Research Topics
Genomes and Genes
| Yuri A BlednovSummaryAffiliation: University of Texas Country: USA Publications
Research Grants
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Detail Information
Publications
Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanolYuri A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas A 4800, 1 University Station, 2500 Speedway MBB 1 124, Austin, TX 78712 1095, USA
Behav Brain Res 165:110-25. 2005..9 and 72.0 cM, respectively) null mutant mice. These data show that disruption of the chemokine network interferes with motivational effects of alcohol...- Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant miceY A Blednov
Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Texas 78712 1095, USA
J Pharmacol Exp Ther 298:521-30. 2001..These results provide evidence that GIRK2 channels mediate specific behaviors, including anxiety and convulsions, and may influence effects of ethanol on these behaviors... - Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanolY A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station A4800, Austin, TX 78712 0159, USA
Neuropharmacology 56:814-20. 2009..The studies provide the first evidence that TRPV1 is important for specific behavioral actions of ethanol... - Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actionsYuri A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX, USA
Int J Neuropsychopharmacol 11:775-93. 2008..These data show the importance of mGluR5 for several actions of alcohol and support the hypothesis that some effects of acamprosate require mGluR5 signalling... - Perception of sweet taste is important for voluntary alcohol consumption in miceY A Blednov
Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
Genes Brain Behav 7:1-13. 2008..Thus, deletion of any one of three different genes involved in detection of sweet taste leads to a substantial reduction of alcohol intake without any changes in pharmacological actions of ethanol... - Blockade of the leptin-sensitive pathway markedly reduces alcohol consumption in miceYuri A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station A4800, Austin, TX 78712 0159, USA
Alcohol Clin Exp Res 28:1683-92. 2004..We addressed the role of leptin in alcohol-related behaviors by studying ethanol consumption in two strains of spontaneously mutant mice that lack leptin (ob/ob) or the leptin receptor (db/db)... - Mice lacking metabotropic glutamate receptor 4 do not show the motor stimulatory effect of ethanolYuri A Blednov
University of Texas, Waggoner Center for Alcohol and Addiction Research, I University Station A4800, Austin, TX 78712 0159, USA
Alcohol 34:251-9. 2004..Consistent with findings of other studies, these results confirm the lack of correlation between ethanol-induced motor stimulation and consumption of ethanol measured in a self-administration paradigm in mice... - Reduced alcohol consumption in mice lacking preprodynorphinYuri A Blednov
University of Texas, Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
Alcohol 40:73-86. 2006..These results indicate that deletion of preprodynorphin leads to substantial reduction of alcohol intake in female mice, and suggest that this is caused by decreased orosensory reward of alcohol (sweet taste and/or palatability)... - Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J miceYuri A Blednov
Waggoner Center for Alcohol and Addictions Research, University of Texas, Austin, TX 78712 0159, USA
Alcohol Clin Exp Res 29:1949-58. 2005..No strain has been found to consume more ethanol than B6. In one of our laboratories (Texas), we noted a markedly greater intake of ethanol in an F1 hybrid of B6 and FVB/NJ (FVB) mice... - Hybrid mice as genetic models of high alcohol consumptionY A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, 2500 Speedway MBB 1 124, Austin, TX 78712, USA
Behav Genet 40:93-110. 2010..These new genetic models offer some advantages over inbred strains because they provide high, sustained, alcohol intake, and should allow mapping of loci important for the genetic architecture of these traits... - Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadolYuri A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station, Austin, TX 78712 0159, USA
Addict Biol 15:45-61. 2010..These results are consistent with earlier proposals that deletion of Gad2 (on 129N2 background) reduces synaptic GABA but also suggest changes in extrasynaptic receptor function... - GIRK2 deficient mice. Evidence for hyperactivity and reduced anxietyY A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, A4800, 2500 Speedway, MBB 1 124, Austin, TX 78712 1095, USA
