Research Topics
Genomes and Genes | Max D CooperSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The evolution of adaptive immune systemsMax D Cooper
Division of Developmental and Clinical Immunology, Departments of Medicine, Microbiology, Pediatrics, and Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Cell 124:815-22. 2006..The convergent evolution of these remarkably different adaptive immune systems involved innovative genetic modification of innate-immune-system components...- A conserved gene family encodes transmembrane proteins with fibronectin, immunoglobulin and leucine-rich repeat domains (FIGLER)Delicia L Munfus
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
BMC Biol 5:36. 2007..A bioinformatics approach was therefore used to identify IL-7 receptor related genes in the hope of identifying the elusive human cytokine... - Variable lymphocyte receptors in hagfishZeev Pancer
Division of Developmental and Clinical Immunology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 102:9224-9. 2005..The development of two very different strategies for receptor diversification at the dawn of vertebrate evolution approximately 500 million years ago attests to the fitness value of a lymphocyte-based system of anticipatory immunity... - Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitmentChristopher L Haga
Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 104:9770-5. 2007..Although its ligand is presently unknown, we conclude that FCRL5 has the functional potential to serve as an inhibitory coreceptor on mature B cells in humans... - Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cellsGotz R A Ehrhardt
Division of Clinical and Developmental Immunology, University of Alabama at Birmingham, Birmingham, Birmingham, AL 35294, USA
J Exp Med 202:783-91. 2005..Cell surface FcRH4 expression thus marks a unique population of memory B cells with distinctive morphology, functional capabilities, and tissue localization... - Antibody responses of variable lymphocyte receptors in the lampreyMatthew N Alder
Office of Fundamental Immunology Research, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA
Nat Immunol 9:319-27. 2008..Lacking a thymus and the ability to respond to soluble protein antigens, lampreys seem to have evolved a B cell-like system for adaptive humoral responses... - Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genesZhixin Zhang
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, 35294, USA
Nat Immunol 7:616-24. 2006..These findings indicate a direct activating function for Pax5 in RAG-mediated immunoglobulin V(H)-to-DJ(H) recombination... - IgEb immune complexes activate macrophages through FcgammaRIV bindingMasayuki Hirano
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nat Immunol 8:762-71. 2007..IgE(b) antibody-mediated modification of macrophage responses may therefore influence mouse asthma models and strain-dependent differences in parasite susceptibility... - FcRH1: an activation coreceptor on human B cellsChuen Miin Leu
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, WTI378, Birmingham, AL 35294 3300, USA
Blood 105:1121-6. 2005..Concomitant FcRH1 ligation enhances B-cell antigen receptor (BCR)-induced Ca(2+) mobilization and proliferation. FcRH1 thus has the potential to serve as an activating coreceptor on B cells... - Contribution of Vh gene replacement to the primary B cell repertoireZhixin Zhang
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Immunity 19:21-31. 2003..Surprisingly, the residual 3' sequences of replaced V(H) genes contribute charged amino acids to the CDR3 region, a hallmark of autoreactive antibodies... - Diversity and function of adaptive immune receptors in a jawless vertebrateMatthew N Alder
Howard Hughes Medical Institute, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Science 310:1970-3. 2005..These findings reveal that two strikingly different modes of antigen recognition through rearranged lymphocyte receptors have evolved in the jawless and jawed vertebrates... - FcR-like 2 Inhibition of B cell receptor-mediated activation of B cellsTanisha A Jackson
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 185:7405-12. 2010..These findings suggest a negative immunomodulatory function for FCRL2 in the regulation of memory B cells... - Differential B cell expression of mouse Fc receptor homologsRandall S Davis
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, 35294 3300, USA
Int Immunol 16:1343-53. 2004..The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells... - Structure and specificity of lamprey monoclonal antibodiesBrantley R Herrin
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 105:2040-5. 2008..quot; Remarkable antigen-binding specificity, avidity, and stability predict that these unusual LRR-based monoclonal antibodies will find many biomedical uses... - Somatic diversification of variable lymphocyte receptors in the agnathan sea lampreyZeev Pancer
