Research Topics
| Lyndon CooperSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Immediate implant placement and restoration in the anterior maxilla: a tissue-related approach. Observations at 12 months after loadingOnder Solakoglu
International Fellow of Oral and Maxillofacial Implants, Department of Periodontology, University of North Carolina at Chapel Hill, USA
Int J Periodontics Restorative Dent 26:571-9. 2006..This tissue-related, esthetically driven treatment strategy is comprehensively presented with a follow-up of 12 months postoperatively...- Immediate mandibular rehabilitation with endosseous implants: simultaneous extraction, implant placement, and loadingLyndon F Cooper
Department of Prosthodontics, University of North Carolina School of Dentistry Bone Biology, Chapel Hill 27599, USA
Int J Oral Maxillofac Implants 17:517-25. 2002.... - Objective criteria: guiding and evaluating dental implant estheticsLyndon F Cooper
Department of Prosthodontics, UNC School of Dentistry, Chapel Hill, NC 27599, USA
J Esthet Restor Dent 20:195-205. 2008 - Three-year evaluation of single-tooth implants restored 3 weeks after 1-stage surgeryLyndon F Cooper
Department of Prosthodontics, University of North Carolina, Chapel Hill, NC 27599 7450, USA
Int J Oral Maxillofac Implants 22:791-800. 2007..A secondary objective was to determine peri-implant tissue responses at these implants... - The immediate loading of dental implantsLyndon F Cooper
Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina School of Dentistry, Chapel Hill, North Carolina, USA
Compend Contin Educ Dent 28:216-25; quiz 226. 2007.... - A role for surface topography in creating and maintaining bone at titanium endosseous implantsL F Cooper
Department of Prosthodontics, School of Dentistry, The University of North Carolina at Chapel Hill, 27599 7450, USA
J Prosthet Dent 84:522-34. 2000..A variety of claims are made regarding the effects of surface topography on implant osseointegration. Many in vivo and in vitro experimental observations have key limitations in their interpretations... - Fluoride modification effects on osteoblast behavior and bone formation at TiO2 grit-blasted c.p. titanium endosseous implantsLyndon F Cooper
Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina at Chapel Hill, 404 Brauer Hall, CB 7450, Chapel Hill, NC 27511, USA
Biomaterials 27:926-36. 2006..The mechanism(s) by which fluoride ion modification of c.p.titanium enhanced osteoblastic differentiation and osseointegration merit careful investigation... - Immediate fixed restoration of the edentulous maxilla after implant placementLyndon Cooper
Department of Prosthodontics, School of Dentistry, University of North Carolina, 114 Dental Research Center, CB 7455, Chapel Hill, NC 27599, USA
J Oral Maxillofac Surg 63:97-110. 2005..When the treatment plan is transferred directly from the tomographic template to the surgical template to the conversion prosthesis used for immediate loading, the surgical and prosthodontic management of this procedure is well defined... - Investigation of a thermoplastic polymeric carrier for bone tissue engineering using allogeneic mesenchymal stem cells in granular scaffoldsDimitrios Mylonas
Department of Prosthodonthics, UNC School of Dentistry, Chapel Hill, NC 27599, USA
J Prosthodont 16:421-30. 2007.... - The current and future treatment of edentulismLyndon F Cooper
Stallings Distinguished Professor Chair, Department of Prosthodontics, University of North Carolina School of Dentistry, Chapel Hill, NC 27599, USA
J Prosthodont 18:116-22. 2009..The importance of therapeutic technical quality can be underscored, but should not overwhelm the broader concerns for assuring the overall health and well-being of the edentulous population... - Factors influencing primary dental implant stability remain unclearLyndon F Cooper
Prosthodontics and Dental Research, UNC School of Dentistry, Chapel Hill, NC 27599, USA
J Evid Based Dent Pract 10:44-5. 2010.... - A multicenter 12-month evaluation of single-tooth implants restored 3 weeks after 1-stage surgeryL Cooper
Department of Prosthodontics, University of North Carolina, 404 Brauer Hall CB 7450, Chapel Hill, North Carolina 27599, USA
Int J Oral Maxillofac Implants 16:182-92. 2001..This 2-component system is suited to a single-stage, rapid loading protocol for esthetic single-tooth replacement... - Incipient analysis of mesenchymal stem-cell-derived osteogenesisL F Cooper
1 Dental Research Center, University of North Carolina School of Dentistry, Chapel Hill, 27559 7450, USA
J Dent Res 80:314-20. 2001.... - Comparison of radiographic and clinical outcomes following immediate provisionalization of single-tooth dental implants placed in healed alveolar ridges and extraction socketsLyndon F Cooper
Department of Prosthodontics, University of North Carolina, Chapel Hill, NC 27599, USA
