Research Topics
| Esteban González BurchardSummaryAffiliation: University of California Country: USA Publications Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmaticsKeyan Salari Department of Medicine, University of California, San Francisco, California 94143-1732, USA Genet Epidemiol 29:76-86 Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthmaHarriet Corvol Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA Pharmacogenet Genomics 19:489-96 Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthmaMariam Naqvi University of California, San Francisco, California 94110, USA J Asthma 44:639-48 The PTGDR gene is not associated with asthma in 3 ethnically diverse populationsYuhjung J Tsai University of California, San Francisco, San Francisco, CA 94143 2911, USA J Allergy Clin Immunol 118:1242-8 Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthmaShweta Choudhry University of California San Francisco, San Francisco, CA 94143 0833, USA Am J Respir Crit Care Med 171:563-70 Inhaled corticosteroids and augmented bronchodilator responsiveness in Latino and African American asthmatic patientsMariam Naqvi University of California, San Francisco, California 94143 2911, USA Ann Allergy Asthma Immunol 100:551-7 CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthmaShweta Choudhry University of California San Francisco, DNA Bank Lung Biology Center, San Francisco General Hospital, Bldg 30, 5th Floor, Room 3501H, 1001 Potrero Avenue, San Francisco, CA 94110, USA Am J Respir Crit Care Med 172:173-82 Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthmaNatalie C Battle University of California, San Francisco, San Francisco, CA 94143 2911, USA Am J Respir Crit Care Med 175:881-7 Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 regionShweta Choudhry Institute for Human Genetics, University of California, San Francisco, CA, USA Hum Genet 123:455-68 An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severityMax A Seibold Department of Medicine, University of California San Francisco, San Francisco, CA 94143 2911, USA Hum Mol Genet 17:2681-90 | Collaborators
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Detail Information
Publications
Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmaticsKeyan Salari
Department of Medicine, University of California, San Francisco, California 94143-1732, USA
Genet Epidemiol 29:76-86
Department of Medicine, University of California, San Francisco, California 94143-1732, USA
Genet Epidemiol 29:76-86
..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation...
Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthmaHarriet Corvol
Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
Pharmacogenet Genomics 19:489-96
Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
Pharmacogenet Genomics 19:489-96
..Therefore, we reasoned that interactions between the IL6 and IL6R genes might be associated with bronchodilator drug responsiveness to albuterol in asthmatic patients...
Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthmaMariam Naqvi
University of California, San Francisco, California 94110, USA
J Asthma 44:639-48
University of California, San Francisco, California 94110, USA
J Asthma 44:639-48
..We conclude that ethnic-specific differences in bronchodilator drug responsiveness exist between Mexicans, Puerto Ricans, and African Americans with asthma. This may be of importance in asthma management...
The PTGDR gene is not associated with asthma in 3 ethnically diverse populationsYuhjung J Tsai
University of California, San Francisco, San Francisco, CA 94143 2911, USA
J Allergy Clin Immunol 118:1242-8
University of California, San Francisco, San Francisco, CA 94143 2911, USA
J Allergy Clin Immunol 118:1242-8
..CLINICAL IMPLICATIONS: Asthma candidate genes provide insights to pathophysiology and potentially new therapeutic targets, although the PTGDR gene was not found to be a significant risk factor for asthma in 3 populations...
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthmaShweta Choudhry
University of California San Francisco, San Francisco, CA 94143 0833, USA
Am J Respir Crit Care Med 171:563-70
University of California San Francisco, San Francisco, CA 94143 0833, USA
Am J Respir Crit Care Med 171:563-70
..These findings underscore the need for additional research on racial/ethnic differences in asthma morbidity and drug responsiveness...
Inhaled corticosteroids and augmented bronchodilator responsiveness in Latino and African American asthmatic patientsMariam Naqvi
University of California, San Francisco, California 94143 2911, USA
Ann Allergy Asthma Immunol 100:551-7
University of California, San Francisco, California 94143 2911, USA
Ann Allergy Asthma Immunol 100:551-7
..This underscores the need for an improved understanding of ethnic-specific drug-drug interactions, particularly in those subgroups experiencing the highest burden of asthma morbidity and mortality in the United States...
CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthmaShweta Choudhry
University of California San Francisco, DNA Bank Lung Biology Center, San Francisco General Hospital, Bldg 30, 5th Floor, Room 3501H, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 172:173-82
University of California San Francisco, DNA Bank Lung Biology Center, San Francisco General Hospital, Bldg 30, 5th Floor, Room 3501H, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 172:173-82
..CONCLUSIONS: Our data suggest a gene-by-environment interaction between CD14 genotypes and ETS, which affects pulmonary function and IgE levels among Latinos with asthma...
Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthmaNatalie C Battle
University of California, San Francisco, San Francisco, CA 94143 2911, USA
Am J Respir Crit Care Med 175:881-7
University of California, San Francisco, San Francisco, CA 94143 2911, USA
Am J Respir Crit Care Med 175:881-7
..CONCLUSIONS: Gene-gene interaction between the IL-13 and IL-4Ralpha genes may play an important role in asthma among African Americans...
Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 regionShweta Choudhry
Institute for Human Genetics, University of California, San Francisco, CA, USA
Hum Genet 123:455-68
Institute for Human Genetics, University of California, San Francisco, CA, USA
Hum Genet 123:455-68
..3 region. Our results provide strong evidence that the previously linked 5q23 region is associated with asthma in Puerto Ricans. The detection of causative variants in this region will require fine mapping and functional validation...
An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severityMax A Seibold
Department of Medicine, University of California San Francisco, San Francisco, CA 94143 2911, USA
Hum Mol Genet 17:2681-90
Department of Medicine, University of California San Francisco, San Francisco, CA 94143 2911, USA
Hum Mol Genet 17:2681-90
..Female asthmatics may be insulated from the deleterious effects of the 818T allele by estrogen-mediated upregulation in BK channel activity...
Genetic ancestry and risk of breast cancer among U.S. LatinasLaura Fejerman
Division of General Internal Medicine and Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143 1732, USA
Cancer Res 68:9723-8
Division of General Internal Medicine and Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143 1732, USA
Cancer Res 68:9723-8
..39; 95% CI, 1.06-2.11; P=0.013). Further work is needed to determine if the association is due to genetic differences between populations or possibly due to environmental factors not measured...
Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformationHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Cerebrovasc Dis 27:176-82
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Cerebrovasc Dis 27:176-82
..These results suggest that inflammatory pathways, including the IL-1beta cytokine, may play an important role in ICH...
Augmentation of bronchodilator responsiveness by leukotriene modifiers in Puerto Rican and Mexican childrenHaig Tcheurekdjian
Department of Medicine, University of California, San Francisco, USA
Ann Allergy Asthma Immunol 102:510-7
Department of Medicine, University of California, San Francisco, USA
Ann Allergy Asthma Immunol 102:510-7
..Ethnic-specific interactions between different asthma medications are not well described...
Race, ethnicity and social class and the complex etiologies of asthmaKatherine A Drake
Department of Biopharmaceutical Sciences, UCSF Lung Biology Center, University of California, San Francisco, CA 94143 2911, USA
Pharmacogenomics 9:453-62
Department of Biopharmaceutical Sciences, UCSF Lung Biology Center, University of California, San Francisco, CA 94143 2911, USA
Pharmacogenomics 9:453-62
..Herein, we review salient differences in the etiologies of asthma by race, ethnicity and social class, and argue for their continued use as variables in asthma research...
ORMDL3 gene is associated with asthma in three ethnically diverse populationsJoshua Galanter
Lung Biology Center, Department of Medicine, Institute for Human Genetics, University of California, San Francisco, California 94143 2911, USA
Am J Respir Crit Care Med 177:1194-200
Lung Biology Center, Department of Medicine, Institute for Human Genetics, University of California, San Francisco, California 94143 2911, USA
Am J Respir Crit Care Med 177:1194-200
..However, inconsistent SNP-level results suggest that further studies will be needed to determine the mechanism by which ORMDL3 predisposes to asthma...
