G Cotsarelis

..Ultimately, these findings provide potential targets for the treatment of hair loss and other disorders of skin and hair...

..Understanding the signals important for directing movement and differentiation of bulge cells into different lineages will be important for developing treatments based on stem cells as well as clarifying their role in skin disease...

..epithelial stem cells? How many different kinds are there, and how do they differ functionally? Where exactly in the skin epithelium is each of the putative stem cell subpopulations located, and can we selectively manipulate any of them?..

..Here, we outline the characteristics of common hair loss diseases, and discuss ways in which recent advances in hair follicle biology could be translated into effective therapies for these conditions...

..Ultimately, this information will assist efforts to develop cell-based and cell-targeted treatments for skin disease...

..Finally, we also present evidence that quiescent bulge cells undergo apoptosis during follicle remodeling in catagen, indicating that a subpopulation of bulge cells is not permanent...

..Our findings have implications for both gene therapy and developing treatments for wounds because it will be necessary to consider epidermal and hair follicle stem cells as distinct populations...

..These findings demonstrate the utility of the K15 promoter for targeting epithelial stem cells in the hair follicle bulge and set the stage for elucidating the role of bulge cells in skin biology...

..These findings suggest treatments for wounds, hair loss and other degenerative skin disorders...

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..Considerations and obstacles for using gene therapy to treat alopecias and skin disease are discussed. A theoretical framework for future gene therapy treatments for cutaneous and systemic disorders is presented...

..This suggests that the hair follicle is important but not necessary for normal wound healing...

..The advent of techniques for cultivating inductive dermal cells and competent epithelial stem cells creates the opportunity to bioengineer hair follicles for the treatment of hair loss...

..These findings suggest that VDR and HR, which are both zinc finger proteins, may be in the same genetic pathway that controls postnatal cycling of the hair follicle...

..In aggregate, these studies suggest that reduced regenerative capacity in adults via deletion of a developmentally essential DDR gene is sufficient to cause the premature appearance of age-related phenotypes...

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..Our data also demonstrate that the combination of DNA macroarray, LCM and quantitative real-time PCR is a powerful approach for the study of gene expression in defined cell populations with limited starting material...

..We conclude that desmoglein expression patterns define compartments of cells in similar states of differentiation within the cutaneous epithelium, and reveal a hierarchy of differentiation among these compartments...

..This immunohistochemical staining may be useful in differentiating trichilemmal carcinoma from other clear cell neoplasms...

..These findings demonstrate the importance of the companion layer, and particularly the Dsg1 and Dsg3 in this layer, in anchoring the anagen hair to the follicle...

..33]) and alopecia areata totalis/universalis (52.3 [23.1, 81.5]) were not significantly lower than in normals. Our findings have implications regarding therapeutics, clinical trial design, and understanding the triggers for alopecia...

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..This simple approach has possible biological applications in our study of gene functions in skin, and perhaps future clinical applications for treatment of skin based disorders...

..New work by Weiner et al. (2007) in this issue of Cell now shows that Foxn1 also contributes to hair color by marking which cells are to receive pigment from melanocytes...

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..However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development...

..Some result in hair follicles; others are hair follicle-like. The challenge calls for the development of a set of criteria to define a hair follicle so that bioengineered products in the future can be evaluated...

..These data show that CD34 is required for TPA-induced hair follicle stem cell activation and tumor formation in mice...

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..We also plan to use this system as a model for studying scarring alopecias. Patients with disorders such as alopecia, basal cell carcinoma, hair follicle tumors, or chronic wounds may ultimately benefit from this research. ..

..Our results should have major implications for understanding skin biology and developing future treatments for wounds, alopecia and other degenerative skin disorders. ..

..The role of Bnc's in the EGFr pathway will be discerned. The studies will impact on understanding stem cell biology and the role of Bnc's in wound healing, hair cycling and skin regeneration. ..

..Ultimately, the findings could impact on medical problems related to wound healing, scar formation, aging and other degenerative conditions. ..

..Patients with alopecia, hair shaft disorders, basal cell carcinoma, hair follicle tumors, or chronic wounds could potentially benefit from this research. ..

..Our results should have major implications for understanding skin biology and developing future treatments for wounds, alopecia and other degenerative skin disorders. ..

..This would be the first transgenic inducible injury model that mimics Barrett's esophagus. It should be a valuable resource for those interested in studying the pathogenesis, chemoprevention and treatment of Barrett's esophagus. ..

..Patients with alopecia, hair shaft disorders, basal cell carcinoma, hair follicle tumors, or chronic wounds could potentially benefit from this research. ..