Research Topics
Genomes and Genes | Jonathan A BernsteinSummaryAffiliation: University of Cincinnati Country: USA Publications
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Publications
The addition of zafirlukast to cetirizine improves the treatment of chronic urticaria in patients with positive autologous serum skin test resultsScott E Bagenstose
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0563, USA
J Allergy Clin Immunol 113:134-40. 2004..These results also suggest that routine screening of patients with chronic urticaria with the ASST might be useful in formulating therapeutic algorithms in the management of chronic urticaria...
Perfluorosulfonic acid membrane catalysts for optical sensing of anhydrides in the gas phaseSubasri M Ayyadurai
Department of Chemical and Materials Engineering, University of Cincinnati, Cincinnati, Ohio 45221, USA
Anal Chem 82:6265-72. 2010....
Update on angioedema: evaluation, diagnosis, and treatmentJonathan A Bernstein
Division of Immunology Allergy Section, Department of Internal Medicine, University of Cincinnati, Ohio, USA
Allergy Asthma Proc 32:408-12. 2011..The objective of this article is to provide an overview of the differential diagnosis of angioedema that reflects the angioedema guidelines that are currently in development...
Is burning semen syndrome a variant form of seminal plasma hypersensitivity?Jonathan A Bernstein
University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0563, USA
Obstet Gynecol 101:93-102. 2003..To identify an index population of Gulf War couples with burning semen syndrome and to determine whether burning semen syndrome was secondary to seminal plasma hypersensitivity...
Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerabilityJonathan A Bernstein
Bernstein Clinical Research Center, Cincinnati, OH, USA
Curr Med Res Opin 23:2441-52. 2007..Azelastine hydrochloride (Astelin) nasal spray 0.1% solution is a second-generation intranasal antihistamine available in the US for treatment of both seasonal allergic rhinitis (SAR) and nonallergic vasomotor rhinitis (VMR)...
Ecallantide: its pharmacology, pharmacokinetics, clinical efficacy and tolerabilityJonathan A Bernstein
University of Cincinnati, Department of Internal Medicine, Division of Immunology Allergy Section, 231 Albert Sabin Way ML 563, Cincinnati, OH 45267 0563, USA
Expert Rev Clin Immunol 6:29-39. 2010..Phase IV postmarketing surveillance studies to monitor the incidence of these reactions will be implemented by the company now that the drug has been US FDA approved...
Double-blind, placebo-controlled trial of reformulated azelastine nasal spray in patients with seasonal allergic rhinitisJonathan A Bernstein
Bernstein Clinical Research Center, Cincinnati, Ohio 45267 0563, USA
Am J Rhinol Allergy 23:512-7. 2009....
Health effects of air pollutionJonathan A Bernstein
Department of Internal Medicine, Division of Immunology Allergy, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0563, USA
J Allergy Clin Immunol 114:1116-23. 2004....
Interfacing computers and the internet with your allergy practiceJonathan A Bernstein
University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 563, Cincinnati, Ohio 45267 0563, USA
Clin Rev Allergy Immunol 27:115-21. 2004..This article will review how computers and the internet have begun to interface with the allergy subspecialty practice in these various areas...
Evaluation of cleaning activities on respiratory symptoms in asthmatic female homemakersJonathan A Bernstein
Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Ann Allergy Asthma Immunol 102:41-6. 2009..Women are usually the primary persons responsible for cleaning their homes, but little information is available regarding the health impact of cleaning in the nonoccupational setting...
A pilot study to investigate the effects of combined dehumidification and HEPA filtration on dew point and airborne mold spore counts in day care centersJ A Bernstein
Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0563, USA
Indoor Air 15:402-7. 2005..Clinicians should emphasize to their patients the importance of dehumidification and HEPA filtration to improve indoor air quality in the home and workplace...
Chronic urticaria: an evolving storyJonathan A Bernstein
Department of Internal Medicine, Division of Immunology/Allergy Section, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Isr Med Assoc J 7:774-7. 2005
Health effects of ultraviolet irradiation in asthmatic children's homesJonathan A Bernstein
Department of Internal Medicine, Division of Immunology, Allergy Section, Cincinnati, Ohio, USA
J Asthma 43:255-62. 2006..Centrally installed ultraviolet (UV) irradiation units were investigated to determine the potential health benefits in mold-sensitized asthmatic children...
Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitisJonathan A Bernstein
University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0053, USA
J Asthma 45:287-92. 2008..5 to 5 kb per tag SNP--or studies incorporating microarray analyses of the entire "OR genome" in well-characterized nVMR patients are required...
Hereditary angioedema: a current state-of-the-art review, VIII: current status of emerging therapiesJonathan A Bernstein
University of Cincinnati, Ohio, USA
Ann Allergy Asthma Immunol 100:S41-6. 2008..To provide an overview on the current status of emerging therapies for hereditary angioedema (HAE) in the United States...
The health effects of non-industrial indoor air pollutionJonathan A Bernstein
Department of Internal Medicine, Allergy Section, Division of Immunology, University of Cincinnati, Cincinnati, OH 45267 0563, USA
J Allergy Clin Immunol 121:585-91. 2008....
Allergic and mixed rhinitis: Epidemiology and natural historyJonathan A Bernstein
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267 0563, USA
Allergy Asthma Proc 31:365-9. 2010....
Alteration of brain activation patterns in nonallergic rhinitis patients using functional magnetic resonance imaging before and after treatment with intranasal azelastineJonathan A Bernstein
Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati College of Medicine, Ohio, USA
Ann Allergy Asthma Immunol 106:527-32. 2011....
Cyanobacteria: an unrecognized ubiquitous sensitizing allergen?Jonathan A Bernstein
Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati College of Medicine, Ohio 45267 0563, USA
Allergy Asthma Proc 32:106-10. 2011..001). This is the first study to show that cyanobacterial allergenicity resides in nontoxin-containing components of this organism...
Respiratory sensitization of a food manufacturing worker to konjac glucomannanJonathan A Bernstein
University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, Ohio 45267-0563, USA
J Asthma 44:675-80. 2007
A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitisJonathan A Bernstein
Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0563, USA
Ann Allergy Asthma Immunol 107:171-8. 2011....
Is trimellitic anhydride skin testing a sufficient screening tool for selectively identifying TMA-exposed workers with TMA-specific serum IgE antibodies?Jonathan A Bernstein
Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Occup Environ Med 53:1122-7. 2011..Trimellitic anhydride (TMA) can elicit specific IgE-mediated immune responses leading to asthma. This single-blinded study investigated the ability of TMA skin testing to identify workers with TMA-serum specific IgE antibodies...
Human seminal plasma hypersensitivity: an under-recognized women's health issueJonathan A Bernstein
Department of Internal Medicine, University of Cincinnati College of Medicine, Division of Immunology Allergy Section, Cincinnati, OH 45267 0563, USA
Postgrad Med 123:120-5. 2011..In most cases, treatment using ? 1 of the above approaches has been very successful...
Old and new causes of occupational asthmaSantiago Quirce
Department Allergy, Hospital La Paz Health Research Institute IdiPAZ, Madrid, Spain
Immunol Allergy Clin North Am 31:677-98, v. 2011..The purpose of this article is to review the most common representative LMW and HMW causes of occupational asthma over the past 70 years, with specific emphasis on newer causes reported over the past 5 years...
MK-0633, a potent 5-lipoxygenase inhibitor, in chronic obstructive pulmonary diseaseJonathan A Bernstein
Bernstein Allergy Group, Bernstein Clinical Research Center, Inc 8444 Winton Rd, Cincinnati, OH 45231, USA
Respir Med 105:392-401. 2011..Clinicaltrials.gov identifier: NCT00418613...
Successful treatment of autoimmune chronic idiopathic urticaria with intravenous cyclophosphamideJonathan A Bernstein
University of Cincinnati College of Medicine, Department of Internal Medicine, Ohio, USA
Ann Allergy Asthma Immunol 89:212-4. 2002..These autoantibodies have been reported to be present in >45% of patients with CIU. Their functional role in the pathogenesis of CIU remains poorly understood...
