Research Topics
| Leslie CroffordSummaryAffiliation: University of Kentucky Country: USA Publications
Research Grants
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Detail Information
Publications
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2Annaleise V Sampey
University of Michigan, Ann Arbor, MI, USA
Arthritis Res Ther 7:114-7. 2005..The focus of this article is to review some recent advances in our understanding of mechanisms specific to the regulation of inducible mPGES-1 in inflammatory arthritis...- Violence, stress, and somatic syndromesLeslie J Crofford
Center for the Advancement of Women s Health, University of Kentucky, USA
Trauma Violence Abuse 8:299-313. 2007..Understanding the relationship between violence, stress, and somatic syndromes will help in clarifying the consequences of violence exposure to long-term health and health-related quality of life... - Pain management in fibromyalgiaLeslie J Crofford
University of Kentucky, Lexington, Kentucky 40536, USA
Curr Opin Rheumatol 20:246-50. 2008..This review addresses newer strategies for the treatment of pain in patients with fibromyalgia that may be also useful in patients with other rheumatic diseases... - Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalinLeslie J Crofford
University of Kentucky, Internal Medicine, Room J 503 Kentucky Clinic, 740 S Limestone Street, Lexington, KY 40536 0284, USA
Pain 136:419-31. 2008..In those who respond, pregabalin demonstrated durability of effect for relieving FM pain... - The relationship of fibromyalgia to neuropathic pain syndromesLeslie J Crofford
University of Kentucky, Lexington, Kentucky 40536, USA
J Rheumatol Suppl 75:41-5. 2005..In this afterword, a synthesis of the information presented in these proceedings and opinion as to how FM relates to classical neuropathic pain syndromes is provided... - Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trialLeslie J Crofford
University of Michigan, Ann Arbor, USA
Arthritis Rheum 52:1264-73. 2005..FMS affects an estimated 2% of the population, predominantly women. This trial was designed to evaluate the efficacy and safety of pregabalin, a novel alpha(2)-delta ligand, for treatment of symptoms associated with FMS... - Immunomodulatory therapy for SSc: will high-intensity immunosuppression with stem cell rescue improve outcome?Leslie J Crofford
Women s Health Program, Chief Division of Rheumatology, Room J 503, Kentucky Clinic, 740 S Limestone St, Lexington, KY 40536, USA
Curr Rheumatol Rep 7:142-9. 2005..New studies to compare these approaches with conventional immunomodulatory therapy are underway... - Adverse effects of chronic opioid therapy for chronic musculoskeletal painLeslie J Crofford
Division of Rheumatology and Women s Health, University of Kentucky, Room J 503, Kentucky Clinic, 740 S Limestone Street, Lexington, KY 40536, USA
Nat Rev Rheumatol 6:191-7. 2010..Patients with chronic musculoskeletal pain should avoid the long-term use of opioids unless the benefits are determined to outweigh risks, in which case, the use of chronic opioids should be regularly re-evaluated... - A pilot study: pain, fatigue and stress in maternal relatives of adolescent female psychiatric inpatients assessed for juvenile primary fibromyalgia syndromeKaren Lommel
Division of Rheumatology and College of Public Health, Department of Psychiatry, University of Kentucky, Lexington, KY 40509, USA
Int J Adolesc Med Health 23:59-63. 2011..We compared the relatives of adolescents who met the criteria for juvenile primary fibromyalgia syndrome (JPFS) to relatives of adolescents who did not meet the criteria for JPFS... - A pilot study of a combined intervention for management of juvenile primary fibromyalgia symptoms in adolescents in an inpatient psychiatric unitKaren Lommel
Department of Psychiatry, Division of Rheumatology, 3470 Blazer Parkway, University of Kentucky, Lexington, KY 40509, USA
Int J Adolesc Med Health 23:193-7. 2011..Very little is known about the prevalence and treatment on inpatient psychiatric units... - Major enzymatic pathways in dermal wound healing: current understanding and future therapeutic targetsMohit Kapoor
Department of Internal Medicine, Rheumatology Division, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
Curr Opin Investig Drugs 7:418-22. 2006..The major therapeutic targets within these processes will also be highlighted... - Violence against women and postpartum depressionMatthew J Garabedian
Department of Obstetrics and Gynecology, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0293, USA
J Womens Health (Larchmt) 20:447-53. 2011..We examined the association between these violence exposures and self-reported history of postpartum depression (PPD)... - Pharmaceutical treatment options for fibromyalgiaLeslie J Crofford
Division of Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0680, USA
