RICHARD NATHAN BERGMAN

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding
    Gregg W Van Citters
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90089-9142, USA
    J Clin Endocrinol Metab 87:5191-8. 2002
  2. ncbi Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm
    Aparna Nittala
    Max McGee National Research Center for Juvenile Diabetes and Human and Molecular Genetics Center, Medical College of Wisconsin, Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, Wl 53226, USA
    Biomed Eng Online 5:44. 2006
  3. ncbi Free fatty acids and pathogenesis of type 2 diabetes mellitus
    R N Bergman
    Diabetes Research Center, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Trends Endocrinol Metab 11:351-6. 2000
  4. ncbi Atypical antipsychotics and glucose homeostasis
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Clin Psychiatry 66:504-14. 2005
  5. ncbi Why visceral fat is bad: mechanisms of the metabolic syndrome
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Obesity (Silver Spring) 14:16S-19S. 2006
  6. ncbi Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Med 120:S3-8; discussion S29-32. 2007
  7. ncbi The minimal model of glucose regulation: a biography
    Richard N Bergman
    Department of Physiology and Biophysics, USC Diabetes Research Center, Keck-USC School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Adv Exp Med Biol 537:1-19. 2003
  8. ncbi Orchestration of glucose homeostasis: from a small acorn to the California oak
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, Los Angeles, CA 90033, USA
    Diabetes 56:1489-501. 2007
  9. ncbi A better index of body adiposity
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 19:1083-9. 2011
  10. ncbi Minimal model: perspective from 2005
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Horm Res 64:8-15. 2005

Research Grants

  1. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    RICHARD NATHAN BERGMAN; Fiscal Year: 2010
  2. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 2003
  3. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 2000
  4. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 2002
  5. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 2009
  6. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 2007
  7. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 2006
  8. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 2005
  9. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Richard Bergman; Fiscal Year: 2003
  10. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 1992

Detail Information

Publications78

  1. ncbi Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding
    Gregg W Van Citters
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90089-9142, USA
    J Clin Endocrinol Metab 87:5191-8. 2002
    ..Glucose is not the primary cause of hyperinsulinemia in the fat-fed dog. Corequisite meal-related signals may be permissive for development of hyperinsulinemia...
  2. ncbi Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm
    Aparna Nittala
    Max McGee National Research Center for Juvenile Diabetes and Human and Molecular Genetics Center, Medical College of Wisconsin, Children s Research Institute, Children s Hospital of Wisconsin, Milwaukee, Wl 53226, USA
    Biomed Eng Online 5:44. 2006
    ..Dimensional analysis of the model is up to now not available...
  3. ncbi Free fatty acids and pathogenesis of type 2 diabetes mellitus
    R N Bergman
    Diabetes Research Center, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Trends Endocrinol Metab 11:351-6. 2000
    ..Overall, effects of FFA can lead to several components of the insulin resistance syndrome and risk for diabetes. Reduction in FFA might be the appropriate therapy for these disorders...
  4. ncbi Atypical antipsychotics and glucose homeostasis
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Clin Psychiatry 66:504-14. 2005
    ..Goals of this review are to outline the pathogenesis of nonimmune diabetes and to survey the available literature related to why antipsychotics may lead to this disease...
  5. ncbi Why visceral fat is bad: mechanisms of the metabolic syndrome
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Obesity (Silver Spring) 14:16S-19S. 2006
  6. ncbi Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Med 120:S3-8; discussion S29-32. 2007
    ..The elucidation of these interrelated pathologies may help reveal points where medical intervention can reduce metabolic disease...
  7. ncbi The minimal model of glucose regulation: a biography
    Richard N Bergman
    Department of Physiology and Biophysics, USC Diabetes Research Center, Keck-USC School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Adv Exp Med Biol 537:1-19. 2003
  8. ncbi Orchestration of glucose homeostasis: from a small acorn to the California oak
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, Los Angeles, CA 90033, USA
    Diabetes 56:1489-501. 2007
  9. ncbi A better index of body adiposity
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 19:1083-9. 2011
    ..It can be used in the clinical setting even in remote locations with very limited access to reliable scales. The BAI estimates %adiposity directly...
  10. ncbi Minimal model: perspective from 2005
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Horm Res 64:8-15. 2005
    ..Even today, the model continues to be a subject of scientific discovery and discourse...