Physiol Behav 74:109-17. 2001..Taken together, this data demonstrates that GIRK2 null mutant mice have reduced anxiety with signs of hyperactivity. We suggest that the functional block of dopamine D3 receptors may be a reason for this phenotype... - Hyperactivity and dopamine D1 receptor activation in mice lacking girk2 channelsY A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas A4800, 2500 Speedway, MBB 1 124, Austin, TX 78712 1095, USA
Psychopharmacology (Berl) 159:370-8. 2002..Co-localization of GIRK2 channels and dopamine receptors in the mesolimbic system suggests a role in regulation of motor activity... - Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugsYuri A Blednov
Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712 0159, USA
J Pharmacol Exp Ther 304:30-6. 2003..Overall, these data confirm the crucial role of the GABAA receptor in mechanisms mediating sedative/hypnotic effects... - Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studiesYuri A Blednov
Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology and Department Pharmacology Toxicology, University of Texas, Austin, USA
Addict Biol 17:108-20. 2012..Specifically, they suggest a novel role for neuroimmune signaling in regulation of alcohol consumption... - GABAA receptor alpha 1 and beta 2 subunit null mutant mice: behavioral responses to ethanolY A Blednov
Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas, Austin, TX 78712 1095, USA
J Pharmacol Exp Ther 305:854-63. 2003..The unique effects of deletion of these two GABAA receptor subunits on ethanol responses are discussed in terms of the distinct changes in different populations of GABAA receptors... - Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in miceY A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, 2500 Speedway MBB 1 124, Austin, TX 78712 0159, USA
Brain Behav Immun 25:S92-S105. 2011..These results suggest that activation of immune signaling promotes alcohol consumption and alters certain aspects of alcohol reward/aversion... - Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive ?2-containing GABA(A) receptorsY A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station, Austin, TX 78712, USA
J Pharmacol Exp Ther 336:145-54. 2011.... - Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolaseYuri A Blednov
Department of Neurobiology, Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX 78712 0159, USA
Neuropsychopharmacology 32:1570-82. 2007..These data suggest that increased endocannabinoid signaling increased ethanol consumption owing to decreased acute ethanol intoxication... - Characterization of two mutations, M287L and Q266I, in the ?1 glycine receptor subunit that modify sensitivity to alcoholsCecilia M Borghese
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712 0159, USA
J Pharmacol Exp Ther 340:304-16. 2012..The behavioral characterization of these knockin mice is presented in a companion article (J Pharmacol Exp Ther 340:317-329, 2012)... - Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor ?1 subunitYuri A Blednov
Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX 78712 0159, USA
J Pharmacol Exp Ther 340:317-29. 2012..Thus, in addition to reducing ethanol action on the GlyRs, these mutations reduced glycinergic inhibition, which may also alter sensitivity to GABAergic drugs... - Over-expression of the fyn-kinase gene reduces hypnotic sensitivity to ethanol in miceStephen L Boehm
Waggoner Center for Alcohol and Addiction Research, University of Texas, 2500 Speedway, MBB 1 124, Austin, TX 78712, USA
Neurosci Lett 372:6-11. 2004.... - gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actionsStephen L Boehm
Waggoner Center for Alcohol and Addiction Research, University of Texas, 1 University Station A4800, Austin, TX 78712 0159, USA
Biochem Pharmacol 68:1581-602. 2004..However, three-way validation is hampered by the incomplete behavioral characterization of many of the mutant mice, and additional subunits are likely to be linked to alcohol actions as behavioral testing progresses... - Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutantGeoffrey S Findlay
Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712, USA
J Neurosci 23:8051-9. 2003.... - Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on beta2/beta3 GABAA receptor subunitsStephen L Boehm
University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin TX, 78712 0159, USA
J Pharmacol Exp Ther 309:1154-9. 2004..These data suggest that fyn-kinase may alter the function of GABA(A) receptors, perhaps via actions on beta2 and/or beta3 receptor subunits... - Toward understanding the genetics of alcohol drinking through transcriptome meta-analysisMegan K Mulligan
Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 103:6368-73. 2006..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation... - Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intakeA R Ozburn
