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Genomes and GenesSpecies | Jason H T BatesSummaryAffiliation: University of Vermont Country: USA Publications
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Publications
The conceptual basis of mathematics in cardiology IV: statistics and model fittingJason H T Bates
Department of Medicine, University of Vermont, Burlington 05405, USA
Coron Artery Dis 14:267-77. 2003..Each article concludes with one or more examples illustrating application of the concepts covered to cardiovascular medicine and biology...- The conceptual basis of mathematics in cardiology III: linear systems theory and integral transformsJason H T Bates
Department of Medicine, University of Vermont, HSRF Room 228, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
Coron Artery Dis 14:185-96. 2003..Each article concludes with one or more examples illustrating application of the concepts covered to cardiovascular medicine and biology... - Applying fuzzy logic to medical decision making in the intensive care unitJason H T Bates
HSRF, Room 228, University of Vermont, 149 Beaumont Avenue, Burlington, VT 05405-0075, USA
Am J Respir Crit Care Med 167:948-52. 2003 - The conceptual basis of mathematics in cardiology: (II). Calculus and differential equationsJason H T Bates
Department of Medicine, University of Vermont, Burlington, 05405 0075, USA
Coron Artery Dis 14:135-48. 2003..Each article concludes with one or more examples illustrating application of the concepts covered to cardiovascular medicine and biology... - The conceptual basis of mathematics in cardiology: (I) algebra, functions and graphsJason H T Bates
Department of Medicine, University of Vermont, Burlington 05405 0075, USA
Coron Artery Dis 14:41-59. 2003..Each article concludes with one or more examples illustrating application of the concepts covered to cardiovascular medicine and biology... - Time dependence of recruitment and derecruitment in the lung: a theoretical modelJason H T Bates
Vermont Lung Center, Department of Medicine, University of Vermont, Burlington, Vermont 05446, USA
J Appl Physiol 93:705-13. 2002..We conclude that our model captures the time-dependent mechanical behavior of the lung due to gradual R/D of lung units... - Unrestrained video-assisted plethysmography: a noninvasive method for assessment of lung mechanical function in small animalsJason H T Bates
Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, USA
J Appl Physiol 104:253-61. 2008..36, 0.44 and 0.37 ml, respectively. We conclude that UVAP, a noninvasive method, is able to provide usefully accurate estimates of sRaw and breathing pattern parameters in mice... - Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supineDavid A Kaminsky
Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Appl Physiol 104:10-9. 2008..Thus heterogeneity appears to be a fundamental feature of bronchoconstriction and is not unique to mild asthma... - Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanismsScott S Wagers
Vermont Lung Center, Department of Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Appl Physiol 102:221-30. 2007..8% loss of visible lung area in A/J mice compared with 28% in antigen-sensitized and -challenged mice (P < 0.02). We conclude that the physiology of AHR depends on the mouse model used and the route of bronchial agonist administration... - Computational assessment of airway wall stiffness in vivo in allergically inflamed mouse models of asthmaAna Cojocaru
Vermont Lung Center, University of Vermont College of Medicine, Burlington, VT, USA
J Appl Physiol 104:1601-10. 2008..These results support the notion that acutely inflamed BALB/c mice represent an animal model of functionally normal airway smooth muscle in a transiently abnormal lung... - Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of ?-receptor affinity in murine models of asthmaLennart K A Lundblad
Vermont Lung Center, Department of Medicine, University of Vermont, 149 Beaumont Ave, Burlington, VT 05401, USA
Respir Res 12:27. 2011..To test this hypothesis we studied the effect of long-term inhaled albuterol stereoisomers on immediate allergic response (IAR) and airway hyperresponsiveness (AHR) in mouse models of asthma... - Airway hyperresponsiveness in allergically inflamed mice: the role of airway closureLennart K A Lundblad
Vermont Lung Center, The University of Vermont College of Medicine, HSRF 230, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
Am J Respir Crit Care Med 175:768-74. 2007..Allergically inflamed mice exhibit airway hyperresponsiveness to inhaled methacholine, which computer simulations of lung impedance suggest is due to enhanced lung derecruitment and which we sought to verify in the present study... - Parenchymal tethering, airway wall stiffness, and the dynamics of bronchoconstrictionJason H T Bates