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nature 430:174-80. 2004..Different evolutionary strategies were thus used to generate highly diverse lymphocyte receptors through rearrangement of LRR modules in agnathans (jawless fish) and of immunoglobulin gene segments in gnathostomes (jawed vertebrates)... - V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B-cell differentiationYui-Hsi Wang
Division of Developmental and Clinical Immunology, and Department of Medicine, University of Alabama at Birmingham and the Howard Hughes Medical Institute, Birmingham, AL 35294, USA
Blood 101:1030-7. 2003..These findings validate the principle of intraclonal V(D)J diversification during B-cell generation and define a manipulable model of human B-cell differentiation... - Molecular mechanism of serial VH gene replacementZhixin Zhang
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Ann N Y Acad Sci 987:270-3. 2003..Serial VH replacements may represent an additional mechanism for diversification of the primary B cell repertoire... - The molecular basis and biological significance of VH replacementZhixin Zhang
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
Immunol Rev 197:231-42. 2004..VH replacement can thus play a complex role in the generation of the primary B-cell repertoire... - The inhibitory potential of Fc receptor homolog 4 on memory B cellsGotz R A Ehrhardt
Divisions of Developmental and Clinical Immunology and Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 100:13489-94. 2003..These findings indicate the potential for FcRH4 to abort B cell receptor signaling by recruiting SHP-1 and SHP-2 to its two membrane distal ITIMs... - An extended family of Fc receptor relativesRandall S Davis
Division of Developmental and Clinical Immunology, University of Alabama, Birmingham, USA
Eur J Immunol 35:674-80. 2005..Their ligands, function, and prospective roles as diagnostic B cell markers and therapeutic targets are topics of intense interest... - Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lampreyZeev Pancer
Department of Medicine, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
Proc Natl Acad Sci U S A 101:13273-8. 2004..Thus, the TCR-like gene cannot account for the receptor diversity that is required for the immune responses reported for lamprey, but it could have been easily modified to serve as an evolutionary precursor of modern TCR and Ig genes... - Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene familyRandall S Davis
Division of Hematology/Oncology, University of Alabama at Birmingham, AL 35294, USA
Immunol Rev 190:123-36. 2002..The unique individual and polymorphic properties of the FcR/FcRH members indicate a remarkably diverse Fc receptor gene family with immunoregulatory function... - Differential surrogate light chain expression governs B-cell differentiationYui-Hsi Wang
Department of Medicine, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, 1824 6th Avenue S, Birmingham, AL 35294-3300, USA
Blood 99:2459-67. 2002.... - Exploring lymphocyte differentiation pathwaysMax D Cooper
Howard Hughes Medical Institute and Medicine, Pediatrics, Microbiology and Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-3300, USA
Immunol Rev 185:175-85. 2002..A recurring theme in this essay is the interplay between understanding normal lymphocyte differentiation and the defects that underlie immunodeficiency diseases and lymphoid malignancies... - The transient expression of pre-B cell receptors governs B cell developmentPeter D Burrows
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, WTI 378, 1824 6th Avenue South, Birmingham, AL 35294-3300, USA
Semin Immunol 14:343-9. 2002..Silencing of the surrogate light chain genes, VpreB and lambda5, then terminates preBCR expression to permit cell cycle exit, recombinase gene upregulation, and VJ(L) rearrangement by small pre-B cells destined to become B cells... - Mast cell regulation via paired immunoglobulin-like receptor PIR-BChing Cheng Chen
Department of Microbiology, University of Alabama at Birmingham, 35294, USA
Immunol Res 26:191-7. 2002..This analysis suggests that PIR-B may serve to control mast cell activity... - Variable domains and a VpreB-like molecule are present in a jawless vertebrateJohn P Cannon
Department of Molecular Genetics, All Children's Hospital, 801 Sixth Street South, St. Petersburg, FL 33701, USA
Immunogenetics 56:924-9. 2005..This is the first indication of a molecule related to the B cell receptor (BCR) complex in a species that diverged prior to the jawed vertebrates in which RAG-mediated adaptive immunity is first encountered... - The evolution of adaptive immunityZeev Pancer
Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
Annu Rev Immunol 24:497-518. 2006.... - Recognition strategies in the innate immune system of ancestral chordatesKonstantin Khalturin
Zoological Institute, Christian Albrechts University, Olshausenstrasse 40, 24098 Kiel, Germany
