Nalini S Bora

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi Type I collagen is the autoantigen in experimental autoimmune anterior uveitis
    Nalini S Bora
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA
    J Immunol 172:7086-94. 2004
  2. ncbi Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization
    Puran S Bora
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, 301E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    J Immunol 174:491-7. 2005
  3. ncbi Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization
    Puran S Bora
    Department of Ophthalmology and Visual Science, Kentucky Lions Eye Center, University of Louisville, KY, USA
    FEBS J 273:1403-14. 2006
  4. ncbi Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU)
    Nalini S Bora
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, School of Medicine, University of Louisville, 40202, USA
    Ocul Immunol Inflamm 13:183-9. 2005
  5. ncbi Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration
    Puran S Bora
    Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40202, USA
    Proc Natl Acad Sci U S A 100:2679-84. 2003
  6. ncbi Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells
    Jeong Hyeon Sohn
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky, USA
    Nat Med 9:206-12. 2003
  7. ncbi Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion
    Barbara J McLaughlin
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Invest Ophthalmol Vis Sci 44:3669-74. 2003
  8. ncbi Molecular characterization of human eye and heart fatty acid ethyl ester synthase/carboxylesterase by site-directed mutagenesis
    Puran S Bora
    Department of Internal Medicine, Division of Cardiology and Geriatric Medicine, Saint Louis University Medical Center, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 312:1094-8. 2003
  9. ncbi Pathogenesis of age-related macular degeneration
    Tongalp H Tezel
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA
    Trends Mol Med 10:417-20. 2004
  10. ncbi Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis
    Purushottam Jha
    Department of Ophthalmology, Jones Eye Institute, Little Rock, AR 72205, USA
    Invest Ophthalmol Vis Sci 48:5091-100. 2007

Collaborators

Detail Information

Publications21

  1. ncbi Type I collagen is the autoantigen in experimental autoimmune anterior uveitis
    Nalini S Bora
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA
    J Immunol 172:7086-94. 2004
    ..Although human anterior uveitis has been historically characterized as a collagen disease, this is first time collagen has been directly identified as the target autoantigen in uveitis...
  2. ncbi Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization
    Puran S Bora
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, 301E Muhammad Ali Boulevard, Louisville, KY 40202, USA
    J Immunol 174:491-7. 2005
    ..It is possible that a similar mechanism may be involved in the pathophysiology of other angiogenesis essential diseases...
  3. ncbi Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization
    Puran S Bora
    Department of Ophthalmology and Visual Science, Kentucky Lions Eye Center, University of Louisville, KY, USA
    FEBS J 273:1403-14. 2006
    ..These results may provide insight into the link between heavy alcohol consumption and exudative AMD...
  4. ncbi Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU)
    Nalini S Bora
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, School of Medicine, University of Louisville, 40202, USA
    Ocul Immunol Inflamm 13:183-9. 2005
    ..Therefore, inhibition of these enzymes may abrogate intraocular inflammation in experimental autoimmune anterior uveitis (EAAU)...
  5. ncbi Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration
    Puran S Bora
    Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40202, USA
    Proc Natl Acad Sci U S A 100:2679-84. 2003
    ..Because the Icon binds selectively to the CNV in exudative AMD as well as to laser-induced CNV, the Icon might also be efficacious for treating patients with exudative AMD...
  6. ncbi Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells
    Jeong Hyeon Sohn
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky, USA
    Nat Med 9:206-12. 2003
    ..These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance...
  7. ncbi Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion
    Barbara J McLaughlin
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Invest Ophthalmol Vis Sci 44:3669-74. 2003
    ..In this study, a novel role in the retina for a regulatory protein in the complement system, CD46, is proposed...
  8. ncbi Molecular characterization of human eye and heart fatty acid ethyl ester synthase/carboxylesterase by site-directed mutagenesis
    Puran S Bora
    Department of Internal Medicine, Division of Cardiology and Geriatric Medicine, Saint Louis University Medical Center, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 312:1094-8. 2003
    ....
  9. ncbi Pathogenesis of age-related macular degeneration
    Tongalp H Tezel
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA
    Trends Mol Med 10:417-20. 2004
  10. ncbi Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis
    Purushottam Jha
    Department of Ophthalmology, Jones Eye Institute, Little Rock, AR 72205, USA
    Invest Ophthalmol Vis Sci 48:5091-100. 2007
    ..Experimental autoimmune anterior uveitis (EAAU) serves as an animal model of human idiopathic anterior uveitis. This study was undertaken to investigate the role of apoptosis in the resolution of EAAU...
  11. ncbi Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal neovascularization by adiponectin
    Puran S Bora
    Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, 4301 West Markham, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    FEBS Lett 581:1977-82. 2007
    ..Thus, APN inhibited choroidal angiogenesis and may have therapeutic implications in the treatment of wet age related macular degeneration...
  12. ncbi Intraocular diseases - anterior uveitis
    Nalini S Bora
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Chem Immunol Allergy 92:213-20. 2007
    ..Recently, type I collagen was identified as the target autoantigen in EAAU. Thus, human AU may be an e xample of autoimmunity to local ocular collagen...
  13. ncbi CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration
    Nalini S Bora
    Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 178:1783-90. 2007
    ..Thus, our results suggest that the inhibition of complement by soluble CD59 may provide a novel therapeutic alternative to current treatment...
  14. ncbi Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H
    Nalini S Bora
    Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 177:1872-8. 2006
    ..Thus, specific blockade of the alternative pathway may represent a therapeutically relevant strategy for the inhibition of CNV...
  15. ncbi Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU)
    Purushottam Jha
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    J Immunol 176:7221-31. 2006
    ....
  16. ncbi The complement system plays a critical role in the development of experimental autoimmune anterior uveitis
    Purushottam Jha
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Invest Ophthalmol Vis Sci 47:1030-8. 2006
    ..The role of complement in ocular autoimmunity was explored in a experimental autoimmune anterior uveitis (EAAU) animal model...
  17. ncbi Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells
    Bharati Matta
    Department of Ophthalmology, Jones Eye Institute, Little Rock, AR 72205, USA
    Am J Pathol 173:1440-54. 2008
    ..In conclusion, T-cell nonresponsiveness because of active suppression mediated by T-regulatory cells facilitates the development of tolerance to MAA in EAAU...
  18. ncbi Complement system and the eye
    Purushottam Jha
    Department of Ophthalmology, Jones Eye Institute, 4301 West Markham, 523, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Adv Exp Med Biol 586:53-62. 2006
  19. ncbi Complement, innate immunity and ocular disease
    Jeong Hyeon Sohn
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Chem Immunol Allergy 92:105-14. 2007
    ....
  20. ncbi The role of complement system in ocular diseases including uveitis and macular degeneration
    Purushottam Jha
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA
    Mol Immunol 44:3901-8. 2007
    ..Currently, several clinical trials using complement inhibitors are going on. It is possible that, in the near future, complement inhibitors might be used as therapeutic agents in eye clinics...
  21. ncbi The role of complement in ocular pathology
    Nalini S Bora
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 523, Little Rock, AR 72205, USA
    Semin Immunopathol 30:85-95. 2008
    ..It is hoped that in the future recombinant complement regulatory proteins will be used as novel therapeutic agents in the clinic for the treatment of keratitis, uveitis, and age-related macular degeneration...