University of Vermont College of Medicine, Burlington, VT 05405 0075, USA
J Appl Physiol 102:1912-20. 2007.... - Exaggerated airway narrowing in mice treated with intratracheal cationic proteinJason H T Bates
Vermont Lung Center, University of Vermont College of Medicine, Burlington, VT 05405 0075, USA
J Appl Physiol 100:500-6. 2006.... - The synergistic interactions of allergic lung inflammation and intratracheal cationic proteinJason H T Bates
Vermont Lung Center, Burlington, Vermont, USA
Am J Respir Crit Care Med 177:261-8. 2008..We hypothesized that more severe AHR in mice could be achieved by imbuing them with more than one mechanism of AHR... - Bronchodilatory effect of deep inspiration on the dynamics of bronchoconstriction in miceJason H T Bates
Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont
J Appl Physiol 103:1696-705. 2007.... - Acid aspiration-induced airways hyperresponsiveness in miceGilman B Allen
Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, Vermont, USA
J Appl Physiol 107:1763-70. 2009..We conclude that acid aspiration triggers an acute AHR, driven principally by breakdown of epithelial barrier integrity within the airways... - Modeling the dynamics of recruitment and derecruitment in mice with acute lung injuryChristopher B Massa
Univ of Vermont, HSRF 228, 149 Beaumont Ave, Burlington, VT 05405 0075, USA
J Appl Physiol 105:1813-21. 2008..Our computational model of lung recruitment and derecruitment dynamics is thus capable of accurately mimicking data from mice with acute lung injury and may provide insight into the altered biophysics of the injured lung... - The response to recruitment worsens with progression of lung injury and fibrin accumulation in a mouse model of acid aspirationGilman B Allen
Vermont Lung Center, Department of Medicine, University of Vermont, Burlington, Vermont, USA
Am J Physiol Lung Cell Mol Physiol 292:L1580-9. 2007..This injury manifests as progressively increasing alveolar instability, likely due to surfactant dysfunction caused by increasing levels of alveolar protein and fibrin... - Choosing the frequency of deep inflation in mice: balancing recruitment against ventilator-induced lung injuryGilman B Allen
Vermont Lung Center, Department of Medicine, University of Vermont, Fletcher Allen Health Care, Burlington, VT 05405, USA
Am J Physiol Lung Cell Mol Physiol 291:L710-7. 2006..Differences between LVDI and HV suggest that an optimal frequency range of DI exists, within which the benefits of maintaining an open lung outweigh injury incurred from overdistention... - Oscillation mechanics of the human lung periphery in asthmaDavid A Kaminsky
Vermont Lung Center, Departments of Medicine and Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
J Appl Physiol 97:1849-58. 2004.... - The allergic mouse model of asthma: normal smooth muscle in an abnormal lung?Scott Wagers
Vermont Lung Center, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Appl Physiol 96:2019-27. 2004..This has implications for the pathophysiology of asthma and suggests that at least some types of asthma may benefit from therapies aimed at manipulating surface tension at the air-liquid interface in the lungs... - Inhaled salmeterol and/or fluticasone alters structure/function in a murine model of allergic airways diseaseErik P Riesenfeld
Vermont Lung Center, University of Vermont, Burlington, Vermont, USA
Respir Res 11:22. 2010..We examined the link between physiological function and structural changes following treatment fluticasone and salmeterol separately or in combination in a mouse model of allergic asthma... - Airway and tissue mechanics in a murine model of asthma: alveolar capsule vs. forced oscillationsShinichiro Tomioka
Vermont Lung Center, Fletcher Allen Health Care, Department of Medicine, University of Vermont, Burlington 05405-0075, USA
J Appl Physiol 93:263-70. 2002.... - Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway diseaseJohn F Alcorn
Department of Pathology, University of Vermont, Burlington, Vermont 05405, USA
Am J Respir Crit Care Med 176:974-82. 2007..The cytokine transforming growth factor (TGF)-beta has been shown to have a central role in asthma pathogenesis and in mouse models of allergic airway disease... - Measuring the lung function in the mouse: the challenge of sizeCharles G Irvin
Vermont Lung Center, Department of Medicine, College of Medicine, University of Vermont, Room 226, HSRF, 149 Beaumont Avenue, Burlington, VT 05405, USA