Int J Oral Maxillofac Implants 25:1222-32. 2010..Secondary outcomes were to compare marginal bone adaptation and soft tissue changes over time... - Transcriptional regulation involving the intronic heat shock element of the rat hsp27 geneL F Cooper
Department of Biochemistry and Biophysics, School of Medicine, 308 Brauer Hall, CB 7450, University of North Carolina, Chapel Hill, NC 27599, USA
Biochim Biophys Acta 1490:348-54. 2000..Mutation of the i-HSE reversed this effect. Further study is required to define the mechanism by which the i-HSE-containing region of the hsp27 promoter may mediate negative regulation of hsp27 transcription... - Five-year prospective evaluation of mandibular overdentures retained by two microthreaded, TiOblast nonsplinted implants and retentive ball anchorsLyndon F Cooper
Department of Prosthodontics, UNC School of Dentistry, 330 Brauer Hall, CB 7450, Chapel Hill, NC 27599 7450, USA
Int J Oral Maxillofac Implants 23:696-704. 2008..The aim of this 5-year prospective evaluation was to assess the bone and peri-implant mucosa responses at unsplinted, microthread implants supporting mandibular overdentures and to determine patient responses to therapy... - Estrogen-induced resistance to osteoblast apoptosis is associated with increased hsp27 expressionL F Cooper
University of North Carolina, Dental Research Center, Chapel Hill, North Carolina, USA
J Cell Physiol 185:401-7. 2000..Similar treatment increased SMER14 cell hsp27 levels. The concurrent reduction in induced apoptosis suggests a possible estrogenic mechanism for increasing and/or maintaining the number of viable osteoblasts in bone... - Evidence-based guidelines for the care and maintenance of complete dentures: a publication of the American College of ProsthodontistsDAVID FELTON
Department of Prosthodontics, School of Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
J Prosthodont 20:S1-S12. 2011..These guidelines reflect the views of the task force... - Immediate loading of implants in edentulous mandible maintaining vertical dimension: A clinical reportBehnoush Rashedi
School of Dentistry, University of Pennsylvania, Philadelphia, USA
J Prosthet Dent 91:114-8. 2004..This process assisted in the patient's adaptation to the interim removable partial denture and ensured the maintenance of the vertical dimension of occlusion during all aspects of therapy... - Evaluation of a predictive model for implant surface topography effects on early osseointegration in the rat tibia modelA Abron
The Dental Research Center and School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
J Prosthet Dent 85:40-6. 2001..CONCLUSION: Implant surfaces with a proposed ideal pit morphology (which possess a calculated biomechanical significance) enhanced bone formation at early periods after placement in the rat tibia model... - Formation of mineralizing osteoblast cultures on machined, titanium oxide grit-blasted, and plasma-sprayed titanium surfacesL F Cooper
Department of Prosthodontics, University of North Carolina School of Dentistry, Chapel Hill, USA
Int J Oral Maxillofac Implants 14:37-47. 1999..Similar molecular and cellular assessment of in vivo responses to implant surface topography may contribute to improved engineering of endosseous implants... - Spatiotemporal assessment of fetal bovine osteoblast culture differentiation indicates a role for BSP in promoting differentiationL F Cooper
Department of Prosthodontics, University of North Carolina School of Dentistry, Chapel Hill 27599 7450, USA
J Bone Miner Res 13:620-32. 1998..Matrix protein-cell interactions may be examined using this spatiotemporally defined model... - Immunolocalization of stress proteins and extracellular matrix proteins in the rat tibiaJ C Tiffee
University of North Carolina, Dental Research Center, Chapel Hill 27599, USA
Tissue Cell 32:141-7. 2000..They also suggest that hsps have cytoprotective and biosynthetic functions within osteoblasts and chondrocytes, but apoptotic signals may override these effects in some instances, resulting in apoptosis... - Titanium surface topography alters cell shape and modulates bone morphogenetic protein 2 expression in the J774A.1 macrophage cell lineJ Takebe
Dental Research Center, University of North Carolina School of Dentistry, Chapel Hill, North Carolina 27599, USA
J Biomed Mater Res A 64:207-16. 2003..This first demonstration of BMP-2 expression by cpTi adherent macrophages suggests that the macrophage may contribute surface-specific osteoinductive signals during bone formation at implanted alloplastic surfaces... - Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2C M Champagne
Dental Research Center, University of North Carolina School of Dentistry, Chapel Hill, NC 27599 7450, USA
