Research Topics
Species | Molly A BrewerSummaryAffiliation: University of Arizona Country: USA Publications
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Detail Information
Publications
Cactus pear: a natural product in cancer chemopreventionDa ming Zou
Department of Obstetrics and Gynecology, Arizona Health Sciences Center, University of Arizona, Tucson, Arizona 85724, USA
Nutr J 4:25. 2005..To find a natural product that can be used in chemoprevention of cancer, we tested Arizona cactus fruit solution, the aqueous extracts of cactus pear, for its anti-cancer effects in cultured cells and in an animal model...- Fluorescence spectroscopy as a biomarker in a cell culture and in a nonhuman primate model for ovarian cancer chemopreventive agentsMolly Brewer
University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biomed Opt 7:20-6. 2002..The objective of this study was to compare the effects of chemopreventive agents on natural fluorescence emission of ovarian cells in a cell culture and in a primate model as a feasibility trial to monitor drug activity... - Combination of 4-HPR and oral contraceptive in monkey model of chemoprevention of ovarian cancerMolly Brewer
Department of Ob Gyn, University of Arizona, College of Medicine, Tucson, AZ 8572, USA
Front Biosci 12:2260-8. 2007..However, the combination of 4-HPR with OCP had a larger effect on expression of retinoid receptors. Apoptosis was detected in the 4-HPR group (equivalent dose: 200 mg/day)... - In vitro model of normal, immortalized ovarian surface epithelial and ovarian cancer cells for chemoprevention of ovarian cancerMolly Brewer
Department of Gynecologic Oncology, University of Texas, The M D Anderson Cancer Center, Houston, TX 77030, USA
Gynecol Oncol 98:182-92. 2005..However, the effectiveness of its application for different populations has been questioned because of the genetic differences among normal, high risk, and women with cancer... - Exploratory study of ovarian intraepithelial neoplasiaMolly A Brewer
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Arizona Cancer Center, Room 1968G, 1515 North Campbell Avenue, Tucson, AZ 85724 5024, USA
Cancer Epidemiol Biomarkers Prev 14:299-305. 2005.... - Imaging of the ovaryMolly A Brewer
Biomedical Engineering Program, University of Arizona, 1515 N Campbell Ave, Room 1968, Tucson, AZ 85724 5024, USA
Technol Cancer Res Treat 3:617-27. 2004..The combination of optical technologies supported by modern molecular biology may lead to an instrument that can accurately detect early carcinogenesis... - Preneoplastic changes in ovarian tissuesMolly A Brewer
Department of Obstetrics and Gynecology, Arizona Cancer Center, Tucson, Arizona 85724 5024, USA
Anal Quant Cytol Histol 26:207-16. 2004..To test whether histologically normal epithelium within ovarian inclusion cysts and stroma exhibit changes in nuclear chromatin pattern that indicate the presence of occult ovarian lesions... - Prevention of ovarian cancer: intraepithelial neoplasiaMolly A Brewer
Department of Obstetrics and Gynecology, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
Clin Cancer Res 9:20-30. 2003..New prevention strategies hold significant promise to reduce the mortality from ovarian cancer... - Endogenous fluorescence spectroscopy of cell suspensions for chemopreventive drug monitoringNathaniel D Kirkpatrick
Division of Biomedical Engineering, University of Arizona, Tucson, AZ, USA
Photochem Photobiol 81:125-34. 2005..Given that each cell line has been shown to have a different apoptotic response to 4HPR, fluorescence redox values along with changes in tryptophan fluorescence may be a response as well as an endpoint marker for chemopreventive drugs... - Endogenous optical biomarkers of ovarian cancer evaluated with multiphoton microscopyNathaniel D Kirkpatrick
Biomedical Engineering Program, University of Arizona, Arizona, USA
Cancer Epidemiol Biomarkers Prev 16:2048-57. 2007..Additionally, multiwavelength 2PEF provided an estimation of the cellular redox ratio of epithelial cells... - Optical imaging of the cervixRebekah A Drezek
Bioengineering Department, Rice University, Houston, Texas, USA
Cancer 98:2015-27. 2003..Applying the Littenberg assessment will help ensure that superior, not simply alternative, technologies are implemented... - Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesisLida P Hariri
Department of Biomedical Engineering, The University of Arizona, College of Medicine, Tucson, AZ USA
Cancer Biol Ther 10:438-47. 2010..We present combined OCT-LIF imaging in a rat ovarian carcinogenesis model, providing preliminary criteria for normal cyclic, acyclic and SCST ovaries which support the potential of OCT-LIF for ovarian imaging... - Clinical research device for ovarian cancer detection by optical spectroscopy in the ultraviolet C-visibleRonie George
University of Arizona, College of Optical Sciences, 1630 East University Boulevard, Tucson, Arizona 85724, USA
J Biomed Opt 15:057009. 2010..If proven effective, this technique can be useful in screening women at high risk of developing ovarian cancer to determine whether oophorectomy is necessary... - Laparoscopic optical coherence tomography imaging of human ovarian cancerLida P Hariri
Department of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721 0104, USA
Gynecol Oncol 114:188-94. 2009..In this study, we developed the first ever laparoscopic OCT (LOCT) device, evaluated the safety and feasibility of LOCT, and characterized the microstructural features of human ovaries in vivo... - Computer-aided identification of ovarian cancer in confocal microendoscope imagesSaurabh Srivastava
University of Arizona, Department of Electrical and Computer Engineering, 360 W 34th St, Apt K, New York, New York 10001, USA
J Biomed Opt 13:024021. 2008..The results suggest it is possible to automatically identify pathology based on texture features extracted from confocal microendoscope images and that the machine performance is superior to that of a human observer... - Parallel factor analysis of ovarian autofluorescence as a cancer diagnosticRonie George
College of Optical Sciences, University of Arizona, Tucson, Arizona 85721
Lasers Surg Med 44:282-95. 2012..We evaluate the potential of these changes in fluorescence to predict a diagnosis of malignancy and to estimate the risk of developing ovarian cancer... - Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancerSetsuko K Chambers
Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724 5024, USA
Clin Cancer Res 16:5320-8. 2010..This phase II trial evaluated bevacizumab plus erlotinib in platinum-resistant ovarian cancer; exploratory biomarker analyses, including that of tumor vascular endothelial growth factor A (VEGF-A), were also done... - Specific keynote: chemoprevention of ovarian cancer: the journey beginsRobert F Ozols
Fox Chase Cancer Center
Gynecol Oncol 88:S59-66; discussion S67-70. 2003 - Guidelines for referral of the patient with an adnexal massBobbie S Gostout
Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Clin Obstet Gynecol 49:448-58. 2006..Premenopausal women should be referred if the CA 125 is elevated above 200 U/mL, there is an evidence of metastatic disease or ascites, or strong family history of breast or ovarian cancer... - Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forwardGary J Kelloff
National Cancer Institute, Bethesda, Maryland 20852, USA
Clin Cancer Res 12:3661-97. 2006....