Research Topics
Species | Christopher S CoffeySummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Detail Information
Publications
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validationChristopher S Coffey
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
BMC Bioinformatics 5:49. 2004..One advantage of the MDR method is that it provides an internal prediction error for validation. We summarize our use of this internal prediction error for model validation...- Reporting of model validation procedures in human studies of genetic interactionsChristopher S Coffey
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Nutrition 20:69-73. 2004 - Properties of internal pilots with the univariate approach to repeated measuresChristopher S Coffey
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
Stat Med 22:2469-85. 2003..At this time, we caution against using an internal pilot design with repeated measures without first conducting simulations to document the amount of test size inflation possible for the conditions of interest... - Effect of comorbidity and body mass index on the survival of African-American and Caucasian patients with colon cancerRobert B Hines
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 7331, USA
Cancer 115:5798-806. 2009..The objectives of the current study were to quantify the impact of comorbidity and body mass index (BMI) on survival and to assess whether these 2 variables account for the decreased survival among African Americans... - Racial differences in the competing risks of mortality and ESRD after acute myocardial infarctionBritt B Newsome
Center for Outcomes Effectiveness Research and Education, University of Alabama at Birmingham, Birmingham, AL, USA
Am J Kidney Dis 52:251-61. 2008..This is counterintuitive given the known 4-fold greater incidence of end-stage renal disease (ESRD) in African Americans. We describe racial differences in the rate of progression to ESRD and address the competing risk of mortality... - Efficacy of bosentan in a small cohort of adult patients with pulmonary arterial hypertension related to congenital heart diseaseRaymond L Benza
Tinsley Harrison Towers, Room 328A, 1900 University Blvd, Birmingham, AL 35294 0006, USA
Chest 129:1009-15. 2006..This study was designed to assess the tolerability and efficacy of the oral endothelin receptor antagonist bosentan in adult patients with pulmonary arterial hypertension (PAH) related to congenital heart disease (CHD)... - Prevalence of renal artery stenosis in high-risk veterans referred to cardiac catheterizationRaed A Aqel
Birmingham s Veterans Affair Medical Center, Division of Cardiovascular Disease, Birmingham, Alabama 35233, USA
J Hypertens 21:1157-62. 2003..The goal of this study is to determine the prevalence and predictors of renal artery stenosis in hypertensive veterans referred for coronary angiography... - Two-stage testing in microarray analysis: what is gained?David B Allison
Department of Biostatistics, University of Alabama at Birmingham, USA
J Gerontol A Biol Sci Med Sci 57:B189-92. 2002..Therefore, investigators are encouraged to consider alternative analytic approaches... - Stroke and the statistics of the aspirin/clopidogrel secondary prevention trialsGeorge Howard
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Curr Opin Neurol 20:71-7. 2007.... - Detection of gene x gene interactions in genome-wide association studies of human population dataSolomon K Musani
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Hered 63:67-84. 2007..Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene x gene interactions in human data... - Alterations in the fibrinolytic cascade post-transplant: evidence of a bimodal expression patternRaymond L Benza
Department of Medicine, Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0006, USA
J Heart Lung Transplant 26:494-7. 2007.... - Adaptive clinical trials: progress and challengesChristopher S Coffey
Department of Biostatistics, School of Public Health, University of Alabama Birmingham, Birmingham, Alabama, USA
Drugs R D 9:229-42. 2008..In this review, we summarize the existing methods and current controversies with the intent of providing a clarification that will enable these individuals to participate in these much-needed discussions... - Survival advantage of black patients with kidney disease after acute myocardial infarctionBritt B Newsome
Center for Outcomes Effectiveness Research and Education, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
Clin J Am Soc Nephrol 1:993-9. 2006..Further investigation into the reasons for ethnic differences in survival and progression of kidney disease is warranted... - Predictive capacity of three comorbidity indices in estimating mortality after surgery for colon cancerRobert B Hines
Department of Epidemiology, University of Alabama at Birmingham, 1922 7th Ave S, Birmingham, AL 35294, USA
J Clin Oncol 27:4339-45. 2009.... - The Association of the Metabolic Syndrome with PAI-1 and t-PA LevelsChristopher S Coffey
Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Cardiol Res Pract 2011:541467. 2011..Conclusions. Our study demonstrates that those with the Met S have significantly higher levels of PAI-1 and t-PA antigen, factors known to increase the risk of cardiovascular disease... - High-grade tumor differentiation is an indicator of poor prognosis in African Americans with colonic adenocarcinomasDominik Alexander
