S Corvera

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Phosphoinositides in membrane traffic
    S Corvera
    Program in Molecular Medicine, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Cell Biol 11:460-5. 1999
  2. ncbi Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01615, USA
    Traffic 2:859-66. 2001
  3. ncbi Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada
    Silvia Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:2193-201. 2006
  4. ncbi Signal transduction: stuck with FYVE domains
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Sci STKE 2000:pe1. 2000
  5. ncbi Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01615, USA
    Trends Cell Biol 8:442-6. 1998
  6. ncbi Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 271:21939-43. 1996
  7. ncbi Multivalent endosome targeting by homodimeric EEA1
    J J Dumas
    Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 8:947-58. 2001
  8. ncbi ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1
    S E Langille
    Program in Molecular Medicine, Worcester, Massachusetts 01605, USA
    J Biol Chem 274:27099-104. 1999
  9. ncbi Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Biol Chem 270:18260-3. 1995
  10. ncbi Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655
    J Biol Chem 265:2413-6. 1990

Research Grants

  1. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
  2. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2007
  3. Diabetes Mellitus and the Control of Energy Metabolism
    Silvia Corvera; Fiscal Year: 2005
  4. PI 3-kinase Effectors in Insulin Responsive Systems
    Silvia Corvera; Fiscal Year: 2005
  5. Novel Imaging Technologies applied to Insulin Action
    Silvia Corvera; Fiscal Year: 2004
  6. PI3 KINASE EFFECTORS IN INSULIN RESPONSIVE SYSTEMS
    Silvia Corvera; Fiscal Year: 2001
  7. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010

Collaborators

  • H Stenmark
  • H Meisner
  • MITCHELL LAZAR
  • Olga Gealekman
  • Juerg Straubhaar
  • Michael P Czech
  • My Chouinard
  • Richard A Perugini
  • Alison Burkart
  • Vishwajeet Puri
  • Sarah Nicoloro
  • Leanne Wilson-Fritch
  • D Hartley
  • J J Dumas
  • Khan Van Tran
  • Nina Guseva
  • Celia Hartigan
  • Kunal Gurav
  • Michael Thompson
  • Matthew Gorgoglione
  • Sarah Apotheker
  • S E Langille
  • Anil Chawla
  • Sarah M Nicoloro
  • Sarah M C Nicoloro
  • Srijana Ranjit
  • Silvana Konda
  • Chenyi Lin
  • Patricia C Chui
  • John Leszyk
  • D G Lambright
  • D Rajamani
  • E Sudharshan
  • S Hayes
  • E Merithew
  • D Lawe
  • V Patki
  • A Chawla
  • M P Czech
  • J J Holik
  • J K Klarlund
  • J M Buxton

Detail Information

Publications14

  1. ncbi Phosphoinositides in membrane traffic
    S Corvera
    Program in Molecular Medicine, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Cell Biol 11:460-5. 1999
    ..A novel phosphoinositide appears to regulate effectors involved in the formation of multivesicular endosomes...
  2. ncbi Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01615, USA
    Traffic 2:859-66. 2001
    ....
  3. ncbi Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada
    Silvia Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:2193-201. 2006
    ....
  4. ncbi Signal transduction: stuck with FYVE domains
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Sci STKE 2000:pe1. 2000
    ..The Perspective also addresses how proteins with FYVE domains and protein internalization are involved in signal transduction...
  5. ncbi Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01615, USA
    Trends Cell Biol 8:442-6. 1998
    ..This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides has revealed novel potential interconnections between these fundamental cellular processes...
  6. ncbi Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 271:21939-43. 1996
    ..PI 3-kinase complexes occur upstream or independently of mitogenic signal transduction pathways in T cells...
  7. ncbi Multivalent endosome targeting by homodimeric EEA1
    J J Dumas
    Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 8:947-58. 2001
    ..A unique mode of membrane engagement deduced from the quaternary structure of the C-terminal region provides insight into the structural basis of endosome tethering...
  8. ncbi ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1
    S E Langille
    Program in Molecular Medicine, Worcester, Massachusetts 01605, USA
    J Biol Chem 274:27099-104. 1999
    ..Further, co-localization of GRP1 with ARF6, combined with its demonstrated ability to activate ARF6, suggests a physiological role for GRP1 in regulating ARF6 functions...
  9. ncbi Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Biol Chem 270:18260-3. 1995
    ..Thus, these results show important functional differences between the alpha and beta isoforms of p85 in vivo and point to c-cbl as a potentially important mediator of some of the functions of PI-3 kinase in intact cells...
  10. ncbi Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655
    J Biol Chem 265:2413-6. 1990
    ..These results suggest that insulin induces an increase in the assembly of cytosolic clathrin onto the plasma membrane in conjunction with its ability to increase the concentration of receptors on the cell surface...
  11. ncbi Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity
    Olga Gealekman
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01615, USA
    Circulation 123:186-94. 2011
    ..The objective of this study was to measure angiogenesis in visceral and subcutaneous adipose tissue and to establish whether there is a relationship between obesity, metabolic status, and the angiogenic properties of these depots...
  12. ncbi Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
    Leanne Wilson-Fritch
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01601, USA
    J Clin Invest 114:1281-9. 2004
    ....
  13. ncbi Cidea is associated with lipid droplets and insulin sensitivity in humans
    Vishwajeet Puri
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 105:7833-8. 2008
    ..The data support a model whereby failure of this pathway results in ectopic lipid accumulation, insulin resistance, and its associated comorbidities in humans...
  14. ncbi Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production
    Olga Gealekman
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Am J Physiol Endocrinol Metab 295:E1056-64. 2008
    ..Thus, the interplay between VEGF and ANGPTL4 could lead to a net expansion of the adipose tissue capillary network, required for adipose tissue growth, in response to PPARgamma activators...

Research Grants19

  1. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
    ..4) Define the mechanism of action of WDFY2 by identifying proteins that specifically interact with its WD-40 motifs using proteomic and 2-hybrid approaches. ..
  2. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2007
    ..4) Define the mechanism of action of WDFY2 by identifying proteins that specifically interact with its WD-40 motifs using proteomic and 2-hybrid approaches. ..
  3. Diabetes Mellitus and the Control of Energy Metabolism
    Silvia Corvera; Fiscal Year: 2005
    ..Collaborative efforts between investigators in these areas and those involved in chemistry and therapeutics are envisioned to result from this meeting. ..
  4. PI 3-kinase Effectors in Insulin Responsive Systems
    Silvia Corvera; Fiscal Year: 2005
    ..To test the hypothesis that signal transduction to nuclear import requires endosomal localization, we will study two paradigms; the TGFbeta to Smad2 pathway, and the insulin to p42/44 MAP kinase pathway. ..
  5. Novel Imaging Technologies applied to Insulin Action
    Silvia Corvera; Fiscal Year: 2004
    ..SPECIFIC AIM 4: To test the hypothesis that insulin stimulates budding of GLUT4 vesicles from the juxtanuclear region by imaging at higher spatial and temporal resolution. ..
  6. PI3 KINASE EFFECTORS IN INSULIN RESPONSIVE SYSTEMS
    Silvia Corvera; Fiscal Year: 2001
    ..3) To characterize the structure and general function of accessory peptides that have been found to interact with EEA1. 4) To determine which of the known PI-3 kinases present in mammalian cells is relevant for EEA1 function. ..
  7. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
    ..4) Define the mechanism of action of WDFY2 by identifying proteins that specifically interact with its WD-40 motifs using proteomic and 2-hybrid approaches. ..