Research Topics
| L ChangSummaryAffiliation: University of Hawaii Country: USA Publications
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Detail Information
Publications
Structural and metabolic brain changes in the striatum associated with methamphetamine abuseLinda Chang
Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
Addiction 102:16-32. 2007..To review structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine, as well as in children with prenatal methamphetamine exposure...- Lower glial metabolite levels in brains of young children with prenatal nicotine exposureLinda Chang
Division of Neurology, Department of Medicine, John A Burns School of Medicine, University of Hawai i at Manoa, 7th floor University Tower, Honolulu, HI 96813, USA
J Neuroimmune Pharmacol 7:243-52. 2012..These alterations were not influenced by the amount of nicotine exposure prenatally. However, the effects of PNE on energy metabolism may be sex specific, with greater alterations in girls... - Correlations between Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (1H MRS) in schizophrenic patients and normal controlsCheuk Y Tang
Department of Radiology, Mount Sinai School of Medicine NY, NY 10029, USA
BMC Psychiatry 7:25. 2007..DTI is thus sensitive to demyelination and other structural abnormalities. DTI has also shown abnormalities in these regions... - Impact of apolipoprotein E ?4 and HIV on cognition and brain atrophy: antagonistic pleiotropy and premature brain agingL Chang
Department of Medicine, John A Burns School of Medicine, The Queen s Medical Center, Honolulu, Hawaii 96813, USA
Neuroimage 58:1017-27. 2011..Whether APOE?4 allele(s) and age may influence brain atrophy in HIV patients is unknown and was evaluated... - Insights from recent positron emission tomographic studies of drug abuse and dependenceLinda Chang
Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii, Queen s University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
Curr Opin Psychiatry 19:246-52. 2006..Recent positron emission tomographic studies demonstrate a variety of abnormalities in the brains of addicted individuals. This review aims to discuss and highlight these findings... - Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory responseLinda Chang
Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu 96813, USA
Biol Psychiatry 57:967-74. 2005.... - Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patientsLinda Chang
Department of Medicine, John A Burns School of Medicine, University of Hawai, Honolulu, HI, USA
Antivir Ther 9:431-40. 2004..The relationships between neurometabolites and macrophage chemoattractant protein (MCP-1) in serum and cerebrospinal fluid (CSF) were evaluated in HIV patients before and after antiretroviral treatment... - Adaptation of the attention network in human immunodeficiency virus brain injuryLinda Chang
Medical Department, Brookhaven National Laboratory, Upton, NY, USA
Ann Neurol 56:259-72. 2004..Exceeding the brain reserve capacity may lead to attention deficits and cognitive impairment in HIV patients... - Additive effects of HIV and chronic methamphetamine use on brain metabolite abnormalitiesLinda Chang
Department of Medicine, John A Burns School of Medicine, University of Hawaii, 1356 Lusitana St, 7th Floor, Honolulu, HI 96813, USA
Am J Psychiatry 162:361-9. 2005..The authors sought to determine whether HIV and a history of chronic methamphetamine use might have additive or interactive effects on brain metabolite abnormalities... - Smaller subcortical volumes and cognitive deficits in children with prenatal methamphetamine exposureLinda Chang
Department of Medicine, John A Burns School of Medicine, University of Hawai i, HI 96813, USA
Psychiatry Res 132:95-106. 2004..These preliminary findings suggest prenatal Meth exposure may be neurotoxic to the developing brain... - Brain metabolite abnormalities in the white matter of elderly schizophrenic subjects: implication for glial dysfunctionLinda Chang
Department of Medicine, John A Burns School of Medicine, Honolulu, Hawaii 96813, USA
Biol Psychiatry 62:1396-404. 2007.... - Combined and independent effects of chronic marijuana use and HIV on brain metabolitesL Chang
Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
J Neuroimmune Pharmacol 1:65-76. 2006..These findings suggest chronic MJ use may lead to decreased neuronal and glial metabolites, but may normalize the decreased glutamate in HIV patients... - Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivationL Chang
Department of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
Brain 129:1096-112. 2006.... - Altered neurometabolites and motor integration in children exposed to methamphetamine in uteroL Chang
Division of Neurology, Department of Medicine, John A Burns School of Medicine, Queen s University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
