Research Topics
| E ConnickSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
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Detail Information
Publications
HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse modelBradford K Berges
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Retrovirology 3:76. 2006..Thus, this model shows considerable promise to study long-term in vivo HIV infection and pathogenesis...- CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissueElizabeth Connick
Division of Infectious Diseases, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
J Immunol 178:6975-83. 2007..Mechanisms underlying the exclusion of CTL from lymphoid follicles as well as the role of lymphoid follicles in perpetuating other chronic pathogens merit further investigation... - Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapyElizabeth Connick
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
Clin Infect Dis 39:1852-5. 2004..Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy... - Immune reconstitution in HIV-1-infected individuals treated with potent antiretroviral therapyE Connick
University of Colorado Health Sciences Center, Department of Medicine, Division of Infectious Diseases, Denver 80262, USA
J Investig Dermatol Symp Proc 6:212-8. 2001.... - Relationship between human immunodeficiency virus type 1 (HIV-1)-specific memory cytotoxic T lymphocytes and virus load after recent HIV-1 seroconversionE Connick
Department of Medicine, Division of Infectious Disease, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Infect Dis 184:1465-9. 2001..0220) and highest Gag precursor CTL frequencies (P=.0128). These data suggest that host factors that restrict viral replication may be important determinants of the level of HIV-1-specific precursor CTL... - Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic responseE Connick
University of Colorado Health Sciences Center, Box B168, 4200 E Ninth Ave, Denver, CO 80220, USA
J Infect Dis 181:358-63. 2000..Plasma virus suppression <100 copies/mL was not significantly correlated with increases in CD4+ T cells or functional immune reconstitution... - Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 TeamD R Kuritzkes
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Infect Dis 181:491-7. 2000..Suppression of plasma HIV-1 RNA despite presence of zidovudine resistance mutations implies that the presence of these mutations does not preclude a durable response to treatment with a potent 3-drug regimen... - Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen. ACTG 375 team. AIDS Clinical Trials GroupH Valdez
Division of Infectious Diseases, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Ohio 44106, USA
AIDS 14:11-21. 2000.... - Reduced antiretroviral drug susceptibility among patients with primary HIV infectionS J Little
Department of Medicine, University of California, San Diego, USA
JAMA 282:1142-9. 1999..The transmission of drug-resistant human immunodeficiency virus (HIV) has been documented, but the prevalence of such transmission is unknown... - Phase 1 trial of a single dose of recombinant human interleukin-12 in human immunodeficiency virus-infected patients with 100-500 CD4 cells/microLM A Jacobson
Positive Health Program, Department of Medicine, University of California, San Francisco, CA 94110, USA
J Infect Dis 182:1070-6. 2000..Single rhIL-12 doses of 30-300 ng/kg were well tolerated and had biologic activity that could potentially be of benefit in the treatment of HIV disease or its complications... - Ototoxicity associated with use of nucleoside analog reverse transcriptase inhibitors: a report of 3 possible cases and review of the literatureJ Simdon
Investigational Drugs Section, Veterans Affairs Medical Center, Denver, CO, USA
Clin Infect Dis 32:1623-7. 2001..Prospective studies are necessary to determine the incidence of tinnitus and hearing loss among HIV-1-infected patients and their relationship to the use of NRTIs... - Persistence of Kaposi sarcoma-associated herpesvirus (KSHV)-infected cells in KSHV/HIV-1-coinfected subjects without KSHV-associated diseasesThomas B Campbell
Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Infect Dis 191:367-71. 2005..These findings provide evidence that, in the absence of KSHV-associated diseases, latent infection of lymph node cells provides a mechanism for the persistence of KSHV in KSHV/HIV-1-coinfected persons... - Lymphoid follicles are sites of heightened human immunodeficiency virus type 1 (HIV-1) replication and reduced antiretroviral effector mechanismsJoy M Folkvord
University of Colorado Health Sciences Center, Division of Infectious Disease, Denver, Colorado 80262, USA
AIDS Res Hum Retroviruses 21:363-70. 2005..1 cells/mm2) and perforin (median, 4.0 cells/mm2) was low and not significantly different in F and EF. Deficiencies of multiple antiretroviral proteins within F may contribute to heightened replication at that site... - alpha-Defensins 1, 2, and 3 are expressed by granulocytes in lymphoid tissues of HIV-1-seropositive and -seronegative individualsJoy M Folkvord
Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, 80262, USA
J Acquir Immune Defic Syndr 42:529-36. 2006..The role of alpha-defensins in controlling HIV-1 replication merits further investigation... - Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunctionMichelle D'Souza
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
J Immunol 179:1979-87. 2007..0078). Thus, PD-1 expression on HIV-specific CD4(+) T cells is driven by persistent HIV replication, providing a potential target for enhancing the functional capacity of HIV-specific CD4(+) T cells... - Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) miceBradford K Berges
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
Virology 373:342-51. 2008.... - Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infectionStephanie M Dillon
Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Acquir Immune Defic Syndr 48:1-12. 2008..Activation and depletion of DCs in blood with accumulation in lymphoid tissue may contribute to HIV-associated chronic immune activation and T-cell dysfunction... - Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapyKimberly Smith
