Tao ChengSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Toward 'SMART' stem cellsT Cheng
Department of Radiation Oncology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
Gene Ther 15:67-73. 2008..The goal of this special issue on stem cells in Gene Therapy is to review some fundamental and critical aspects of current stem cell research that have translational potential...- Cell cycle inhibitors in normal and tumor stem cellsTao Cheng
Department of Radiation Oncology, University of Pittsburgh School of Medicine, PA 15213, USA
Oncogene 23:7256-66. 2004..Therefore, understanding how cell cycle inhibitors control stem cells may offer new strategies not only for therapeutic manipulations of normal stem cells but also for novel therapies selectively targeting TSCs... - Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21Brian J Leibowitz
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
Mol Cancer Res 9:616-25. 2011..These studies help to better understand p53 functions in tissue injury and regeneration and to potentially improve strategies to protect or mitigate intestinal damage induced by radiation... - In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4CYouzhong Yuan
University of Pittsburgh Cancer Institute and Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh PA 15213, USA
Nat Cell Biol 6:436-42. 2004.... - Cell cycle entry of hematopoietic stem and progenitor cells controlled by distinct cyclin-dependent kinase inhibitorsTao Cheng
Department of Radiation Oncology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
Int J Hematol 75:460-5. 2002..Therefore, the distinct roles of p21, p27, and TGF-beta1 in hematopoietic cells offer attractive targets for specific manipulation of the stem or progenitor cell populations in therapeutic strategies... - ADAR1 is required for hematopoietic progenitor cell survival via RNA editingRichard XuFeng
University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 106:17763-8. 2009..Moreover, we have obtained direct evidence that ADAR1 functions in HPCs via an RNA-editing dependent mechanism. Therefore, ADAR1 plays an essential role in adult hematopoiesis through its RNA editing activity in HPCs... - Flow cytometry-based cell cycle measurement of mouse hematopoietic stem and progenitor cellsHongmei Shen
Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA
Methods Mol Biol 430:77-86. 2008..The second details the staining of bromodeoxyuridine incorporated into replicating DNA as a measure for the cycling cell fraction within a specific hematopoietic cell subset... - p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusionBin Wu
University of Pittsburgh Cancer Institute, Hillman Cancer Center, Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Gut 56:645-54. 2007..It has been shown that PUMA plays an essential role in apoptosis induced by a variety of stimuli in different tissues through a mitochondrial pathway... - Hematopoietic stem cells are not the direct target of spontaneous leukemic transformation in p18(INK4C)-null reconstituted miceYouzhong Yuan
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Cancer Res 66:343-51. 2006..The data also support the notion that p18 has an independent role in T cell maintenance such that CD3+ CD8+ cells, unlike HSCs, are more accessible to leukemogenic transformation after the loss of p18... - Hematopoietic stem cell exhaustion impacted by p18 INK4C and p21 Cip1/Waf1 in opposite mannersHui Yu
Department of Radiation Oncology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, PA, USA
Blood 107:1200-6. 2006.... - The CDK inhibitors: potential targets for therapeutic stem cell manipulations?M J Boyer
Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Gene Ther 15:117-25. 2008.... - Regenerative response in ischemic brain restricted by p21cip1/waf1Jianhua Qiu
Neuroscience Center, Harvard Medical School, Boston, MA 02129, USA
J Exp Med 199:937-45. 2004..Therefore, p21 is an intrinsic suppressor to neural regeneration after brain injury and may serve as a common molecular regulator restricting proliferation among stem cell pools from distinct tissue types... - Human HTm4 is a hematopoietic cell cycle regulatorJose L Donato
Department of Medicine, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 109:51-8. 2002..Overexpression of HTm4 can cause cell cycle arrest at the G(0)/G(1) phase. Thus, HTm4 is a novel hematopoietic modulator for the G(1)-S cell cycle transition... - Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transferLi-Ying Sung
Center for Regenerative Biology and Department of Animal Science, University of Connecticut, Storrs, Connecticut 06269, USA
Nat Genet 38:1323-8. 2006..We found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency... - Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosisRunzi Qi
Institute of Immunology, Second Military Medical University, Shanghai, People s Republic of China
Cancer Res 63:8323-9. 2003..These findings suggest that Notch1 signaling may participate in the development of HCC cells, affecting multiple pathways that control both cell proliferation and apoptosis... - P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cellsByeong Chel Lee
Center for Regenerative Medicine and Technology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Genes Dev 17:1592-604. 2003..These data suggest a new class of receptors participating in the regulation of the stem cell compartment... - Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cellsSebastian Stier
Center for Regenerative Medicine and Technology, AIDS Research Center and Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Blood 102:1260-6. 2003..This approach may be useful for relative ex vivo human stem cell expansion... - Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcomeSebastian Stier
Partners AIDS Research Center, MGH Cancer Center, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
Blood 99:2369-78. 2002..Notch1 offers an attractive target for stem cell manipulation strategies, particularly in the context of immunodeficiency and acquired immunodeficiency syndrome...
Research Grants
- Stem Cell Efficiency Regulated by CDK InhibitorsTao Cheng; Fiscal Year: 2010....
- Negative Effects of Irradiated Hosts on Transplanted Hematopoietic Stem CellsTao Cheng; Fiscal Year: 2009..Results from our proposed studies will yield novel strategies for enhancing the engraftment efficiency of transplanted HSCs in irradiated recipients. ..
- Stem Cell Efficiency Regulated by CDK InhibitorsTao Cheng; Fiscal Year: 2007....
- Stem Cell Efficiency Regulated by CDK InhibitorsTao Cheng; Fiscal Year: 2004..Despite the supportive data in mES cells, the mechanism governing hES cell proliferation could be entirely different. Strengths fo th ..
- Stem Cell Efficiency Regulated by CDK InhibitorsTao Cheng; Fiscal Year: 2004..The central hypothesis to be tested is that targeting progenitor-specific CDKIs at stem cell level is able to enhance stem cell efficiency without necessarily affecting stem cell cycling or number. ..
- CDK INHIBITORS AND STEM CELL REGULATIONTao Cheng; Fiscal Year: 2003..abstract_text> ..
- Negative Effects of Irradiated Hosts on Transplanted Hematopoietic Stem CellsTao Cheng; Fiscal Year: 2010..Results from our proposed studies will yield novel strategies for enhancing the engraftment efficiency of transplanted HSCs in irradiated recipients. ..