Neuroimage 48:391-7. 2009..These findings combined with their poorer performance on VMI also suggest accelerated but aberrant neuronal and glial development in these brain regions... - Greater than age-related changes in brain diffusion of HIV patients after 1 yearLinda Chang
Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii at Manoa, and the Queen s Medical Center, University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
J Neuroimmune Pharmacol 3:265-74. 2008..Measurements of MD in the genu may be useful for monitoring disease progression in HIV brain infection... - Antiretroviral treatment is associated with increased attentional load-dependent brain activation in HIV patientsL Chang
Department of Medicine, Division of Neurology, John A Burns School of Medicine, University of Hawaii at Manoa, The Queen s Medical Center University Tower, 1356 Lusitana Street, Honolulu, HI 96813, USA
J Neuroimmune Pharmacol 3:95-104. 2008.... - Effects of age and sex on brain glutamate and other metabolitesLinda Chang
Department of Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
Magn Reson Imaging 27:142-5. 2009..These findings indicate that brain glutamate concentrations decline markedly with age, and may be especially useful as a marker for brain diseases that are affected by aging... - Decreased brain dopamine transporters are related to cognitive deficits in HIV patients with or without cocaine abuseLinda Chang
Department of Medicine, University of Hawai i, John A Burns School of Medicine, The Queen s Medical Center, Honolulu, HI 96813, USA
Neuroimage 42:869-78. 2008.... - A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to ageL Chang
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
Neuroimage 23:1336-47. 2004..Aging may further exacerbate brain metabolites associated with inflammation in HIV patient and thereby increase the risk for cognitive impairment... - Increased glial metabolites predict increased working memory network activation in HIV brain injuryT Ernst
Medical Department, Brookhaven National Laboratory, Building 490, P O Box 5000, Upton, NY 11973 5000, USA
Neuroimage 19:1686-93. 2003..The same mechanism may also contribute to cognitive dysfunction in other brain diseases that involve inflammation... - Different activation patterns for working memory load and visual attention loadD Tomasi
Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave, Upton, NY 11973, USA
Brain Res 1132:158-65. 2007..Conversely, VA tasks activated more strongly an occipito-parietal network comprising the postcentral (PostCG) and the superior occipital (SOG) gyri, suggesting complex visual processing in this network... - Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortexN D Volkow
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Am J Psychiatry 158:2015-21. 2001..Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers... - Sex differences in sensory gating of the thalamus during auditory interference of visual attention tasksD Tomasi
Medical Department, Building 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
Neuroscience 151:1006-15. 2008..Together, these sex-specific differences in brain activation during the VA task, at different cognitive and acoustic levels suggest differences in auditory gating of the thalamus for men and women... - fMRI-acoustic noise alters brain activation during working memory tasksD Tomasi
Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA
Neuroimage 27:377-86. 2005.... - Lower diffusion in white matter of children with prenatal methamphetamine exposureC C Cloak
Department of Medicine, John A Burns School of Medicine, Queen s University Tower, Honolulu, HI 96813, USA
Neurology 72:2068-75. 2009..Whether microstructural brain changes associated with prenatal methamphetamine exposure can be detected with diffusion tensor imaging (DTI) is unknown... - Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patientsLinda Chang
Medical Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
Neuroimage 17:1638-48. 2002..Metabolite concentrations, rather than metabolite ratios, should be measured since [CR], a commonly used reference for metabolite ratios, varies with disease severity in both frontal lobe and basal ganglia... - Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIVC C Cloak
Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Queen's University Tower, 7th Floor, 1356 Lusitana St, Honolulu, HI 96813, USA
J Neuroimmunol 157:147-52. 2004..43, p=0.05). These findings suggest increased brain water diffusion may reflect increased glial activation or inflammation, which in turn, may contribute to the cognitive deficits in HIV patients... - Practice-induced changes of brain function during visual attention: a parametric fMRI study at 4 TeslaD Tomasi
