Eric C Bielefeld

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi Damage and threshold shift resulting from cochlear exposure to paraquat-generated superoxide
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 207:35-42. 2005
  2. ncbi The role of oxidative stress in noise-induced hearing loss
    Donald Henderson
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Ear Hear 27:1-19. 2006
  3. ncbi NAC for noise: from the bench top to the clinic
    Richard D Kopke
    Hough Ear Institute, 3400 N W 56th Street, Oklahoma City, OK 73112, USA
    Hear Res 226:114-25. 2007
  4. ncbi Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Negat Results Biomed 7:4. 2008
  5. ncbi Age-related hearing loss: is it a preventable condition?
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 264:98-107. 2010
  6. ncbi Age-related hearing loss in the Fischer 344/NHsd rat substrain
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, United States
    Hear Res 241:26-33. 2008
  7. ncbi A comparison of the protective effects of systemic administration of a pro-glutathione drug and a Src-PTK inhibitor against noise-induced hearing loss
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Noise Health 7:24-30. 2005
  8. ncbi Influence of sympathetic fibers on noise-induced hearing loss in the chinchilla
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, United States
    Hear Res 223:11-9. 2007
  9. ncbi The effects of acoustic environment after traumatic noise exposure on hearing and outer hair cells
    Chiemi Tanaka
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 250:10-8. 2009
  10. ncbi Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, NY, USA
    Hear Res 265:63-9. 2010

Detail Information

Publications15

  1. ncbi Damage and threshold shift resulting from cochlear exposure to paraquat-generated superoxide
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 207:35-42. 2005
    ..Outer and inner hair cell losses were consistent with PTS. The similarities between PQ ototoxicity and noise-induced hearing loss suggest the possibility of similar biochemical pathways involving superoxide...
  2. ncbi The role of oxidative stress in noise-induced hearing loss
    Donald Henderson
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Ear Hear 27:1-19. 2006
    ....
  3. ncbi NAC for noise: from the bench top to the clinic
    Richard D Kopke
    Hough Ear Institute, 3400 N W 56th Street, Oklahoma City, OK 73112, USA
    Hear Res 226:114-25. 2007
    ..Early clinical trials with NAC are mentioned...
  4. ncbi Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Negat Results Biomed 7:4. 2008
    ..Acetyl L-carnitine (ALCAR) is known to enhance mitochondrial bioenergetics and membrane efficiency. Therefore, ALCAR was targeted as a possible pharmacologic intervention to prevent, or even restore, hearing loss from aging...
  5. ncbi Age-related hearing loss: is it a preventable condition?
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 264:98-107. 2010
    ..Using the animal models, different techniques for prevention of ARHL have been developed and tested. The current review discusses ARHL patterns in humans and animal models, followed by discussions of the different prevention techniques...
  6. ncbi Age-related hearing loss in the Fischer 344/NHsd rat substrain
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, United States
    Hear Res 241:26-33. 2008
    ..Collectively, these findings suggest damage to the outer hair cells, but anatomical examination of the outer hair cells revealed a relative lack of cell loss compared to the magnitude of the hearing and DPOAE loss...
  7. ncbi A comparison of the protective effects of systemic administration of a pro-glutathione drug and a Src-PTK inhibitor against noise-induced hearing loss
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Noise Health 7:24-30. 2005
    ..There were no significant side effects (i.e.: appetite loss, weight loss, lethargy, etc.) related to either of the drug treatments. KX1-004 produced at least as much protection as L-NAC, but at a significantly lower concentration...
  8. ncbi Influence of sympathetic fibers on noise-induced hearing loss in the chinchilla
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, United States
    Hear Res 223:11-9. 2007
    ..Effects of SCGectomy on OHC loss were small. Results of the study suggest that sympathetic fibers do exert some influence on susceptibility to noise, but the influence may not be a major one...
  9. ncbi The effects of acoustic environment after traumatic noise exposure on hearing and outer hair cells
    Chiemi Tanaka
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 250:10-8. 2009
    ..The results suggest that post-noise acoustic environment influenced the degree of hearing loss and OHC deterioration after traumatic noise exposure...
  10. ncbi Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, NY, USA
    Hear Res 265:63-9. 2010
    ..The mechanisms underlying these unexpected, permanent salicylate-induced reductions in neural activity are discussed...
  11. ncbi Ameliorative effects of an augmented acoustic environment on age-related hearing loss in middle-aged Fischer 344/NHsd rats
    Chiemi Tanaka
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Laryngoscope 119:1374-9. 2009
    ..To investigate the effects of an augmented acoustic environment (AAE) on age-related hearing loss (ARHL) and outer hair cell (OHC) pathology in middle-aged Fischer 344/NHsd (F344/NHsd) rats...
  12. ncbi Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: function and morphology
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, NY 14214, USA
    Hear Res 248:39-47. 2009
    ..Hu, B.H., Henderson, D., 2008. Age-related hearing loss in the Fischer 344/NHsd rat substrain. Hear. Res. 241, 26-33], the results suggest that disruption of prestin is the major cause of DPOAE loss and loss of cochlear sensitivity...
  13. ncbi Protective effect of N-acetyl-L-cysteine (L-NAC) against styrene-induced cochlear injuries
    Wei Ping Yang
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, New York 14214, USA
    Acta Otolaryngol 129:1036-43. 2009
    ..Styrene exposure causes hair cell death through both apoptotic and necrotic pathways and treatment with N-acetyl-L-cysteine (L-NAC) reduces styrene ototoxicity...
  14. ncbi Apoptotic outer hair cell death in the cochleae of aging Fischer 344/NHsd rats
    Bo Hua Hu
    Center for Hearing and Deafness, State University of New York at Buffalo, Department of Communicative Disorders and Sciences, Buffalo, NY 14214, USA
    Hear Res 245:48-57. 2008
    ....
  15. ncbi Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    Acta Otolaryngol 127:914-9. 2007
    ..The studies further reveal the potential for the use of NAC in a clinical population exposed to noise...