Waggoner Center for Alcoholism and Addiction Research, Institute for Neuroscience, University of Texas at Austin, 1 University Station, Austin, TX 78712 0159, USA
Behav Genet 40:551-63. 2010..Results obtained offer insights about factors that determine SAP and RAP in these new genetic models of alcohol consumption... - Wheel running, voluntary ethanol consumption, and hedonic substitutionAngela Renee Ozburn
Waggoner Center for Alcohol and Addiction Research, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
Alcohol 42:417-24. 2008..Collectively, the results support theories of hedonic substitution and suggest that female C57BL/6J mice express ethanol seeking and craving under these specific conditions... - Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptorsIgor Ponomarev
Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
J Neurosci 26:5673-83. 2006.... - A pervasive mechanism for analgesia: activation of GIRK2 channelsY A Blednov
Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas, Austin 78712, USA
Proc Natl Acad Sci U S A 100:277-82. 2003..Furthermore, this pathway accounts for essentially all of the antinociceptive effects in males, although females appear to recruit additional signal transduction mechanisms for some analgesic drugs... - Deletion of the fyn-kinase gene alters behavioral sensitivity to ethanolStephen L Boehm
Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Texas 78712 0159, USA
Alcohol Clin Exp Res 27:1033-40. 2003..However, in vivo acute tolerance to ethanol was not examined directly... - An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin miceC M Borghese
Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, University of Texas at Austin, Austin, TX 78712 0159, USA
J Pharmacol Exp Ther 319:208-18. 2006..This knockin mouse line should be useful in determining which behavioral actions of volatile anesthetics and ethanol are mediated by the GABA(A)Rs containing the alpha(1) subunit... - Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of miceG S Findlay
Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, University of Texas at Austin, 78712, USA
J Pharmacol Exp Ther 300:526-34. 2002..These results support the idea that glycine receptors contribute to some behavioral actions of ethanol and that ethanol sensitivity can be changed in vivo by transgenic expression of a single receptor subunit... - Alcohol trait and transcriptional genomic analysis of C57BL/6 substrainsM K Mulligan
Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX, USA
Genes Brain Behav 7:677-89. 2008..H2afz, Psen1, Wdfy1 and Clu were also identified as candidate genes that may be involved in influencing alcohol consumption... - Convergent analysis of cDNA and short oligomer microarrays, mouse null mutants and bioinformatics resources to study complex traitsI Ponomarev
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, USA
Genes Brain Behav 3:360-8. 2004..Our results point to the increasing potential of the convergent approach and biological databases to investigate genetic mechanisms of complex traits... - Male transgenic glycine receptor alpha1 (S267Q) mutant mice display a hyperekplexia-like increase in acoustic startle responsesG S Findlay
Waggoner Center for Alcohol and Addiction Research (A4800, Section of Neurobiology, University of Texas at Austin, Austin, TX 78712, USA
Pharmacol Biochem Behav 82:215-22. 2005.... - Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanolDavid F Werner
Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Pharmacol Exp Ther 319:219-27. 2006..Overall, these studies demonstrate that the postsynaptic effects of ethanol at GABAergic synapses containing the alpha1 subunit are important for specific ethanol-induced behavioral effects... - Reduced ethanol-induced conditioned taste aversion and conditioned place preference in GIRK2 null mutant miceKatherine G Hill
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97201 3098, USA
Psychopharmacology (Berl) 169:108-14. 2003..Under some conditions, GIRK2 knockout mice consume more ethanol than wild types, but it is unclear whether they do so because they are more sensitive to ethanol's rewarding effects or less sensitive to its aversive effects... - delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-olStephen L Boehm
Department of Psychology, State University of New York at Binghamton, 13902, USA
Eur J Pharmacol 541:158-62. 2006....
Research Grants
- Biochemical and Genetic Determinants of Differences in Alcohol ConsumptionYURI BLEDNOV; Fiscal Year: 2007..Alcantara - Austin, Texas; S. Bergeson - Austin, Texas; R. D. Mayfield - Austin, Texas; R. Davis - Houston, Texas; A. Ryabinin - Portland, Oregon; B. Tabakoff - Aurora, Colorado). ..