Research Topics
Species | R BuckiSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Hypogelsolinemia, a disorder of the extracellular actin scavenger system, in patients with multiple sclerosisAlina Kułakowska
Department of Neurology, Medical University of Białystok, 15 230 Białystok, Poland
BMC Neurol 10:107. 2010....- Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juiceKatarzyna Leszczynska
Department of Diagnostic Microbiology, Medical University of Bialystok, 15 230 Bialystok, Poland
BMC Microbiol 9:187. 2009..pylori potential of cathelicidin LL-37 peptide, which is naturally present in gastric juice, its optimized synthetic analog WLBU2, and the non-peptide antibacterial agent ceragenin CSA-13... - Release of the antimicrobial peptide LL-37 from DNA/F-actin bundles in cystic fibrosis sputumR Bucki
Dept of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Eur Respir J 29:624-32. 2007..A combination of factors that dissolve DNA/filamentous-actin aggregates together with lipopolysaccharide-binding agents may represent a potential treatment for the chronic infections that occur in cystic fibrosis airways... - Resistance of the antibacterial agent ceragenin CSA-13 to inactivation by DNA or F-actin and its activity in cystic fibrosis sputumRobert Bucki
Department of Physiology and the Institute for Medicine and Engineering, 1010 Vagelos Research Laboratories, University of Pennsylvania, 3340 Smith Walk, Philadelphia, PA 19104, USA
J Antimicrob Chemother 60:535-45. 2007.... - Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13Robert Bucki
Department of Physiology, Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
J Antimicrob Chemother 62:329-35. 2008.... - Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall componentsRobert Bucki
University of Pennsylvania, Institute for Medicine and Engineering, Philadelphia, PA 19104, USA
J Immunol 181:4936-44. 2008..These data suggest that extracellular gelsolin is involved in the host immune recognition of LTA or LPS following release of these molecules from the bacterial outer membrane during cell division or attack by drugs and immune components... - Plasma gelsolin: function, prognostic value, and potential therapeutic useRobert Bucki
University of Pennsylvania, Institute for Medicine and Engineering, Vagelos Research Laboratories, Philadelphia, PA 19104, USA
Curr Protein Pept Sci 9:541-51. 2008..This review summarizes current data supporting a role of plasma gelsolin in extracellular fluids and the potential for its use as a diagnostic marker or therapeutic treatment in several medical conditions... - Cathelicidin LL-37: a multitask antimicrobial peptideRobert Bucki
Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
Arch Immunol Ther Exp (Warsz) 58:15-25. 2010..A better understanding of LL-37's biological properties is necessary for its possible therapeutic application for immunomodulatory purposes as well as in treating bacterial infection... - Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugateRobert Bucki
Department of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Antimicrob Agents Chemother 54:2525-33. 2010..The combined antibacterial and anti-inflammatory activities of D2S suggest its potential as an alternative to natural CAPs in the prevention and treatment of some bacterial infections... - Plasma gelsolin modulates cellular response to sphingosine 1-phosphateRobert Bucki
Univ of Pennsylvania, Inst for Medicine and Engineering, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
Am J Physiol Cell Physiol 299:C1516-23. 2010..These findings suggest that gelsolin-mediated regulation of S1P bioactivity may be important to maintain immunomodulatory balance at inflammatory sites... - Interaction of the gelsolin-derived antibacterial PBP 10 peptide with lipid bilayers and cell membranesRobert Bucki
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Antimicrob Agents Chemother 50:2932-40. 2006.... - Flavonoid inhibition of platelet procoagulant activity and phosphoinositide synthesisR Bucki
University of Pennsylvania, Institute for Medicine and Engineering, 1010 Vagelos Research Laboratories, Philadelphia, PA 19104, USA
J Thromb Haemost 1:1820-8. 2003..These data favor a role for PIP2 in the antiplatelet effects of flavonoids... - Antibacterial activities of rhodamine B-conjugated gelsolin-derived peptides compared to those of the antimicrobial peptides cathelicidin LL37, magainin II, and melittinRobert Bucki
Department of Physiology and the Institute for Medicine and Engineering, Vagelos Research Laboratories, University of Pennsylvania, Philadelphia 19104, USA
Antimicrob Agents Chemother 48:1526-33. 2004.... - Involvement of phosphatidylinositol 4,5-bisphosphate in phosphatidylserine exposure in platelets: use of a permeant phosphoinositide-binding peptideR Bucki
University of Pennsylvania, Institute for Medicine and Engineering, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, Pennsylvania 19104, USA
Biochemistry 40:15752-61. 2001..The use of a membrane-permeant and fluorescent peptide which binds to PIP2 is a promising tool to investigate the role of PIP2 in various cellular processes... - Involvement of the Na+/H+ exchanger in membrane phosphatidylserine exposure during human platelet activationRobert Bucki
University of Pennsylvania, Department of Physiology, Institute for Medicine and Engineering, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
Biochim Biophys Acta 1761:195-204. 2006..All these results would indicate that the mechanism that results in PS exposure uses redundant pathways inextricably linked to the physio-pathological requirements of this process... - Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeabilityFitzroy J Byfield
Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, 19104, USA
Am J Physiol Cell Physiol 300:C105-12. 2011..Such a mechanism may help to maintain tissue fluid homeostasis... - Potential of ceragenin CSA-13 and its mixture with pluronic F-127 as treatment of topical bacterial infectionsK Leszczynska
Department of Diagnostic Microbiology, Medical University of Białystok, Białystok, Poland
J Appl Microbiol 110:229-38. 2011..However, at higher concentrations, CSA-13 can cause lysis of erythrocytes. This study was designed to assess in vitro antibacterial and haemolytic activity of CSA-13 in the presence of pluronic F-127... - The antimicrobial activity of the cathelicidin LL37 is inhibited by F-actin bundles and restored by gelsolinDaniel J Weiner
