Research Topics
Genomes and Genes
| L W CastellaniSummaryAffiliation: University of California Country: USA Publications
| Collaborators
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Detail Information
Publications
Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosisJennifer M P Woo
Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
Arthritis Res Ther 12:R93. 2010....- Studies with apolipoprotein A-II transgenic mice indicate a role for HDLs in adiposity and insulin resistanceL W Castellani
Department of Medicine, University of California, Los Angeles 90095, USA
Diabetes 50:643-51. 2001.... - Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistanceLawrence W Castellani
Departments of Medicine Cardiology University of California, Los Angeles, Los Angeles, California 90095, USA
J Biol Chem 283:11633-44. 2008.... - Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-IILawrence W Castellani
Department of Medicine, 47 123 CHS, University of California, Los Angeles, CA 90095, USA
J Lipid Res 45:2377-87. 2004..Rosiglitazone treatment significantly ameliorated IR in the apoA-II transgenic mice, suggesting that the underlying mechanisms of IR in this animal model may share common features with certain types of human IR... - Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosisD M Shih
Division of Cardiology, Department of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 275:17527-35. 2000..These data demonstrate that PON1 deficiency promotes LDL oxidation and atherogenesis in apoE KO mice... - Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particlesL W Castellani
Department of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
J Clin Invest 100:464-74. 1997..We conclude that overexpression of apoAII converts HDL from an anti- to a proinflammatory particle and that paraoxonase plays a role in this transformation... - Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosisD M Shih
Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
Nature 394:284-7. 1998..When fed on a high-fat, high-cholesterol diet, PON1-null mice were more susceptible to atherosclerosis than their wild-type littermates... - Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2B Ivandic
Department of Microbiology and Molecular Genetics and Molecular Biology Institute, Division of Cardiology, University of California, Los Angeles 90095, USA
Arterioscler Thromb Vasc Biol 19:1284-90. 1999..These data also provide a possible mechanism for the observation that there is an increased incidence of coronary artery disease in many chronic inflammatory diseases... - In vivo interactions of apoA-II, apoA-I, and hepatic lipase contributing to HDL structure and antiatherogenic functionsC C Hedrick
Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
J Lipid Res 42:563-70. 2001..Our data suggest that as the ratio of apoA-II to apoA-I is increased, the HDL become larger because of inhibition of HL, and lose their antiatherogenic properties... - A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2A Mouzeyan
Department of Microbiology, University of California, Los Angeles, CA 90095, USA
J Lipid Res 41:573-82. 2000..6) between B6By alleles and hypo-response to diet. Examination of known genes in this region suggested that this locus represents a novel gene affecting plasma lipids and atherogenesis in response to diet... - HDL and the inflammatory response induced by LDL-derived oxidized phospholipidsM Navab
Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1736, USA
Arterioscler Thromb Vasc Biol 21:481-8. 2001..It is proposed that LDL-derived oxidized phospholipids and HDL may be part of a system of nonspecific innate immunity and that the detection of proinflammatory HDL may be a useful marker of susceptibility to atherosclerosis... - Mapping a gene for combined hyperlipidaemia in a mutant mouse strainL W Castellani
Department of Medicine, University of California, Los Angeles 90095, USA
Nat Genet 18:374-7. 1998..This region is syntenic to human chromosome 1q21-q23, which has recently been shown to harbour a gene associated with FCHL in families from a Finnish isolate... - Identification of ALOX5 as a gene regulating adiposity and pancreatic functionM Mehrabian
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Diabetologia 51:978-88. 2008..In the present study, we sought to further examine the role of 5-LO in adiposity and pancreatic function... - Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHLP Pajukanta
UCLA, Department of Human Genetics, Gonda Neuroscience and Genetics Research Center, Los Angeles, California 90095 7088, USA
Mamm Genome 12:238-45. 2001..Further studies identifying and sequencing the Hyplip1 gene will show whether the same gene predisposes to hyperlipidemia in human and mouse... - Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophagesJ L Escary
Lipid Research Laboratory, West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA
J Lipid Res 40:397-404. 1999..Thus, increasing cholesteryl-ester hydrolysis, without concomitantly decreasing ACAT activity or increasing cholesterol efflux, is not sufficient to protect against atherosclerosis. hormone-sensitive lipase overexpression in macrophages... - Upstream transcription factor 1 influences plasma lipid and metabolic traits in miceSulin Wu
Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Hum Mol Genet 19:597-608. 2010..In all three mouse model settings, notable sex specificity was observed, consistent with human studies showing differences in association with USF1 gene polymorphisms between sexes... - Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J)M Mehrabian
Department of Medicine, University of California, Los Angeles, CA 90095, USA
J Lipid Res 41:1936-46. 2000..Our results suggest that novel genes are likely to be important in the control of HDL metabolism, and they provide evidence of genetic factors influencing the interaction of LCAT with HDL... - Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosisXuping Wang
Department of Medicine, University of California, Los Angeles 90095 1679, USA
Arterioscler Thromb Vasc Biol 24:1928-34. 2004..The congenic allowed us to confirm the QTL result and to further characterize the properties and location of the underlying gene... - Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approachD A Purcell-Huynh
Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024, USA
J Clin Invest 96:1845-58. 1995..0001), indicating that apoAII expression influences HDL cholesterol levels. Molecular studies suggested that structural differences in the apoAII polypeptide of the two strains may contribute to differences in clearance of the protein... - Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratioM Navab
Department of Medicine, School of Medicine, College of Letters and Sciences, University of California, Los Angeles 90095, USA
J Clin Invest 99:2005-19. 1997..We conclude that: (a) mildly oxidized LDL can induce an increased apoJ/PON ratio, and (b) the apoJ/PON ratio may prove to be a better predictor of atherosclerosis than the total cholesterol/HDL cholesterol ratio... - Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modificationsDonald L Puppione
The Molecular Biology Institute and The Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
Biochim Biophys Acta 1764:1363-71. 2006.... - NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protectionBerenice Barajas
Department of Medicine, University of California, Center for Health Sciences, Los Angeles, CA 90095, USA
Arterioscler Thromb Vasc Biol 31:58-66. 2011..To test the hypothesis that NF-E2-related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties... - Dissection of multigenic obesity traits in congenic mouse strainsDaria Estrada-Smith
Department of Human Genetics, Gonda Goldschmeid Center for Neuroscience and Human Genetics Research, 695 Charles E Young Dr South, Room 6524, Los Angeles, CA 90095 7088, USA
Mamm Genome 15:14-22. 2004..When fed an atherogenic diet, several traits associated with metabolic syndrome were observed in the distal MOB congenic, while alterations in plasma lipoproteins were observed in the middle MOB congenic strain... - Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemiaHooman Allayee
Department of Human Genetics, Gonda Genetics Research Center, of California, Los Angeles, Calif 90095, USA
Circ Res 92:1262-7. 2003..Our results demonstrate that apoA-II is biochemically and genetically associated with FCH and may serve as a useful marker for understanding the mechanism by which FCH develops... - Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db miceRichard C Davis
Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Diabetes 59:1616-25. 2010..To identify metabolic derangements contributing to diabetes susceptibility in the leptin receptor-deficient obese C57BLKS/J-db/db (BKS-db) mouse strain... - Positional cloning of the combined hyperlipidemia gene Hyplip1Jackie S Bodnar
Department of Medicine, University of California, Los Angeles, 47 123 CHS, UCLA School of Medicine, Los Angeles, California 90095, USA
Nat Genet 30:110-6. 2002..These results reveal a new pathway of potential clinical significance that contributes to plasma lipid metabolism... - Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traitsMargarete Mehrabian
Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
Nat Genet 37:1224-33. 2005.... - Validation of candidate causal genes for obesity that affect shared metabolic pathways and networksXia Yang
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Nat Genet 41:415-23. 2009..Integration of gene expression in the design and analysis of traditional F(2) intercross studies allows high-confidence prediction of causal genes and identification of pathways and networks involved... - Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G malesLawrence W Castellani
