Research Topics
Genomes and GenesSpecies | Clareann H BunkerSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-CaribbeansPatrick R Shea
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Prostate 68:354-9. 2008..However, whether RNASEL variation contributes to the increased risk of prostate cancer observed in populations of African ancestry remains unclear...- High prevalence of screening-detected prostate cancer among Afro-Caribbeans: the Tobago Prostate Cancer SurveyClareann H Bunker
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Cancer Epidemiol Biomarkers Prev 11:726-9. 2002..These data support the hypothesis that populations of African descent share genetic and/or lifestyle factors that contribute to their elevated risk for prostate cancer... - A randomized trial of lycopene supplementation in Tobago men with high prostate cancer riskClareann H Bunker
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Nutr Cancer 57:130-7. 2007..Lowering of serum PSA may not be an appropriate endpoint for the long-term studies needed to evaluate lycopene supplementation for reducing prostate cancer initiation or progression... - Association analysis of WNT10B with bone mass and structure among individuals of African ancestryJoseph M Zmuda
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:437-47. 2009..This analysis implicates the WNT10B locus as a genetic element in the regulation of bone mass and structural geometry... - Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometryYingze Zhang
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Bone 46:1131-7. 2010..05). These results suggest that FZD1 expression is regulated in a haplotype-dependent manner in osteoblasts and that these same haplotypes may be associated with biomechanical indices of bone strength... - Adipose tissue infiltration in skeletal muscle: age patterns and association with diabetes among men of African ancestryIva Miljkovic-Gacic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Clin Nutr 87:1590-5. 2008..Although obesity is strongly associated with diabetes, the greater prevalence of diabetes in persons of African ancestry than in those of other ancestries cannot be explained simply by differences in total or central adiposity... - Molecular variation in neuropeptide Y and bone mineral density among men of African ancestryLouis J Goodrich
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, Pittsburgh, PA 15261, USA
Calcif Tissue Int 85:507-13. 2009..05). These results suggest that genetic variation at the NPY locus may contribute to bone density, independently of body weight... - Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean menIva Miljkovic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Obesity (Silver Spring) 17:1396-401. 2009..03 and 0.007, respectively). Our results suggest a novel association between common nonsynonymous coding variants in CPT1B and ectopic skeletal muscle fat among middle-aged and older African ancestry men... - Genetic determination of adiponectin and its relationship with body fat topography in multigenerational families of African heritageIva Miljkovic-Gacic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Metabolism 56:234-8. 2007..Adiponectin may serve as a promising quantitative intermediate trait in studies designed to map the genes underlying diabetes and obesity in this population... - Fat infiltration in muscle: new evidence for familial clustering and associations with diabetesIva Miljkovic-Gacic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Obesity (Silver Spring) 16:1854-60. 2008..Therefore, our aim is to determine genetic and environmental contributions to measures of skeletal muscle composition, and describe their associations with type 2 diabetes in multigenerational families of African ancestry... - Functional characterization of genetic variation in the Frizzled 1 (FZD1) promoter and association with bone phenotypes: more to the LRP5 story?Laura M Yerges
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:87-96. 2009..This study indicates that a cis-regulatory polymorphism in the FZD1 promoter region may have a functional role in determining bone structural geometry... - Natural history and correlates of hip BMD loss with aging in men of African ancestry: the Tobago Bone Health StudyYahtyng Sheu
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:1290-8. 2009..Additional studies are needed to better define the natural history and factors underlying bone loss with aging in men of African ancestry... - Bioactive androgens and glucuronidated androgen metabolites are associated with subcutaneous and ectopic skeletal muscle adiposity among older black menIva Miljkovic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Metabolism 60:1178-85. 2011..Longitudinal studies are needed to further evaluate the relationship between androgens and androgen metabolites with changes in skeletal muscle fat distribution with aging and the incidence of T2DM... - Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: the Tobago Family Health StudyXiaojing Wang