  11. ncbi Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 52:2168-74. 2003
    ..Thus S(I), a direct measure of insulin sensitivity, is determined more by genetic factors rather than measures such as HOMA, which reflect fasting insulin...
  12. ncbi Accurate assessment of beta-cell function: the hyperbolic correction
    Richard N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California
    Diabetes 51:S212-20. 2002
    ..The disposition index is likely to remain the most accurate physiologic measure for testing hypotheses and solutions to these challenges in whole organisms...
  13. ncbi The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes
    R N Bergman
    Diabetes Research Center, Keck School of Medicine, Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA 90089, USA
    Eur J Clin Invest 32:35-45. 2002
    ..Several landmark clinical studies are underway to investigate if their initial promise is supported by data from large-scale trials...
  14. ncbi Central role of the adipocyte in the metabolic syndrome
    R N Bergman
    Department of Physiology and Biophysics, Keck School of Medicine and University of Southern California Diabetes Research Center, Los Angeles, Calif, USA
    J Investig Med 49:119-26. 2001
    ..The integrated response of the organism to central adiposity is complex, involving several organs and tissue beds. An investigation into the integrated response may help to explain the features of the metabolic syndrome...
  15. ncbi Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog
    Stella P Kim
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Diabetes 52:2453-60. 2003
    ....
  16. ncbi Insulin resistance and hypertension: the Insulin Resistance Atherosclerosis study
    Mohammed F Saad
    Division of Clinical Epidemiology, Department of Medicine, UCLA Medical School, 924 Westwood Blvd, Suite 335 Mail Box 15, Los Angeles, Calif 90024, USA
    Hypertension 43:1324-31. 2004
    ..Neither insulin resistance nor insulinemia was related to hypertension or blood pressure in patients with type 2 diabetes in the 3 ethnic groups...
  17. ncbi Reduced access to insulin-sensitive tissues in dogs with obesity secondary to increased fat intake
    Martin Ellmerer
    Department of Physiology and Biophysics, University of Southern California School of Medicine, 1333 San Pablo St, MMR 626, Los Angeles, CA 90033, USA
    Diabetes 55:1769-75. 2006
    ..We speculate that the observed diet-induced defects in stimulation of tissue perfusion contribute to the development of peripheral insulin resistance...
  18. ncbi Mechanism of action in dogs of slow-acting insulin analog O346
    Martin Ellmerer
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 88:2256-62. 2003
    ..Reduced liver clearance of O346 is suggested to be the major mechanism for the protracted action...
  19. ncbi Extreme insulin resistance of the central adipose depot in vivo
    Steven D Mittelman
    Keck School of Medicine, University of Southern California, Department of Physiology and Biophysics, Los Angeles, California 90089-9142, USA
    Diabetes 51:755-61. 2002
    ..Thus, the omental adipose bed represents a highly insulin-resistant depot that drains directly into the portal vein. Increased free fatty acid flux to the liver may account for hepatic insulin resistance in the moderately obese state...
  20. ncbi Beta-cell "rest" accompanies reduced first-pass hepatic insulin extraction in the insulin-resistant, fat-fed canine model
    Stella P Kim
    Department of Physiology and Biophysics, Keck School of Medicine of USC, 1333 San Pablo St MMR 626, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 292:E1581-9. 2007
    ..This may provide a secondary physiological mechanism to preserve pancreatic beta-cell function during insulin resistance...
  21. ncbi Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia
    Stella P Kim
    Department of Physiology and Biophysics, Keck School of Medicine of the University of Southern California, 1333 San Pablo St MMR 626, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 292:E1590-8. 2007
    ..Thus enhanced nocturnal FFA, but not glucose, may be responsible for development of insulin resistance and fasting hyperinsulinemia in the fat-fed dog model...
  22. ncbi Critical role of the mesenteric depot versus other intra-abdominal adipose depots in the development of insulin resistance in young rats
    Karyn J Catalano
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Diabetes 59:1416-23. 2010
    ..However, it is unclear to what extent the portally drained mesenteric fat depot influences this susceptibility...
  23. ncbi Increased susceptibility to insulin resistance associated with abdominal obesity in aging rats
    Karyn J Catalano
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, 1333 San Pablo St, MMR 624, Los Angeles, CA 90033, USA
    Obes Res 13:11-20. 2005
    ..DISCUSSION: These data suggest that, in rodents, youth affords significant protection against obesity-induced insulin resistance...
