D B Carr

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Gestational diabetes or lesser degrees of glucose intolerance and risk of preeclampsia
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    Hypertens Pregnancy 30:153-63. 2011
  2. ncbi Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes Care 29:2078-83. 2006
  3. ncbi Maternal hemodynamic changes associated with furosemide treatment
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
    Hypertens Pregnancy 26:173-8. 2007
  4. ncbi A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function
    Darcy B Carr
    Department of ObstetricsGynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes 54:340-7. 2005
  5. ncbi Modestly elevated glucose levels during pregnancy are associated with a higher risk of future diabetes among women without gestational diabetes mellitus
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes Care 31:1037-9. 2008
  6. ncbi Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes 53:2087-94. 2004
  7. ncbi Hemodynamically-directed atenolol therapy is associated with a blunted rise in maternal sFLT-1 levels during pregnancy
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Hypertens Pregnancy 28:42-55. 2009
  8. ncbi Preeclampsia and risk of developing subsequent diabetes
    D B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Hypertens Pregnancy 28:435-47. 2009
  9. ncbi Diabetic nephropathy in pregnancy: suboptimal hypertensive control associated with preterm delivery
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Am J Hypertens 19:513-9. 2006
  10. ncbi The relationship between hemodynamics and inflammatory activation in women at risk for preeclampsia
    D B Carr
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98195 6460, USA
    Obstet Gynecol 98:1109-16. 2001

Detail Information

Publications39

  1. ncbi Gestational diabetes or lesser degrees of glucose intolerance and risk of preeclampsia
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    Hypertens Pregnancy 30:153-63. 2011
    ..We evaluated the association of 1-h oral glucose challenge test (OGCT) and 3-h oral glucose tolerance test (OGTT) results with preeclampsia...
  2. ncbi Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes Care 29:2078-83. 2006
    ..We sought to determine whether a history of gestational diabetes mellitus (GDM) further increases the risk of cardiovascular disease (CVD) in parous women with first-degree relatives with type 2 diabetes...
  3. ncbi Maternal hemodynamic changes associated with furosemide treatment
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
    Hypertens Pregnancy 26:173-8. 2007
    ..To assess the pharmacodynamic effects of furosemide in pregnancy...
  4. ncbi A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function
    Darcy B Carr
    Department of ObstetricsGynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes 54:340-7. 2005
    ..However, such changes did not improve beta-cell function, suggesting that this degree of lifestyle modifications may be limited in preventing type 2 diabetes over the long term...
  5. ncbi Modestly elevated glucose levels during pregnancy are associated with a higher risk of future diabetes among women without gestational diabetes mellitus
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes Care 31:1037-9. 2008
    ..To determine whether 1-h oral glucose challenge test (OGCT) or 3-h oral glucose tolerance test (OGTT) results below gestational diabetes mellitus (GDM) criteria are associated with developing diabetes...
  6. ncbi Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes 53:2087-94. 2004
    ..Of the NCEP criteria, waist circumference and triglycerides may best identify insulin resistance and visceral adiposity in individuals with a fasting plasma glucose <6.4 mmol/l...
  7. ncbi Hemodynamically-directed atenolol therapy is associated with a blunted rise in maternal sFLT-1 levels during pregnancy
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Hypertens Pregnancy 28:42-55. 2009
    ..Cardiac output and sFlt-1 are elevated prior to clinical evidence of preeclampsia. Early treatment of high cardiac output with atenolol decreases the risk for preeclampsia. We hypothesized that atenolol would impact circulating sFlt-1...
  8. ncbi Preeclampsia and risk of developing subsequent diabetes
    D B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Hypertens Pregnancy 28:435-47. 2009
    ..Determine whether preeclampsia is associated with developing diabetes...
  9. ncbi Diabetic nephropathy in pregnancy: suboptimal hypertensive control associated with preterm delivery
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Am J Hypertens 19:513-9. 2006
    ....
  10. ncbi The relationship between hemodynamics and inflammatory activation in women at risk for preeclampsia
    D B Carr
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98195 6460, USA
    Obstet Gynecol 98:1109-16. 2001
    ....
