Frank Booth

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi The future: genes, physical activity and health
    F W Booth
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Acta Physiol (Oxf) 199:549-56. 2010
  2. ncbi Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery
    F W Booth
    Veterinary Medicine Bldg E102, University of Missouri, Columbia, MO 65211, USA
    J Physiol 587:5527-39. 2009
  3. ncbi Linking performance and chronic disease risk: indices of physical performance are surrogates for health
    F W Booth
    Department of Biomedical Sciences, Dalton Cardiovascular Institute, Univerwity of Missouri, 1600 East Rollins St, Columbia, MO 65211, USA
    Br J Sports Med 42:950-2. 2008
  4. ncbi Lifetime sedentary living accelerates some aspects of secondary aging
    Frank W Booth
    Dept of Biomedical Sciences, Univ of Missouri, 1600 East Rollins St, Columbia MO 65203
    J Appl Physiol 111:1497-504. 2011
  5. ncbi Fundamental questions about genes, inactivity, and chronic diseases
    Frank W Booth
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Physiol Genomics 28:146-57. 2007
  6. ncbi Physically active subjects should be the control group
    Frank W Booth
    Health Activity Center, Department of Biomedical Sciences and of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
    Med Sci Sports Exerc 38:405-6. 2006
  7. ncbi Reduced physical activity and risk of chronic disease: the biology behind the consequences
    Frank W Booth
    Department of Biomedical Sciences, University of Missouri, 1600 East Rollins St, Columbia, MO, 65211, USA
    Eur J Appl Physiol 102:381-90. 2008
  8. ncbi The biochemical basis of the health effects of exercise: an integrative view
    Frank W Booth
    Department of Biomedical Sciences, Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri 65211, USA
    Proc Nutr Soc 63:199-203. 2004
  9. ncbi Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle
    R Tyler Morris
    Department Medical Pharmacology and physiology, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 96:398-404. 2004
  10. ncbi Basic concepts about genes, inactivity and aging
    F W Booth
    Health Activity Center, Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Scand J Med Sci Sports 20:1-4. 2010

Research Grants

  1. EXERCISE-INDUCED GROWTH OF SKELETAL MUSCLE
    Frank Booth; Fiscal Year: 1999
  2. SATELLITE STEM CELL BIOLOGY
    Frank Booth; Fiscal Year: 2007
  3. SATELLITE STEM CELL BIOLOGY
    Frank Booth; Fiscal Year: 2005
  4. Failed rescue of old skeletal muscle from atrophy
    Frank Booth; Fiscal Year: 2004
  5. EXERCISE INDUCED GROWTH OF SKELETAL MUSCLE
    Frank Booth; Fiscal Year: 2003
  6. Proteomics: Inactivity-induced muscle insulin resistance
    Frank Booth; Fiscal Year: 2002