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Neuroimage 23:1414-21. 2004..Since short-term practice-effects in the prefrontal cortex may be similar to attentional load-effects, studies of attentional load need to take practice effects into account... - Effect of aging on brain metabolism in antiretroviral-naive HIV patientsThomas Ernst
Medical Department, Brookhaven National Laboratory, Upton, NY, USA
AIDS 18:S61-7. 2004..The goal of this pilot study was to evaluate the interaction between aging and HIV infection in the brain using proton magnetic resonance spectroscopy (H-MRS)... - Functional GI disorders: from animal models to drug developmentE A Mayer
UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Gut 57:384-404. 2008.... - Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinenceN D Volkow
Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA
J Neurosci 21:9414-8. 2001..These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals... - Methamphetamine and AIDS: 1HMRS studies in a feline model of human diseaseC C Cloak
Medical Department, Brookhaven National Laboratory, Buliding 490, Upton, NY, USA
J Neuroimmunol 147:16-20. 2004..The decreased glutamate in FIV cats normalized with MA exposure. FIV and MA both affect brain metabolites individually and combined. 1HMRS is useful for evaluating the effects of FIV and drug abuse in the brain... - Approaches to the modulation of abdominal painE A Mayer
UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
Can J Gastroenterol 13:65A-70A. 1999.... - Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patientsT Ernst
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Neurology 59:1343-9. 2002..The current study aims to determine whether patients who are HIV-1 positive and have normal cognitive function also show increased brain activation on fMRI... - Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAARTLinda Chang
Medical Department, Brookhaven National Laboratory, Upton, NY, USA
Antivir Ther 8:17-26. 2003..We aimed to evaluate whether brain abnormalities will improve 3 months after HAART... - Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinenceGene Jack Wang
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Am J Psychiatry 161:242-8. 2004..In this study, the authors assessed whether metabolism recovers with protracted abstinence... - Common deactivation patterns during working memory and visual attention tasks: an intra-subject fMRI study at 4 TeslaDardo Tomasi
Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
Hum Brain Mapp 27:694-705. 2006..The task-dependent balance of activation and deactivation might allow maximization of resources for the activated network... - Basic pathophysiologic mechanisms in irritable bowel syndromeE A Mayer
UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Dig Dis 19:212-8. 2001..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events... - Declined neural efficiency in cognitively stable human immunodeficiency virus patientsThomas Ernst
Department of Medicine, University of Hawaii at Manoa, and the Queen s Medical Center, Honolulu, HI 96813, USA
Ann Neurol 65:316-25. 2009..To determine whether brain activation changes in clinically and neurocognitively normal human immunodeficiency virus (HIV)-infected and in HIV-seronegative control (SN) participants over a 1-year period... - Lower brain glutamate is associated with cognitive deficits in HIV patients: a new mechanism for HIV-associated neurocognitive disorderThomas Ernst
Department of Medicine, John A Burns School of Medicine, University of Hawai i, and Queen s Medical Center, Honolulu, Hawai i 96813, USA
J Magn Reson Imaging 32:1045-53. 2010..To determine whether subjects with human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) show altered concentrations of brain glutamate (GLU), and whether lower GLU levels correlate with cognitive deficits... - Neuropsychological deficits in adolescent methamphetamine abusersGeorge King
Department of Psychiatry, John A Burns School of Medicine, 1356 Lusitana St 4th Floor, Honolulu, HI 96813, USA
Psychopharmacology (Berl) 212:243-9. 2010..Methamphetamine (METH) is a widely abused psychostimulant that is associated with neurotoxicity and neurocognitive impairments in adults. However, the effects of METH use on neurocognitive performance of adolescents are unclear... - Adaptation of brain glutamate plus glutamine during abstinence from chronic methamphetamine useThomas Ernst
Department of Medicine, John A Burns School of Medicine, The University of Hawaii at Manoa, 1356 Lusitana Street, 7th Floor, Honolulu, HI 96813, USA
J Neuroimmune Pharmacol 3:165-72. 2008..Since craving may contribute to relapse, medications that normalize GLX may minimize craving in METH users... - Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine usersLinda Chang
Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY, 11973 5000, USA