Division of Pulmonary Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Am J Respir Cell Mol Biol 28:738-45. 2003..These findings may have therapeutic implications for treatments previously thought to alter only the viscoelastic properties of airway secretions and amplify the possible advantage of gelsolin in CF treatment... - The occurrence of Helicobacter pylori antigens in dental plaque; an association with oral health status and oral hygiene practicesD B Namiot
Department of Prosthetic Dentistry, Medical University of Białystok, Poland
Adv Med Sci 55:167-71. 2010..Since in the oral cavity H. pylori is mostly found in dental plaque, the aim of the study was to determine whether the oral health status and oral hygiene practices affect the incidence of H. pylori antigens in dental plaque... - Effect of triiodothyronine on the content of phospholipids in the rat liver nucleiR Bucki
Department of Physiology, Medical School of Białystok, Poland
J Physiol Pharmacol 51:535-40. 2000..It is concluded that excess of triiodothyronine affects the content of phospholipids in the nuclei. The changes in the content of phospholipids in the nuclei largely reflect changes in their content in the liver... - A series of cationic sterol lipids with gene transfer and bactericidal activityR A S Randazzo
Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, 1024 Vagelos Research Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
Bioorg Med Chem 17:3257-65. 2009..Cationic lipids can be optimized for both gene delivery and antibacterial applications by similar modifications... - Novel cationic lipids with enhanced gene delivery and antimicrobial activityDavid E Fein
Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Mol Pharmacol 78:402-10. 2010..Mixtures of DS and D(2)S can improve transfection activity over common lipofection reagents, and D(2)S has strong antimicrobial action suited for the suppression of bacterial-mediated inflammation... - Inactivation of endotoxin by human plasma gelsolinRobert Bucki
Department of Physiology and Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, Pennsylvania 19104, USA buckirob mail med upenn edu
Biochemistry 44:9590-7. 2005..These results show a strong effect of LPS on plasma gelsolin function and suggest that some effects of endotoxin in vivo may be mediated or inhibited by plasma gelsolin... - Bacterial endotoxin as inhibitor of the enzymatic activity of human thrombinRobert Bucki
Department of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Eur J Haematol 76:510-5. 2006..When added to platelet-rich plasma, after activation with collagen, LPS-inhibited thrombin activity. LPS-mediated inhibition of thrombin activity may contribute to the hemostasis dysfunctions observed during endotoxemia... - Flavonoid-mediated inhibition of actin polymerization in cold-activated plateletsJennifer J Pastore
Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Research Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA
Platelets 16:362-7. 2005..These data confirm the important links that exist between agonist- and cold-mediated platelet activation, suggesting a possible advantage of incorporating the use of flavonoids to allow platelet hypothermic-storage... - Gelsolin concentration in cerebrospinal fluid from patients with multiple sclerosis and other neurological disordersA Kulakowska
Department of Neurology, Medical University of Bialystok, Bialystok, Poland
Eur J Neurol 15:584-8. 2008..Gelsolin is a highly conserved intracellular actin-binding protein with an extracellular isoform, plasma gelsolin, for which there is not yet a clearly defined function... - Patient factors affecting culture of Helicobacter pylori isolated from gastric mucosal specimensK Leszczynska
Department of Diagnostic Microbiology, Medical University of Białystok, Poland
Adv Med Sci 55:161-6. 2010..The aim of the study was to analyze some of the factors that may affect the outcome of H. pylori culture from endoscopic gastric mucosal specimens... - Diabetes affects phospholipid content in the nuclei of the rat liverM Zendzian-Piotrowska
Department of Physiology, Medical Academy of Bialystok, Poland
Horm Metab Res 32:386-9. 2000..The specific activity of each phospholipid fraction, was elevated in this group. It is concluded that insulin is involved in the regulation of the nuclear phospholipid content... - Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathwayM Marzec
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Oncogene 26:5606-14. 2007..These findings identify mTOR as a novel key target of NPM/ALK and suggest that mTOR inhibitors may prove effective in therapy of ALK-induced malignancies... - Delayed loss of control of plasma lipopolysaccharide levels after therapy interruption in chronically HIV-1-infected patientsEmmanouil Papasavvas
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
AIDS 23:369-75. 2009..Increased circulating levels of lipopolysaccharide (LPS) have been demonstrated in HIV-1-infected progressors. We investigated the effect of antiretroviral therapy (ART) interruptions on plasma LPS levels... - Anionic poly(amino acid)s dissolve F-actin and DNA bundles, enhance DNase activity, and reduce the viscosity of cystic fibrosis sputumJay X Tang
Dept. of Physics, Brown University, Providence, Rhode Island, USA
Am J Physiol Lung Cell Mol Physiol 289:L599-605. 2005..These findings suggest that soluble multivalent anions have potential alone or in combination with other mucolytic agents to selectively dissociate the large bundles of charged biopolymers that form in CF sputum... - Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealantsSarah E Michaud
Hematology Division, Brigham and Women's Hospital, LMRC #302, 221 Longwood Ave, Boston, MA 02115, USA
Thromb Res 107:245-54. 2002.... - Oral health status and oral hygiene practices of patients with peptic ulcer and how these affect Helicobacter pylori eradication from the stomachDorota B Namiot
Department of Prosthetic Dentistry, Medical University of Białystok, Białystok, Poland
Helicobacter 12:63-7. 2007..Since oral health status could correspond to oral infection with H. pylori, the aim of the study was to determine whether oral health and oral hygiene practices affect the efficacy of H. pylori eradication from the stomach...