Research Topics
| Priscilla M ClarksonSummaryAffiliation: University of Massachusetts Country: USA Publications
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Detail Information
Publications
Oral contraceptive use and exercise-induced muscle damage and recoveryKathleen J Savage
Department of Exercise Science, University of Massachusetts, Amherst, MA, USA
Contraception 66:67-71. 2002..05). Women taking oral contraceptives had a delayed strength recovery after eccentric exercise...- Serum creatine kinase levels and renal function measures in exertional muscle damagePriscilla M Clarkson
Department of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA
Med Sci Sports Exerc 38:623-7. 2006..This study determined the magnitude of CK elevation and the effect on renal function produced by exercise in a large subject group... - A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition StudyMatthew C Kostek
Department of Exercise Science, University of South Carolina, Columbia, SC, USA
Eur J Appl Physiol 110:315-24. 2010..Thus, in an elderly population but not a young population, a polymorphism in the IGF1 gene may be predictive of differences in body composition, primarily in black females... - Variability in muscle size and strength gain after unilateral resistance trainingMonica J Hubal
Department of Exercise Science, Totman Building, University of Massachusetts, Amherst, MA 01003, USA
Med Sci Sports Exerc 37:964-72. 2005..Men had only a slight advantage in relative size gains compared with women, whereas women outpaced men considerably in relative gains in strength... - Sex differences in response to maximal eccentric exerciseKimberly A Sewright
Department of Kinesiology, Totman Building, University of Massachusetts, Amherst, MA 01003, USA
Med Sci Sports Exerc 40:242-51. 2008..This study examined sex differences in strength loss, muscle soreness, and serum creatine kinase (CK) and myoglobin (Mb) after high-intensity eccentric exercise of the elbow flexors in a large group of men and women... - Alterations in mRNA expression and protein products following spinal cord injury in humansMaria L Urso
Department of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA
J Physiol 579:877-92. 2007..Increased protein levels for PSMD11 and the metallothioneins 5 days post-SCI, specifically along the cell periphery, indicate that proteins in this region may be early targets for degradation post-SCI... - Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquitination and oxidative stress in humansKimberly A Reich
Muscle Biology and Imaging Laboratory, Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts, USA
J Appl Physiol 109:1404-15. 2010..The gene expression patterns were not reversed on RL, suggesting that molecular responses to short-term periods of skeletal muscle inactivity may persist after activity resumes... - Inflammatory gene changes associated with the repeated-bout effectMonica J Hubal
Department of Kinesiology, University of Massachusetts, Amherst, MA, USA
Am J Physiol Regul Integr Comp Physiol 294:R1628-37. 2008..Contrary to our hypothesis, several inflammatory genes were transcriptionally upregulated (rather than attenuated) after a repeated exercise bout, potentially indicating a role for these genes in the adaptation process... - ACTN3 and MLCK genotype associations with exertional muscle damagePriscilla M Clarkson
Dept of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA
J Appl Physiol 99:564-9. 2005..These results show that variations in genes coding for specific myofibrillar proteins influence phenotypic responses to muscle damaging exercise... - ACTN3 genotype is associated with increases in muscle strength in response to resistance training in womenPriscilla M Clarkson
Dept of Exercise Science, Univ of Massachusetts, Amherst, MA 01003, USA
J Appl Physiol 99:154-63. 2005..01), suggesting that ACTN3 is one of many genes contributing to genetic variation in muscle performance and adaptation to exercise... - Activation of nuclear factor-?B following muscle eccentric contractions in humans is localized primarily to skeletal muscle-residing pericytesRobert D Hyldahl
Department of Kinesiology, University of Massachusetts, Amherst, MA 01003, USA
FASEB J 25:2956-66. 2011..Our results provide the first evidence of NF-?B activation in human muscle following ECs and suggest a novel role for muscle residing pericytes in the early adaptive response to ECs... - Muscle function in men and women during maximal eccentric exerciseMonica J Hubal
Muscle Biology and Imaging Laboratory, Department of Kinesiology, Totman Building, University of Massachusetts, Amherst, Massachusetts, USA
J Strength Cond Res 22:1332-8. 2008..Thus, there is no reason to suspect that women may be more vulnerable to fatigue-related injury... - Knockdown of metallothionein 1 and 2 does not affect atrophy or oxidant activity in a novel in vitro modelRobert D Hyldahl
Muscle Biology and Imaging Laboratory, Department of Kinesiology, University of Massachusetts, Amherst, MA 01003, USA
J Appl Physiol 109:1515-23. 2010..We therefore conclude that the novel SR model results in a strong atrophy response and an increase in oxidant activity in cultured myotubes and that knockdown of MT does not affect that response... - Exercise-induced muscle damage in humansPriscilla M Clarkson