Psychiatry Res 114:65-79. 2002..These findings suggest that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function... - Association between psychiatric symptoms and craving in methamphetamine usersHelenna Nakama
Department of Psychiatry, John A Burns School of Medicine, The Queen s Medical Center, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
Am J Addict 17:441-6. 2008..Therefore, methamphetamine users, regardless of their usage patterns, may benefit from treatment of their psychiatric symptoms in order to minimize craving and subsequent relapse to drug use... - Building infrastructure for HIV/AIDS and mental health research at institutions serving minoritiesRichard Yanagihara
Department of Pediatrics, John A Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo St, BSB320L, Honolulu, HI 96813, USA
Am J Public Health 99:S82-6. 2009..Although our analysis is drawn from lessons learned at an institution serving a largely Asian and Pacific Islander population, analogous situations may be found for other institutions serving minorities... - Psychiatric symptoms and HPA axis function in adolescent methamphetamine usersGeorge King
Department of Medicine, John A Burns School of Medicine, Honolulu, HI 96812, USA
J Neuroimmune Pharmacol 5:582-91. 2010..The results further suggest that treatment approaches should focus on stress-coping strategies to decrease the probability of relapse... - Functional imaging studies in cannabis usersLinda Chang
Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813
Neuroscientist 13:422-32. 2007..Considerable further work, employing longitudinal designs, is also required to determine whether cannabis use causes permanent functional alterations in the brains of adults... - Higher diffusion in striatum and lower fractional anisotropy in white matter of methamphetamine usersDaniel Alicata
Department of Psychiatry, John A Burns School of Medicine, Honolulu, HI 96813, USA
Psychiatry Res 174:1-8. 2009..The higher ADC in the basal ganglia suggests greater inflammation or less myelination in these brain regions of those with younger age of first METH use and greater METH usage... - Regional variations and the effects of age and gender on glutamate concentrations in the human brainNapapon Sailasuta
Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA
Magn Reson Imaging 26:667-75. 2008..Our results also highlight the importance of brain region, age and gender matching in clinical studies... - The human immunodeficiency virus reduces network capacity: acoustic noise effectDardo Tomasi
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Ann Neurol 59:419-23. 2006..Increased acoustic noise (AN) during working memory leads to increased brain activation in healthy individuals and may have greater impact in human immunodeficiency virus (HIV) patients... - Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?Rita Z Goldstein
State University of New York at Stony Brook, Brookhaven National Laboratory, P O Box 5000, Upton, NY 11973 5000, USA
Am J Psychiatry 164:43-51. 2007..This study attempted to examine the brain's sensitivity to monetary rewards of different magnitudes in cocaine abusers and to study its association with motivation and self-control... - Decreased brain dopaminergic transporters in HIV-associated dementia patientsGene-Jack Wang
Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA
Brain 127:2452-8. 2004..The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals... - Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disordersLinda Chang
Brookhaven National Laboratory, Upton, NY 11973, USA
J Clin Psychiatry 64:7-14. 2003..Examples of such a rational therapeutic approach include anticonvulsants that elevate brain GABA levels and are effective for the treatment of epilepsy and anxiety disorder... - Imaging the addicted human brainJoanna S Fowler
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Sci Pract Perspect 3:4-16. 2007..The authors give examples of key findings illustrating how each technique has extended and deepened our knowledge of the neurobiological bases of drug abuse and addiction, and they address potential clinical and therapeutic applications... - Review article: epidemiology and quality of life in functional gastrointestinal disordersL Chang
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Aliment Pharmacol Ther 20:31-9. 2004..The presence of extra-intestinal symptoms appears to have a major if not greater impact on health care visits, excess health care costs and health-related quality of life in patients with functional gastrointestinal disorders... - The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patientsE A Mayer
CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 16:1357-66. 2002.... - k-Space based summary motion detection for functional magnetic resonance imagingElisabeth C Caparelli