Mol Immunol 41:1077-87. 2004..To understand better the evolution of adaptive immune systems, more comparative data from jawless vertebrates (lamprey or hagfish) and a representative of Acrania (e.g. Amphioxus) are clearly needed... - Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gatewayRyo Goitsuka
Research Institute for Biological Sciences, Tokyo University of Science, Noda, Chiba 278 0022, Japan
Proc Natl Acad Sci U S A 104:15063-8. 2007..We conclude that chCATH-B1 is well placed to serve a protective antimicrobial role at the M cell gateway... - TCL1 participates in early embryonic development and is overexpressed in human seminomasMaria Grazia Narducci
Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, 00167 Rome, Italy
Proc Natl Acad Sci U S A 99:11712-7. 2002..This finding suggests that TCL1 dysregulation could contribute to the development of this germinal cell cancer as well as lymphoid malignancies... - Isolation and characterization of lymphocyte-like cells from a lampreyWerner E Mayer
, Abteilung Immungenetik, Corrensstrasse 42, , Germany
Proc Natl Acad Sci U S A 99:14350-5. 2002..The data suggest that the evolution of lymphocytes in the lamprey has reached a stage poised for the emergence of adaptive immunity... - Antigen recognition by variable lymphocyte receptorsByung Woo Han
Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
Science 321:1834-7. 2008..The concave surface assembled from the most highly variable regions of the LRRs, along with diversity in the sequence and length of the highly variable insert, can account for the recognition of diverse antigens by VLRs... - Inhibition of immune cell functionMax D Cooper
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Immunol Rev 224:7-10. 2008 - Discriminating gene expression profiles of memory B cell subpopulationsGotz R A Ehrhardt
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
J Exp Med 205:1807-17. 2008.... - Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cellsRandall S Davis
Division of Hematology Oncology, University of Alabama, Bimingham 35294, USA
Int Immunol 14:1075-83. 2002..FcRX transcripts are found primarily in secondary lymphoid tissues, where they are expressed by B lineage cells. FcRX thus may function as a secreted or intracellular protein in normal and neoplastic B cells... - Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytesTatiana Uinuk-Ool
Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, D 72076 Tubingen, Germany
Proc Natl Acad Sci U S A 99:14356-61. 2002..It reopens the question of the stage jawless fishes reached in the evolution of their immune system... - The functions of the thymus system and the bursa system in the chicken. 1966Max D Cooper
J Immunol 176:6370-404. 2006 - New nomenclature for Fc receptor-like moleculesLois J Maltais
Nat Immunol 7:431-2. 2006 - Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptorsKyoko Masuda
Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
EMBO J 24:4052-60. 2005..These findings disclose a prethymic stage of T-cell development programmed for immigration of the thymus, which is genetically separable from intrathymic stages... - Macrophage migration inhibitory factor (MIF) of jawed and jawless fishes: implications for its evolutionary originAkie Sato
Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, Tubingen D 72076, Germany
Dev Comp Immunol 27:401-12. 2003..It also reveals a high degree of convergent evolution among the members of the family. Finally, it suggests that the divergence of MIF and DDT occurred before the emergence of nematodes in metazoan evolution... - Identification and characterization of a TAP-family gene in the lampreyTatiana S Uinuk-Ool
Abteilung Immungenetik, Max Planck Institut fur Biologie, Corrensstrasse 42, 72076, Tubingen, Germany
Immunogenetics 55:38-48. 2003..The lamprey protein also contains sequence stretches that resemble the putative peptide interacting parts of the TAP1 and TAP2 molecules, but are peppered with ABCB9-specific residues... - Impaired T- and B-cell development in Tcl1-deficient miceSang Moo Kang
University of Alabama at Birmingham and the Howard Hughes Medical Institute, USA
Blood 105:1288-94. 2005..This analysis indicates a significant role for Tcl1, a coactivator of Akt signaling, in normal T- and B-cell development and function... - Why study the evolution of immunity?Gary W Litman
Department of Pediatrics, University of South Florida Children's Research Institute, St. Petersburg, Florida 33701, USA
Nat Immunol 8:547-8. 2007
Research Grants
- IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYHarry Schroeder; Fiscal Year: 2007....
- Characterization of the Lamprey Adaptive Immune SystemMax Cooper; Fiscal Year: 2007..The experiments proposed here will define biological and structural features of the VLRs in order to explore their potential for health-related uses. ..
- Comparison of B Cell Differentiation in Mice and HumansMax Cooper; Fiscal Year: 2007..This comparative analysis will define novel features of B cell differentiationthat are likely to have significant clinical implications. ..