Department of Infectious Diseases, Rush Medical College of Rush University, Chicago, IL 60612, USA
AIDS 18:1953-6. 2004..This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART... - Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infectionAndrew J Leigh Brown
University of Edinburgh, Edinburgh, Scotland
J Virol 78:2242-6. 2004..This supports the view that variation in PR function is directly responsible for variation in fitness among strains in primary infection... - Antiretroviral-drug resistance among patients recently infected with HIVSusan J Little
Antiviral Research Center, Department of Medicine, University of California San Diego, San Diego 92103, USA
N Engl J Med 347:385-94. 2002..Among persons in North America who are newly infected with the human immunodeficiency virus (HIV), the prevalence of transmitted resistance to antiretroviral drugs has been estimated at 1 to 11 percent... - Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced diseaseHernan Valdez
Case Western Reserve University, University Hospitals of Cleveland Center for AIDS Research, Ohio, USA
AIDS 16:1859-66. 2002..The clinical significance of incomplete reconstitution of CD4 lymphocyte number, phenotype, and proliferative function in HIV-1 infection remains to be determined... - Microanatomic relationships between CD8+ cells and HIV-1-producing cells in human lymphoid tissue in vivoJoy M Folkvord
Division of Infectious Disease, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Acquir Immune Defic Syndr 32:469-76. 2003..Further studies are necessary to determine whether HIV-1-specific CD8+ T cells aggregate around virus-producing cells in lymphoid tissue... - CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIVAndrew Zloza
Department of Immunology and Microbiology, Rush-Presbyterian-St Luke's Medical Center, 1735 W Harrison Street, 614 Cohn, Chicago, IL 60612, USA
Blood 102:2156-64. 2003..Collectively, these data suggest a role of CD4dimCD8bright T cells in both normal T-cell biology and HIV pathogenesis... - Suppression of leukemia inhibitor factor in lymphoid tissue in primary HIV infection: absence of HIV replication in gp130-positive cellsAnnelie Tjernlund
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
AIDS 17:1303-10. 2003..Furthermore, HIV-1 replication did not occur in cells expressing the LIF signaling receptor, gp130, indicating that LIF may be associated with control of HIV-1 replicating cells in vivo... - Role of Baseline pol Genotype in HIV-1 Fitness EvolutionJan Weber
Department of Virology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Acquir Immune Defic Syndr 33:448-60. 2003..65, P < 0.0001). However, our results suggest that the preexistence of secondary mutations in protease genetic background may have implications in HIV-1 fitness evolution and virologic response to antiretroviral therapy... - Relationship between in vitro human immunodeficiency virus type 1 replication rate and virus load in plasmaThomas B Campbell
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Virol 77:12105-12. 2003..44; P = 0.019). These data suggest that different RT-PR alleles are important determinants of HIV-1 replication rates and that HIV-1 replication rate explains much of the variability in plasma virus load in chronic HIV-1 infection... - MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group studyDavid W Haas
Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue, North, Suite 105, Nashville, TN 37212, USA
J Acquir Immune Defic Syndr 34:295-8. 2003..It is concluded with 95% confidence that phase 1 viral decay differences between exon 26 TT and CC groups are unlikely to exceed 18%... - Incomplete immune reconstitution after initiation of highly active antiretroviral therapy in human immunodeficiency virus-infected patients with severe CD4+ cell depletionHoward M Lederman
Eudowood Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Infect Dis 188:1794-803. 2003..009) and mumps skin test antigen (29% vs. 17%; P=.001). Although the subjects had only partial responses to immune function testing, the rate of opportunistic infections was very low, and none of the tests was predictive of risk... - SDF-1alpha is a potent inducer of HIV-1-Specific CD8+ T-cell chemotaxis, but migration of CD8+ T cells is impaired at high viral loadsAmie L Meditz
Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
AIDS Res Hum Retroviruses 24:977-85. 2008..Improved understanding of the determinants of CTL localization may provide insight into novel therapies to enhance delivery of CTL to sites of HIV-1 replication... - Challenges in the study of patients with HIV type 1 seroconversionElizabeth Connick
Clin Infect Dis 40:1355-7. 2005 - Incomplete antibody evolution and seroreversion after treatment of primary HIV type 1 infection: what is the clinical significance?Elizabeth Connick
Clin Infect Dis 40:874-5. 2005 - Immunophenotypic alterations in acute and early HIV infectionLena Al-Harthi
Department of Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
Clin Immunol 125:299-308. 2007.... - Fish oil and fenofibrate for the treatment of hypertriglyceridemia in HIV-infected subjects on antiretroviral therapy: results of ACTG A5186John G Gerber
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
J Acquir Immune Defic Syndr 47:459-66. 2008..AIDS Clinical Trials Group A5186 examined the safety and efficacy of fish oil plus fenofibrate in subjects not achieving serum TG levels < or =200 mg/dL with either agent alone...
Research Grants
- CD8+TCell Antiretroviral Mechanisms in Lymphoid TissueElizabeth Connick; Fiscal Year: 2003..These studies could provide important insight into the immunopathogenesis of HIV-1 infection and suggest alternative targets for immune therapies. ..
- IMMUNOPATHOGENESIS OF ACUTE HIV-1 INFECTIONElizabeth Connick; Fiscal Year: 2007..abstract_text> ..
- Sex Differences in Plasma HIV-1 RNA ConcentrationsElizabeth Connick; Fiscal Year: 2007....