Department of Epidemiology, University of Alabama-Birmingham, Birmingham, Alabama 35294-7331, USA
Cancer 103:2163-70. 2005.... - The confounding of race and geography: how much of the excess stroke mortality among African Americans is explained by geography?Dongyan Yang
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Ala, USA
Neuroepidemiology 23:118-22. 2004..DISCUSSION: These results suggest that a significant, although relatively small, proportion of the excess mortality traditionally attributed to race is rather a factor of geography... - Is Bayesian analysis ready for use in phase III randomized clinical trials? Beware the sound of the sirensGeorge Howard
Department of Biostatistics, University of Alabama at Birmingham, AL 35294-0022, USA
Stroke 36:1622-3. 2005 - Missing data in randomized clinical trials for weight loss: scope of the problem, state of the field, and performance of statistical methodsMai A Elobeid
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 4:e6624. 2009..Herein, we meta-analytically evaluate the extent of missing data, the frequency with which various analytic methods are employed to accommodate dropouts, and the performance of multiple statistical methods... - The effects of intentional weight loss as a latent variable problemChristopher S Coffey
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Stat Med 24:941-54. 2005.... - Internal pilots for a class of linear mixed models with Gaussian and compound symmetric dataMatthew J Gurka
Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia School of Medicine, P O Box 800717, Charlottesville, VA 22908 0717, USA
Stat Med 26:4083-99. 2007..Planning a new tortuosity study illustrates how the new methods help to avoid sample sizes that are too small or too large while still controlling the type I error rate... - Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levelsFolkert W Asselbergs
Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
Genomics 89:362-9. 2007..These results support the idea that the interplay between the renin-angiotensin, bradykinin, and fibrinolytic systems might play an important role in t-PA and PAI-1 biology... - The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levelsFolkert W Asselbergs
Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
Thromb Haemost 96:471-7. 2006..In addition, the results support the idea that the biology of t-PA and PAI-1 is different between females and males... - Reliability and validity of blood pressure measurement in the Secondary Prevention of Small Subcortical Strokes studyPablo E Pergola
Department of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Blood Press Monit 12:1-8. 2007..Reliable and unbiased blood pressure measurement is critical to successful completion of the trial... - The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental contextFolkert W Asselbergs
Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
Hum Genet 122:275-81. 2007..The present study emphasizes the importance of including environmental factors in genetic analyses to fully comprehend the genetic architecture of a specific trait... - Adverse effects of beta-blocker therapy for patients with heart failure: a quantitative overview of randomized trialsDennis T Ko
Division of Cardiology, Schulich Heart Centre, and the Department of Medicine, Sunnybrook and Women's College Health Sciences Center, University of Toronto, Toronto, Ontario
Arch Intern Med 164:1389-94. 2004..This information should alleviate concerns about prescribing this life-saving therapy to patients with HF... - Relative perioperative bradycardia does not lead to adverse outcomes after cardiac transplantationDaniel R Goldstein
Department of Internal Medicine, Division of Cardiovascular Medicine, Yale University School of Medicine, 3FM Cardiology, 333 Cedar St, New Haven CT 06520, USA
Am J Transplant 3:484-91. 2003..Amiodarone may modify the recipients' immune response by delaying the occurrence of rejection... - Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunctionDennis T Ko
Section of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520-8025, USA
JAMA 288:351-7. 2002..The risks of these adverse effects should be put in the context of the documented benefits of these medications... - Changes in antibiotic prescribing for children after a community-wide campaignJoseph F Perz
Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA
JAMA 287:3103-9. 2002..001]; among black children, 18% [P<.001]). CONCLUSIONS: A community-wide educational intervention reduced antibiotic prescription levels among children in Knox County... - Percent of cancer in the biopsy set predicts pathological findings after prostatectomyDavid J Grossklaus
Department of Urologic Surgery and Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Urol 167:2032-5; discussion 2036. 2002..This finding adds additional credence to the inclusion of percent of tumor in the biopsy set in models for the preoperative prediction of pathological stage and should be factored into discussions with patients on treatment options...