Anxiety sensitivity, asthma control, and quality of life in adults with asthmaKimberly M Avallone
Department of Psychology, University of Cincinnati, Cincinnati, OH 45221 0376, USA
J Asthma 49:57-62. 2012..The aim of this study was to examine the role of anxiety sensitivity (AS) in terms of asthma control and asthma-related quality of life in a sample of adults with a physician-verified diagnosis of asthma...
Hereditary angioedema: Validation of the end point time to onset of relief by correlation with symptom intensityJonathan A Bernstein
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267 0563, USA
Allergy Asthma Proc 32:36-42. 2011..009 and p = 0.0036, respectively). The association with the intensity of single symptoms confirmed that the time to onset of symptom relief is an appropriate end point for assessing the efficacy of C1-INH therapy...
Characterization of a population of monozygotic twins with asthmaMaureen E Miller
Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0563, USA
J Asthma 42:325-30. 2005....
Characterization of a population presenting with suspected mold-related health effectsR Carter Bobbitt
Department of Internal Medicine, Division of Immunology/Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Ann Allergy Asthma Immunol 94:39-44. 2005..Medical history, skin testing, and current indoor mold sampling practices have significant limitations in establishing a causal link among mold exposure health effects...
Is exhaled nitric oxide a useful adjunctive test for assessing asthma?Jonathan A Bernstein
University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology Allergy Section, Ohio, USA
J Asthma 46:955-60. 2009....
Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitisDominique Brandt
Center for Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, Ohio, USA
Ann Allergy Asthma Immunol 96:526-32. 2006..CONCLUSIONS: Specific questionnaire responses may help primary care physicians accurately diagnose NAVMR. Questions asked of patients by physicians to diagnose allergic rhinitis do not correlate well with physician diagnosis...
A case of progesterone-induced anaphylaxis, cyclic urticaria/angioedema, and autoimmune dermatitisI Leonard Bernstein
Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0563, USA
J Womens Health (Larchmt) 20:643-8. 2011..We report a detailed immunological evaluation of such a woman responsive to a gonadotropin hormone-releasing agonist (GHRA)...
Allergy and immunotherapy: are they related to migraine headache?Vincent T Martin
Department of Internal Medicine, Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0535, USA
Headache 51:8-20. 2011..Several studies have reported that migraine headaches are more common in patients with allergic rhinitis and that immunotherapy decreases the frequency of headache in atopic headache sufferers...
A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthmaYui Hsi Wang
Division of Allergy and Immunology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Exp Med 207:2479-91. 2010..Our findings highlight the plasticity of T(H)2 memory cells and suggest that IL-17-producing T(H)2 cells may represent the key pathogenic T(H)2 cells promoting the exacerbation of allergic asthma...
The -159 C-->T polymorphism of CD14 is associated with nonatopic asthma and food allergyJessica G Woo
Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati Medical Center, Ohio, USA
J Allergy Clin Immunol 112:438-44. 2003..CD14, the receptor for LPS, plays an important role in innate immunity. A polymorphism in the promotor for CD14, -159 C-->T, has been implicated in atopy...
Clinical and occupational outcomes in health care workers with natural rubber latex allergyDavid I Bernstein
University of Cincinnati College of Medicine, Division of Immunology, Department of Internal Medicine, Cincinnati, Ohio 45267 0563, USA
Ann Allergy Asthma Immunol 90:209-13. 2003..There is limited information pertaining to clinical outcomes and economic consequences of natural rubber latex (NRL) allergy in health care workers (HCWs)...
Characterization of patients with suspected seminal plasma hypersensitivityJ Wesley Sublett
Division of Immunology Allergy Section, Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267 0563, USA
Allergy Asthma Proc 32:467-71. 2011..Additional research investigating the epidemiology, immunopathogenesis, and treatment of this disorder is warranted...
Clinical and laboratory investigation of allergy to genetically modified foodsJonathan A Bernstein
Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
Environ Health Perspect 111:1114-21. 2003..In 1999, researchers found that migrant health workers can become sensitized to certain Bt spore extracts after exposure to Bt spraying...