Collaborators

Detail Information

Publications58

  1. ncbi The future: genes, physical activity and health
    F W Booth
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Acta Physiol (Oxf) 199:549-56. 2010
    ..The future needs to understand the molecular basis for how the body becomes dysfunctional when its level of physical activity does not match the norm of physical activity that selected our inherited genome...
  2. ncbi Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery
    F W Booth
    Veterinary Medicine Bldg E102, University of Missouri, Columbia, MO 65211, USA
    J Physiol 587:5527-39. 2009
    ..Additionally, the scientific criteria that the authors demand to be met to legitimately use the terms 'exercise pill' and 'exercise mimetic' are presented...
  3. ncbi Linking performance and chronic disease risk: indices of physical performance are surrogates for health
    F W Booth
    Department of Biomedical Sciences, Dalton Cardiovascular Institute, Univerwity of Missouri, 1600 East Rollins St, Columbia, MO 65211, USA
    Br J Sports Med 42:950-2. 2008
    ..In this review, evidence is presented for the assertion that research on elite athletes and chronic disease prevention by exercise is actually addressing the same biochemical, physiological and genomic phenomena...
  4. ncbi Lifetime sedentary living accelerates some aspects of secondary aging
    Frank W Booth
    Dept of Biomedical Sciences, Univ of Missouri, 1600 East Rollins St, Columbia MO 65203
    J Appl Physiol 111:1497-504. 2011
    ..In summary, physical inactivity plays a major role in the secondary aging of many essential physiological functions, and this aging can be prevented through a lifetime of physical activity...
  5. ncbi Fundamental questions about genes, inactivity, and chronic diseases
    Frank W Booth
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Physiol Genomics 28:146-57. 2007
    ....
  6. ncbi Physically active subjects should be the control group
    Frank W Booth
    Health Activity Center, Department of Biomedical Sciences and of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
    Med Sci Sports Exerc 38:405-6. 2006
  7. ncbi Reduced physical activity and risk of chronic disease: the biology behind the consequences
    Frank W Booth
    Department of Biomedical Sciences, University of Missouri, 1600 East Rollins St, Columbia, MO, 65211, USA
    Eur J Appl Physiol 102:381-90. 2008
    ..This review focuses on the supporting data for the aforementioned two outcomes. Our primary goal is to better understand how a physically inactive lifestyle initiates maladaptations that cause chronic disease...
  8. ncbi The biochemical basis of the health effects of exercise: an integrative view
    Frank W Booth
    Department of Biomedical Sciences, Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri 65211, USA
    Proc Nutr Soc 63:199-203. 2004
    ..Future experiments will be needed to test the validity of the ideas presented...
  9. ncbi Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle
    R Tyler Morris
    Department Medical Pharmacology and physiology, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 96:398-404. 2004
    ..Am J Physiol Cell Physiol: 285: C391-C398, 2003) were reanalyzed together, the recovery-induced increase in p70S6k-phos from immobilization-atrophy was significantly attenuated in soleus muscles of the old group...
  10. ncbi Basic concepts about genes, inactivity and aging
    F W Booth
    Health Activity Center, Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Scand J Med Sci Sports 20:1-4. 2010
    ..In this short review, we speculate that the lack of daily physical activity induces evolutionarily selected mechanisms to use or lose, one of which is related to nutritional status...
  11. ncbi Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy
    Frank W Booth
    Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA
    J Appl Physiol 93:3-30. 2002
    ..We hope that this information will provide readers with a starting point for developing additional strategies of their own in the ongoing war against inactivity-induced chronic health conditions...
  12. ncbi Temporal alterations in protein signaling cascades during recovery from muscle atrophy
    Thomas E Childs
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Cell Physiol 285:C391-8. 2003
    ..Thus the time course of increase in molecules of signaling pathways differed as the young rat soleus muscle regrew from an atrophied state...
  13. ncbi Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent
    Espen E Spangenburg
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Am J Physiol Endocrinol Metab 284:E340-50. 2003
    ....
  14. ncbi Selected Contribution: Identification of differentially expressed genes between young and old rat soleus muscle during recovery from immobilization-induced atrophy
    J Scott Pattison
    Department of Biomedical Sciences, University of Missouri at Columbia, Columbia, Missouri 65211, USA
    J Appl Physiol 95:2171-9. 2003
    ..The mRNAs identified as differentially expressed between young and old recovery may modulate muscle growth that could highlight new candidate mechanisms to explain the failure of old soleus muscle to recover lost muscle mass...
  15. ncbi Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferation
    Espen E Spangenburg
    Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211, USA
    Am J Physiol Cell Physiol 283:C204-11. 2002
    ..These data suggest that LIF induces satellite cell proliferation by activation of the JAK2-STAT3 signaling pathway, suggesting that this may be an important pathway in muscle growth and/or hypertrophy...
  16. ncbi Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissue
    Matthew J Laye
    Research Service, Harry S Truman Memorial VA Hospital, Deptartment of Nutritional Sciences, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 106:161-8. 2009
    ..This study is the first to demonstrate that the transition from high to low daily physical activity causes rapid, tissue-specific changes in FAO...
  17. ncbi Expression profiling identifies dysregulation of myosin heavy chains IIb and IIx during limb immobilization in the soleus muscles of old rats
    J Scott Pattison
    Department of Biomedical Sciences, University of Missouri at Columbia, Columbia, MO 65211, USA
    J Physiol 553:357-68. 2003
    ..Therefore, deficiencies in pre-translational signals that normally upregulate myosin heavy chain IIb and IIx mRNAs during atrophy may exist in the soleus muscle of old animals...
  18. ncbi Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells
    Shuichi Machida
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    J Cell Physiol 196:523-31. 2003