Bone 30:26-31. 2002..This first study of macrophage BMP-2 expression indicates that the macrophage is capable of physiological regulation consistent with a key role in osteoinduction for osseous wound healing... - Effect of vitamin D pretreatment of human mesenchymal stem cells on ectopic bone formationI J De Kok
Bone Biology and Implant Therapy Laboratory, University of North Carolina School of Dentistry, Chapel Hill 27599, USA
J Oral Implantol 32:103-9. 2006..Predifferentiation strategies require confirmation in vivo... - Influence of an LRP5 cytoplasmic SNP on Wnt signaling and osteoblastic differentiationJ Guo
Curriculum in Oral Biology, Bone Biology and Implant Therapy Laboratory, 404 Brauer Hall, CB 7450 School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
Bone 40:57-67. 2007..LRP5 signaling is affected by the cytoplasmic SNP, p.V1525A. mRNA levels of Runx2 and Osterix were not affected by this SNP... - Evidence-based guidelines for the care and maintenance of complete dentures: a publication of the American College of ProsthodontistsDAVID FELTON
Department of Prosthodontics, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
J Am Dent Assoc 142:1S-20S. 2011..These guidelines reflect the views of the task force... - Comparison of bone graft matrices for human mesenchymal stem cell-directed osteogenesisC T Harris
Bone Biology and Implant Therapy Laboratory, University of North Carolina School of Dentistry, Chapel Hill, North Carolina 27599, USA
J Biomed Mater Res A 68:747-55. 2004..The necessary induction of hMSCs along the osteoblastic lineage may be dependent, in part, on the local microenvironment established by the scaffold chemistry and interactions with the host... - Periapical abscess formation and resolution adjacent to dental implants: a clinical reportN R Chaffee
School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Prosthet Dent 85:109-12. 2001..The risk of periapical infection at teeth adjacent to implants must be minimized... - A modular approach to dental implant therapy: the appropriate selection of one- and two-stage surgeriesLyndon F Cooper
Bone Biology and Implant Therapy Laboratory, Department of Prosthodontics, University of North Carolina, School of Dentistry, Chapel Hill, North Carolina, USA
Compend Contin Educ Dent 23:4-12. 2002..The biological and mechanical advantages of conus implant-abutment interfaces reinforce the selection of modular implants for the broad application of one-stage dental implant procedures... - What physical and/or biochemical characteristics of roughened endosseous implant surfaces particularly enhance their bone-implant contact capability?Lyndon F Cooper
University of North Carolina at Chapel Hill, USA
Int J Oral Maxillofac Implants 20:307-12. 2005 - Advancing dental implant surface technology--from micron- to nanotopographyGustavo Mendonça
Universidade Catolica de Brasilia, Pos Graduacao em Ciencias Genomicas e Biotecnologia, SGAN Quadra 916, Av W5 Norte 70 790 160 Brasília, DF, Brazil
Biomaterials 29:3822-35. 2008..Nanoscale modification of titanium endosseous implant surfaces can alter cellular and tissue responses that may benefit osseointegration and dental implant therapy... - A retrospective radiographic analysis of bone loss following placement of TiO2 grit-blasted implants in the posterior maxilla and mandiblePaige Warren
Department of Prosthodontics, University of North Carolina, Chapel Hill, USA
Int J Oral Maxillofac Implants 17:399-404. 2002..CONCLUSIONS: Several clinical advantages for maintaining crestal bone at implants supporting posterior prostheses can be identified... - The effect of hydrofluoric acid treatment of TiO2 grit blasted titanium implants on adherent osteoblast gene expression in vitro and in vivoJuanli Guo
Dental Research Center, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Biomaterials 28:5418-25. 2007..In vivo assessments of implant adherent cell phenotypes provide further insight into the mechanisms affecting alloplast-tissue interactions... - Investigation of allogeneic mesenchymal stem cell-based alveolar bone formation: preliminary findingsIngeborg J De Kok
School of Dentistry, University of North Carolina, Chapel Hill, NC 27599, USA
Clin Oral Implants Res 14:481-9. 2003..At 9 weeks, labelled cells were present within the lacunae of newly formed bone. We conclude that autologous and allogeneic MSCs have the capacity to regenerate bone within craniofacial defects... - Facial distortion secondary to idiopathic gingival hyperplasia: surgical management and oral reconstruction with endosseous implantsPaul S Tiwana
Department of Oral and Maxillofacial Surgery, The University of North Carolina Hospitals and School of Dentistry, Chapel Hill, NC 27599-7450, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:153-7. 2005..Restoration of esthetics and function with a maxillary denture and mandibular overdenture were completed 3 months later. No disease recurrence was noted at the 6-month postoperative interval... - The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide productionKai Soo Tan