Pharmacoeconomic considerations for allergen immunotherapyJonathan A Bernstein
University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Clin Allergy Immunol 18:151-64. 2004
Air pollution and allergic diseaseHaejin Kim
Department of Internal Medicine, University of Cincinnati College of Medicine, OH 45267 0563, USA
Curr Allergy Asthma Rep 9:128-33. 2009..Health care providers and the general community should also support public policy designed to improve outdoor air quality by developing programs that provide incentives for industry to comply with controlling pollution emissions...
Successful C1 inhibitor short-term prophylaxis during redo mitral valve replacement in a patient with hereditary angioedemaJonathan A Bernstein
Department of Internal Medicine, Division of Immunology Allergy Section, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, Ohio, USA
J Cardiothorac Surg 5:86. 2010..We report a case of successful short-term prophylaxis with C1 esterase inhibitor in a 51-year-old man with hereditary angioedema who underwent redo mitral valve reconstructive surgery...
Immune responses in farm workers after exposure to Bacillus thuringiensis pesticidesI L Bernstein
Division of Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Environ Health Perspect 107:575-82. 1999..Specific IgG and IgE antibodies to vegetative organisms were present in all groups of workers. Exposure to Bt sprays may lead to allergic skin sensitization and induction of IgE and IgG antibodies, or both...
Suppressive effect of IL-4 on IL-13-induced genes in mouse lungFred D Finkelman
Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 174:4630-8. 2005..These results provide a potential explanation for the dominant role of IL-13 in induction of goblet cell hyperplasia and airway hyperresponsiveness in asthma...
V75R576 IL-4 receptor alpha is associated with allergic asthma and enhanced IL-4 receptor functionKimberly A Risma
Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 169:1604-10. 2002..These data illustrate the importance of studying snps in combination, because the functional significance of a given snp may only be evident in a specific setting of additional snps in the same or different genes...
Questionnaire diagnosis of nonallergic rhinitisDominique Brandt
Department of Internal Medicine, Division of Immunology/Allergy Section, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Clin Allergy Immunol 19:55-67. 2007
Material safety data sheets: are they reliable in identifying human hazards?Jonathan A Bernstein
University of Cincinnati College of Medicine, Cincinnati, OH 45267-0563, USA
J Allergy Clin Immunol 110:35-8. 2002..Health care professionals have an obligation to better educate themselves regarding the interpretation of MSDSs and to recognize that they sometimes provide incomplete data...
Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot studyDavid I Bernstein
Division of Immunology, University of Cincinnati College of Medicine, Ohio 45267, USA
Ann Allergy Asthma Immunol 88:272-8. 2002..No significant laboratory abnormalities were detected. CONCLUSIONS: This study did not show trends supporting the efficacy of GSE in the treatment of SAR...
The use of penicillin skin testing to assess the prevalence of penicillin allergy in an emergency department settingAli S Raja
Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH 45221 0769, USA
Ann Emerg Med 54:72-7. 2009..We hypothesize that ED-based testing is possible and that the false-positive rate of patients with self-reported penicillin allergy are greater than 90%...
Seminal plasma hypersensitivity reactions: an updated reviewJ Wesley Sublett
University of Cincinnati College of Medicine, Cincinnati, OH, USA
Mt Sinai J Med 78:803-9. 2011..Infertility has not been demonstrated to be directly related to seminal plasma hypersensitivity, although women with the condition frequently have difficulty conceiving due to their inability to have unprotected sexual intercourse...
A novel case of mealworm-induced occupational rhinitis in a school teacherJonathan A Bernstein
University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, 231 Bethesda Avenue, ML #563, Cincinnati, OH 45267-0563, USA
Allergy Asthma Proc 23:41-4. 2002....
Is response to allergen immunotherapy a good phenotypic marker for differentiating between allergic rhinitis and mixed rhinitis?Andrew M Smith
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267 0563, USA
Allergy Asthma Proc 32:49-54. 2011..However, these data support the classification of MR as a distinct rhinitis phenotype because MR patients required significantly more medications after a full course of AIT to control their nonallergic-induced symptoms...