Department of Medicine, University of California Los Angeles, 90095, USA
J Lipid Res 47:1366-77. 2006..The human MPO transgenic model will facilitate studies of MPO involvement in atherosclerosis and lipid homeostasis... - Chylomicronemia elicits atherosclerosis in mice--brief reportMichael M Weinstein
Departments of Medicine, University of California, Los Angeles, USA
Arterioscler Thromb Vasc Biol 30:20-3. 2010..In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis... - Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic miceAaron Tward
Department of Medicine, University of California, Los Angeles 90095 1679, USA
Circulation 106:484-90. 2002..To evaluate whether PON1 protects against atherosclerosis and lipid oxidation in a dose-dependent manner, we generated and studied human PON1 transgenic mice... - A high-resolution association mapping panel for the dissection of complex traits in miceBrian J Bennett
Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Genome Res 20:281-90. 2010..This resource, termed the Hybrid Mouse Diversity Panel, makes possible the integration of multiple data sets and should prove useful for systems-based approaches to complex traits and studies of gene-by-environment interactions... - The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activityMark O Goodarzi
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Becker B 128, Los Angeles, California 90048, USA
J Clin Endocrinol Metab 90:4816-23. 2005..Haplotypes comprising six single nucleotide polymorphisms (SNPs) (intron 7 to intron 9) of the lipoprotein lipase (LPL) gene appear to influence risk for atherosclerosis and insulin resistance in Mexican-Americans... - ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopeniaXuebing Feng
Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA, USA
J Lipid Res 48:794-805. 2007..Correlations of IgG anti-OxPL with lupus-like disease, atherosclerosis, and bone loss suggested a shared pathway of these disease processes... - Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXRYanqiao Zhang
Department of Biological Chemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
Genes Dev 18:157-69. 2004..Our data suggest that PGC-1alpha plays an important physiological role in maintaining energy homeostasis during fasting by decreasing triglyceride production/secretion while it increases fatty acid beta-oxidation to meet energy needs... - The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemiaNadine S Sauter
Larry L Hillblom Islet Research Center, University of California Los Angeles, Los Angeles, California 90095 7345, USA
Endocrinology 149:2208-18. 2008..Insulin mRNA was reduced in islets from mice fed a HFD but normalized in the IL-1Ra group. Our results show that IL-1Ra improves beta-cell survival and function, and support the potential role for IL-1Ra in the treatment of diabetes... - Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient miceWeibin Shi
Department of Radiology, University of Virginia, Charlottesville 22908, USA
Biochem Biophys Res Commun 317:223-9. 2004..56; P<0.0001). Thus, macrophage apoE-deficiency alleviates severe hyperlipidemia by slowing hepatic VLDL production and consequently reduces atherosclerosis in LDLR(-/-) mice... - ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36Maria C de Beer
Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
J Lipid Res 45:706-15. 2004..These results demonstrate that apoA-II exerts a marked effect on HDL binding and selective lipid uptake by the class B scavenger receptors and establishes a potentially important relationship between apoA-II and CD36... - Heritability of subclinical atherosclerosis in Latino families ascertained through a hypertensive parentAnny H Xiang
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles 90033, USA
Arterioscler Thromb Vasc Biol 22:843-8. 2002..Heritability is particularly evident in younger family members, suggesting that acquired factors contribute progressively to IMT variability with aging... - Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/6J miceJon H Miyake
Mammalian Cell and Molecular Biology Laboratory, San Diego State University, San Diego, CA, USA
Arterioscler Thromb Vasc Biol 22:121-6. 2002..These data establish the integral role that cholesterol-7-alpha-hydroxylase has in maintaining hepatic cholesterol homeostasis and, thus, in the susceptibility to the formation of gallstones and atherosclerosis... - Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetesMadhu S Dhar
Department of Nutrition, University of Tennessee, Knoxville, TN 37996, USA
J Nutr 134:799-805. 2004.... - Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transitionSonal S Sheth
Department of Human Genetics, Medicine, Molecular Biology Institute, University of California, Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Lipid Res 46:123-34. 2005..These results indicate a role for Txnip in the metabolic response to feeding and the maintenance of the redox status...