Comprehensive Center for Inflammatory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, 404 Brauer Hall, CB #7450, Chapel Hill, NC 27511, USA
Biomaterials 27:5170-7. 2006..The responses of J744A.1 cells to surface and superimposed LPS stimulation suggest only modest effects of the modeled endosseous implant surface on adherent cell pro-inflammatory cytokine expression and NO signaling... - A retrospective analysis of peri-implant tissue responses at immediate load/provisionalized microthreaded implantsIngeborg J De Kok
Department of Prosthodontics, Bone Biology and Implant Therapy Laboratory, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Int J Oral Maxillofac Implants 21:405-12. 2006..Control of peri-implant tissues can be achieved to provide predictable and esthetic treatment for anterior tooth replacement using dental implants... - The role of abutment-attachment selection in resolving inadequate interarch distance: a clinical reportAbdullah S Alsiyabi
Prosthodontics Department, Military Dental Services, Royal Army of Oman, Sultanate of Oman
J Prosthodont 14:184-90. 2005..A guide for abutment-attachment selection using one commercially available implant system is given... - Evaluation of mesenchymal stem cells following implantation in alveolar sockets: a canine safety studyIngeborg J De Kok
Department of Prosthodontics, University of North Carolina, Chapel Hill, North Carolina, USA
Int J Oral Maxillofac Implants 20:511-8. 2005..CONCLUSIONS: An alveolar socket model may be an appropriate model for initial clinical investigation of MSC-mediated bone repair... - Immediate loading of dental implants in partially edentulous patients: a clinical reportMaria Chatzistavrou
Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill 27599, USA
J Prosthodont 12:26-9. 2003..This report presents a case of a partially edentulous patient successfully restored with a fixed implant prosthesis following an immediate loading protocol... - Prosthetic complications in an implant-retained mandibular overdenture population: initial analysis of a prospective studyNancy R Chaffee
Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
J Prosthet Dent 87:40-4. 2002..The clinical success of implant-retained, tissue-supported mandibular overdenture prostheses has been documented. However, few studies have evaluated the return visits and associated cost required to maintain these prostheses... - Human adipose-derived adult stem cells produce osteoid in vivoKevin C Hicok
Artecel Sciences, Durham, North Carolina, USA
Tissue Eng 10:371-80. 2004..In summary, the data demonstrate the ability of ADAS cells to form osteoid matrix in vivo. Because of their abundance and accessibility, ADAS cells may prove to be a novel cell therapeutic for bone repair and regeneration... - Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZCai Bin Cui
Department of Periodontology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Cell Biol 23:1004-13. 2003..These data indicate that TAZ is a transcription coactivator for Cbfa1 and may be involved in the regulation of osteoblast differentiation... - Effects of Delta12-prostaglandin J2 on bone regeneration and growth factor expression in ratsDamrong Damrongsri
Department of Anatomy, School of Dentistry, Chulalongkorn University, Bangkok, Thailand
Clin Oral Implants Res 17:48-57. 2006..Enhanced expression of BMP-2 and -6 as well as PDGF-A and -B may be involved in Delta(12)-PGJ(2)-induced new bone formation... - Is the tissue-integrated interface a periodontium analogue: myth or metaphor?Lyndon F Cooper
Bone Biology and Implant Therapy Laboratory, Graduate Prosthodontics Program, University of North Carolina School of Dentistry, Chapel Hill, USA
Int J Prosthodont 16:32-4; discussion 47-51. 2003
Research Grants
- Inflammatory Control of Periodontal RegenerationLyndon Cooper; Fiscal Year: 2007..Characterization of inflammatory signaling effects of the emergence bone forming cells for tissue repair may identify new therapeutic targets and avenues for treatment of chronic inflammatory diseases like periodontitis. ..
- Inflammatory Control of Periodontal RegenerationLyndon Cooper; Fiscal Year: 2009..Characterization of inflammatory signaling effects of the emergence bone forming cells for tissue repair may identify new therapeutic targets and avenues for treatment of chronic inflammatory diseases like periodontitis. ..
- Inflammatory Control of Periodontal RegenerationLyndon F Cooper; Fiscal Year: 2010..Characterization of inflammatory signaling effects of the emergence bone forming cells for tissue repair may identify new therapeutic targets and avenues for treatment of chronic inflammatory diseases like periodontitis. ..