Research Topics
Species | B N BeckerSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathwayShreyas Das
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
BMC Cell Biol 10:94. 2009..The process to reverse EMT is not well established. Our purpose is to define signaling pathways and transcription factors that maintain the TGF-beta-induced mesenchymal state...- Simultaneous pancreas-kidney and pancreas transplantationB N Becker
Division of Nephrology, Department of Medicine, University of Wisconsin, 2500 Overlook Terrace, Madison, WI 53705, USA
Minerva Urol Nefrol 54:213-26. 2002..It can improve survival and limit many diabetic-related complications, while improving quality of life, especially in those individuals also afflicted with diabetic-related kidney disease... - Erythropoietin therapy may retard progression in chronic renal transplant dysfunctionBryan N Becker
Department of Medicine, University of Wisconsin Medical School, Madison 53792, USA
Nephrol Dial Transplant 17:1667-73. 2002..Recent data suggests that erythropoietin therapy may actually retard the progression of chronic kidney disease (CKD). Transplant recipients with evidence of chronic allograft dysfunction could respond in a similar manner to erythropoietin... - Strategic planning for departmental divisions in an academic health care centerBryan N Becker
Department of Medicine and School of Business, University of Wisconsin-Madison, USA
Am J Med 119:357-65. 2006 - Reassessing the impact of cytomegalovirus infection in kidney and kidney-pancreas transplantationBryan N Becker
Division of Nephrology, Department of Medicine, School of Pharmacy, University of Wisconsin, Madison, Madison, WI, USA
Am J Kidney Dis 39:1088-95. 2002..This finding may require reassessment of prophylaxis strategies and the development of alternative or novel anti-CMV regimens... - Type 2 angiotensin II receptor expression in human renal allografts: an association with chronic allograft nephropathyB N Becker
Department of Medicine, University of Wisconsin, Department of Veterans Affairs Hospital, Madison 53705, USA
Clin Nephrol 57:19-26. 2002..Whether the other predominant Ang II receptor, the type 2 Ang II receptor (AT2R), has a fibrotic or sparing role in adult human renal tissue is unknown... - Vitamin D as immunomodulatory therapy for kidney transplantationBryan N Becker
Department of Medicine, B 3063 UW Nephrology, University of Wisconsin, 2500 Overlook Terrace, Madison, WI 53705, USA
Transplantation 74:1204-6. 2002..Such provocative data and the availability of newer 1alpha,25-(OH)(2)D(3) analogs that may limit side effects (e.g. hypercalcemia) have created interest in examining this secosteroid clinically in kidney transplantation... - Commentary: dinosaurs fated for extinction? Health care delivery at academic health centersBryan N Becker
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
Acad Med 85:759-62. 2010..This commentary outlines recommendations to stave off extinction and enhance the next generation of clinical care delivery at AHCs... - Simultaneous pancreas-kidney transplantation reduces excess mortality in type 1 diabetic patients with end-stage renal diseaseB N Becker
Departments of Medicine and Surgery, University of Wisconsin, Madison 53792, USA
Kidney Int 57:2129-35. 2000..Simultaneous pancreas-kidney (SPK) transplantation can restore normoglycemia and thus may improve outcomes... - Using renal transplantation to evaluate a simple approach for predicting the impact of end-stage renal disease therapies on patient survival: observed/expected life spanB N Becker
Departments of Medicine, Pediatrics, and Surgery, University of Wisconsin, Madison, WI 53792, USA
Am J Kidney Dis 35:653-9. 2000..This simple ratio is easy to use and may be a helpful tool for assessing the survival benefits of risk-factor modifications and therapeutic advances in transplantation and ESRD care... - Mycophenolate mofetilB N Becker
Department of Medicine, University of Wisconsin Medical School, Madison, USA
Transplant Proc 31:2777-8. 1999..MMF has taken its place in our immunosuppressive armamentarium. It has proven efficacy in preventing AR in a variety of types of transplantation... - Risk factors for hospitalization in well-dialyzed chronic hemodialysis patientsB N Becker
University of Wisconsin, Madison, WI 53792, USA
Am J Nephrol 19:565-70. 1999..Hospital costs attributable to renal failure in the US exceed $2 billion per year. The present healthcare climate continues to force dialysis providers to focus on these issues in order to optimize patient care while limiting cost... - Peripheral vascular disease and renal transplant artery stenosis: a reappraisal of transplant renovascular diseaseB N Becker