  24. ncbi Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle
    Cathryn M Kolka
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, California, USA
    Diabetes 59:619-26. 2010
    ..Here we asked whether interstitial insulin diffusion is reduced in physiological obesity induced by a high-fat diet (HFD)...
  25. ncbi Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal
    Jenny D Chiu
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, 1333 San Pablo St, MMR 626, Los Angeles, CA 90033, USA
    Diabetes 57:828-35. 2008
    ....
  26. ncbi Metabolic syndrome, hyperinsulinemia, and cancer
    Isabel R Hsu
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA 90033, USA
    Am J Clin Nutr 86:s867-71. 2007
    ..The resulting syndrome-elevated nocturnal FFAs and elevated insulin-may synergize and increase the risk of some cancers. This possible scenario needs further study...
  27. ncbi Experimental hyperlipidemia dramatically reduces access of insulin to canine skeletal muscle
    Jenny D Chiu
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 17:1486-92. 2009
    ..The diversion of insulin from the interstitium under hyperlipidemic conditions may play a role in the insulin resistance observed coincident with elevated nocturnal FFAs as is observed in obesity...
  28. ncbi Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes
    Martha L Cruz
    Departments of Preventive Medicine and Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Diabetes Care 25:1631-6. 2002
    ..01) and negatively related to S(i) (P < 0.001). CONCLUSIONS: -These findings support the hypothesis that specific accumulation of visceral fat in addition to overall adiposity in Hispanic children increases the risk of type 2 diabetes...
  29. ncbi Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance
    Morvarid Kabir
    Dept of Physiology and Biophysics, University of Southern California Keck School of Medicine, 1333 San Pablo Street, MMR 626, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 288:E454-61. 2005
    ....
  30. ncbi Investigation of the effect of acepromazine on intravenous glucose tolerance tests in dogs
    Viorica Ionut
    Departments of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Am J Vet Res 65:1124-7. 2004
    ....
  31. ncbi Albumin binding of acylated insulin (NN304) does not deter action to stimulate glucose uptake
    Melvin K Dea
    Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Diabetes 51:762-9. 2002
    ..In ISF, there was no reduction in NN304 elimination. Thus, this acylated insulin analog demonstrates blunted kinetics in plasma, and full efficacy in the compartment of action, ISF...
  32. ncbi Pathogenesis and prediction of diabetes mellitus: lessons from integrative physiology
    Richard N Bergman
    Department of Physiology and Biophysics, Center for Diabetes Research, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Mt Sinai J Med 69:280-90. 2002
    ..Such analysis may well lead to analogous conceptual understanding of other important integrated biological systems, and provide approaches for early intervention in the pathogenic process of other chronic and devastating diseases...
  33. ncbi Greater omentectomy improves insulin sensitivity in nonobese dogs
    Maya Lottati
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Obesity (Silver Spring) 17:674-80. 2009
    ..postsurgery: 6.7 +/- 1.2 pmol/l/mg/dl, P = 0.9). These findings provide new evidence for the deleterious role of visceral fat in insulin resistance, and suggest that a greater OM procedure may effectively improve insulin sensitivity...
  34. ncbi Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans
    Mary Helen Black
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Diabetes 57:1048-56. 2008
    ....
  35. ncbi Exenatide can reduce glucose independent of islet hormones or gastric emptying
    Viorica Ionut
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 295:E269-77. 2008
    ..We hypothesize that receptors in the portal vein, via a neural mechanism, increase glucose clearance independent of islet hormones...
  36. ncbi Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study
    Xiuqing Guo
    Medical Genetics Institutes, Cedars Sinai Medical Center, 8700 Beverly Blvd, 665W, Los Angeles, CA 90048, USA
    Diabetes 55:1723-30. 2006
    ..Therefore, a quantitative trait locus at 3q27, likely distinct from the APM1 gene, contributes to the variation of plasma adiponectin levels in the Hispanic-American population...
  37. ncbi OGTT-derived measures of insulin sensitivity are confounded by factors other than insulin sensitivity itself
    Katrin Hucking
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 16:1938-45. 2008
    ....