    ..Thus, inactivation of FoxO1 by IGF-I plays a critical role in rat skeletal satellite cell proliferation through regulation of p27Kip1 expression...
  19. ncbi Inactivity induces increases in abdominal fat
    Matthew J Laye
    Department of Medical Pharmacology and Physiology, 1600 East Rollins, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol 102:1341-7. 2007
    ....
  20. ncbi Regrowth of skeletal muscle atrophied from inactivity
    Shuichi Machida
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Med Sci Sports Exerc 36:52-9. 2004
    ..The purpose of the review is to provide current knowledge about the biology of muscle regrowth from inactivity-induced atrophy...
  21. ncbi Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat
    R Tyler Morris
    Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, 1600 E Rollins, Columbia, MO 65201, USA
    J Appl Physiol 104:708-15. 2008
    ..Therefore, even in a genetic animal model of extreme overeating, daily physical activity promotes improved health of skeletal muscle...
  22. ncbi Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model
    R Scott Rector
    Division of Gastroenterology and Hepatology, Univ of Missouri, Columbia, MO 65212, USA
    Am J Physiol Gastrointest Liver Physiol 300:G874-83. 2011
    ..However, daily exercise may offer additional health benefits on glucose homeostasis and hepatic mitochondrial function compared with restricted diet alone...
  23. ncbi Increased mitochondrial glycerol-3-phosphate acyltransferase protein and enzyme activity in rat epididymal fat upon cessation of wheel running
    David S Kump
    Department of Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, MO 65211, USA
    Am J Physiol Endocrinol Metab 290:E480-9. 2006
    ..Casein kinase-2alpha protein level and activity were unchanged. We conclude that an increase in mtGPAT protein might contribute to the overshoot in triacylglycerol synthesis...
  24. ncbi Age-associated decrease in muscle precursor cell differentiation
    Simon J Lees
    Dept of Biomedical Sciences, Univ of Missouri Columbia, Veterinary Medicine Bldg, 1600 East Rollins, Rm E102, Columbia, MO 65211, USA
    Am J Physiol Cell Physiol 290:C609-15. 2006
    ..Furthermore, there is an age-associated decrease in muscle-specific protein expression in differentiating MPCs despite normal MyoD and elevated myogenin levels...
  25. ncbi Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia
    Brian T Steffen
    Department of Medical Pharmacology, Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri 65211, USA
    J Appl Physiol 105:1950-8. 2008
    ....
  26. ncbi Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells
    Simon J Lees
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Am J Physiol Cell Physiol 295:C1238-46. 2008
    ..These findings have implications for developing treatment strategies aimed at increasing the proliferation of MPCs and regenerative capacity of aged skeletal muscle...
  27. ncbi Sustained rise in triacylglycerol synthesis and increased epididymal fat mass when rats cease voluntary wheel running
    David S Kump
    Department of Biomedical Sciences, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA
    J Physiol 565:911-25. 2005
    ....
  28. ncbi GSK-3beta negatively regulates skeletal myotube hypertrophy
    Dharmesh R Vyas
    Department of Veterinary Biomedical Sciences, and the Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri 65211, USA
    Am J Physiol Cell Physiol 283:C545-51. 2002
    ..These data suggest that the IGF-I-induced increase in skeletal myotube size is signaled, in part, through the inhibition of GSK-3beta...
  29. ncbi Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals
    Shuichi Machida
    Department of Biomedical Sciences, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA
    Exp Gerontol 39:1521-5. 2004
    ..In summary, satellite cells in old rats have nuclear accumulation of proteins inhibiting the cell cycle as compared to young, growing animals...
  30. ncbi Fibroblast growth factor 2-stimulated proliferation is lower in muscle precursor cells from old rats
    Seth S Jump
    Department of Biomedical Science, University of Missouri Columbia, Columbia, MO 65211, USA
    Exp Physiol 94:739-48. 2009
    ..These findings provide insight for the development of effective treatment strategies that target the age-related impairments of MPC proliferation in old skeletal muscle...
  31. ncbi Sedentary death syndrome
    Simon J Lees
    Dept. of Biomedical Sciences, Univ. of Missouri-Columbia, Columbia, MO, USA
    Can J Appl Physiol 29:447-60; discussion 444-6. 2004
    ..Therefore, to obtain causal mechanisms for SeDS in order to allow for scientifically based prevention and therapy strategies, physically active subjects must serve as the control group...
  32. ncbi Exercise and gene expression: physiological regulation of the human genome through physical activity
    Frank W Booth
    Departments of Biomedical Sciences and Physiology and the Dalton Cardiovascular Institute, University of Missouri, Columbia, MO 65211, USA
    J Physiol 543:399-411. 2002
    ..In summary, in sedentary cultures, daily physical activity normalizes gene expression towards patterns established to maintain the survival in the Late Palaeolithic era...
  33. ncbi Muscle precursor cells isolated from aged rats exhibit an increased tumor necrosis factor- alpha response
    Simon J Lees
    Department of Biomedical Sciences, University of Missouri Columbia, USA
    Aging Cell 8:26-35. 2009
    ....
  34. ncbi Physical inactivity is a disease
    Simon J Lees
    Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, Mo. 65211, USA
    World Rev Nutr Diet 95:73-9. 2005
  35. ncbi Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise
    David S Kump
    Department of Biomedical Sciences, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA
    J Physiol 562:829-38. 2005
    ....
  36. ncbi Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF rats
    R Scott Rector
    Harry S Truman Memorial VA Hospital, Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65201, USA
    Am J Physiol Endocrinol Metab 298:E1179-87. 2010
    ..However, diabetes prevention through increased physical activity appears to be mediated in part through maintenance of skeletal muscle mitochondrial function...
  37. ncbi Transcriptional profiling identifies extensive downregulation of extracellular matrix gene expression in sarcopenic rat soleus muscle
    J Scott Pattison
    Department of Biomedical Sciences, and the Dalton Cardiovascular Institute, University of Missouri at Columbia, Columbia, Missouri 65211, USA
    Physiol Genomics 15:34-43. 2003