Curr Rheumatol Rep 6:274-80. 2004..This paper will review the rationale for the different types of pharmaceutical treatments that may be useful for the treatment of FMS and issues regarding new drug development for this indication... - Juvenile primary fibromyalgia syndrome in an inpatient adolescent psychiatric populationKaren Lommel
University of Kentucky College of Medicine, Department of Psychiatry, 3470 Blazer Parkway, Lexington, Kentucky 40509, USA
Int J Adolesc Med Health 21:571-9. 2009..The purpose of this study was to identify the clinical and demographic characteristics of adolescent females admitted to a psychiatric hospital who meet the criteria for Juvenile Primary Fibromyalgia Syndrome (JPFS)... - Objective measures of disordered sleep in fibromyalgiaRonald D Chervin
Michael S Aldrich Sleep Disorders Laboratory, Ann Arbor, MI 48109 5845, USA
J Rheumatol 36:2009-16. 2009..However, measures that consistently and objectively distinguish FM patients remain elusive... - Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgiaSamuel A McLean
Chronic Pain and Fatigue Research Center, University of Michigan Medical Center, 24 Frank Lloyd Wright Drive, PO Box 385, Ann Arbor, MI 48106, USA
Arthritis Rheum 52:3660-9. 2005.... - Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizingMichael E Geisser
Department of Physical Medicine and Rehabilitation, University of Michigan Health System, Ann Arbor, MI 48109, USA
Pain 102:243-50. 2003..They also suggest that catastrophic thoughts about pain may play a role in increased pain perception in this population... - Violence against Women Raises Risk of Cervical CancerAnn L Coker
Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY 40536 0293, USA
J Womens Health (Larchmt) 18:1179-85. 2009..The purpose of this cross-sectional analysis was to determine if women who had experienced violence had higher prevalence rates of invasive cervical cancer... - Sleep stage dynamics in fibromyalgia patients and controlsJoseph W Burns
Michigan Tech Research Institute, Michigan Technological University, 3600 Green Court, Suite 100, Ann Arbor, MI 48105, USA
Sleep Med 9:689-96. 2008..To determine whether previously described sleep stage dynamics, reflecting the mean duration of specific sleep stages, may have clinical utility in a sample of patients with fibromyalgia syndrome (FMS) and controls... - Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null miceFumiaki Kojima
Division of Rheumatology, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
J Immunol 180:8361-8. 2008..Pharmacologic inhibition of mPGES-1 may therefore impact both the inflammation and the autoimmunity associated with human diseases such as rheumatoid arthritis... - Self-regulatory deficits in fibromyalgia and temporomandibular disordersLise Solberg Nes
Department of Psychology, University of Kentucky, Lexington, KY, USA
Pain 151:37-44. 2010.... - Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndromeLeslie J Crofford
Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
Brain Behav Immun 18:314-25. 2004..The abnormalities in FMS patients are consistent with loss of HPA axis resiliency... - Chronic widespread pain and fibromyalgia: what we know, and what we need to knowDaniel J Clauw
Division of Rheumatology, Department of Medicine, University of Michigan Medical School, 101 Simpson, Ann Arbor, MI 48109 0723, USA
Best Pract Res Clin Rheumatol 17:685-701. 2003..g. NSAIDs, corticosteroids), neuroactive compounds [especially those that raise central levels of noradrenaline (norepinephrine) or serotonin] are most effective for treating central pain... - COX-2: Where are we in 2003? - Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory diseaseLeslie J Crofford
Associate Professor of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, Michigan, USA
Arthritis Res Ther 5:25-7. 2003..Clinical data suggest that protective PGs are derived from cyclooxygenase (COX)-1 because studies have now confirmed that drugs specifically inhibiting COX-2 are not cross-reactive with aspirin in patients with AERD... - The hypothalamic-pituitary-adrenal axis in the pathogenesis of rheumatic diseasesLeslie J Crofford
Department of Internal Medicine and Rheumatology, University of Michigan, Room 5510, MSRB I, 1150 W Medical Center Dr, An Arbor, MI 48109 0680, USA
Endocrinol Metab Clin North Am 31:1-13. 2002..Availability of technology to study better central components of the HPA axis may shed further light on its role in the pathogenesis of inflammatory autoimmune rheumatic diseases and musculoskeletal pain syndromes... - Memory beliefs and function in fibromyalgia patientsJennifer M Glass
Institute for Social Research, University of Michigan, 426 Thompson Street, Ann Arbor, MI 48106, United States
J Psychosom Res 58:263-9. 2005..The aim of this study was to investigate memory beliefs and their relationship to actual memory function in fibromyalgia (FM) patients... - Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: a time course studyMohit Kapoor