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Bone Miner Res 22:527-36. 2007..Heritabilities of areal and volumetric BMD were moderate in our large families of African descent but differed for trabecular and cortical BMD... - Lipoprotein subclass and particle size differences in Afro-Caribbeans, African Americans, and white Americans: associations with hepatic lipase gene variationIva Miljkovic-Gacic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Metabolism 55:96-102. 2006..Our findings indicate that the higher frequency of the LIPC -514T allele found in men of African origin living in different environments significantly contributes to the more favorable distribution of HDL subclasses compared with whites... - Leptin receptor Gln223Arg polymorphism and breast cancer risk in Nigerian women: a case control studyMichael N Okobia
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
BMC Cancer 8:338. 2008..This study was designed to assess the role of this polymorphism in breast cancer susceptibility in Nigerian women... - Sex and genetic effects on upper and lower body fat and associations with diabetes in multigenerational families of African heritageIva Miljkovic-Gacic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Metabolism 57:819-23. 2008..Our findings also suggest that, in this population, leg fat is associated with diabetes independent of overall adiposity... - Prostate cancer screening parameters in a high-risk African-Caribbean populationClareann H Bunker
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
Urology 63:737-41. 2004..The screening was highly efficacious, with a positive predictive value of 56% for an elevated PSA level and 40% for an elevated PSA level and/or abnormal DRE findings... - Human herpesvirus 8 seroprevalence among Tobago women and the role of sexual lifestyle behaviorAlicia C McDonald
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Med Virol 81:264-70. 2009..51, 95% CI = 1.09-5.78) in women. HHV-8 age-specific rates were similar between genders. Sexual activity may not be a major contributor to HHV-8 infection among Tobago women... - Greater adipose tissue infiltration in skeletal muscle among older men of African ancestryIva Miljkovic
Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, 130 North Bellefield Avenue, Room 542, Pittsburgh, PA 15213, USA
J Clin Endocrinol Metab 94:2735-42. 2009..Skeletal muscle fat has been identified as an important depot that increases with aging and may contribute to the development of diabetes... - Correlates of trabecular and cortical volumetric BMD in men of African ancestryYahtyng Sheu
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsuburgh, Pennsylvania 15261, USA
J Bone Miner Res 24:1960-8. 2009..Longitudinal studies are needed to gain a better understanding of the mechanisms underlying these differential associations that may show new insight into the etiology of trabecular and cortical bone loss in men... - Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestryMichael N Okobia
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Prostate 71:1054-63. 2011..This case-control study was designed to evaluate the association between germline variations in chromosome 8q24 and prostate cancer risk in Afro-Caribbean Tobago men, a population of predominantly West African ancestry... - Adipose tissue and volumetric bone mineral density of older Afro-Caribbean menLaura M Yerges-Armstrong
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Bone Miner Res 25:2221-8. 2010..Additional research is needed to better understand the mechanisms underlying the relationship between body fat distribution and bone mass... - The association of bone mineral density with prostate cancer risk in the Osteoporotic Fractures in Men (MrOS) StudyGhada N Farhat
University of Pittsburgh, Department of Epidemiology and Division of Cancer Prevention and Population Science, University of Pittsburgh Medical Center, Cancer Pavilion, Suite 4C, 5150 Centre Avenue, Pittsburgh, PA 15232, USA
Cancer Epidemiol Biomarkers Prev 18:148-54. 2009..However, no associations were observed with low-grade disease. Our results provide support for an inverse association between BMD and PCa risk. Possible pathophyisological mechanisms linking BMD and PCa should be elucidated... - Markers of inflammation are heritable and associated with subcutaneous and ectopic skeletal muscle adiposity in African ancestry familiesIva Miljkovic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
Metab Syndr Relat Disord 9:319-26. 2011..Longitudinal studies are needed to further evaluate the relationship between inflammation with changes in skeletal muscle AT distribution with aging and the incidence of T2DM... - Correlates of bone mineral density among postmenopausal women of African Caribbean ancestry: Tobago women's health studyDeanna D Hill
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, USA
Bone 43:156-61. 2008..This may reflect low European admixture. Correlates of BMD among Caribbean women of West African ancestry were similar to those reported for U.S. Black and White women... - MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neckScott M Langevin
University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213 1863, USA
Cancer 117:1454-62. 2011..However, the aberrant miR-137 promoter methylation observed in squamous cell carcinoma of the head and neck (SCCHN) suggests a tumor-specific molecular defect that may contribute to disease progression... - ADRB2 gene variants, dual-energy x-ray absorptiometry body composition, and hypertension in Tobago men of African descentTracey Samantha Beason