    ..Finally, multiple mRNAs that differ between young growing and old, sarcopenic muscles were identified and may highlight new candidate mechanisms that regulate skeletal muscle mass during sarcopenia...
  38. ncbi Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
    R Scott Rector
    Division of Gastroenterology and Hepatology, 5 Hospital Drive, CE405 Clinical Support and Education Building, University of Missouri Columbia, Columbia, MO 65212, USA
    J Hepatol 52:727-36. 2010
    ....
  39. ncbi Sirt1 increases skeletal muscle precursor cell proliferation
    Christopher R Rathbone
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Eur J Cell Biol 88:35-44. 2009
    ..These findings could have clinical significance since MPC proliferation has important implications in regulating skeletal muscle growth, maintenance, and repair, and the aging-related loss of skeletal muscle mass...
  40. ncbi Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation
    Shuichi Machida
    Department of Biomedical Sciences, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA
    Proc Nutr Soc 63:337-40. 2004
    ..The purpose of the present review is to provide current understanding of the cellular and molecular events underlying IGF-1 induced proliferation of satellite cells...
  41. ncbi Insulin-like growth factor-induced transcriptional activity of the skeletal alpha-actin gene is regulated by signaling mechanisms linked to voltage-gated calcium channels during myoblast differentiation
    Espen E Spangenburg
    Department of Biomedical Sciences, University of Missouri, Columbia 65211, USA
    Endocrinology 145:2054-63. 2004
    ....
  42. ncbi IGF-I activates the mouse type IIb myosin heavy chain gene
    R Andrew Shanely
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Am J Physiol Cell Physiol 297:C1019-27. 2009
    ..In summary, IGF-I stimulation of C2C12 myotubes increases mouse type IIb MyHC promoter activity, likely through signaling of PI3K, GSK-3beta, beta-catenin, and a Tcf/Lef binding site at -1,206 to -1,201 bp in the promoter...
  43. ncbi Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats
    Matthew J Laye
    Division of Gastroenterology and Hepatology, University of Missouri Columbia, Columbia, MO 65212, USA
    J Physiol 587:3729-39. 2009
    ..Reduced ability to increase WAT mitochondrial content does not appear to be a primary cause of insulin resistance, but may play a key role in the worsening of the disease condition...
  44. ncbi Perivascular fat alters reactivity of coronary artery: effects of diet and exercise
    Matthew S Reifenberger
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Med Sci Sports Exerc 39:2125-34. 2007
    ..The purpose of this study was to test the hypothesis that PAT of porcine coronary artery blunts constriction similarly and that this anticontractile effect of PAT is altered by diet and/or exercise training...
  45. ncbi FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progression
    Christopher R Rathbone
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Muscle Nerve 37:84-9. 2008
    ..Our findings suggest that attenuating increased FoxO3a may restore MPC proliferation to prevent atrophy and improve the regenerative capacity of skeletal muscle...
  46. ncbi Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats
    R Scott Rector
    Division of Gastroenterology and Hepatology, University of Missouri Columbia, Columbia, MO 65212, USA
    Am J Physiol Gastrointest Liver Physiol 294:G619-26. 2008
    ....
  47. ncbi Neurobiology of exercise
    Rod K Dishman
    Department of Exercise Science, The University of Georgia, Ramsey Center, 330 River Road, Athens, GA 30602 6554, USA
    Obesity (Silver Spring) 14:345-56. 2006
    ....
  48. ncbi Physical activity and dietary intervention for chronic diseases: a quick fix after all?
    Frank W Booth
    J Appl Physiol 100:1439-40. 2006
  49. ncbi An obligation for primary care physicians to prescribe physical activity to sedentary patients to reduce the risk of chronic health conditions
    Manu V Chakravarthy
    Department of Internal Medicine, University of Pennsylvania, Philadelphia, USA
    Mayo Clin Proc 77:165-73. 2002
    ....
  50. ncbi Unlike myofibers, neuromuscular junctions remain stable during prolonged muscle unloading
    Michael R Deschenes
    Department of Kinesiology, The College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Neurol Sci 210:5-10. 2003
    ..This may be of benefit during post-unloading rehabilitative measures where effective neuromuscular communication is essential...
  51. ncbi Control of the size of the human muscle mass
    Michael J Rennie
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, DD1 4HN, Scotland, United Kingdom
    Annu Rev Physiol 66:799-828. 2004
    ....
  52. ncbi Inactivity and inaction: we can't afford either
    Manu V Chakravarthy
    Arch Pediatr Adolesc Med 157:731-2. 2003
  53. ncbi Eating, exercise, and "thrifty" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases
    Manu V Chakravarthy
    Division of Endocrinology, Metabolism and Lipid Research, Department of Internal Medicine, Washington University School of Medicine, St Louis 63110, USA
    J Appl Physiol 96:3-10. 2004
    ..Therefore, the identification of such "thrifty gene" candidates would help provide insight into the pathogenetic processes of the numerous physical inactivity-mediated disorders...
  54. ncbi Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription
    Dinakar Iyer
    Department of Medicine, Division of Endocrinology, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 42:7477-86. 2003
    ..Phosphorylation of the MADS box may constitute a novel mechanism for regulation of SRF-dependent actin gene transcription...
  55. ncbi Metabolic responses to reduced daily steps in healthy nonexercising men
    Rasmus H Olsen
    JAMA 299:1261-3. 2008
  56. ncbi In response to Point:Counterpoint: "Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy"
    Frank W Booth
    J Appl Physiol 103:1105. 2007
  57. ncbi Leukemia inhibitory factor restores the hypertrophic response to increased loading in the LIF(-/-) mouse
    Espen E Spangenburg
    Section of Neurobiology, Physiology, and Behavior, University of California, Davis, 95616, USA
    Cytokine 34:125-30. 2006
    ..These data demonstrate for the first time that LIF expression in loaded skeletal muscle is critical for the development of skeletal muscle hypertrophy in the functional overload model...
  58. ncbi Transient induction of cyclin A in loaded chicken skeletal muscle
    Martin Fluck
    Dept of Anatomy, Univ of Bern, Buhlstrasse 26, 3000 Bern 9, Switzerland
    J Appl Physiol 95:1664-71. 2003
    ....

