ injury after lower torso ischemia/reperfusion (I/R)...
Short-term effects of hydroxyethylstarch resuscitation on systemic and regional hemodynamics and metabolism in a brain-dead canine modelFabio A De Luca
Division of Applied Physiology, Heart Institute InCor, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
J Surg Res 169:132-8. 2011....
Modified duodenal diverticulization technique for the management of duodenal fistulasRuy J Cruz
Department of Surgery, University of Santo Amaro Medical School, Sao Paulo, Brazil
Am J Surg 199:e29-33. 2010..We herein describe an alternative technique of duodenal diverticulization used to treat 3 patients that sustained posttraumatic duodenal fistula...
Duodenal obstruction - an unusual presentation of Strongyloides stercoralis enteritis: a case reportRuy J Cruz
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
World J Emerg Surg 5:23. 2010..Intestinal obstruction is a poorly recognized and probably underreported complication of strongyloidiasis. We present herein an unusual case, of complete duodenal obstruction caused by S. stercoralis...
Single-staple technique for pancreas allograft procurementRuy J Cruz
Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, PA, USA
Ann Transplant 15:71-3. 2010..In this letter we described an alternative stapling technique in order to reduce the number of loads as well as cost during pancreas procurement...
Spontaneous intratumoral bleeding and rupture of giant gastric stromal tumor (> 30 cm) in a young patientRuy J Cruz
Department of Surgery, University of Santo Amaro Medical School, Sao Paulo, Brazil
World J Surg Oncol 6:76. 2008..We report an unusual case, in which a giant gastric GIST - in a young patient - presented as spontaneous intratumoral bleeding followed by intraluminal rupture...
Early hemodynamics and metabolic changes after total abdominal evisceration for experimental multivisceral transplantationRuy J Cruz
Starzl Transplantation Institute Liver, Intestinal and Multivisceral Transplant Services, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 3442, USA
Acta Cir Bras 24:156-61. 2009..Despite the known deleterious effects of hepatosplanchnic exenteration the impact of this procedure on systemic hemodynamics and metabolism remains to be determined...
Effects of fluid resuscitation on cardiovascular performance after posttraumatic pneumonectomyRuy J Cruz
Research Division, University of Sao Paulo Medical School, Brazil
J Trauma 68:604-10. 2010..In this study, we evaluated the hemodynamic and echocardiographic changes induced by pneumonectomy and fluid resuscitation after hemorrhagic shock...
Hepatosplanchnic vasoregulation and oxygen consumption during selective aortic blood flow reduction and reperfusionRuy J Cruz
Research Division, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pennsylvania
J Surg Res 171:532-9. 2011..In this study, we developed an experimental model to selectively reduce the abdominal aortic blood flow in order to assess the initial impact of selective hepatosplanchnic hypoperfusion on regional blood flow redistribution...
Low hematocrit impairs gastric mucosal CO2 removal during experimental severe normovolemic hemodilutionDaniel Perin
Research Division, Heart Institute, , , SP, Brazil
Clinics 61:445-52. 2006..However, a very low hematocrit induced gastric mucosal acidosis, suggesting that gastric mucosal CO2 monitoring may be useful during major surgery or following trauma...
Regional blood flow distribution and oxygen metabolism during mesenteric ischemia and congestionRuy J Cruz
Research Division, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
J Surg Res 161:54-61. 2010..For these reasons we decided to assess the initial impact of venous mesenteric occlusion on intestinal blood flow distribution, and correlate these findings with other systemic and regional perfusion markers...
Fluid replacement with hypertonic or isotonic solutions guided by mixed venous oxygen saturation in experimental hypodynamic sepsisLuciana Rahal
Department of Surgery and LIM26, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
J Trauma 67:1205-12. 2009..Our hypothesis was that a hypertonic isoncotic solution would improve the benefits of crystalloids replacement guided by mixed venous oxygen saturation...
Modified multivisceral transplantation with spleen-preserving pancreaticoduodenectomy for patients with familial adenomatous polyposis "Gardner's Syndrome"Ruy J Cruz
Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Transplantation 91:1417-23. 2011..This study focuses on the indications of MMVTx for patients with familial adenomatous polyposis (FAP) and the technical feasibility of performing spleen-preserving pancreaticoduodenectomy (SPPD)...
Oxygen consumption, pCO2 gradients and regional blood flow distribution in an alternative model of intestinal autotransplantationRuy J Cruz
Research Division, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
J Surg Res 130:13-9. 2006..In addition, we sought to obtain evidence that intestinal pCO2 measurement can be a useful method for monitoring graft perfusion and early histological changes after small bowel transplantation...
Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challengesKareem M Abu-Elmagd
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Ann Surg 250:567-81. 2009..To assess the evolution of visceral transplantation in the milieu of surgical technical modifications, new immunosuppressive protocols, and other management strategies...
Small volume resuscitation with 3% hypertonic saline solution decrease inflammatory response and attenuates end organ damage after controlled hemorrhagic shockRodrigo Vincenzi
Research Division, InCor, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil
Am J Surg 198:407-14. 2009..The aim of this study was to test the potential immunomodulatory benefits of 3% hemorrhagic shock resuscitation over standard fluid resuscitation...
Low hematocrit levels increase intracranial pressure in an animal model of cryogenic brain injuryHumberto K Tango
Laboratory of Medical Investigation LIM 08 Anestesiologia, Anesthesia Department, University of Sao Paulo Medical School, Sao Paulo, Brazil
J Trauma 66:720-6. 2009....
The synergistic effects of pentoxifylline on systemic and regional perfusion after hemorrhage and hypertonic resuscitationRuy J Cruz
Research Division, Heart Institute, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Anesth Analg 102:1518-24. 2006..7 +/- 3.9 mm Hg) when compared with isolated HS infusion (48.2 +/- 6.4 to 39.4 +/- 5.5 mm Hg). We conclude that PTX as an adjunct drug during hypertonic resuscitation improves cardiovascular performance and gastric mucosal oxygenation...
Initial hepatosplanchnic blood flow distribution and oxygen metabolism in experimental model of hypotensive brain deathFabio A De Luca
Division of Applied Physiology, Heart Institute InCor, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Ann Transplant 14:38-46. 2009..We investigated the early metabolic changes and blood flow redistribution in splanchnic territory in an experimental model that mimics marginal brain-dead (BD) donor...
The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitroPenny L Sappington
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 616 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
Biochem Pharmacol 70:1579-92. 2005..Moreover, our findings suggest that esters with these general characteristics, perhaps because of their greater lipophilicity or electrophilicity, are more potent anti-inflammatory agents than are the parent carboxylates...
Blood loss after fluid resuscitation with isotonic or hypertonic saline for the initial treatment of uncontrolled hemorrhage induced by spleen ruptureEdson Y Varicoda
Research Division, , , Brazil
J Trauma 55:112-7. 2003....
Modified "liver-sparing" multivisceral transplant with preserved native spleen, pancreas, and duodenum: technique and long-term outcomeRuy J Cruz
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, 3459 Fifth Avenue, MUH 7 South, Pittsburgh, PA 15213, USA
J Gastrointest Surg 14:1709-21. 2010..Modification of the originally described multivisceral transplant operation was introduced at our institution 17 years ago. Donor liver was spared, and native spleen along with pancreaticoduodenal complex was preserved...
Surgical shunt versus TIPS for treatment of variceal hemorrhage in the current era of liver and multivisceral transplantationGuilherme Costa
Intestinal Rehabilitation and Transplantation Center, Thomas East Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, UPMC Montefiore 7 South, 3459 Fifth Avenue, Pittsburgh, PA 15213 2582, USA
Surg Clin North Am 90:891-905. 2010..Liver and multivisceral transplantation are also briefly discussed as important parts of the algorithmic management of these complex patients, particularly those with hepatic decompensation and portomesenteric venous thrombosis...
Hepatitis C recurrence is not adversely affected by the use of donation after cardiac death liver allograftsRan Tao
Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Liver Transpl 16:1288-95. 2010..0-19.7) were the only independent risk factors for severe recurrence. In summary, although there was a trend of poorer overall outcomes in DCD patients, the use of DCD livers did not appear to adversely affect HCV recurrence after LT...
Ethyl pyruvate ameliorates ileus induced by bowel manipulation in miceTomoyuki Harada
Department of Critical Care Medicine, Pittsburgh, PA 15261, USA
Surgery 138:530-7. 2005..Treatment with EP ameliorated these effects of gut manipulation. CONCLUSIONS: EP warrants further evaluation as a therapeutic agent to ameliorate postoperative ileus...
Intracolonic obstruction induced by a retained surgical sponge after trauma laparotomyRuy J Cruz
Emergency Department, University of Santo Amaro Medical School, , Brazil
J Trauma 55:989-91. 2003
Systemic and regional effects of supraceliac aortic occlusion during experimental hepatic vascular exclusionRuy J Cruz
Division of Applied Physiology, Heart Institute InCor, and Department of Surgery, University of Sao Paulo Medical School, Rua Marivaldo Fernandes, 140, Sao Paulo, SP 04792 060, Brazil
Am J Surg 185:388-93. 2003..Supraceliac aortic occlusion (AO) has been recommended to avoid hypotension during hepatic vascular exclusion (HVE). We hypothesized that AO may negatively affect splanchnic perfusion during HVE...
