Research Topics
| Constance ChuSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Closing the gap between bench and bedside research for early arthritis therapies (EARTH): report from the AOSSM/NIH U-13 Post-Joint Injury Osteoarthritis Conference IIConstance R Chu
University of Pittsburgh, Department of Orthopaedic Surgery, Cartilage Restoration Center, Pittsburgh, Pennsylvania 15213, USA
Am J Sports Med 39:1569-78. 2011..Systematic study of posttraumatic osteoarthritis is anticipated to advance understanding and treatment of all forms of osteoarthritis...- The in vitro effects of bupivacaine on articular chondrocytesC R Chu
Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, School of Medicine, 3471 Fifth Ave, Suite 911, Pittsburgh, Pennsylvania 15213, USA
J Bone Joint Surg Br 90:814-20. 2008..125% bupivacaine for up to 60 minutes, the viability of both bovine and human chondrocytes was similar to that of control groups. These data show that prolonged exposure 0.5% and 0.25% bupivacaine solutions are potentially chondrotoxic... - The 2007 ABC Traveling Fellowship: building international orthopaedic bridgesConstance R Chu
University of Pittsburgh, 3471 Fifth Avenue, Suite 911, Pittsburgh, PA 15213, USA
J Bone Joint Surg Am 90:672-4. 2008 - Clinical diagnosis of potentially treatable early articular cartilage degeneration using optical coherence tomographyConstance R Chu
University of Pittsburgh, Department of Orthopaedic Surgery, 3471 Fifth Avenue, Suite 1010, Pittsburgh, Pennsylvania 15213, USA
J Biomed Opt 12:051703. 2007.... - In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytesConstance R Chu
Cartilage Restoration Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
Arthroscopy 22:693-9. 2006..This study was conducted to test the hypotheses that (1) 0.5% bupivacaine is toxic to articular chondrocytes, and (2) the intact articular surface protects chondrocytes from the effects of short-term exposure to 0.5% bupivacaine... - In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilageConstance R Chu
Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, BST E1640, Pittsburgh, PA 15261, USA
J Bone Joint Surg Am 92:599-608. 2010..This in vivo study was conducted to determine whether a single intra-articular injection of 0.5% bupivacaine results in chondrocyte morbidity and rapid chondrolysis... - Animal models for cartilage regeneration and repairConstance R Chu
Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Tissue Eng Part B Rev 16:105-15. 2010..A multifactorial analysis of each animal model should be carried out when planning in vivo studies. Ultimately, the scientific goals of the study will be critical in determining the appropriate animal model... - Clinical optical coherence tomography of early articular cartilage degeneration in patients with degenerative meniscal tearsConstance R Chu
Cartilage Restoration Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Arthritis Rheum 62:1412-20. 2010..This study tested the hypotheses that OCT can be used clinically to identify early cartilage degeneration and that OCT findings correlate with magnetic resonance imaging (MRI) T2 values and arthroscopy results... - Arthroscopic microscopy of articular cartilage using optical coherence tomographyConstance R Chu
Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
Am J Sports Med 32:699-709. 2004..Optical coherence tomography is an echograph of infrared light that can yield microscopic cross-sectional images of articular cartilage without removing or damaging the tissue... - Sustained hypoxia enhances chondrocyte matrix synthesisChristian H Coyle
Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Orthop Res 27:793-9. 2009..These studies show that sustained hypoxia enhances articular chondrocyte matrix synthesis and viability in three-dimensional alginate culture... - Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix contentDavid M Bear
Cartilage Restoration Center, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Biomedical Science Tower E1640, Pittsburgh, PA 15261, USA
J Orthop Res 28:546-52. 2010..Our results demonstrate the ability of OCT and T2 mapping to detect early cartilage degeneration in clinically normal appearing cartilage... - Lidocaine potentiates the chondrotoxicity of methylprednisoloneVenkat Seshadri
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Arthroscopy 25:337-47. 2009..This study examined the viability of bovine articular chondrocytes after exposure to methylprednisolone, methylprednisolone with lidocaine, and methylprednisolone in a simulated inflammatory environment... - Multicomponent T2* mapping of knee cartilage: technical feasibility ex vivoYongxian Qian
MR Research Center, Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Magn Reson Med 64:1426-31. 2010..A map of decay types presented spatial distribution of these T2* decays. These results showed the technical feasibility of multicomponent T2* mapping on human knee cartilage explants... - Optical coherence tomography detection of subclinical traumatic cartilage injuryDavid M Bear
Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Orthop Trauma 24:577-82. 2010..This study tests the hypothesis that OCT detects acute articular cartilage injury after impact at energy levels resulting in chondrocyte death and microstructural changes, but insufficient to produce macroscopic surface damage... - Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitroJohn C Karpie
Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Sports Med 35:1621-7. 2007..Intra-articular lidocaine is commonly used... - Tonic activation of hypoxia-inducible factor 1alpha in avascular articular cartilage and implications for metabolic homeostasisPeter U Brucker
