Research Topics
| A BystritskySummaryAffiliation: University of California Country: USA Publications
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Publications
Computational non-linear dynamical psychiatry: a new methodological paradigm for diagnosis and course of illnessA Bystritsky
Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, United States
J Psychiatr Res 46:428-35. 2012..They may also provide a new, more descriptive and ultimately more predictive approach leading to better understanding of the interrelationship between psychological, neurobiological, and genetic underpinnings of mental illness...
A pilot controlled trial of bupropion XL versus escitalopram in generalized anxiety disorderAlexander Bystritsky
Department of Psychiatry, University of California, Los Angeles, CA, USA
Psychopharmacol Bull 41:46-51. 2008..To compare the efficacy and safety of bupropion XL (150 to 300 mg/day) with the selective serotonin reuptake inhibitor escitalopram (10 to 20 mg/day) in outpatients diagnosed with generalized anxiety disorder (GAD)...
Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activityByoung Kyong Min
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
BMC Neurosci 12:23. 2011....
A preliminary study of fMRI-guided rTMS in the treatment of generalized anxiety disorderAlexander Bystritsky
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 6968, USA
J Clin Psychiatry 69:1092-8. 2008..The goal of this pilot study was to evaluate whether functional magnetic resonance imaging (fMRI)-guided rTMS is effective in reducing symptoms of GAD...
A review of low-intensity focused ultrasound pulsationAlexander Bystritsky
Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
Brain Stimul 4:125-36. 2011..In this study, we review over 50 years of research data on the use of focused ultrasound (FUS) in neuronal tissue and live brain, and propose novel applications of this noninvasive neuromodulation method...
A pilot study of cranial electrotherapy stimulation for generalized anxiety disorderAlexander Bystritsky
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 6968, USA
J Clin Psychiatry 69:412-7. 2008..The goal of this study was to evaluate the efficacy of CES in alleviating anxiety in patients with DSM-IV-diagnosed GAD...
A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD)Alexander Bystritsky
Department of Psychiatry, University of California, Los Angeles, CA, USA
J Altern Complement Med 14:175-80. 2008..Whether R. rosea is effective in reducing similar symptoms in clinical samples is unknown. The goal of this pilot study was to evaluate whether R. rosea is effective in reducing symptoms of generalized anxiety disorder (GAD)...
Treatment-resistant anxiety disordersA Bystritsky
UCLA, Department of Psychiatry, Los Angeles, CA 90095 6968, USA
Mol Psychiatry 11:805-14. 2006..In addition, we would like to review current strategies that could be helpful in reducing treatment resistance and aiding people chronically suffering from these severe and disabling conditions...
Clinical and subthreshold panic disorderAlexander Bystritsky
The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095 8346, USA
Depress Anxiety 27:381-9. 2010..The purpose of this study was to add to the accumulating evidence of significant comorbidity and disability associated with subthreshold PD...
Quality-of-life changes among patients with obsessive-compulsive disorder in a partial hospitalization programA Bystritsky
University of California, Los Angeles, Neuropsychiatric Institute and Hospital, 90024, USA
Psychiatr Serv 50:412-4. 1999..No significant association between changes in YBOCS scores and QOL scores was found...
Social functioning and quality of life comparisons between obsessive-compulsive and schizophrenic disordersA Bystritsky
UCLA Department of Psychiatry and Biobehavioral Sciences, 300 UCLA Medical Plaza, Los Angeles, California 90095, USA
Depress Anxiety 14:214-8. 2001..We concluded that patients with severe OCD and patients with schizophrenia are equally socially impaired. However, OCD patients experience greater significant functional improvement with multimodal treatment...
A retrospective review of clinical characteristics and treatment response in body dysmorphic disorder versus obsessive-compulsive disorderS Saxena
Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, Calif 90095, USA
J Clin Psychiatry 62:67-72; quiz 73. 2001..Although BDD and OCD respond to similar medications and cognitive-behavioral therapy (CBT), their response to treatment has never been directly compared...
