Research Topics
| V ButterweckSummaryAffiliation: University of Florida Country: USA Publications
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Publications
Flavonoids of St. John's Wort reduce HPA axis function in the ratV Butterweck
Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
Planta Med 70:1008-11. 2004..Our data suggest that besides hypericin, flavonoids of SJW play an important role in the modulation of HPA axis function. Furthermore, the results support the hypothesis that flavonoids are involved in the antidepressant effects of SJW...- Hyperforin in St. John's wort drug interactionsRajanikanth Madabushi
Department of Pharmaceutics, College of Pharmacy, University of Florida, P.O. 100494, Gainesville, 32610, USA
Eur J Clin Pharmacol 62:225-33. 2006..In the present paper clinical significant SJW interactions are critically evaluated against the background of hyperforin... - Isolation and HPLC quantitative analysis of antioxidant flavonoids from Alternanthera tenella CollaMarcos J Salvador
Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Avenida dos Bandeirantes, 3900, 14040 901 Ribeirao Preto, Sao Paulo, Brasil
Z Naturforsch C 61:19-25. 2006..Moreover, the total soluble phenolic contents of the extract and fractions were measured using the Folin-Ciocalteau reagent and the quantitative analysis of flavone C-glycosides major constituents was performed by HPLC... - Effects of St. John's wort extract and single constituents on stress-induced hyperthermia in miceOliver Grundmann
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
Planta Med 72:1366-71. 2006..1 mg/kg. In conclusion, using open field stress as a psychological stressor to induce hyperthermia in mice we were able to detect putative anxiolytic effects of SJW extract and single consituents... - Potential of pharmacokinetic profiling for detecting herbal interactions with drugsVeronika Butterweck
Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
Clin Pharmacokinet 47:383-97. 2008..Effective screening tools that accurately predict metabolic herb-drug interactions would offer a tremendous advantage because it is not possible to study all potential herb-drug interactions in clinical trials... - Comparative evaluation of two different Opuntia ficus-indica extracts for blood sugar lowering effects in ratsVeronika Butterweck
College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, USA
Phytother Res 25:370-5. 2011..The results suggest that both OFI extracts exert hypoglycemic activities in rats in doses as low as 6 mg/kg but that the effects of the proprietary stem/fruit blend were more pronounced in our model... - Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in miceVeronika Butterweck
College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, PO Box 100494, FL 32610, USA
J Pharm Pharmacol 59:549-52. 2007..Thus, our data suggests that the hypothermic--and therefore the sleep-inducing--effects of hops extract are possibly mediated through activation of melatonin receptors... - Herbal medicines in the management of urolithiasis: alternative or complementary?Veronika Butterweck
College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, Florida 32610, USA
Planta Med 75:1095-103. 2009..The present review therefore critically evaluates the potential usefulness of herbal medicines in the management of urolithiasis... - Toxicological and Pharmacokinetic Evaluation of Concomitant Intake of Grapefruit Juice and Simvastatin in Rats after Repeated Treatment over 28 DaysVeronika Butterweck
College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
Planta Med 75:1196-202. 2009.... - St. John's wort: role of active compounds for its mechanism of action and efficacyVeronika Butterweck
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32608, USA
Wien Med Wochenschr 157:356-61. 2007..Although there are some open questions, the bulk of data suggests that several groups of active compounds are contributing to the antidepressant efficacy of the plant extract... - Anxiolytic effects of fractions obtained from Passiflora incarnata L. in the elevated plus maze in miceC Sampath
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
Phytother Res 25:789-95. 2011..The results suggest that the active principle of passion flower seems to be in the chloroform fraction and to a lower extent in the butanol fraction... - Mechanism of St. John's wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine systemO Grundmann
College of Pharmacy, Department of Pharmaceutics, University of Florida, PO Box 100494, Gainesville, FL 32610, USA
