Research Topics
Species | Edward F ChangSummaryAffiliation: University of California Country: USA Publications
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Publications
Epilepsy surgery trends in the United States, 1990-2008D J Englot
Correspondence and reprint requests to Dr Chang
Neurology 78:1200-6. 2012..To examine national time trends of resective surgery for the treatment of medically refractory epilepsy before and after Class I evidence demonstrating its efficacy and subsequent practice guidelines recommending early surgical evaluation...- Predictors of seizure freedom after surgery for malformations of cortical developmentEdward F Chang
Northern California Comprehensive Epilepsy Center, San Francisco, San Francisco, CA 94143, USA
Ann Neurol 70:151-62. 2011..Our aim was to examine a surgical series of patients with cortical malformations to determine the prognostic factors associated with long-term seizure control... - Neuronal responses to passive movement in the globus pallidus internus in primary dystoniaEdward F Chang
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Neurophysiol 98:3696-707. 2007..There is an apparent preservation of GPi somatotopic organization in dystonia in comparison with prior studies of GPi somatotopic organization in non-human primates and humans with Parkinson's disease... - Magnetic source imaging for the surgical evaluation of electroencephalography-confirmed secondary bilateral synchrony in intractable epilepsyEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, California 94143, USA
J Neurosurg 111:1248-56. 2009..Whole-head magnetoencephalography (MEG) has superior spatial resolution compared with traditional EEG, and can potentially elucidate seizure foci in challenging epilepsy cases in which patients are undergoing evaluation for surgery... - Preoperative prognostic classification system for hemispheric low-grade gliomas in adultsEdward F Chang
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 109:817-24. 2008..As a result, the objective in the present study was to design a preoperative scoring system to prognosticate long-term outcomes in patients with LGGs... - Multiinstitutional validation of the University of California at San Francisco Low-Grade Glioma Prognostic Scoring System. Clinical articleEdward F Chang
Brain Tumor Research Center, Department of Neurosurgery, University of California, San Francisco, California 94143, USA
J Neurosurg 111:203-10. 2009..The objective of this study was to validate the scoring system in a large patient group drawn from multiple external institutions... - Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformationsEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 65:31-7; discussion 37-8. 2009..The optimal management of seizures associated with cerebral cavernous malformations (CCMs) is unclear. The aim of this study was to determine the efficacy of surgery in the management of CCM-associated seizures... - Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patientsEdward F Chang
Northern California Comprehensive Epilepsy Center, Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg Pediatr 5:123-30. 2010..The authors' aim was to identify factors that predict seizure control following excision... - Cortical spatio-temporal dynamics underlying phonological target detection in humansEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
J Cogn Neurosci 23:1437-46. 2011.... - Long-term benefit sustained after bilateral pallidal deep brain stimulation in patients with refractory tardive dystoniaEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 88:304-10. 2010..Tardive dystonia (TD) can be a highly disabling, permanent condition related to the use of dopamine-receptor-blocking medications. Our aim was to evaluate the long-term effect of bilateral pallidal deep brain stimulation (DBS) for TD... - Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain: improvement of long-term survival. Clinical articleEdward F Chang
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:566-73. 2011..Given the lack of long-term survival data, the prognostic significance of eloquent brain tumor location and the role of functional mapping during resective surgery in presumed eloquent brain regions are unknown... - Homotopic organization of essential language sites in right and bilateral cerebral hemispheric dominanceEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosurg 114:893-902. 2011..Language dominance in the right hemisphere is rare. Therefore, the organization of essential language sites in the dominant right hemisphere is unclear, especially compared with cases involving the more prevalent left dominant hemisphere... - Incidence and management of venous air embolisms during awake deep brain stimulation surgery in a large clinical seriesEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 89:76-82. 2011..The diagnosis and management of VAE in patients undergoing awake deep brain stimulation (DBS) lead implantation in the sitting position are underreported... - Categorical speech representation in human superior temporal gyrusEdward F Chang
Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
Nat Neurosci 13:1428-32. 2010..Our results provide direct evidence for acoustic-to-higher order phonetic level encoding of speech sounds in human language receptive cortex... - Seizure characteristics and control following resection in 332 patients with low-grade gliomasEdward F Chang
Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, California 94143, USA
J Neurosurg 108:227-35. 2008..The aim of this study was to identify factors that influenced perioperative seizure characteristics and postoperative seizure control... - Intraoperative subcortical stimulation mapping for hemispherical perirolandic gliomas located within or adjacent to the descending motor pathways: evaluation of morbidity and assessment of functional outcome in 294 patientsG Evren Keles
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
J Neurosurg 100:369-75. 2004..The purpose of this retrospective analysis was to assess the morbidity and functional outcome associated with this method, thus allowing the surgeon to predict the likelihood of causing a temporary or permanent motor deficit... - Single-trial speech suppression of auditory cortex activity in humansAdeen Flinker
Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, California 94720, USA
J Neurosci 30:16643-50. 2010..Importantly, single-trial high-gamma power (?(High), 70-150 Hz) robustly tracked individual auditory events and exhibited stable responses across trials for suppressed and nonsuppressed regions... - Role of extent of resection in the long-term outcome of low-grade hemispheric gliomasJustin S Smith
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave, Room M 779, San Francisco, CA 94143 0112, USA
J Clin Oncol 26:1338-45. 2008..The prognostic role of extent of resection (EOR) of low-grade gliomas (LGGs) is a major controversy. We designed a retrospective study to assess the influence of EOR on long-term outcomes of LGGs... - Supratentorial cavernous malformations in eloquent and deep locations: surgical approaches and outcomes. Clinical articleEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:814-27. 2011..We hypothesized that an organized system of approaches can guide operative planning and lead to acceptable neurological outcomes in surgical patients... - Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumorsAlfredo Quinones-Hinojosa
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Neurosurgery 64:260-8; discussion 268. 2009..Meningiomas arising from the falcotentorial junction are relatively rare, and the description of the surgical nuances in approaching these tumors is limited. We describe our surgical management of these lesions in detail... - Progressive degradation and subsequent refinement of acoustic representations in the adult auditory cortexShaowen Bao
Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94143 0732, USA
J Neurosci 23:10765-75. 2003.... - Postoperative seizures following the resection of convexity meningiomas: are prophylactic anticonvulsants indicated? Clinical articleMichael E Sughrue
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:705-9. 2011..Given the paucity of tumor-type and site-specific data, the authors evaluated the incidence of postoperative seizures in patients with convexity meningiomas and no prior seizures... - Assessment of morbidity following resection of cingulate gyrus gliomas. Clinical articleMatthew C Tate
Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:640-7. 2011..The goal of the present study is to define the short- and long-term morbidity profile associated with resection of gliomas within this region... - Temporal plasticity in the primary auditory cortex induced by operant perceptual learningShaowen Bao
Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94143 0732, USA
Nat Neurosci 7:974-81. 2004..We conclude that this auditory perceptual learning results in improvements in temporal processing, which may be mediated by enhanced cortical response dynamics... - Volumetric extent of resection and residual contrast enhancement on initial surgery as predictors of outcome in adult patients with hemispheric anaplastic astrocytomaG Evren Keles
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
J Neurosurg 105:34-40. 2006.... - Factors associated with seizure freedom in the surgical resection of glioneuronal tumorsDario J Englot
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
Epilepsia 53:51-7. 2012..Achieving seizure control in patients with glioneuronal tumors remains underappreciated, as tumor-related epilepsy significantly affects patients' quality-of-life... - Long term outcome following repeat transsphenoidal surgery for recurrent endocrine-inactive pituitary adenomasEdward F Chang
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA
Pituitary 13:223-9. 2010..Our data suggest that when performed by experienced transsphenoidal surgeons, durable tumor control can be obtained in these frequently locally aggressive tumors with acceptable rates of post-operative morbidity... - Critical period window for spectral tuning defined in the primary auditory cortex (A1) in the ratEtienne de Villers-Sidani
W M Keck Center for Integrative Neuroscience, Coleman Laboratory, Department of Otolaryngology, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 27:180-9. 2007..We also found that postnatal sound exposure in this epoch led to striking alterations in the cortical representation of sound intensity... - Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomasEdward F Chang
Department of Neurological Surgery, Division of Endocrinology, University of California, San Francisco, California 94143, USA
J Neurosurg 108:736-45. 2008..The authors' aim was to determine predictors of recurrence and overall survival and to define patient subgroups that may benefit from radiotherapy... - Predictors of seizure freedom in the surgical treatment of supratentorial cavernous malformationsDario J Englot
Department of Neurological Surgery, University of California, San Francisco, California
J Neurosurg 115:1169-74. 2011.... - Predictors of seizure freedom after resection of supratentorial low-grade gliomas. A reviewDario J Englot
Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 115:240-4. 2011..Achieving freedom from seizures is of utmost importance in surgical planning, but the factors associated with seizure control remain incompletely understood... - Early surgical intervention in adult patients with ganglioglioma is associated with improved clinical seizure outcomesIsaac Yang
Department of Neurological Surgery, University of California at Los Angeles, Los Angeles, California, USA
J Clin Neurosci 18:29-33. 2011..Our findings also support that an early surgical intervention is significantly associated with improved clinical seizure control... - Falcotentorial meningiomas: clinical, neuroimaging, and surgical features in six patientsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, The Brain Tumor Research Center, University of California at San Francisco, California 94143 0112, USA
Neurosurg Focus 14:e11. 2003..As a result, their clinical presentation and surgical management are not well described. During the past 3 years, the authors have treated six patients with falcotentorial meningiomas... - The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhageJustin S Smith
Department of Neurological Surgery, UCSF Brain and Spinal Injury Center, San Francisco General Hospital and University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
J Trauma 63:75-82. 2007..The purpose of this study was to investigate whether routine follow-up computed tomography (CT) for patients with head injury, in the absence of clinical indications, alters patient management... - Extent of surgical resection predicts seizure freedom in low-grade temporal lobe brain tumorsDario J Englot
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
Neurosurgery 70:921-8; discussion 928. 2012..Achieving seizure control in patients with low-grade temporal lobe gliomas or glioneuronal tumors remains highly underappreciated, because seizures are the most frequent presenting symptom and significantly impact patient quality-of-life... - Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of responseDario J Englot
Department of Neurological Surgery, University of California, San Francisco, California
J Neurosurg 115:1248-55. 2011..However, it is important to recognize that complete seizure freedom is rarely achieved using VNS and that a quarter of patients do not receive any benefit from therapy... - Excess mortality for patients with residual disease following resection of pituitary adenomasMichael E Sughrue
California Center for Pituitary Disorders, University of California, 400 Parnassus Avenue, Room A 808, San Francisco, CA 94143 0350, USA
Pituitary 14:276-83. 2011.... - Pre-operative dopamine agonist therapy improves post-operative tumor control following prolactinoma resectionMichael E Sughrue
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA
Pituitary 12:158-64. 2009..We sought to determine whether preoperative treatment with dopamine agonists alters the outcome of surgical intervention... - Heme regulation in traumatic brain injury: relevance to the adult and developing brainEdward F Chang
Department of Neurosurgery, University of California, San Francisco, San Francisco, California 94143-0520, USA
J Cereb Blood Flow Metab 25:1401-17. 2005..These findings suggest novel clinical therapeutic options for further translational study... - Development of spectral and temporal response selectivity in the auditory cortexEdward F Chang
Coleman Memorial Laboratory, Department of Otolaryngology, W M Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143 0444, USA