  11. ncbi Intra-abdominal fat accumulation predicts the development of the metabolic syndrome in non-diabetic Japanese-Americans
    J Tong
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System 151 and University of Washington, 1660 South Columbian Way, Seattle, WA 98108, USA
    Diabetologia 50:1156-60. 2007
    ..Our aim was to determine whether IAF accumulation predicts the future development of MetS in non-diabetic Japanese-Americans...
  12. ncbi Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans
    K M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Veterans Affairs Puget Sound Health Care System, Harborview Medical Center, University of Washington, Seattle, WA, USA
    Diabetologia 48:2330-3. 2005
    ..The aim of this study was to further elucidate the relationship between resistin and insulin sensitivity, body fat distribution and the metabolic syndrome in humans...
  13. ncbi Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies
    K M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 50:2516-25. 2007
    ..We sought to determine the day-to-day variability of measures of beta cell function derived from an OGTT...
  14. ncbi Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects
    J Tong
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Diabetologia 50:439-42. 2007
    ..We have examined whether in humans increased PP levels are associated with increased intra-abdominal fat (IAF), and thereby insulin resistance...
  15. ncbi Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice
    M F Hebert
    Department of Pharmacy, University of Washington, Seattle, Washington, USA
    Clin Pharmacol Ther 85:607-14. 2009
    ..Women with GDM in whom glyburide treatment has failed may benefit from alternative medication or dosage escalation; however, fetal safety should be kept in mind...
  16. ncbi Low-dose, short-acting, angiotensin-converting enzyme inhibitors as rescue therapy in pregnancy
    T R Easterling
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Obstet Gynecol 96:956-61. 2000
    ..To assess the risks and potential benefits of low-dose angiotensin-converting enzyme (ACE) inhibitor treatment in pregnancies complicated by severe hypertension...
  17. ncbi An examination of beta-cell function measures and their potential use for estimating beta-cell mass
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Diabetes Obes Metab 10:63-76. 2008
    ..However, until beta-cell volume can be quantified reliably and non-invasively, we will need to rely on the ability of glucose to potentiate insulin release as the best surrogate estimate of the number of beta-cells...
  18. ncbi Treatment of hypertension in pregnancy: effect of atenolol on maternal disease, preterm delivery, and fetal growth
    T R Easterling
    Department of Obstetrics and Gynecology, University of Washington, Seattle, 98195, USA
    Obstet Gynecol 98:427-33. 2001
    ..To assess the impact of antihypertensive therapy initiated early in pregnancy on maternal and fetal outcomes...
  19. ncbi Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study
    M F Hebert
    Department of Pharmacy, University of Washington, Seattle, Washington, USA
    Clin Pharmacol Ther 84:248-53. 2008
    ..58 +/- 22 ml/min; P < 0.002) were higher during pregnancy than postpartum. These data are consistent with increased hepatic and/or intestinal CYP3A and renal P-gp activities during pregnancy...
  20. ncbi Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes
    Miriam Cnop
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Diabetes Care 30:677-82. 2007
    ..First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia...
  21. ncbi Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
    R L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System 151, University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetologia 48:1350-8. 2005
    ..We therefore sought to determine whether the impaired beta cell adaptation is due to inadequate expansion of the beta cell population or to a lack of an adaptive increase in insulin release...
  22. ncbi Clonidine pharmacokinetics in pregnancy
    M L Buchanan
    Department of Pharmacy, University of Washington, 1959 NE Pacific Street, H 375 Health Sciences Center, Box 357630, Seattle, WA 98195 7630, USA
    Drug Metab Dispos 37:702-5. 2009
    ..0 +/- 0.1 (venous). In conclusion, clonidine is cleared more rapidly in pregnant women than in nonpregnant subjects. At the time of delivery, the fetus is exposed to similar plasma clonidine concentrations as the mother...
  23. ncbi Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Diabetes Care 32:335-41. 2009
    ..First, we assessed the validity of the DI(O) by demonstrating that a hyperbolic relationship exists between oral indexes of insulin sensitivity and beta-cell function...
  24. ncbi Diet-induced weight loss is associated with an improvement in beta-cell function in older men
    Kristina M Utzschneider
    Department of Medicine, Veterans Affairs Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 89:2704-10. 2004
    ..05). Thus, the weight loss-associated improvements in both insulin sensitivity and beta-cell function may explain the beneficial effects of a lifestyle intervention on delaying the development of diabetes in older subjects...