Department of Medicine, University of Wisconsin Medical School, Madison 53792, USA
Clin Transplant 13:349-55. 1999..Older transplant recipients, prone to peripheral vascular disease (PVD), may have pseudoRTAS with PVD involving their iliac system... - The impact of hypoalbuminemia in kidney-pancreas transplant recipientsB N Becker
Department of Medicine, University of Wisconsin Medical School, Madison 53792, USA
Transplantation 68:72-5. 1999..Diabetes can compound hypoalbuminemia's detrimental effects. Kidney-pancreas transplantation alters the diabetic milieu; yet, some patients continue to be hypoalbuminemic... - Chronic allograft nephropathy uniformly affects recipients of cadaveric, nonidentical living-related, and living-unrelated graftsNancy R Krieger
Department of Surgery, University of Wisconsin Medical School, Madison, WI 53792-7375, USA
Transplantation 75:1677-82. 2003..The disparities in overall graft survival, despite the similarities in CAN rates, suggests that other factors, in addition to CAN, influence the increase in graft loss in CAD transplant recipients... - Posttransplant infection in enteric versus bladder-drained simultaneous pancreas-kidney transplant recipientsJ D Pirsch
Department of Medicine, University of Wisconsin Medical School, Madison 53792, USA
Transplantation 66:1746-50. 1998..The most common cause of morbidity after pancreas transplantation is infection, particularly recurrent urinary tract infection... - Alemtuzumab induction and recurrence of glomerular disease after kidney transplantationJulio Pascual
Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53713, USA
Transplantation 83:1429-34. 2007..An increase in the incidence of autoimmune diseases has been described in patients receiving alemtuzumab... - Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantationRolf N Barth
Department of Surgery, Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, 53792-7375, USA
Transpl Int 19:885-92. 2006..Because of the higher incidence of early rejection, we recommend a modified strategy of immunosuppression including a brief course of a calcineurin inhibitor... - 1,25-(OH(2))D(3) alters the transforming growth factor beta signaling pathway in renal tissueJ K Aschenbrenner
Department of Surgery, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
J Surg Res 100:171-5. 2001..These effects, in combination with the immunomodulatory actions of vitamin D, may alter the evolution of chronic rejection in renal transplants... - Epithelial cell polarity and improved early outcomes in delayed graft function: a pilot study of polyclonal vs monoclonal antibodiesYolanda T Becker
Department of Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA
Nephrol Dial Transplant 19:2886-92. 2004..33+/-6.48 ml/min; P = 0.002). CONCLUSION: Though a pilot study, these data suggest that a purified polyclonal antibody preparation may help conserve functional kidney mass during DGF with potential benefits on transplant function overall... - Preemptive transplantation for patients with diabetes-related kidney diseaseBryan N Becker
Department of Medicine, University of Wisconsin-Madison, USA
Arch Intern Med 166:44-8. 2006..This observation and the discrepancies between RR of graft loss and RR of mortality deserve further study... - Blood pressure control in kidney transplantation: therapeutic implicationsN C Premasathian
Department of Medicine, University of Wisconsin, Madison, WI, USA
J Hum Hypertens 18:871-7. 2004..Their role in a compromised RTx, however, deserves further study. ACEI/ARBs have clear benefits, improving graft survival in individuals with elevated systolic blood pressure and proteinuria. CCBs are not as efficacious in this setting... - Sirolimus monotherapy following Campath-1H inductionV Rao
University of Wisconsin Medical School, Madison, Wisconsin, USA
Transplant Proc 35:128S-130S. 2003..Wound healing, leukopenia, and anemia were not significant problems. In conclusion, monotherapy has been well tolerated with a favorable side effect profile. However, a rejection rate of 28% was noted... - Superior long-term results of simultaneous pancreas-kidney transplantation from pediatric donorsLuis A Fernandez
Division of Transplantation, Department of Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792 7375, USA
Am J Transplant 4:2093-101. 2004..15; pancreas 75% vs. 76%, p = 0.10, respectively). Pediatric donors represent a valuable source of organs, providing excellent short- and long-term outcomes. Wide utilization of pediatric organs will substantially increase the donor pool... - Care of the potential organ donorKenneth E Wood
Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, USA
N Engl J Med 351:2730-9. 2004 - Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experienceElizabeth A Sadowski
Department of Radiology, Medical Physics, Nephrology, and Biostatistics, University of Wisconsin, 600 Highland Ave, E3 311 CSC, Madison, WI 53792, USA
Radiology 236:911-9. 2005.... - Prevention of chronic allograft nephropathy with vitamin DDebra A Hullett
Division of Transplantation, Department of Surgery, University of Wisconsin Madison, 600 Highland Avenue, Madison, WI, USA
Transpl Int 18:1175-86. 2005..Taken together our data suggests that 1,25-(OH)(2)D(3) mitigates CAN in this model by altering TGFbeta-1 and matrix-regulating molecules... - Noninvasive assessment of early kidney allograft dysfunction by blood oxygen level-dependent magnetic resonance imagingArjang Djamali
Department of Medicine, University of Wisconsin Madison, Madison, WI, USA
Transplantation 82:621-8. 2006..We hypothesized that BOLD-MRI could accurately discriminate different types of rejection early after kidney transplantation... - BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunctionArjang Djamali
Department of Medicine, University of Wisconsin Madison, Madison, WI 53713, USA
Am J Physiol Renal Physiol 292:F513-22. 2007..BOLD-MRI demonstrated significant changes in medullary and cortical oxygen bioavailability in allografts with CAN. These correlated with serum/urine biomarkers of OS, suggesting an association between intrarenal oxygenation and OS... - Vascular access outcomes and medication use: a USRDS studyAlexander S Yevzlin
School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53713, USA
Semin Dial 19:535-9. 2006..Antiplatelet agents had a significant negative association with access patency in this cohort. In contrast to other published data, it was difficult to identify any beneficial effect of specific medications on access patency... - Medical care of kidney transplant recipients after the first posttransplant yearArjang Djamali
Department of Medicine, Nephrology Section, University of Wisconsin Madison, School of Medicine, 3034 Fish Hatchery Road, Suite B, Madison, WI 53713, USA
Clin J Am Soc Nephrol 1:623-40. 2006..This article reviews the contemporary aspects of care for these patients... - Donation after cardiac death: the University of Wisconsin experienceAnthony M D'Alessandro
Department of Surgery, University of Wisconsin Medical School, USA
Ann Transplant 9:68-71. 2004..The objective of this analysis was to compare the results of transplantation of livers, pancreases, kidneys, and lungs from donation after cardiac death (DCD) donors to organs transplanted from donation after brain death (DBD) donors... - Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot studyStuart J Knechtle
Department of Surgery, University of Wisconsin Medical School, Madison, WI, USA
Am J Transplant 3:722-30. 2003..This clinical trial provides insight into the use of Campath-1H induction in combination with rapamycin maintenance monotherapy... - Increasing hematocrit reduces early posttransplant cardiovascular risk in diabetic transplant recipientsArjang Djamali
Department of Medicine, University of Wisconsin, Madison, USA
Transplantation 76:816-20. 2003..Prospective studies of anemia management therapy in this setting are warranted to determine whether this will reduce early posttransplant CV risk... - Factors affecting employment at initiation of dialysisRebecca J Muehrer
Department of Medicine, University of Wisconsin Madison School of Medicine and Public Health, Section of Nephrology, Madison, Wisconsin, USA
Clin J Am Soc Nephrol 6:489-96. 2011..The purpose of the study is to understand factors associated with maintaining employment among working-age patients with advanced kidney failure... - Evaluation of eHealth web sites for patients with chronic kidney diseaseJonathan B Jaffery
Department of Medicine, Section of Nephrology, University of Wisconsin Madison, Madison, WI, USA
Am J Kidney Dis 44:71-6. 2004..To date, there have been no systematic evaluations of CKD eHealth Web sites... - Diabetic kidneys can safely expand the donor poolYolanda T Becker
Division of Transplantation, Department of Surgery, University of Wisconsin, Madison 53792, USA
Transplantation 74:141-5. 2002..As such, kidneys from medically marginal donors are being considered for transplantation more frequently, including kidneys from individuals already at risk for renal disease, e.g., diabetic donors... - Rituximab as treatment for refractory kidney transplant rejectionYolanda T Becker
Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, WI, USA
Am J Transplant 4:996-1001. 2004..6 +/- 1.0 mg/dL and decreased to 0.95 +/- 0.7 mg/dL at discharge. The addition of rituximab may improve outcomes in severe, steroid-resistant or antibody-mediated rejection episodes after kidney transplantation... - Donor-derived small cell lung carcinoma in a kidney transplant recipientS Bodvarsson
Department of Internal Medicine, Clinical Science Center, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
Cancer 92:2429-34. 2001..At last follow-up, she was 12 months from completing her therapy and continued in complete remission. CONCLUSIONS: Donor-derived small cell carcinoma and ectopic ACTH production can occur in a patient after kidney transplantation... - Water treatment for hemodialysisN Ismail
Department of Medicine, Vanderbilt University, School of Medicine, Nashville, Tenn 37232 2372, USA
Am J Nephrol 16:60-72. 1996..The pathogenesis of febrile reactions during hemodialysis remains controversial. The weight of evidence, however, favors transmission of endotoxin fragments across dialysis membranes to induce mononuclear cell cytokine production... - A retrospective evaluation of 1,25-dihydroxyvitamin D(3) and its potential effects on renal allograft functionDebra A Hullett
Division of Transplantation, Department of Surgery, University of Wisconsin, and Department of Veterans Affairs Medical Center, Madison, Wisc. 53705, USA
Am J Nephrol 22:515-20. 2002..Such trials may help us elucidate mechanism and duration of action, as well as safety issues related to these novel immunomodulatory agents... - Disease progression and outcomes in type 1 diabetic kidney transplant recipients based on posttransplantation CKD stagingChanigan Smavatkul
Department of Medicine, Nephrology Section, University of Wisconsin School of Medicine and Public Health, Madison, WI 53713, USA
Am J Kidney Dis 50:631-40. 2007..Disease progression rates and outcomes per stage of kidney disease in kidney transplant recipients with type 1 diabetes mellitus are unknown... - CKD stage-to-stage progression in native and transplant kidney diseaseAleksandra Kukla
Department of Medicine, Nephrology Section, University of Wisconsin School of Medicine and Public Health, 3034 Fish Hatchery Road, Madison, WI 53713, USA
Nephrol Dial Transplant 23:693-700. 2008..Kidney half-life and inter-stage progression rates in native chronic kidney disease (CKD) and CKD-transplant (CKD-T) remain unknown... - Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneysElizabeth A Sadowski
Department of Radiology, University of Wisconsin, Madison, WI 53792, USA
Magn Reson Imaging 28:56-64. 2010.... - In-center hemodialysis patients' use of the internet in the United States: a national surveyDorian Schatell
Medical Education Institute Inc, Madison, WI 53719, USA
Am J Kidney Dis 48:285-91. 2006..Proxy use may extend the reach of the Internet to patients who do not have access on their own... - Drug insight: maintenance immunosuppression in kidney transplant recipientsMillie Samaniego
Nephrology Section, Department of Medicine, University of Wisconsin Madison, 3034 Fish Hatchery Road, Suite B, Madison, WI 53713, USA
Nat Clin Pract Nephrol 2:688-99. 2006.... - "Venopathy" at work: recasting neointimal hyperplasia in a new lightAlexander S Yevzlin
Departments of Medicine and Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA
Transl Res 156:216-25. 2010..This review attempts to recast our understanding of NH and redefine research goals for an evolving discipline that focuses on a life-sustaining connection between an artery and vein... - Intrathymic injection of anti-Fas monoclonal antibody prolongs murine non-vascularized cardiac allograft survivalArjang Djamali
Department of Medicine, Nephrology Section, Division of Organ Transplantation, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53792, USA
Transpl Int 17:301-9. 2004.... - Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP)Lesley A Stevens
Division of Nephrology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
Am J Kidney Dis 55:S23-33. 2010..In all 3 data sources, we also explored comorbid conditions and CKD-related complications... - Life after transplantation: new transitions in quality of life and psychological distressRebecca J Muehrer
Section of Nephrology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA
Semin Dial 18:124-31. 2005.... - Disease progression and outcomes in chronic kidney disease and renal transplantationArjang Djamali
Department of Medicine, Nephrology Section, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53713-3125, USA
Kidney Int 64:1800-7. 2003..These data suggest that RTR are a unique subset of patients with CKD whose comorbid conditions likely offset the potential benefits of slower rates of progression... - Long-term follow-up of patients with tertiary hyperparathyroidism treated by resection of a single or double adenomaPeter F Nichol
Department of Surgery, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
Ann Surg 235:673-8; discussion 678-80. 2002..Therefore, the authors recommend in patients with tertiary hyperparathyroidism and enlargement of only one or two parathyroid glands that the resection be limited to these abnormal glands only... - Quantitative MR measures of intrarenal perfusion in the assessment of transplanted kidneys: initial experienceAndrew L Wentland
Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705 2275, USA
Acad Radiol 16:1077-85. 2009.... - L-carnitine treatment of anemiaThomas A Golper
Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Am J Kidney Dis 41:S27-34. 2003.... - A novel method for regional citrate anticoagulation in continuous venovenous hemofiltration (CVVHF)R Michael Hofmann
Department of Medicine, University of Wisconsin, Madison 53705, USA
Ren Fail 24:325-35. 2002..CONCLUSIONS: This novel CVVHF-citrate system achieved excellent clearance and dramatically improved filter patency compared to saline-flush systems. Moreover, it did so with minimal toxicity... - ATR blockade reduces IFN-gamma production in lymphocytes in vivo and in vitroJon A Weidanz
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA
Kidney Int 67:2134-42. 2005..AT(1)R blocker treatment furthermore also inhibited IFN-gamma production in the cytotoxic T-lymphocyte line. CONCLUSION: AT(1)R blockers may have a clinically relevant immunomodulatory role by blocking IFN-gamma production in T cells... - Trends in kidney transplantation rates and disparitiesKelly L Stolzmann
Harvard Medical School, Boston, MA 02132, USA
J Natl Med Assoc 99:923-32. 2007..To examine the likelihood of transplantation and trends over time among persons with end-stage renal disease (ESRD) in Wisconsin... - Campath-1H in renal transplantation: The University of Wisconsin experienceStuart J Knechtle
Department of Surgery, University of Winsconsin Medical School, Madison 53792-7375, USA
Surgery 136:754-60. 2004..CONCLUSIONS: Campath-1H was well tolerated in renal transplant patients and led to significant reductions in incidence of rejection. Patients with delayed graft function experienced significantly improved graft survival... - Kidney and pancreas transplantationRobert S Gaston
University of Alabama at Birmingham, Birmingham, AL, USA
Am J Transplant 3:64-77. 2003 - Functionally significant renal allograft rejection is defined by transcriptional criteriaSteven C Hoffmann
Transplantation Branch, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, USA
Am J Transplant 5:573-81. 2005..Quantitative analysis of selected gene transcripts may enhance the clinical assessment of allografts... - Another cause for the same old problemJohn D Pirsch
Am J Transplant 4:1931-2. 2004 - Donor genomics influence graft events: the effect of donor polymorphisms on acute rejection and chronic allograft nephropathySteven Hoffmann
Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
Kidney Int 66:1686-93. 2004..We assessed polymorphisms from 244 renal allograft donors to better understand the impact of donor polymorphisms on selected transplant outcomes... - KDOQI US commentary on the KDIGO clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in CKDCraig E Gordon
Tufts Center for Guideline Development and Implementation, Tufts Medical Center, Boston, MA, USA
Am J Kidney Dis 52:811-25. 2008..Research recommendations that are of particular interest to the United States are then summarized to highlight future areas of inquiry that would enable updating of the guidelines... - The home is where the donor might beBryan N Becker
Am J Kidney Dis 51:542-4. 2008
Research Grants
- Angiotensin II Receptor Blockade and Chronic RejectionBryan Becker; Fiscal Year: 2003....
- E M Transdifferentiation in Proximal Tubule CellsBryan Becker; Fiscal Year: 2004..abstract_text> ..
- Clinical Translational Research in Transplant NephrologyBryan Becker; Fiscal Year: 2006..It will also work to meet the NIH's goal of increasing the number of physician-scientists conducting high-quality patient-oriented research. ..