Enhancing school-based asthma education efforts using computer-based education for childrenLaura A Nabors
College of Education, Criminal Justice and Human Services, University of Cincinnati, Cincinnati, OH, USA
J Asthma 49:209-12. 2012..Computer-based educational programs are a critical component of asthma education programs and may be a particularly important education method in busy school environments...
Population pharmacokinetics of plasma-derived C1 esterase inhibitor concentrate used to treat acute hereditary angioedema attacksJonathan A Bernstein
Division of Immunology Allergy, Department of Internal Medicine, University of Cincinnati Medical Center and Bernstein Clinical Research Center, Cincinnati, Ohio 45267 0563, USA
Ann Allergy Asthma Immunol 105:149-54. 2010..C1 esterase inhibitor (C1-INH) replacement is recommended as a first-line therapy for acute edema attacks in hereditary angioedema (HAE). Only limited pharmacokinetic analyses of the administered C1-INH in plasma are available...
Are high-dose toxic exposures always associated with reactive airways dysfunction syndrome (RADS)?M A Hickmann
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267-0563, USA
Arch Environ Health 56:439-42. 2001..These cases suggest that the occurrence of reactive airways dysfunction syndrome is unpredictable and may not always occur in heavily exposed individuals...
Allergenicity of the Madagascar hissing cockroachMarjorie S Morgan
Department of Biological Sciences, Wright State University, Dayton, Ohio 45435, USA
Ann Allergy Asthma Immunol 98:258-61. 2007..The Madagascar hissing cockroach (Gromphadorhina portentosa) has become popular as a pet and as an educational tool in classrooms, zoos, and museums...
The approach to conception for women with seminal plasma protein hypersensitivityDavid J Resnick
The New York Presbyterian Hospital, New York, NY, USA
Am J Reprod Immunol 52:42-4. 2004..For women with seminal plasma protein hypersensitivity (SPH) who desire to conceive, this approach is unacceptable. We describe a case report of a woman with an SPH who desired to have unprotected intercourse in order to conceive...
Allergists' attitudes toward environmental control: insights into its current application in clinical practiceDominique M Brandt
J Allergy Clin Immunol 121:1053-4. 2008
High-efficiency particle arrest vacuums and cat allergen exposureJonathan A Bernstein
J Allergy Clin Immunol 112:462-3; author reply 463. 2003
The diagnosis and management of rhinitis: an updated practice parameterDana V Wallace
J Allergy Clin Immunol 122:S1-84. 2008
Global analysis of Escherichia coli RNA degradosome function using DNA microarraysJonathan A Bernstein
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 101:2758-63. 2004....
Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarraysJonathan A Bernstein
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:9697-702. 2002..Our results identify previously unsuspected features of mRNA decay at a global level and also indicate that generalizations about decay derived from the study of individual gene transcripts may have limited applicability...
Aspirin challenge and desensitization for aspirin-exacerbated respiratory disease: a practice paperEric Macy
SCPMG Kaiser Permanente San Diego, California, USA
Ann Allergy Asthma Immunol 98:172-4. 2007....
Genetic association studies: what are they teaching clinicians?Jonathan A Bernstein
J Allergy Clin Immunol 111:465-6. 2003
Assessment of a rhinitis questionnaire in a seasonal allergic rhinitis populationJonathan A Bernstein
Ann Allergy Asthma Immunol 100:512-3. 2008
Escherichia coli spotted double-strand DNA microarrays: RNA extraction, labeling, hybridization, quality control, and data managementArkady B Khodursky
Department of Biochemistry, Biophysics and Molecular Biology, University of Minnesota, St. Paul, USA
Methods Mol Biol 224:61-78. 2003
Patient perceptions of an inhaled asthma medication administered as an inhalation powder via the Diskus or as an inhalation aerosol via a metered-dose inhalerKetan Sheth
Allergy Asthma Section, Arnett Clinic, Lafayette, Indiana 47904, USA
Ann Allergy Asthma Immunol 91:55-60. 2003....