Neuropharmacology 58:767-73. 2010..Our data provide new evidence for the hypothesis that the mechanism of action of STW3-VI is mediated by the interrelationship between the immune, oxidative defense and neuroendocrine system... - Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?Veronika Butterweck
Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
Planta Med 70:784-91. 2004..Efforts to identify all possible interactions will lead to limitless investigations and to inconsistent decisions... - Effect of grapefruit juice, naringin, naringenin, and bergamottin on the intestinal carrier-mediated transport of talinolol in ratsWhocely Victor De Castro
Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, P O BOX 100494, Gainesville, FL 32610, USA
J Agric Food Chem 56:4840-5. 2008..5- to 1.8-fold, respectively. In conclusion, the effect of GFJ on P-gp activity seems to depend on the variety, the concentration of compounds in the juice, and the composition of different ingredients... - An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cellsP Vanachayangkul
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, PO Box 100494, FL 32610, USA
Phytomedicine 17:653-8. 2010..Our data demonstrate that KE as well as khellin and visnagin could prevent renal epithelial cell damage caused by Ox and COM and could therefore play a potential role in the prevention of stone formation associated with hyperoxaluria... - Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cellsWhocely Victor De Castro
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA
J Pharm Sci 96:2808-17. 2007..The in vitro data suggest that compounds present in grapefruit juice are able to inhibit the P-gp activity modifying the disposition of drugs that are P-gp substrates such as talinolol... - Anxiolytic effects of a passion flower (Passiflora incarnata L.) extract in the elevated plus maze in miceO Grundmann
Department of Pharmaceutics, College of Pharmacy, 1600 SW Archer Road, Gainesville, FL 32608, USA
Pharmazie 64:63-4. 2009..In conclusion, using the EPM we were able to detect putative anxiolytic effects of a Passiflora incarnata extract in mice... - Grapefruit-drug interactions: can interactions with drugs be avoided?S U Mertens-Talcott
Department of Pharmaceutics, Center for Food Drug Interaction Research and Education, University of Florida, Gainesville, FL 32610-0494, USA
J Clin Pharmacol 46:1390-416. 2006.... - Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze testOliver Grundmann
College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesvilla, FL 32610, USA
J Ethnopharmacol 110:406-11. 2007..These results indicate that AV extract is an effective anxiolytic agent, and suggest that the anxiolytic-like activities of this plant are mainly mediated via the GABAergic system... - Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in miceOliver Grundmann
College of Pharmacy, Department of Pharmaceutics, University of Florida, PO Box 100494, Gainesville, FL 32610, USA
Phytomedicine 16:295-302. 2009..In conclusion, our study clearly demonstrates that AV extract possesses anxiolytic-like activity and that at least one of its flavonoids, kaempferol, can elicit the same kind of neuropharmacological activity... - Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic systemOliver Grundmann
College of Pharmacy, Department of Pharmaceutics, University of Florida, FL, USA
Planta Med 74:1769-73. 2008..The active dose was effectively antagonized by flumazenil, but not by WAY-100 635. This study is the first demonstration of the IN VIVO, GABA-mediated anxiolytic activity of an HPLC- characterized extract of Passiflora incarnata... - Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral applicationSasiporn Sarawek
College of Pharmacy, Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
Planta Med 74:221-7. 2008..In conclusion, an aqueous ALE, caffeic acid derivatives and flavones exerted XO inhibitory effects in vitro but a hypouricemic activity could not be confirmed after oral administration... - Salvia divinorum and salvinorin A: an update on pharmacology and analytical methodologyOliver Grundmann
College of Pharmacy, Department of Pharmaceutics, University of Florida, FL 32608, USA
Planta Med 73:1039-46. 2007..divinorum... - Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studiesWhocely Victor De Castro
Department of Pharmaceutics, College of Pharmacy, University of Florida, P.O. Box 100494, Gainesville, Florida 32610-0494, USA