Proc Natl Acad Sci U S A 102:16460-5. 2005..They were subsequently renormalized when animals were returned to standard housing conditions as adults... - Isolated trigeminal nerve sarcoid granuloma mimicking trigeminal schwannoma: case reportAlfredo Quinones-Hinojosa
Department of Neurosurgery, University of California at San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 52:700-5 discussion 704-5. 2003..Sarcoid of the trigeminal nerve is exceedingly rare and can mimic trigeminal schwannoma. We review the literature on sarcoid granulomas of the trigeminal nerve and compare their radiological features with the more common schwannoma... - Perinatal asphyxia affects rat auditory processing: implications for auditory perceptual impairments in neurodevelopmental disordersFabrizio Strata
Department of Neuroscience, Section of Physiology, University of Parma, Parma, Italy
PLoS ONE 5:e15326. 2010.... - Characteristics and treatment of seizures in patients with high-grade glioma: a reviewDario J Englot
UCSF Epilepsy Center, University of California, San Francisco, 505 Parnassus Avenue, Box 0138, San Francisco, CA 94143, USA Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 23:227-35. 2012..Antiepileptic drugs remain the mainstay of seizure treatment in HGG, and antiepileptic medication should be started after a tumor-related seizure, but should not be used prophylactically in the absence of seizure activity... - Thrombotic intracranial aneurysms: classification scheme and management strategies in 68 patientsMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:441-54; discussion 441-54. 2005..A classification scheme was devised on the basis of aneurysm, thrombus, and lumen morphology to relate these anatomic features to surgical therapy... - Focal cortical dysplasia: a review of pathological features, genetics, and surgical outcomeVincent Y Wang
Department of Neurological Surgery, University of California, San Francisco, California 94130, USA
Neurosurg Focus 20:E7. 2006..Data from surgical series have shown that surgery often results in significant reduction or cessation of seizures, especially if the entire lesion is resected... - Transsylvian-transinsular approaches to the insula and basal ganglia: operative techniques and results with vascular lesionsMatthew B Potts
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
Neurosurgery 70:824-34; discussion 834. 2012..Transsylvian approaches shorten the surgical distance to these lesions, preserve perisylvian temporal and frontal cortex, and minimize brain transgression... - Comparison of seizure control outcomes and the safety of vagus nerve, thalamic deep brain, and responsive neurostimulation: evidence from randomized controlled trialsJohn D Rolston
Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
Neurosurg Focus 32:E14. 2012..The authors review published results from these pivotal trials and highlight important differences between the trials and devices and their application in clinical use... - Efficacy of vagus nerve stimulation for epilepsy by patient age, epilepsy duration, and seizure typeDario J Englot
Department of Neurological Surgery, Epilepsy Center, University of California, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 22:443-8, v. 2011..In this article, the authors retrospectively studied a patient outcome registry and report the largest, to their knowledge, analysis of VNS outcomes in epilepsy... - Renal cell carcinoma metastatic to the choroid mimicking intraventricular meningiomaAlfredo Quinones-Hinojosa
Department of Neurosurgery, University of California San Francisco, San Francisco, California 94143-0112, USA
Can J Neurol Sci 31:115-20. 2004..We also discuss the use of an under-utilized technique, the contralateral transcallosal approach, in the surgical treatment of this intraventricular lesion... - Environmental noise retards auditory cortical developmentEdward F Chang
W M Keck Center for Integrative Neuroscience, University of California, San Francisco, CA, USA
Science 300:498-502. 2003..These results demonstrate that A1 organization is shaped by a young animal's exposure to salient, structured acoustic inputs-and implicate noise as a risk factor for abnormal child development... - Acute traumatic intraparenchymal hemorrhage: risk factors for progression in the early post-injury periodEdward F Chang
Department of Neurological Surgery, University of California, San Francisco General Hospital, San Francisco, California, USA
Neurosurgery 58:647-56; discussion 647-56. 2006..To characterize the natural course of traumatic intraparenchymal contusions and hematomas (IPHs) and to identify risk factors for IPH progression in the acute post-injury period... - Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injuryEdward F Chang
Department of Neurosurgery, University of California, San Francisco, San Francisco, California 94143 0520, USA
J Neurosci 23:3689-96. 2003..These findings demonstrate that HO-2 expression protects neurons against TBI by reducing lipid peroxidation via the catabolism of free heme...