The 1000 Genomes Project: new opportunities for research and social challengesMarc Via
ELSI Samples Committee, 1000 Genomes Project, and Institute for Human Genetics, University of California at San Francisco, Box 2911, San Francisco, CA 94143, USA
Genome Med 2:3
ELSI Samples Committee, 1000 Genomes Project, and Institute for Human Genetics, University of California at San Francisco, Box 2911, San Francisco, CA 94143, USA
Genome Med 2:3
....
Human population structure and genetic association studiesElad Ziv
Division of General Internal Medicine and Division of Pulmonary Medicine, Department of Medicine, University of California, San Francisco, CA 94115, USA
Pharmacogenomics 4:431-41
Division of General Internal Medicine and Division of Pulmonary Medicine, Department of Medicine, University of California, San Francisco, CA 94115, USA
Pharmacogenomics 4:431-41
..Unlinked genetic markers may be used to detect confounding in association studies. In addition, the information from unlinked markers may be used to adjust genetic associations...
Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populationsHui Ju Tsai
Department of Medicine, University of California, Box 0833, San Francisco, CA, 94143 0833, USA
Hum Genet 118:424-33
Department of Medicine, University of California, Box 0833, San Francisco, CA, 94143 0833, USA
Hum Genet 118:424-33
..These simulations are meant to provide some practical guidelines for investigators conducting association studies in admixed populations...
Admixture-matched case-control study: a practical approach for genetic association studies in admixed populationsHui Ju Tsai
Department of Medicine, Study of African American, Asthma, Genes and Environments, SAGE, University of California, 0833, San Francisco, 94143 0833, USA
Hum Genet 118:626-39
Department of Medicine, Study of African American, Asthma, Genes and Environments, SAGE, University of California, 0833, San Francisco, 94143 0833, USA
Hum Genet 118:626-39
..Our present work demonstrates that admixture-matched case-control strategies can efficiently control population stratification confounding in admixed populations...
Ancestry-environment interactions and asthma risk among Puerto RicansShweta Choudhry
University of California, San Francisco, San Francisco, CA 94143-2911, USA
Am J Respir Crit Care Med 174:1088-93
University of California, San Francisco, San Francisco, CA 94143-2911, USA
Am J Respir Crit Care Med 174:1088-93
..CONCLUSIONS: The observed interaction may help to explain the unique pattern of risk for asthma in Puerto Ricans and the lack of association with SES observed in previous studies when not accounting for varying proportions of ancestry...
Dissecting complex diseases in complex populations: asthma in latino americansShweta Choudhry
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2911, USA
Proc Am Thorac Soc 4:226-33
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2911, USA
Proc Am Thorac Soc 4:226-33
....
African ancestry, socioeconomic status, and kidney function in elderly African Americans: a genetic admixture analysisCarmen A Peralta
Department of Medicine, University of California at San Francisco, San Francisco, California 94124, USA
J Am Soc Nephrol 17:3491-6
Department of Medicine, University of California at San Francisco, San Francisco, California 94124, USA
J Am Soc Nephrol 17:3491-6
..Rather, kidney dysfunction in elderly African Americans seems more attributable to differences in environmental and social factors...
Association between IgE levels and asthma severity among African American, Mexican, and Puerto Rican patients with asthmaMariam Naqvi
University of California, San Francisco, CA 94143 2911, USA
J Allergy Clin Immunol 120:137-43
University of California, San Francisco, CA 94143 2911, USA
J Allergy Clin Immunol 120:137-43
..CLINICAL IMPLICATIONS: Among patients with asthma from 3 ethnically distinct groups, total IgE levels are inversely correlated with baseline lung function and asthma severity...
Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habitMax A Seibold
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
J Allergy Clin Immunol 122:944-950.e3
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
J Allergy Clin Immunol 122:944-950.e3
..Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT1) have chitinolytic activity, but relatively little is known about their expression in human asthma...
Pharmacogenetic response to albuterol among asthmaticsHarriet Corvol
UCSF Lung Biology Center, University of California, San Francisco, CA 94143 2911, USA
Pharmacogenomics 9:505-10
UCSF Lung Biology Center, University of California, San Francisco, CA 94143 2911, USA
Pharmacogenomics 9:505-10
..Herein, we focus on pharmacogenetic associations between genetic variants in the beta(2)-adrenergic receptor gene and bronchodilator response to albuterol among subjects with asthma...