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Metabolism 60:698-705. 2011..50). In a high-obesity and high-hypertension risk population with ancestry in common with African Americans, genetic variation defined by 2 common ADRB2 amino acid substitutions was not associated with body composition or hypertension... - Low prevalence of vitamin D deficiency in elderly Afro-Caribbean menIva Miljkovic
Department of Epidemiology, Graduate School of Public Health, Pittsburgh, University of Pittsburgh, PA 15213, USA
Ethn Dis 21:79-84. 2011..Longitudinal studies are needed to delineate the possible effects of high vitamin D levels in this population on major diseases hypothesized to be associated with vitamin D deficiency... - Trends over time with commonly performed obstetric and gynecologic inpatient proceduresSallie S Oliphant
Division of Urogynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Obstet Gynecol 116:926-31. 2010..To estimate trends over time in inpatient obstetric and gynecologic surgical procedures, and to estimate commonly performed obstetric and gynecologic surgical procedures across a woman's lifespan... - Association of a high mobility group gene (HMGA2) variant with bone mineral densityAllison Kuipers
Department of Epidemiology, Crabtree Hall, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Bone 45:295-300. 2009..Additional research is needed to better understand the role of HMGA2 in the regulation of bone metabolism... - High bone density is associated with prostate cancer in older Afro-Caribbean men: Tobago prostate surveyClareann H Bunker
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cancer Causes Control 17:1083-9. 2006..To test the hypothesis that bone mineral density (BMD), a possible surrogate of lifetime exposure to hormone/growth factor/vitamin D/calcium exposure, is higher in prostate cancer cases than controls... - Identification and association analysis of single nucleotide polymorphisms in the human noggin (NOG) gene and osteoporosis phenotypesSusan P Moffett
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Bone 44:999-1002. 2009..None of the 7 SNPs were associated with BMD at the proximal femur or lumbar spine. Our analysis suggests that a common variation in the noggin gene is unlikely to have a major impact on BMD among older men of African ancestry... - Prostate cancer risk is three-fold higher among men, aged 50-64, of African descent compared with men of Asian-Indian descent in Trinidad and TobagoClareann H Bunker
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Ethn Dis 12:S3-30-3. 2002..To test the hypothesis that the screening-detected prevalence of prostate cancer is higher among men of African descent than among men of Asian-Indian descent living in Trinidad & Tobago... - Anthropometry and breast cancer risk in Nigerian womenMichael N Okobia
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Breast J 12:462-6. 2006.... - Physical activity levels in American-Indian adults: the Strong Heart Family StudyKristi L Storti
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Prev Med 37:481-7. 2009..A limited body of evidence, mostly based on self-report, is available regarding physical activity levels among American-Indian adults... - Pleiotropy and heterogeneity in the expression of bone strength-related phenotypes in extended pedigreesXiaojing Wang
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Bone Miner Res 22:1766-72. 2007..The majority of the phenotypic variation in bone size and volumetric BMD also seems to be strongly influenced by distinct genes for each trait... - Trends in inpatient prolapse procedures in the United States, 1979-2006Keisha A Jones
Division of Urogynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Women s Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Obstet Gynecol 202:501.e1-7. 2010..We sought to describe national trends for inpatient procedures for pelvic organ prolapse from 1979-2006... - Estimates of African, European and Native American ancestry in Afro-Caribbean men on the island of TobagoIva Miljkovic-Gacic
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Hum Hered 60:129-33. 2005..We hypothesize that the degree of European and Native American admixture in the Tobago population is low... - Lower urinary tract injury in women in the United States, 1979-2006Elizabeth A Frankman
Division of Urogynecology, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Women s Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Obstet Gynecol 202:495.e1-5. 2010..We sought to determine age-adjusted rates (AARs) of lower urinary tract injury and incidence in selected inpatient gynecologic and obstetric procedures... - Elevated seroprevalence of human herpesvirus 8 among men with prostate cancerLinda J Hoffman
Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Infect Dis 189:15-20. 2004..253; 95% CI, 0.77-3.54).Conclusions. HHV-8 seropositivity is elevated among men with prostate cancer compared with control subjects, which suggests that HHV-8 plays a role in the development of prostate cancer... - The Khatri Sikh Diabetes Study (SDS): study design, methodology, sample collection, and initial resultsDharambir K Sanghera