  38. ncbi Novel canine models of obese prediabetes and mild type 2 diabetes
    Viorica Ionut
    Dept of Physiology and Biophysics, Keck School of Medicine, Univ of Southern California, 1333 San Pablo St, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 298:E38-48. 2010
    ..These models open new avenues for studying the mechanism of compensatory changes that occur in T2DM and for evaluating new therapeutic strategies to prevent progression or to treat overt diabetes...
  39. ncbi Ethnic heterogeneity in glucoregulatory function during treatment with atypical antipsychotics in patients with schizophrenia
    Marilyn Ader
    Keck School of Medicine, University of Southern California, Department of Physiology and Biophysics, 1333 San Pablo St, MMR 624, Los Angeles, CA 90033, USA
    J Psychiatr Res 42:1076-85. 2008
    ..Atypical antipsychotics induce weight gain and are linked to increased diabetes risk, but their relative impact on factors that elevate disease risk are unknown...
  40. ncbi Exenatide sensitizes insulin-mediated whole-body glucose disposal and promotes uptake of exogenous glucose by the liver
    Dan Zheng
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Diabetes 58:352-9. 2009
    ..We aimed to investigate whether exenatide stimulates glucose turnover directly in insulin-responsive tissues dependent or independent of insulinemia...
  41. ncbi Mode of transcapillary transport of insulin and insulin analog NN304 in dog hindlimb: evidence for passive diffusion
    Marianthe Hamilton-Wessler
    Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    Diabetes 51:574-82. 2002
    ....
  42. ncbi Insulin resistance and associated compensatory responses in african-american and Hispanic children
    Michael I Goran
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Diabetes Care 25:2184-90. 2002
    ..The objective of this study was to compare insulin resistance relative to body fat and the associated compensatory responses in 57 healthy children living in Los Angeles, California (14 Caucasians, 15 African-Americans, and 28 Hispanics)...
  43. ncbi Influence of family history of type 2 diabetes on insulin sensitivity in prepubertal children
    Michael I Goran
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 88:192-5. 2003
    ..In conclusion, a positive FH for T2D does not seem to have any significant effect on insulin sensitivity, as assessed by the minimal model and associated risk factors for T2D in young children...
  44. ncbi Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes
    Michael I Goran
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 89:207-12. 2004
    ....
  45. ncbi Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: a placebo-controlled study of olanzapine and risperidone in dogs
    Marilyn Ader
    Keck School of Medicine, Department of Physiology and Biophysics, University of Southern California, MMR 624, 1333 San Pablo St, Los Angeles, CA 90033, USA
    Diabetes 54:862-71. 2005
    ..These results may explain the diabetogenic effects of atypical antipsychotics and suggest that beta-cell compensation is under neural control...
  46. ncbi Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action
    Viorica Ionut
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo St, Los Angeles CA 90033, USA
    Am J Physiol Endocrinol Metab 291:E779-85. 2006
    ..In conclusion, in dogs with postprandial rises in systemic glucose and GLP-1, the hormone might not have a direct insulinotropic effect and could regulate glycemia via indirect, portohepatic-initiated neural mechanisms...
  47. ncbi Physiological hyperinsulinemia in dogs augments access of macromolecules to insulin-sensitive tissues
    Martin Ellmerer
    Department of Physiology and Biophysics, University of Southern California School of Medicine, 1333 San Pablo St, MMR 626, Los Angeles, CA 90033, USA
    Diabetes 53:2741-7. 2004
    ..Because of the differences between inulin and insulin itself, whether delivery of the bioactive hormone is increased remains speculative...
  48. ncbi Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs
    Joyce M Richey
    Dept of Physiology, Keck School of Medicine, Univ of Southern California, 1333 San Pablo St, MMR 626, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 296:E1311-8. 2009
    ..The findings provide evidence of a peripheral effect of rimonabant to reduce adiposity and body weight, possibly through a direct effect on adipose tissue...
  49. ncbi Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal
    Dan Zheng
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Physiol Endocrinol Metab 298:E346-53. 2010
    ....
  50. ncbi Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q
    Corina Shtir
    Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA 90089, USA
    Hum Hered 63:17-25. 2007
    ..The purpose of this study was to examine carefully heterogeneity underlying evidence for linkage to type 2 diabetes (T2DM) on chromosome 6q from two sets of FUSION families...
