J Blalock

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi The immune system as the sixth sense
    J E Blalock
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA
    J Intern Med 257:126-38. 2005
  2. ncbi N-alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD
    Philip O'Reilly
    Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, THT 422, 1900 University Blvd, Birmingham, Alabama 35294 0006, USA
    Respir Res 10:38. 2009
  3. ncbi Highly related immunoglobulin light chain sequences in different multiple sclerosis patients
    J E Blalock
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294 0005, USA
    J Neuroimmunol 100:98-101. 1999
  4. ncbi Proopiomelanocortin and the immune-neuroendocrine connection
    J E Blalock
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294, USA
    Ann N Y Acad Sci 885:161-72. 1999
  5. ncbi A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation
    Nathaniel M Weathington
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, Alabama 35294, USA
    Nat Med 12:317-23. 2006
  6. ncbi A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    Robert J Snelgrove
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham Lung Health Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 330:90-4. 2010
  7. ncbi The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation
    Matthew T Hardison
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294, USA
    J Immunol 182:4423-31. 2009
  8. ncbi Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries
    Andrew P Miller
    Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 1047 Zeigler Research Bldg, 703 19th St S, Birmingham, AL 35294 0007, USA
    Circulation 110:1664-9. 2004
  9. ncbi Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen
    Philip J O'Reilly
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 5294 0005, USA
    J Neuroimmunol 217:51-4. 2009
  10. ncbi Matrix metalloproteinase activity in pediatric acute lung injury
    Michele Y F Kong
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Int J Med Sci 6:9-17. 2009

Research Grants

  1. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Blalock; Fiscal Year: 2007
  2. A New Pathway for Neutrophil-induced Airway Inflammation
    J Blalock; Fiscal Year: 2009
  3. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2010
  4. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Blalock; Fiscal Year: 2009
  5. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Edwin Blalock; Fiscal Year: 2010
  6. A New Pathway for Neutrophil-induced Airway Inflammation
    J Blalock; Fiscal Year: 2007
  7. IMMUNOTHERAPY OF MYASTHENIA GRAVIS
    J Blalock; Fiscal Year: 2001
  8. Epithelial Ca2+ Channels:Therapeutic Targets in Asthma
    J Blalock; Fiscal Year: 2005
  9. Therapeutics for Chronic Lung Diseases: Antagonists of PGP, Chemokines and CXCR
    J Edwin Blalock; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. ncbi The immune system as the sixth sense
    J E Blalock
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA
    J Intern Med 257:126-38. 2005
    ..Lastly, this review will suggest ways to apply the newfound knowledge of the sixth sense to understand a placebo effect and to treat human disease...
  2. ncbi N-alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD
    Philip O'Reilly
    Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, THT 422, 1900 University Blvd, Birmingham, Alabama 35294 0006, USA
    Respir Res 10:38. 2009
    ..In this study, we investigate if N-alpha-PGP and PGP are biomarkers and potential therapeutic targets for COPD...
  3. ncbi Highly related immunoglobulin light chain sequences in different multiple sclerosis patients
    J E Blalock
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294 0005, USA
    J Neuroimmunol 100:98-101. 1999
    ..The results establish, in principle, that the same or very similar kappa light chain variable regions can be shared between CSF B lymphocytes from different individuals with MS as well as with certain antibodies against MBP...
  4. ncbi Proopiomelanocortin and the immune-neuroendocrine connection
    J E Blalock
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294, USA
    Ann N Y Acad Sci 885:161-72. 1999
    ....
  5. ncbi A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation
    Nathaniel M Weathington
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, Alabama 35294, USA
    Nat Med 12:317-23. 2006
    ..Thus, PGP's activity links degradation of ECM with neutrophil recruitment in airway inflammation, and PGP may be a biomarker and therapeutic target for neutrophilic inflammatory diseases...
  6. ncbi A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    Robert J Snelgrove
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham Lung Health Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 330:90-4. 2010
    ..These studies imply that therapeutic strategies inhibiting LTA(4)H to prevent LTB(4) generation may not reduce neutrophil recruitment because of elevated levels of PGP...
  7. ncbi The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation
    Matthew T Hardison
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 35294, USA
    J Immunol 182:4423-31. 2009
    ....
  8. ncbi Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries
    Andrew P Miller
    Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 1047 Zeigler Research Bldg, 703 19th St S, Birmingham, AL 35294 0007, USA
    Circulation 110:1664-9. 2004
    ....
  9. ncbi Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen
    Philip J O'Reilly
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 5294 0005, USA
    J Neuroimmunol 217:51-4. 2009
    ..This novel, pro-inflammatory role for PE raises the possibility of a self-sustaining pathway of neutrophilic inflammation and may provide biomarkers and therapeutic targets for diseases caused by chronic, neutrophilic inflammation...
  10. ncbi Matrix metalloproteinase activity in pediatric acute lung injury
    Michele Y F Kong
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Int J Med Sci 6:9-17. 2009
    ..These results identify a specific repertoire of MMP isoforms in the lung secretions of pediatric ALI patients, and demonstrate inverse changes in MMPs -8 and -9 with protracted disease...
  11. ncbi Potential role of high-mobility group box 1 in cystic fibrosis airway disease
    Steven M Rowe
    Department University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Am J Respir Crit Care Med 178:822-31. 2008
    ..High-mobility group box 1 (HMGB1) is a potent inflammatory mediator elevated in sepsis and rheumatoid arthritis, although its role in cystic fibrosis (CF) lung disease is unknown...
  12. ncbi A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation
    Amit Gaggar
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 180:5662-9. 2008
    ..These experiments highlight unique protease interactions with structural proteins regulating innate immunity and support a role for these peptides as novel biomarkers and therapeutic targets for chronic, neutrophilic lung diseases...
  13. ncbi Interfering with extracellular matrix degradation to blunt inflammation
    Philip J O'Reilly
    Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, THT 442, 1530 3rd Avenue South, Birmingham, AL 35294 0006, United States
    Curr Opin Pharmacol 8:242-8. 2008
    ..Elucidation of these pathways may provide novel biomarkers and therapeutic targets for chronic lung diseases...
  14. ncbi Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation
    Dongqi Xing
    Department of Medicine, University of Alabama at Birmingham, UAB Station, Birmingham, AL 35294, USA
    Am J Physiol Heart Circ Physiol 292:H2607-12. 2007
    ..E2 inhibits activated RASMC proinflammatory mediator expression and neutrophil chemotactic activity through an ER beta-dependent mechanism...
  15. ncbi Rational design of peptide vaccines for autoimmune disease: harnessing molecular recognition to fix a broken network
    Nathaniel M Weathington
    Department of Physiology and Biophysics, University of Alabama in Birmingham, 35294, USA
    Expert Rev Vaccines 2:61-73. 2003
    ..This article will describe the algorithm for vaccine design, summarize the in vitro and in vivo evidence for its efficacy and discuss possible therapeutic utility in human autoimmune diseases...
  16. ncbi Harnessing a neural-immune circuit to control inflammation and shock
    J Edwin Blalock
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 195:F25-8. 2002
  17. ncbi Possible therapeutic vaccines for canine myasthenia gravis: implications for the human disease and associated fatigue
    F Shawn Galin
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 1918 University Blvd, MCLM 896, Birmingham, AL 35294 0005, USA
    Brain Behav Immun 21:323-31. 2007
    ....
  18. ncbi Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis
    Meenakshi Malik
    Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    J Immunol 178:1013-20. 2007
    ....
  19. ncbi Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro
    Michelle Lin
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106 7286, USA
    Am J Pathol 173:144-53. 2008
    ....
  20. ncbi Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma
    Robert Ten Broeke
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands
    Eur J Pharmacol 476:151-7. 2003
    ..Specific modulation of calmodulin activity might therefore be a potential new target for the treatment of allergic asthma...
  21. ncbi Induction of lung emphysema is prevented by L-arginine-threonine-arginine
    Anneke H van Houwelingen
    Division of Pharmacology and Pathophysiology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P O Box 800 82, 3508 TB Utrecht, The Netherlands
    FASEB J 22:3403-8. 2008
    ..In conclusion, these data indicate that collagen breakdown products, especially PGP, are important in the pathogenesis of COPD and that PGP antagonism via RTR ameliorates lung emphysema...
  22. ncbi Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages
    Robert Ten Broeke
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Lab Invest 84:29-40. 2004
    ..These results may contribute to new therapeutic strategies against oxidative stress in airway diseases...
  23. ncbi Conceptual development of the immune system as a sixth sense
    J Edwin Blalock
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA
    Brain Behav Immun 21:23-33. 2007
    ..Finally, the review will suggest ways to apply the new found knowledge of the sixth sense to understanding a placebo effect and developing new therapeutic approaches for treatment of human diseases...