Cartilage Restoration Laboratory, Pittsburgh, Pennsylvania 15232, USA
Arthritis Rheum 52:3181-91. 2005..The discovery of tonic activation of HIF-1alpha within intact articular cartilage underscores its potential importance to cartilage homeostasis... - Progressive chondrocyte death after impact injury indicates a need for chondroprotective therapyMichal Szczodry
Cartilage Restoration Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Sports Med 37:2318-22. 2009..Impact injury to articular cartilage can lead to posttraumatic osteoarthritis... - A prospective study of autologous chondrocyte implantation in patients with failed prior treatment for articular cartilage defect of the knee: results of the Study of the Treatment of Articular Repair (STAR) clinical trialKenneth Zaslav
Department of Orthopedic Surgery, Advanced Orthopedic Centers, Virginia Commonwealth University, Richmond, VA 23294, USA
Am J Sports Med 37:42-55. 2009..This is a prospective clinical study to assess the effectiveness of autologous chondrocyte implantation in patients who failed prior treatments for articular cartilage defects of the knee... - Optimizing CO2 normalizes pH and enhances chondrocyte viability during cold storageBrian N Dontchos
Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, BST E 1640, Pittsburgh, Pennsylvania 15621, USA
J Orthop Res 26:643-50. 2008..This data shows that an increase in pH decreased bovine chondrocyte viability when refrigerated at 4 degrees C in DMEM, and that optimization of CO(2) normalized pH and improved chondrocyte viability during cold storage in DMEM... - The knee pain map: reliability of a method to identify knee pain location and patternLaura R Thompson
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Arthritis Rheum 61:725-31. 2009..To describe the location and pattern of knee pain in patients with chronic, frequent knee pain using the Knee Pain Map, and to evaluate the inter- and intrarater reliability of the map... - The role of the biochemical and biophysical environment in chondrogenic stem cell differentiation assays and cartilage tissue engineeringKristin E Wescoe
Department of Bioengineering, University of Pittsburgh, 3460 Fifth Avenue, 5113 Rangos Research Center, Pittsburgh, PA 15213, USA
Cell Biochem Biophys 52:85-102. 2008..g., spatial and temporal application of the stimuli, and time of transplantation of an engineered construct. Understanding the necessary microenvironmental signals for cell differentiation will advance cell therapy for cartilage repair... - Controlled release of bioactive TGF-beta 1 from microspheres embedded within biodegradable hydrogelsAlicia J DeFail
Department of Bioengineering, University of Pittsburgh, 200 Lothrop Street, BST 1555W, Pittsburgh, PA 15261, USA
Biomaterials 27:1579-85. 2006..Based on these in vitro observations, we predict that we can develop a microsphere-loaded hydrogel for controlled release of TGF-beta1 to a cartilage wound site... - Recovery of articular cartilage metabolism following thermal stress is facilitated by IGF-1 and JNK inhibitorConstance R Chu
Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
Am J Sports Med 32:191-6. 2004..The data additionally suggest that inadvertent chondrocyte injury may be minimized through potential addition of substances like IGF-1 or JNK inhibitor... - Recovery of chondrocyte metabolic activity after thermal exposureLee D Kaplan
University of Pittsburgh School of Medicine, Department of Orthopaedic Surgery, Pittsburgh, Pennsylvania 15213, USA
Am J Sports Med 31:392-8. 2003.... - Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineeringHuaping Tan
Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
Biomaterials 30:2499-506. 2009..These characteristics provide a potential opportunity to use the injectable, composite hydrogels in tissue engineering applications... - p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-betaRebecca K Studer
VA Pittsburgh Healthcare System, University of Pittsburgh Medical School, Pittsburgh, PA 15240, USA
J Orthop Res 23:454-61. 2005..Use of these inhibitors to minimize cartilage damage in arthritic and mechanically stressed joints should reflect these characteristics... - Hand-held arthroscopic optical coherence tomography for in vivo high-resolution imaging of articular cartilageYingtian Pan
State University of New York, Stony Brook, Department of Biomedical Engineering, Stony Brook, New York 11794 8181, USA
J Biomed Opt 8:648-54. 2003..Successful application of in vivo arthroscopy to porcine articular cartilage demonstrates sufficient resolution and practicality for use in human joints...
Research Grants
- CHONDROPROTECTIVE EFFECTS OF SUPEROXIDE DISMUTASEConstance Chu; Fiscal Year: 2002..These studies will also serve to improve understanding of the relative roles of NO and peroxynitrite on the pathophysiology of arthritis. ..
- Chondrogenesis In SituConstance R Chu; Fiscal Year: 2010....
- Enhanced Clinical Diagnosis of Early OsteoarthritisConstance R Chu; Fiscal Year: 2010..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..
- Chondrogenesis In SituConstance Chu; Fiscal Year: 2009....
- Chondrogenesis In SituConstance Chu; Fiscal Year: 2007....
- Enhanced Clinical Diagnosis of Early OsteoarthritisConstance Chu; Fiscal Year: 2007..Potential advantages of earlier treatment include the possibility of delaying or even preventing the onset of disabling osteoarthritis. ..
- Chondrogenesis In SituConstance R Chu; Fiscal Year: 2010....