Department of Internal Medicine, Division of Rheumatology, Room J 509, Kentucky Clinic, University of Kentucky, Lexington, KY 40536 0284, USA
Prostaglandins Leukot Essent Fatty Acids 76:103-12. 2007..In this study, we show that PPARgamma is upregulated during the resolution phase of wound repair concomitant with the shift to PGD2, and may be responsible for initiating endogenous mechanism resulting in healing/resolution... - Growth factor receptors: implications in tumor biologyDivya Mani Srinivasan
University of Kentucky, Department of Molecular and Biomedical Pharmacology, 800 Rose Street, Lexington, KY 40536-0284, USA
Curr Opin Investig Drugs 6:1246-9. 2005..This review discusses the involvement of growth factor receptors in solid tumor formation and their value as potential anticancer drug targets... - Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercisesPhillip J Mease
Seattle Rheumatology Associates, Seattle, Washington 98104, USA
Arthritis Rheum 59:952-60. 2008.... - Why is the management of fibromyalgia syndrome so difficult for rheumatologists?Elizabeth Scarbrough
University of Kentucky in Lexington, KY 40502, USA
Nat Clin Pract Rheumatol 3:480-1. 2007 - High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot studyRichard A Nash
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Blood 110:1388-96. 2007..Sustained responses including a decrease in dermal fibrosis were observed exceeding those previously reported with other therapies. HDIT and autologous HCT for SSc should be evaluated in a randomized clinical trial... - The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgiaLesley M Arnold
Women s Health Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Pain Med 8:633-8. 2007..To assess symptoms of anxiety and depression in a large cohort of fibromyalgia patients and to determine the impact of these symptoms on response of pain to pregabalin treatment... - Controversies in COX-2 selective inhibitionLee S Simon
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Rheumatol 29:1501-10. 2002 - High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomesPeter A McSweeney
University of Colorado Health Sciences Center, Denver 80262, USA
Blood 100:1602-10. 2002..Responses in skin and mHAQ-DI scores exceed those reported with other therapies, suggesting that HDIT is a promising new therapy for SSc that should be evaluated in prospective randomized studies... - Fibromyalgia: where are we a decade after the American College of Rheumatology classification criteria were developed?Leslie J Crofford
Arthritis Rheum 46:1136-8. 2002 - A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorderLesley M Arnold
University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
Arthritis Rheum 50:2974-84. 2004..To assess the efficacy and safety of duloxetine, a serotonin and norepinephrine reuptake inhibitor, in subjects with primary fibromyalgia, with or without current major depressive disorder... - Recommendations for use of selective and nonselective nonsteroidal antiinflammatory drugs: an American College of Rheumatology white paperSonali P Desai
Arthritis Rheum 59:1058-73. 2008 - Fibromyalgia syndromePhilip J Mease
Swedish Medical Center, The University of Washington School of Medicine, Seattle, WA, USA
J Rheumatol 32:2270-7. 2005..A prioritized list of domains of FM to be investigated was thus developed, key issues and controversies in the field were debated, and consensus on a research agenda on outcome measure development was reached... - Fibromyalgia: combining pharmacological and nonpharmacological approaches to treating the person, not just the painDennis C Turk
Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
J Pain 9:99-104. 2008 - Is there a place for non-selective NSAIDs in the treatment of arthritis?Leslie J Crofford
Joint Bone Spine 69:4-7. 2002
Research Grants
- SYNOVIOCYTE RHO-TYPE GTPASES IN CARTILAGE DESTRUCTIONLeslie Crofford; Fiscal Year: 2002..Ultimately, we will determine the effects of the Rho-type GTPases on synoviocyte adherence to and migration over articular cartilage, production of MMPs, and destruction of the cartilage matrix. ..
- NEUROENDOCRINE FUNCTION IN FIBROMYALGIALeslie Crofford; Fiscal Year: 2004..This award will allow for continuing high quality patient-oriented research in central and peripheral neuroendocrine function in FM and other syndromes of chronic musculoskeletal pain. ..
- Prostaglandin E synthase in rheumatoid arthritisLeslie Crofford; Fiscal Year: 2007..These data will provide the scientific basis by which to determine if mPGES-1 is an appropriate target for therapeutic intervention in arthritis. ..
- Microsomal Prostaglandin E Synthase in Rheumatoid ArthritisLeslie J Crofford; Fiscal Year: 2010..It is our expectation that our work will yield new insights into the role of PGs in the functioning of eicosanoids during initiation and resolution of inflammation and the transition from the innate to the acquired immune response. ..