Predictors of clinical improvement in a randomized effectiveness trial for primary care patients with panic disorderDenise A Chavira
Department of Psychiatry, University of California, San Diego, CA 92037, USA
J Nerv Ment Dis 197:715-21. 2009..A greater understanding of these predictors may help clinicians identify who is at greatest risk for persistent panic-related symptoms and to plan the intensity of interventions accordingly...
Quality of care for primary care patients with anxiety disordersMurray B Stein
Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0985, USA
Am J Psychiatry 161:2230-7. 2004..This study evaluated quality of care for primary care patients with anxiety disorders in university-affiliated outpatient clinics in Los Angeles, San Diego, and Seattle...
Pilot open-label study of nefazodone in panic disorderA Bystritsky
Department of Psychiatry, U C L A School of Medicine, USA
Depress Anxiety 10:137-9. 1999..Low sample size and absence of placebo control indicate the need for a large placebo-controlled trial. The results of this pilot study suggest that nefazodone may be promising in the treatment of panic and justify further research...
Treatment for anxiety disorders: Efficacy to effectiveness to implementationMichelle G Craske
University of California, Los Angeles, Department of Psychology, Franz Hall, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
Behav Res Ther 47:931-7. 2009..Future directions for our research include dissemination and implementation of the CALM program, testing potential alternations to the CALM program, and distance delivery of CALM...
Presleep attributions about arousal during sleep: nocturnal panicMichelle G Craske
Department of Psychology, University of California, Los Angeles 90095 1563, USA
J Abnorm Psychol 111:53-62. 2002..The findings are consistent with a cognitive model of nocturnal panic attacks...
Treating panic disorder in primary care: a collaborative care interventionMichelle G Craske
Department of Psychology, UCLA, Los Angeles, CA, USA
Gen Hosp Psychiatry 24:148-55. 2002..This description is intended to lay the groundwork for continued research efforts in the extension of efficacious treatments into primary care settings...
Visual information processing of faces in body dysmorphic disorderJamie D Feusner
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, 300 UCLA Medical Plaza, Ste 2345, Los Angeles, CA 90024, USA
Arch Gen Psychiatry 64:1417-25. 2007..This study examines abnormalities in visual information processing in BDD that may underlie clinical symptoms...
Obsessive-compulsive hoarding: symptom severity and response to multimodal treatmentSanjaya Saxena
Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, Calif 90095, USA
J Clin Psychiatry 63:21-7. 2002....
Disorder-specific impact of coordinated anxiety learning and management treatment for anxiety disorders in primary careMichelle G Craske
Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
Arch Gen Psychiatry 68:378-88. 2011..Anxiety disorders commonly present in primary care, where evidence-based mental health treatments often are unavailable or suboptimally delivered...
Impaired identity recognition of faces with emotional expressions in body dysmorphic disorderJamie Donald Feusner
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
Psychiatry Res 179:318-23. 2010..This could reflect fundamental abnormalities in visual information processing that are more pronounced for emotional expressions in general, and may relate to their perceptual disturbances...
Regional brain volumes and symptom severity in body dysmorphic disorderJamie D Feusner
Department of Psychiatry, University of California, Los Angeles, CA 90095, United States
Psychiatry Res 172:161-7. 2009..These are in concordance with the involvement of these regions in pathological face processing, which may contribute to the primary symptomatology...
Functional impact and health utility of anxiety disorders in primary care outpatientsMurray B Stein
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093-0985, USA
Med Care 43:1164-70. 2005..Greater awareness of the deleterious impact of anxiety disorders in primary care is warranted...
Does the addition of cognitive behavioral therapy improve panic disorder treatment outcome relative to medication alone in the primary-care setting?Michelle G Craske
Department of Psychology, University of California Los Angeles, 405 Holgard Avenue, Los Angeles, CA 90095, USA
Psychol Med 35:1645-54. 2005..Using an as-treated analysis, we evaluated whether the addition of CBT enhanced outcomes for panic disorder relative to medications alone in the primary-care setting...