Department of Exercise Science, Totman Building, University of Massachusetts, Amherst, MA 01003, USA
Am J Phys Med Rehabil 81:S52-69. 2002.... - Analysis of human skeletal muscle after 48 h immobilization reveals alterations in mRNA and protein for extracellular matrix componentsMaria L Urso
Department of Exercise Science, 110 Totman Bldg, University of Massachusetts, Amherst, 01003, USA
J Appl Physiol 101:1136-48. 2006..Our results suggest that 48 h of immobilization increases mRNA content for components of the UPP and metallothionein function while decreasing mRNA and protein for ECM components as well as decreased phosphorylation of Akt... - Changes in ubiquitin proteasome pathway gene expression in skeletal muscle with exercise and statinsMaria L Urso
Department of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA
Arterioscler Thromb Vasc Biol 25:2560-6. 2005..Statins may alter the response of muscle to exercise stress by altering the action of the UPP, protein folding, and catabolism, disrupting the balance between protein degradation and repair... - Mechanisms of variability in strength loss after muscle-lengthening actionsMonica J Hubal
Department of Kinesiology, Totman Building, University of Massachusetts, Amherst, MA, USA
Med Sci Sports Exerc 39:461-8. 2007.... - Statin myopathy: incidence, risk factors, and pathophysiologyKimberly A Sewright
Department of Kinesiology, University of Massachusetts, Totman Building, 30 Eastman Lane, Amherst, MA 01002, USA
Curr Atheroscler Rep 9:389-96. 2007.... - Exertional rhabdomyolysis: does elevated blood creatine kinase foretell renal failure?Priscilla M Clarkson
Department of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA
Curr Sports Med Rep 5:57-60. 2006 - Exertional rhabdomyolysis and acute renal failure in marathon runnersPriscilla M Clarkson
Kinesiology Department, University of Massachusetts, Amherst, Massachusetts 01003, USA
Sports Med 37:361-3. 2007.... - Exercise-induced rhabdomyolysisStephen P Sayers
Department of Exercise Science, Totman Building, University of Massachusetts, 30 Eastman Lane, Amherst, MA 01003, USA
Curr Sports Med Rep 1:59-60. 2002 - Should resistance exercise be recommended during breast cancer treatment?Priscilla M Clarkson
Department of Kinesiology, University of Massachusetts, Amherst, MA 01003, USA
Med Hypotheses 75:192-5. 2010..Before recommending resistance training during breast cancer treatment, we must have more information about cancer treatment effects on activated satellite cells in human studies... - Case report of exertional rhabdomyolysis in a 12-year-old boyPriscilla M Clarkson
Department of Exercise Science, Totman Building, University of Massachusetts, Amherst, MA 01003, USA
Med Sci Sports Exerc 38:197-200. 2006..Exertional rhabdomyolysis has been well characterized, and many case reports exist. No cases of exertional rhabdomyolysis in young healthy children (preteen) have been published... - Effects of repeated creatine supplementation on muscle, plasma, and urine creatine levelsEric S Rawson
Department of Exercise Science, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Strength Cond Res 18:162-7. 2004..0 kg). Athletes should be aware that the washout period for muscle creatine to return to baseline levels may be longer than 30 days in some individuals, and this may be accompanied by a persistent increase in body mass... - Plasma creatine kinase activity and glutathione after eccentric exerciseJoohyung Lee
Department of Exercise Science, University of Massachusetts, Amherst 01003, USA
Med Sci Sports Exerc 35:930-6. 2003..5 micromol x L-1) compared with individuals with high total glutathione (>3.8 micromol x L-1), but other indicators of muscle damage would be the same between groups... - Neuromuscular variables affecting the magnitude of force loss after eccentric exerciseStephen P Sayers
Department of Exercise Sciences, 110 Totman Building, University of Massachusetts, Amherst, MA 01003, USA
J Sports Sci 21:403-10. 2003..044). In conclusion, lower peak torque, end-range torque and total angular impulse during eccentric contractions and a greater peak torque slope may identify high responders to eccentric exercise... - Effects of ibuprofen topical gel on muscle sorenessRobert D Hyldahl
Department of Kinesiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
Med Sci Sports Exerc 42:614-21. 2010..Muscle soreness is a common symptom after novel exercise and may influence exercise adherence. This study examined the effect of an ibuprofen topical gel and the effect of age and sex on muscle soreness after a gym exercise... - Rhabdomyolysis in a collegiate football playerStephanie A Moeckel-Cole
Muscle Biology and Imaging Laboratory, Department of Kinesiology, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
J Strength Cond Res 23:1055-9. 2009..This case illustrates that rhabdomyolysis can occur after strenuous exercise in the absence of dehydration in otherwise conditioned and healthy athletes... - Oxidative stress, exercise, and antioxidant supplementationMaria L Urso