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Neuroimage 20:1411-8. 2003..This method makes it possible to evaluate brain motion within seconds after a scan and to decide whether a study needs to be repeated... - The effects of tamoxifen and estrogen on brain metabolism in elderly womenThomas Ernst
Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
J Natl Cancer Inst 94:592-7. 2002..Consequently, we assessed the effects of tamoxifen and estrogen on the brain chemistry of elderly women... - The effects of repeated endotoxin exposure on rat brain metabolites as measured by ex vivo 1HMRSSulie L Chang
Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA
J Neuroimmunol 166:39-46. 2005..These findings suggest that chronic inflammation induced by LPS could lead to cell loss/dysfunction, and hence, desensitization of the HPA axis, particularly in the hypothalamus... - Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificityRobert H Paul
Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
J Neuropsychiatry Clin Neurosci 19:283-92. 2007..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy... - Neuropsychological effects of 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) in recreational usersCarla Back-Madruga
Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Clin Neuropsychol 17:446-59. 2003..Our results suggest that a subgroup of MDMA patients, specifically heavy MDMA users, evidence declines in nonverbal (visual) memory, however, other cognitive areas appear to be spared... - A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementiaNed Sacktor
Department of Neurology, Johns Hopkins Bayview Medical Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
J Magn Reson Imaging 21:325-33. 2005..To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia... - Unified structural equation modeling approach for the analysis of multisubject, multivariate functional MRI dataJieun Kim
Department of Applied Mathematics and Statistics, State University of New York at Stony Brook, Stony Brook, New York, USA
Hum Brain Mapp 28:85-93. 2007.... - Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy studyGiovanni Schifitto
University of Rochester, Rochester, New York 14620, USA
AIDS 21:1877-86. 2007..To assess the safety and efficacy of memantine, an uncompetitive antagonist of the N-methyl-D-aspartate receptor as treatment of HIV-associated cognitive impairment... - A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysisPatricia Lani Lee
NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
J Magn Reson Imaging 17:625-33. 2003.... - Relationships between white matter metabolite abnormalities, cognitive and social functioning in elderly schizophrenic subjectsJoseph I Friedman
Schizophr Res 100:356-8. 2008 - The orbitofrontal cortex in methamphetamine addiction: involvement in fearRita Z Goldstein
Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA
Neuroreport 13:2253-7. 2002..051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction... - Regional patterns of brain metabolites in AIDS dementia complexConstantin T Yiannoutsos
Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
Neuroimage 23:928-35. 2004..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age... - Response: images and interventionsLinda Chang
Sci Pract Perspect 3:17-9. 2007 - NeuroAIDS, drug abuse, and inflammation: building collaborative research activitiesJoan W Berman
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Neuroimmune Pharmacol 1:351-99. 2006..Research priorities were identified. Additional information about this meeting is available through links from the NIDA AIDS Research Program website ( http://www.nida.nih.gov/about/organization/arp/arp-websites.htm )...
Research Grants
- Brain Activation in Patients with Early HIV DementiaLinda Chang; Fiscal Year: 2007..The knowledge gained from this study will provide a better understanding of how HIV affects the aging brain (even at middle age), and may lead to future preventive measures (e.g. neuroprotective or anti-inflammatory treatments). ..
- Imaging Studies in Neurotoxicity and NeurodevelopmentLinda Chang; Fiscal Year: 2007..g. glaucoma, HIV, cancer), it is a matter of utmost concern to public health to determine the consequences of frequent cannabis use for the brain. We thus envisage that this project will inform issues of public policy. ..
- Neuroimaging and Mentoring in Drug Abuse ResearchLinda Chang; Fiscal Year: 2007..With the strong publication record, experienced collaborators, and novel approaches, the ongoing projects should be successfully renewed or extended, and lead to new directions in HIV and drug abuse research. ..
- MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRSLinda Chang; Fiscal Year: 2001..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
- Early brain development after prenatal "Ice" exposure: A Longitudinal MR studyLinda Chang; Fiscal Year: 2009..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..