Efficacy of low and higher dose extended-release venlafaxine in generalized social anxiety disorder: a 6-month randomized controlled trialMurray B Stein
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0985, USA
Psychopharmacology (Berl) 177:280-8. 2005..There is a need for new pharmacological treatments for generalized social anxiety disorder (GSAD), which is a common, often disabling condition...
Perceived unmet need for mental health treatment and barriers to care among patients with panic disorderMichelle G Craske
University of California, Los Angeles, CA 90024 1563, USA
Psychiatr Serv 56:988-94. 2005..This study estimated the extent of perceived unmet need for mental health treatment among individuals with panic disorder in primary care settings, investigated the determinants of unmet need, and assessed barriers to care...
CBT intensity and outcome for panic disorder in a primary care settingMichelle G Craske
University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
Behav Ther 37:112-9. 2006..The significance of follow-up booster phone contact is discussed as an index of continued self-management of panic and anxiety following acute treatment...
Augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder using adjunctive olanzapine: a placebo-controlled trialAlexander Bystritsky
Department of Psychiatry and Biobehavioral Sciences, Anxiety Disorders Program, University of California Los Angeles School of Medicine, Neuropsychiatric Institute and Hospital, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
J Clin Psychiatry 65:565-8. 2004..The purpose of this study was to explore the efficacy of adding an atypical antipsychotic, olanzapine, to a serotonin reuptake inhibitor (SRI) in treatment-refractory obsessive-compulsive disorder (OCD)...
Does nocturnal panic represent a more severe form of panic disorder?Michelle G Craske
Department of Psychology, UCLA, 405 Hilgard Ave, Los Angeles, CA 90095-1563. Send reprint requests to Dr. Craske
J Nerv Ment Dis 190:611-8. 2002..The authors conclude that NP may be a specific version of panic disorder characterized by fearful associations with sleep and sleeplike states...
Fluoxetine treatment and testosterone levelsStewart Bell
Private Practice, Arcadia, CA, USA
Ann Clin Psychiatry 18:19-22. 2006..As decreased testosterone has several negative health effects, we conducted a pilot study investigating the effect of fluoxetine treatment on testosterone levels...
Predictors of willingness to consider medication and psychosocial treatment for panic disorder in primary care patientsHolly Hazlett-Stevens
University of California, Los Angeles, CA, USA
Gen Hosp Psychiatry 24:316-21. 2002....
Validation of a brief measure of anxiety-related severity and impairment: the Overall Anxiety Severity and Impairment Scale (OASIS)Laura Campbell-Sills
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0603, USA
J Affect Disord 112:92-101. 2009..A prior investigation with a nonclinical sample supported the reliability and validity of the OASIS; however, to date it has not been validated for use in clinical samples...
Development of a brief diagnostic screen for panic disorder in primary careM B Stein
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0985, USA
Psychosom Med 61:359-64. 1999..The purpose of this study was to determine the utility of a brief screening tool for panic disorder in the primary care setting...
Computer-assisted delivery of cognitive behavioral therapy for anxiety disorders in primary-care settingsMichelle G Craske
Department of Psychology, University of California, Los Angeles, California, USA
Depress Anxiety 26:235-42. 2009..The purpose of the current report is to (1) present the structure and format of the computer-assisted CBT program, and (2) to present evidence for acceptance of the program by clinicians and the effectiveness of the program for patients...
Assessment of beliefs about psychotropic medication and psychotherapy: development of a measure for patients with anxiety disordersAlexander Bystritsky
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
Gen Hosp Psychiatry 27:313-8. 2005..Its brevity may make it particularly useful in primary health care settings...