  25. ncbi Effect of pregnancy on the pharmacokinetics of antihypertensive drugs
    Gail D Anderson
    Department of Pharmacy, University of Washington, Seattle, Washington, USA
    Clin Pharmacokinet 48:159-68. 2009
    ..Higher doses and altered dosage intervals may be needed for antihypertensive drugs used in pregnant women...
  26. ncbi Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution
    Fernando Gerchman
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 94:3781-8. 2009
    ..Although obesity has been, in general, associated with glomerular hyperfiltration, visceral adiposity has been suggested to be associated with reduced glomerular filtration...
  27. ncbi Insulin resistance is the best predictor of the metabolic syndrome in subjects with a first-degree relative with type 2 diabetes
    Kristina M Utzschneider
    VA Puget Sound Health Care System, Seattle, Washington, USA
    Obesity (Silver Spring) 18:1781-7. 2010
    ..Further, as many lean individuals with a first-degree relative with type 2 diabetes are IR and metabolically unhealthy, they may all benefit from metabolic testing...
  28. ncbi Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses
    Kristina M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes Care 29:356-62. 2006
    ..To determine whether the hyperbolic relationship between insulin sensitivity and the acute insulin response to glucose (AIRg) exists in subjects with impaired fasting glucose (IFG) or decreased glucose tolerance...
  29. ncbi Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 53:2867-72. 2004
    ....
  30. ncbi A sister's risk: family history as a predictor of preeclampsia
    Darcy B Carr
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
    Am J Obstet Gynecol 193:965-72. 2005
    ..CONCLUSION: The greater likelihood of preeclampsia among sisters of women with a previous preeclamptic pregnancy is consistent with a pathophysiologic role for genetic and/or behavioral factors that cluster in families...
  31. ncbi Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 54:2235-44. 2005
    ....
  32. ncbi Second-trimester biparietal diameter/nasal bone length ratio is an independent predictor of trisomy 21
    Lan T Tran
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medecine of Perinatal Medecine and University of Washington, Seattle, WA 98195, USA
    J Ultrasound Med 24:805-10. 2005
    ..The purpose of this study was to evaluate the association between the second-trimester fetal biparietal diameter/nasal bone length (BPD/NBL) ratio and trisomy 21...
  33. ncbi Dysregulation of the hypothalamic-pituitary-adrenal axis in postpartum depression
    Sandra N Jolley
    University of Washington, Family and Child Nursing, Seattle, WA 98195, USA
    Biol Res Nurs 8:210-22. 2007
    ..This pattern of higher ACTH levels to stimulate less cortisol is similar to patterns found in women with early life stresses...
  34. ncbi Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 289:E703-9. 2005
    ..These findings underscore the importance of genetic and environmental factors in studying metabolic disease...
  35. ncbi Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat
    Tara M Wallace
    Department of Medicine, VA Puget Sound Health Care System, and University of Washington, Seattle, WA 98108, USA
    Diabetes Care 30:2673-8. 2007
    ..The purpose of this study was to determine the relationship between plasma liver enzyme concentrations, insulin sensitivity, and intra-abdominal fat (IAF) distribution...
  36. ncbi Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy
    Mario Kratz
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 93:959-66. 2008
    ..The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy...
  37. ncbi Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
    M Cnop
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System (151) and University of Washington, 1660 S. Columbian Way, Seattle, WA 98108, USA
    Diabetologia 46:459-69. 2003
    ..Adiponectin could link intra-abdominal fat with insulin resistance and an atherogenic lipoprotein profile...
  38. ncbi Pharmacokinetics and pharmacodynamics of atenolol during pregnancy and postpartum
    Mary F Hebert
    Department of Pharmacy, University of Washington, Seattle, WA 98195-7630, USA
    J Clin Pharmacol 45:25-33. 2005
    ..Atenolol administration did not appear to change the pattern of the increase in cardiac output and the decrease in total peripheral resistance, which normally occurs during pregnancy...
  39. ncbi Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies
    M A Andrew
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Clin Pharmacol Ther 81:547-56. 2007
    ..Amoxicillin may not be an appropriate antibiotic for post-anthrax exposure prophylaxis...