J Agric Food Chem 54:249-55. 2006..The concentration of potentially contributing compounds may crucially influence the magnitude of observed interaction and impair direct comparison of studies in which different juices have been used... - Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cellsSusanne U Mertens Talcott
Department of Pharmaceutics, College of Pharmacy, University of Florida, P O BOX 100494, Gainesville, FL 32610, USA
J Agric Food Chem 55:2563-8. 2007..Based on their relatively low concentrations (< or =3 microg/mL) in citrus, the clinical relevance of these interactions needs to be further elucidated in in vivo studies... - Cimicifuga extract BNO 1055: reduction of hot flushes and hints on antidepressant activityHilke Winterhoff
Institute for Pharmacology and Toxicology, Central Clinic, University of Munster, Domagkstrasse 12, 48149 Munster, Germany
Maturitas 44:S51-8. 2003..These findings in pharmacological tests-a reduction of the frequency of hot flush equivalents and hints on antidepressant activity of Cimicifuga extracts-are in good agreement with the therapeutical responses in climacteric women... - Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral modelsVeronika Butterweck
Institute of Pharmacology and Toxicology, Universitätsklinikum Muenster, Domagkstrasse 12, 48149 Muenster, Germany
Life Sci 73:627-39. 2003..We also could show that hyperforin contributes to the beneficial properties of SJW extract, confirming the hypothesis that the crude SJW extract contains several constituents with antidepressant activity... - Apocynum venetum extract does not induce CYP3A and P-glycoprotein in ratsMichiya Kobayashi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
Biol Pharm Bull 27:1649-52. 2004..These results suggest that, unlike SJW, the recommended dose of AV (3.3 mg/kg/d) would not influence hepatic CYP3A and intestinal P-gp in rats... - Hyperforin-containing extracts of St John's wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in ratsVeronika Butterweck
Section on Functional Neuroanatomy, NIMH, Bethesda, MD 20892, USA
Neuropsychopharmacology 28:2160-8. 2003..These data suggest that hyperforin and hyperforin derivatives are not involved in the regulation of genes that control HPA axis function... - In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRsVeronika Butterweck
Institute of Pharmacology and Toxicology, Westfälische Wilhelms Universität Muenster, Domagkstrasse 12, 48149 Muenster, Germany
Psychopharmacology (Berl) 162:193-202. 2002..Hypericum perforatum L. (St. John's wort; SJW) is one of the leading psychotherapeutic phytomedicines and great effort has been devoted to clarifying its mechanism of action... - [What is known about St. John's wort? Phytochemistry and pharmacology]Veronika Butterweck
Pharm Unserer Zeit 32:212-9. 2003 - Mechanism of action of St John's wort in depression : what is known?Veronika Butterweck
Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Munster, Germany
CNS Drugs 17:539-62. 2003..This review integrates new findings of possible mechanisms that may underlie the antidepressant action of St John's wort and its active constituents with a large body of existing literature... - Long-term effects of an Apocynum venetum extract on brain monoamine levels and beta-AR density in ratsVeronika Butterweck
Institute of Pharmacology and Toxicology, Universitätsklinikum Muenster, Domagkstrasse 12, 48149 Munster, Germany
Pharmacol Biochem Behav 75:557-64. 2003..125I]CYP binding to beta-adrenergic receptors was found to be decreased after 8 weeks treatment with imipramine, whereas AV-extract had no effect on beta-receptor binding... - The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in miceVeronika Butterweck
Institute of Pharmacology and Toxicology, Universitaetsklinikum Muenster, Domagkstrasse 12, Muenster 48149, Germany
Behav Brain Res 144:49-56. 2003..These data suggest that IL-6 plays an important role in the control of emotionality, but not in the regulation of body temperature after psychological stress... - Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral modelsHiroyuki Sakakibara
Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
Biol Pharm Bull 29:1767-70. 2006..The present study clearly demonstrated that EGB exerts an antidepressant effect in these two behavioral models... - Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampusVeronika Butterweck
Institute of Pharmacology and Toxicology, Domagkstrasse 12, 48149 Muenster, Germany
Brain Res 930:21-9. 2002..01). Our data clearly show that long-term, but not short-term administration of St. John's wort and its active constituent hypericin modify levels of neurotransmitters in brain regions involved in the pathophysiology of depression...