Research Grants17

  1. EXERCISE-INDUCED GROWTH OF SKELETAL MUSCLE
    Frank Booth; Fiscal Year: 1999
    ....
  2. SATELLITE STEM CELL BIOLOGY
    Frank Booth; Fiscal Year: 2007
    ..The outcomes of the research will provide a more scientific basis to devise therapies to prevent and treat sarcopenia and physical frailty. ..
  3. SATELLITE STEM CELL BIOLOGY
    Frank Booth; Fiscal Year: 2005
    ....
  4. Failed rescue of old skeletal muscle from atrophy
    Frank Booth; Fiscal Year: 2004
    ..Identifying the inappropriately expressed mRNAs associated with failed muscle regrowth of old muscles will permit a more scientifically-based growth factor rescue of old atrophied muscle. ..
  5. EXERCISE INDUCED GROWTH OF SKELETAL MUSCLE
    Frank Booth; Fiscal Year: 2003
    ..Elucidation of the mechanisms signaling skeletal muscle growth may lead to drugs, gene therapy, or other countermeasures against skeletal muscle wasting in individuals for whom exercise is perhaps impossible. ..
  6. Proteomics: Inactivity-induced muscle insulin resistance
    Frank Booth; Fiscal Year: 2002
    ..Outcomes of this proposal will better establish that healthy active skeletal muscles interact with other organ systems to prevent the metabolic disorders of type 2 diabetes, atherosclerosis, and obesity. ..