Research Grants23

  1. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Blalock; Fiscal Year: 2007
    ..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. (End of Abstract) ..
  2. A New Pathway for Neutrophil-induced Airway Inflammation
    J Blalock; Fiscal Year: 2009
    ..5. Test RTR as an antagonist of the PGP and CXC chemokine pathways in the LPS-mediated pulmonary disease model. ..
  3. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2010
    ..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. ..
  4. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Blalock; Fiscal Year: 2009
    ..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. (End of Abstract) ..
  5. Effect of Macrolide Treatment on a Novel Pathway of Neutrophilic Inflammation in
    J Edwin Blalock; Fiscal Year: 2010
    ..If successful, the current proposal will yield fundamental insights into the disease process and a new and specific biomarker for COPD as well as suggesting new therapeutic targets. (End of Abstract) ..
  6. A New Pathway for Neutrophil-induced Airway Inflammation
    J Blalock; Fiscal Year: 2007
    ..5. Test RTR as an antagonist of the PGP and CXC chemokine pathways in the LPS-mediated pulmonary disease model. ..
  7. IMMUNOTHERAPY OF MYASTHENIA GRAVIS
    J Blalock; Fiscal Year: 2001
    ..Is there restricted usage of TCR by AChR 100-116 specific T-cells recognized by CTCR8? 6. Can EAMG-associated T-cells of other specificities be identified with complementary peptides to different AChR T-cell epitopes? ..
  8. Epithelial Ca2+ Channels:Therapeutic Targets in Asthma
    J Blalock; Fiscal Year: 2005
    ..Can the level of NO production be modulated by agents that open or close AEC SOC? 5. Which form of NOS is involved in regulation of airway responsiveness by agents that modify AEC SOC? ..
  9. Therapeutics for Chronic Lung Diseases: Antagonists of PGP, Chemokines and CXCR
    J Edwin Blalock; Fiscal Year: 2010
    ..In addition, we will evaluate PGP as a novel biomarker for COPD as well as a prognosticator of potential utility of (D-P)G(D-P) as a therapeutic agent. ..