Exercise Science Department, University of Massachusetts, 110 Totman Building, Amherst, MA 01003, USA
Toxicology 189:41-54. 2003.... - Short-term immobilization after eccentric exercise. Part I: contractile propertiesStephen P Sayers
Human Physiology Laboratory, Department of Health Sciences, Boston University, Sargent College of Health and Rehabilitation Sciences, 635 Commonwealth Avenue, Boston, MA 02215, USA
Med Sci Sports Exerc 35:753-61. 2003..We hypothesized that immobilization after eccentric exercise would result in an enhanced M-wave and a change in contractile properties toward characteristics of faster muscle fibers... - Molecular responses of human muscle to eccentric exerciseYi Wen Chen
Center for Genetic Medicine, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
J Appl Physiol 95:2485-94. 2003.... - Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndromeEmidio E Pistilli
Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, 3700 Hamilton Walk, A601 Richards Building, Philadelphia, PA 19140, USA
Cytokine 43:45-53. 2008..04), and baseline muscle quality (p=0.04). All associations were consistent in showing a potential involvement of the IL-15 pathway with muscle and bone phenotypes and predictors of metabolic syndrome... - Two cases of exertional rhabdomyolysis precipitated by personal trainersBrian L Springer
Wright State University School of Medicine, Department of Emergency Medicine, Dayton, OH, USA
Med Sci Sports Exerc 35:1499-502. 2003..DISCUSSION: In these two cases individuals, both well educated and experienced in fitness, were encouraged by fitness instructors in a local health club to overexertion during their exercise routine leading to rhabdomyolysis... - ACE ID genotype and the muscle strength and size response to unilateral resistance trainingLinda S Pescatello
School of Allied Health, University of Connecticut, Storrs, CT 06269 2101, USA
Med Sci Sports Exerc 38:1074-81. 2006..wk) unilateral, upper-arm resistance training (RT) program in the trained (T, nondominant) and untrained (UT, dominant) arms... - The creatine kinase response to eccentric exercise with atorvastatin 10 mg or 80 mgAmy K Kearns
Division of Cardiology, Henry Low Heart Center, Hartford Hospital, 87 Seymour Street, Hartford, CT 06102, USA
Atherosclerosis 200:121-5. 2008..This study examined the CK response to downhill walking in subjects treated with low and high dose of atorvastatin... - PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young malesJulieta Uthurralt
Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
BMC Med Genet 8:55. 2007..We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better define genetic predisposition loci for metabolic syndrome... - An assessment of statin safety by muscle expertsPaul D Thompson
Division of Cardiology, Hartford Hospital, Hartford, Connecticut 06102, USA
Am J Cardiol 97:69C-76C. 2006..The panel was composed of a clinical cardiologist, an exercise physiologist and skeletal muscle expert, and an expert in preventive cardiology who also examined skeletal muscle complications of statin use... - The muscle strength and size response to upper arm, unilateral resistance training among adults who are overweight and obeseLinda S Pescatello
University of Connecticut, Storrs, Connecticut 06269, USA
J Strength Cond Res 21:307-13. 2007..These findings indicate the short-term relative and allometric muscle strength response to RT may be attenuated among adults who are overweight and obese... - IGF-II gene region polymorphisms related to exertional muscle damageJoseph M Devaney
Children s National Medical Center, Washington, District of Columbia, USA
J Appl Physiol 102:1815-23. 2007..In women, fewer significant associations appeared... - Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and womenEmidio E Pistilli
Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown, WV 26506 9227, USA
Obesity (Silver Spring) 15:392-402. 2007..The objective of this study was to examine the effects of single nucleotide polymorphisms (SNPs) in the human RST gene on muscle, bone, and adipose tissue phenotypes and in response to resistance training (RT)... - Youth football: heat stress and injury riskMichael F Bergeron
Med Sci Sports Exerc 37:1421-30. 2005 - CK-MM autoantibodies: prevalence, immune complexes, and effect on CK clearanceGordon L Warren
Division of Physical Therapy, Georgia State University, Atlanta, Georgia 30302, USA
Muscle Nerve 34:335-46. 2006..Thus, the relatively low blood CK levels seen in some individuals following injury may be attributed partly or entirely to an autoantibody-enhanced clearance of CK... - Subcutaneous fat alterations resulting from an upper-body resistance training programMatthew A Kostek
Department of Kinesiology, University of Connecticut, Storrs, CT 06269 2101, USA
Med Sci Sports Exerc 39:1177-85. 2007..To reexamine this concept, we compared subcutaneous fat measurements before and after resistance training among 104 subjects (45 men, 59 women)... - American College of Sports Medicine roundtable on hydration and physical activity: consensus statementsDouglas J Casa
Department of Kinesiology, University of Connecticut, 2095 Hillside Road, U-1110, Storrs, CT 06269-1110, USA
Curr Sports Med Rep 4:115-27. 2005