  51. ncbi Pulsatile changes in free fatty acids augment hepatic glucose production and preserves peripheral glucose homeostasis
    Isabel R Hsu
    Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    Am J Physiol Endocrinol Metab 299:E131-6. 2010
    ..These data suggest that the pattern of FFA may have a role in regulation of glucose homeostasis, which may have consequences in the obese or insulin-resistant state where the SNS is known to be altered...
  52. ncbi Deconvolution as a novel approach to analyze moment-to-moment free fatty acid release
    Katrin Hucking
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, 1333 San Pablo Street, Mudd Memorial Research 626, Los Angeles CA 90033, USA
    Obesity (Silver Spring) 15:2416-23. 2007
    ..It is, then, necessary to understand and characterize adipose tissue lipolysis to elucidate its effect on metabolism. In this study, we introduce deconvolution as a method to detect and quantify pulsatile FFA release...
  53. ncbi Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Becker B 131, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 92:293-6. 2007
    ..The most common haplotype (haplotype 1) was protective, whereas the fourth most common haplotype (haplotype 4) conferred risk for insulin resistance and atherosclerosis...
  54. ncbi Burst-like control of lipolysis by the sympathetic nervous system in vivo
    Katrin Hucking
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Clin Invest 111:257-64. 2003
    ..The extinction of lipid fuel bursts by beta(3)-blockade implies a role for the CNS in the maintenance of cyclic provision of lipid fuels...
  55. ncbi Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort
    Tasha E Fingerlin
    Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Diabetes 51:1644-8. 2002
    ..We conclude that variation in these three SNPs in the calpain-10 gene is unlikely to confer susceptibility to type 2 diabetes in this Finnish cohort...
  56. ncbi AKA-Glucose: a program for kinetic and epidemiological analysis of frequently sampled intravenous glucose tolerance test data using database technology
    Raymond C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Diabetes Technol Ther 7:298-307. 2005
    ..The Bergman Minimal Model enables estimation of two key indices of glucose/ insulin dynamics: glucose effectiveness and insulin sensitivity...
  57. ncbi Utility of a surrogate measure of insulin resistance in American Indians: the Strong Heart Study
    Helaine E Resnick
    MedStar Research Institute, Washington, DC, USA
    Ethn Dis 12:523-9. 2002
    ....
  58. ncbi Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns
    Karen L Mohlke
    Department of Genetics, University of North Carolina, 4109 F Neurosciences Research Building, 103 Mason Farm Road, CB 7264, 27599 7264, Chapel Hill, NC, USA
    Hum Genet 118:245-54. 2005
    ..Furthermore, our data do not support a reported maternal inheritance pattern of T2DM but instead show a strong effect of recall bias...
  59. ncbi Genomic scan of glucose and insulin metabolism phenotypes: the HERITAGE Family Study
    Ping An
    Division of Biostatistics, and the Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 52:246-53. 2003
    ..Fine mapping and association studies of candidate genes within these genomic regions are warranted...
  60. ncbi Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods
    Leora Henkin
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Epidemiol 13:211-7. 2003
    ..In this report, we describe the methods of the IRAS Family Study, which was designed to identify the genetic and environmental risk factors for insulin resistance and visceral adiposity...
  61. ncbi Surrogates
    Richard N Bergman
    Obesity (Silver Spring) 16:721-2. 2008
  62. ncbi What for genetics?
    Richard N Bergman
    Obesity (Silver Spring) 16:507-8. 2008
  63. ncbi Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes Care 26:2796-803. 2003
    ..To determine the meaning of S(i) = 0 derived from the frequently sampled intravenous glucose tolerance test...
  64. ncbi Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes 52:2490-6. 2003
    ..The fat measures explained 27% of the model R2 for SI, 16% for AIR, and 16% for DI. Thus, fat distribution is an important determinant of both insulin resistance and insulin secretion...
  65. ncbi A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston Salem, NC 27157, USA
    Diabetes 54:290-5. 2005
    ..Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations...
  66. ncbi Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study
    Margarita Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:2251-5. 2005
    ..The benefits from an exercise program on Si are likely to be substantial in the general population given the high frequency of the LIPC -514C allele, particularly in whites...
  67. ncbi Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes
    Cristen J Willer
    Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor 48109 2029, USA
    Diabetes 56:256-64. 2007
    ..03), although we also replicated 4 of 58 SNPs from genes that had only one previous report of association...