Functional MRI changes during panic anticipation and imagery exposureA Bystritsky
Department of Psychiatry, UCLA/NPI, 300 UCLA Medical Plaza, 2335 Los Angeles, CA 90095, USA
Neuroreport 12:3953-7. 2001..We propose that this pattern of activity may enhance the encoding and retrieval of strong emotional events, facilitating the recapitulation of traumatic experiences and leading to panic disorder in vulnerable individuals...
The Composite International Diagnostic Interview (CIDI-Auto): problems and remedies for diagnosing panic disorder and social phobiaAdrienne Means-Christensen
University of California, San Diego, CA 92037, USA
Int J Methods Psychiatr Res 12:167-81. 2003..We did not examine the false positive rate for the unmodified or modified CIDI, but this is an important issue that needs to be evaluated in future research...
St John's wort versus placebo in obsessive-compulsive disorder: results from a double-blind studyKenneth A Kobak
Dean Foundation for Health Research and Education, Middleton, Wisconsin 53562, USA
Int Clin Psychopharmacol 20:299-304. 2005..9%) and placebo (16.7%) (P=0.905). Only one patient from each group discontinued due to adverse events [sinus infection (St John's wort); confusion (placebo)]. The results fail to support the efficacy of St John's wort for OCD...
Moving treatment research from clinical trials to the real worldPeter P Roy-Byrne
Department of Psychiatry and Behavioral Sciences, University of Washington at Harborview Medical Center, Seattle 98014, USA
Psychiatr Serv 54:327-32. 2003....
A randomized effectiveness trial of cognitive-behavioral therapy and medication for primary care panic disorderPeter P Roy-Byrne
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine at Harborview Medical Center, Seattle, USA
Arch Gen Psychiatry 62:290-8. 2005....
Quetiapine augmentation in obsessive-compulsive disorder resistant to serotonin reuptake inhibitors: an open-label studyAnn M Bogan
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA 94305, USA
J Clin Psychiatry 66:73-9. 2005..The poorer results at S2 may reflect the large proportion of hoarders or the less intense treatment. Longer, higher dose, large, double-blind, placebo-controlled comparison trials of atypical antipsychotics are needed...
The effect of attributional processes concerning medication taking on return of fearMark B Powers
Faculty of Social and Behavioral Sciences, University of Amsterdam, Amsterdam, The Netherlands
J Consult Clin Psychol 76:478-90. 2008..These findings highlight the importance of assessing patient attributions regarding the improvements achieved with combined exposure-based and pharmacological treatments for anxiety disorders...
Use of herbal medicine in primary care patients with mood and anxiety disordersPeter P Roy-Byrne
Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, University of Washington School of Medicine, Box 359911, 325 9th Ave, Seattle, WA 98104, USA
Psychosomatics 46:117-22. 2005..Use was not associated with receipt of pharmacotherapy or psychotherapy for anxiety or depression...
Beliefs about psychotropic medication and psychotherapy among primary care patients with anxiety disordersAmy W Wagner
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine at Harborview Medical Center, Seattle, Washington 98104 2499, USA
Depress Anxiety 21:99-105. 2005..Treatment adherence may therefore be increased by addressing these beliefs directly...
Design of the Coordinated Anxiety Learning and Management (CALM) study: innovations in collaborative care for anxiety disordersGreer Sullivan
South Central VA Mental Illness Research Education and Clinical Center, Central Arkansas Veterans Healthcare System, North Little Rock, AR 72214 1706, USA
Gen Hosp Psychiatry 29:379-87. 2007..Since anxiety disorders are most often treated in primary care, quality improvement interventions, such as the Coordinated Anxiety Learning and Management (CALM) intervention, are needed in primary care...
Improving clinical trials: American Society of Clinical Psychopharmacology recommendationsDonald F Klein
New York State Psychiatric Institute and Columbia University, Unit 22, 1051 Riverside Dr, New York, NY 10032, USA
Arch Gen Psychiatry 59:272-8. 2002..The scope of inquiry included identifying means of shifting institutional and regulatory assumptions and processes, even to the point of seeking appropriate national incentives...
