Xinyu Chen

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions
    Xinyu Chen
    Departments of Pathology and Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 163:547-57. 2003
  2. ncbi Par-3 controls tight junction assembly through the Rac exchange factor Tiam1
    Xinyu Chen
    Center for Cell Signaling, Department of Microbiology, HSC, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Cell Biol 7:262-9. 2005
  3. ncbi Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly
    Xinyu Chen
    Center for Cell Signaling, Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 172:671-8. 2006
  4. ncbi Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins
    Yi Hao
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Curr Biol 20:1809-18. 2010
  5. ncbi RNA interference techniques to study epithelial cell adhesion and polarity
    Xinyu Chen
    Center for Cell Signalling, University of Virginia School of Medicine, Charlottesville, USA
    Methods Enzymol 406:362-74. 2006
  6. ncbi Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling
    Xinyu Chen
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:10512-22. 2002
  7. ncbi Defining desmosomal plakophilin-3 interactions
    Stefan Bonne
    Molecular Cell Biology Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology VIB Ghent University, B 9000 Ghent, Belgium
    J Cell Biol 161:403-16. 2003

Collaborators

Detail Information

Publications7

  1. ncbi p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions
    Xinyu Chen
    Departments of Pathology and Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 163:547-57. 2003
    ..Our analyses identify a novel role of p120 in promoting cell surface trafficking of cadherins via association and recruitment of kinesin...
  2. ncbi Par-3 controls tight junction assembly through the Rac exchange factor Tiam1
    Xinyu Chen
    Center for Cell Signaling, Department of Microbiology, HSC, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Cell Biol 7:262-9. 2005
    ..These results define a critical function for Par-3 in tight junction assembly, and reveal a novel mechanism through which Par-3 engages in the spatial regulation of Rac activity and establishment of epithelial polarity...
  3. ncbi Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly
    Xinyu Chen
    Center for Cell Signaling, Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 172:671-8. 2006
    ..Our findings identify LIMK2 as a novel target of Par-3 and uncover a molecular mechanism by which Par-3 could regulate actin dynamics during cell polarization...
  4. ncbi Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins
    Yi Hao
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Curr Biol 20:1809-18. 2010
    ..Defects in signaling through Cdc42 and atypical protein kinase C (aPKC) also cause spindle misorientation. When epithelial cysts are grown in 3D cultures, misorientation creates multiple lumens...
  5. ncbi RNA interference techniques to study epithelial cell adhesion and polarity
    Xinyu Chen
    Center for Cell Signalling, University of Virginia School of Medicine, Charlottesville, USA
    Methods Enzymol 406:362-74. 2006
    ..We discuss the potential challenges and problems associated with the RNAi technique and describe basic protocols for suppressing gene expression using a vector-based short hairpin RNA (shRNA) expression system coupled with nucleofection...
  6. ncbi Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling
    Xinyu Chen
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:10512-22. 2002
    ....
  7. ncbi Defining desmosomal plakophilin-3 interactions
    Stefan Bonne
    Molecular Cell Biology Unit, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology VIB Ghent University, B 9000 Ghent, Belgium
    J Cell Biol 161:403-16. 2003
    ....