  68. ncbi Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 53:3013-9. 2004
    ..001) fasting glucose, respectively, in the IRASFS. This comprehensive genetic analysis of PTPN1 reveals significant association with metabolic traits consistent with the proposed in vivo role for the PTP-1B protein...
  69. ncbi Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor, MRI Center, Winston Salem, NC 27157, USA
    Diabetes 53:1866-75. 2004
    ....
  70. ncbi Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS Family Study
    Braxton D Mitchell
    University of Maryland School of Medicine, Division of Endocrinology, Diabetes, and Nutrition, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Obes Res 12:831-9. 2004
    ..Whether diabetes family history (FH) also predicts visceral fat accumulation and, if so, whether the increased insulin resistance in relatives of diabetic subjects occurs independently of visceral fat accumulation are not known...
  71. ncbi A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:821-9. 2004
    ....
  72. ncbi Frequency of hypoglycaemia during the intravenous glucose tolerance test in overweight children
    Martha L Cruz
    Department of Health Promotion, College of Health Sciences, University of Texas at El Paso, El Paso, TX 79902, USA
    Int J Pediatr Obes 2:122-5. 2007
    ..5% subjects). In addition, only 1.9% of subjects (n=4) had plasma glucose<60 mg/dl at any time during the FSIVGTT. The frequency of hypoglycaemia during the insulin modified FSIVGTT is very low in overweight Hispanic youth...
  73. ncbi Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:304-9. 2008
    ..Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined...
  74. ncbi Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
    Diabetes 55:911-8. 2006
    ..These detailed genetic analyses provide strong evidence of a DI locus on 11q in African-American pedigrees, with additional suggestive evidence of independent AIR loci in the same region...
  75. ncbi MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test
    Ray C Boston
    School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
    Diabetes Technol Ther 5:1003-15. 2003
    ..In contrast to earlier versions of MINMOD and some other minimal model programs, Millennium provides identified estimates of insulin sensitivity and glucose effectiveness for almost every subject...
  76. ncbi Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 57:1093-100. 2008
    ....
  77. ncbi Normal triglyceride levels despite insulin resistance in African Americans: role of lipoprotein lipase
    Anne E Sumner
    Clinical Endocrinology Branch, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1612, USA
    Metabolism 54:902-9. 2005
    ..The lack of an effect of insulin resistance on PH-LPL could allow LPL to clear TG even in the presence of insulin resistance and explain the coexistence of insulin resistance and normotriglyceridemia in African Americans...

Research Grants57

  1. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    RICHARD NATHAN BERGMAN; Fiscal Year: 2010
    ..The studies will unearth new approaches to predict, prevent, treat and possibly cure Type 2 diabetes mellitus. ..
  2. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 2003
    ..Identification of the origin and metabolic actions of such molecules should lead to more accurate identification of those at risk for diabetes, and allow for prevention of the disease. ..
  3. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 2000
    ..This overall research program should yield important information regarding the physiological regulation of hepatic glucose production, and the role of those mechanisms in the pathogenesis of chronic disease. ..
  4. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 2002
    ....
  5. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 2009
    ..Identification of the origin and metabolic actions of such molecules should lead to more accurate identification of those at risk for diabetes, and allow for prevention of the disease. ..
  6. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 2007
    ..Understanding the physiological mechanisms underlying the relationship between obesity and insulin resistance may provide a path whereby intervention may prevent the associated morbidity and mortality. ..
  7. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 2006
    ..Identification of the origin and metabolic actions of such molecules should lead to more accurate identification of those at risk for diabetes, and allow for prevention of the disease. ..
  8. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 2005
    ..abstract_text> ..
  9. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Richard Bergman; Fiscal Year: 2003
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin sensitivity, and consequently to risk of atherosclerosis. ..
  10. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 1992
    ..Clearly, it is this quantitative relationship between insulin secretion and insulin action which is defective in the glucose intolerant state which may precede full-blown diabetes mellitus...
  11. QUANTITATION OF FACTORS REGULATING GLUCOSE TOLERANCE
    Richard Bergman; Fiscal Year: 1993
    ....
  12. QUANTITATIVE STUDIES OF METABOLIC ORGAN DYNAMICS
    Richard Bergman; Fiscal Year: 1993
    ..These studies should clarify the mechanism of insulin resistance at the level of glucose output in experimental diabetes, and could lead to improved therapy to regulate glycemia in this disease...