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Hum Biol 78:43-63. 2006..Such well-characterized population isolates may offer unique advantages in mapping genes for common complex diseases... - A case-cohort study of human herpesvirus 8 seropositivity and incident prostate cancer in TobagoAlicia C McDonald
Department of Epidemiology, University of Pittsburgh, A542 Crabtree Hall, 130 DeSoto Street, Pittsburgh, Pennsylvania, 15261, USA
Infect Agent Cancer 6:25. 2011..abstract:.. - Episiotomy in the United States: has anything changed?Elizabeth A Frankman
Division of Urogynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Obstet Gynecol 200:573.e1-7. 2009..The objective of the study was to describe episiotomy rates in the United States following recommended changes in clinical practice... - MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass indexScott M Langevin
Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
Carcinogenesis 31:864-70. 2010..The observed associations with gender and BMI help to shed light on potential risk factors for an altered methylation state in SCCHN... - Genetic variation in the apolipoprotein D gene among African blacks and its significance in lipid metabolismPurnima P Desai
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, PA 15261, USA
Atherosclerosis 163:329-38. 2002..Further study of these polymorphisms may help to characterize the role of apoD in lipid metabolism, and in cardiovascular disease among African populations... - Single nucleotide polymorphisms in the coding region of the apolipoprotein H (beta2-glycoprotein I) gene and their correlation with the protein polymorphism, anti-beta2glycoprotein I antibodies and cardiolipin binding: description of novel haplotypes and M Ilyas Kamboh
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Ann Hum Genet 68:285-99. 2004..We also found that these haplotypes are associated with the occurrence of APA. Recombinant APOH haplotypes, expressed in COS-1 cells, showed that these mutations also affect the binding of APOH to anionic PL... - Relationships among body composition measures in community-dwelling older womenKristi L Storti
Department of Epidemiology, Graduate School of Public Health, University of Pittsburg, Pittsburgh, Pennsylvania 15261, USA
Obesity (Silver Spring) 14:244-51. 2006..To examine whether simple anthropometric measures provide a good estimate of total and visceral fat in 146 community-dwelling, older white women (mean age, 74.0 +/- 4.1 years)... - ELAC2 and prostate cancer risk in Afro-Caribbeans of TobagoPatrick R Shea
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Hum Genet 111:398-400. 2002.... - Lower reproductive tract fistula repairs in inpatient US women, 1979-2006Heidi W Brown
Division of Urogynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Int Urogynecol J 23:403-10. 2012..The objective of the study was to characterize trends in lower reproductive tract fistula (LRTF) repair in inpatient US women from 1979 to 2006... - Differences in rates of obstructive lung disease between Africans and African AmericansIrene M Gathuru
Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
Ethn Dis 12:S3-107-13. 2002..Rates of ventilatory impairment and reported respiratory symptoms were examined in a cross-sectional study of urban Nigerian civil servants who are in transition to a westernized lifestyle... - Clinical predictors and outcomes of pars plana vitrectomy for retained lens material after cataract extractionLawrence Y Ho
University of Pittsburgh Medical Center Department of Ophthalmology, Pittsburgh, Pennsylvania, USA
Am J Ophthalmol 147:587-594.e1. 2009..To determine current clinical predictors and visual outcomes of patients who undergo pars plana vitrectomy (PPV) for retained lens material... - Trends in stress urinary incontinence inpatient procedures in the United States, 1979-2004Sallie S Oliphant
Division of Urogynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Am J Obstet Gynecol 200:521.e1-6. 2009..The purpose of this study was to describe national trends in surgery for female stress urinary incontinence (SUI)... - Temporal trends in patient-reported angina at 1 year after percutaneous coronary revascularization in the stent era: a report from the National Heart, Lung, and Blood Institute-sponsored 1997-2006 dynamic registryLakshmi Venkitachalam
Cardiovascular Institute, Department of Medicine, School of Medicine, Graduate School of Public Health, University of Pittsburgh, PA, USA
Circ Cardiovasc Qual Outcomes 2:607-15. 2009..Little, however, is known about the temporal impact on patient-reported symptoms and quality of life after PCI... - Genetic and environmental influences on skeletal muscle phenotypes as a function of age and sex in large, multigenerational families of African heritageSteven J Prior
Division of Gerontology, University of Maryland School of Medicine, and Baltimore Geriatric Research, Education and Clinical Center, Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
J Appl Physiol 103:1121-7. 2007.... - Does nondipping of blood pressure at night reflect a trait of blunted cardiovascular responses to daily activities?Katri Raikkonen
University of Helsinki
Ann Behav Med 27:131-7. 2004..Individuals who fail to show a decline in blood pressure (BP) when asleep or at night (labeled nocturnal nondippers) are at elevated risk for hypertension and associated target-organ damage...