Respir Res 4:4. 2003..These advances, resulting in our current ability to measure sophisticated indices of lung function in laboratory animals, are likely to lead to important insights into the mechanisms of lung disease... - Thoracic gas volume measurements in paralyzed miceLennart K A Lundblad
Vermont Lung Center, University of Vermont, Burlington, VT, USA
Ann Biomed Eng 32:1420-7. 2004..This yielded similar results for V(TG) (0.30+/-0.02 ml) as obtained during spontaneous efforts. Our method may prove particularly useful when paralysis is required for the precise measurement of lung mechanics... - Linking parenchymal disease progression to changes in lung mechanical function by percolationJason H T Bates
Vermont Lung Center, University of Vermont College of Medicine, VT, USA
Am J Respir Crit Care Med 176:617-23. 2007..However, merely ascribing mechanical dysfunction of the parenchyma to the vagaries of lesional organization is unhelpful without some understanding of how the two are linked... - Mechanical determinants of airways hyperresponsivenessJason H T Bates
Vermont Lung Center, University of Vermont College of Medicine, Burlington, VA 05405 0075, USA
Crit Rev Biomed Eng 39:281-96. 2011..Each of these groups of factors has potent potential to influence AHR. It is likely, however, that they operate together to produce the AHR characteristic of severe asthma... - Transient mechanical benefits of a deep inflation in the injured mouse lungGilman Allen
Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, Vermont 05405, USA
J Appl Physiol 93:1709-15. 2002..0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute... - Nonlinear and frequency-dependent mechanical behavior of the mouse respiratory systemHenrique T Moriya
Vermont Lung Center, Department of Medicine and Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405-0075, USA
Ann Biomed Eng 31:318-26. 2003..This model may be useful for detecting overinflation of the lung during mechanical ventilation... - Effects of central airway shunting on the mechanical impedance of the mouse lungBenjamin L Schwartz
Vermont Lung Center, Department of Medicine, University of Vermont, 149 Beaumont Avenue, HSRF 228, Burlington, VT 05405, USA
Ann Biomed Eng 39:497-507. 2011..Nevertheless, we conclude that central airway shunting in mice can sometimes be an important physiological phenomenon... - Electrogram fractionation: the relationship between spatiotemporal variation of tissue excitation and electrode spatial resolutionDaniel D Correa de Sa
Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
Circ Arrhythm Electrophysiol 4:909-16. 2011..Fractionation has been demonstrated to result when there is repetitive or asynchronous activation of separate groups of cells within the recording region of a mapping electrode(s)... - Pulmonary mechanics: a system identification perspectiveJason H T Bates
Division of Pulmonary Critical Care Medicine, Department of Medicine, University of Vermont and Fletcher Allen Health Care, Burlington, VT 05405, USA
Conf Proc IEEE Eng Med Biol Soc 2009:170-2. 2009..Furthermore, these changing parameter values can be linked to specific physical processes occurring within the lungs... - Tumor necrosis factor-alpha overexpression in lung disease: a single cause behind a complex phenotypeLennart K A Lundblad
Vermont Lung Center, University of Vermont College of Medicine, HSRF 230, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
Am J Respir Crit Care Med 171:1363-70. 2005..These effects are currently unclear, because a transgenic mouse overexpressing TNF-alpha in the lung has been shown in separate studies to produce elements of both emphysema and pulmonary fibrosis... - Peak pressures during manual ventilationMohamed Turki
Vermont Lung Center, Fletcher Allen Health Care, University of Vermont, College of Medicine, Burlington 05405-0075, USA
Respir Care 50:340-4. 2005..CONCLUSIONS: The high airway pressure during manual ventilation would be considered extreme in the context of conventional mechanical ventilation, which raises questions about whether manual ventilation causes barotrauma... - Dynamic mechanical consequences of deep inflation in mice depend on type and degree of lung injuryGilman Allen
Department of Medicine, Vermont Lung Center, University of Vermont, Bulington, Vermont 05405 0075, USA
J Appl Physiol 96:293-300. 2004..001). We conclude that the effects of DIs in acute lung injury depend on the degree of lung injury but only to the extent that this injury reflects a disruption of the air-liquid interface... - Animal models of asthmaJason H T Bates
Vermont Lung Center and Center for Immunology and Infectious Disease, University of Vermont College of Medicine, HSRF 228, 149 Beaumont Ave, Burlington, VT 05405 0075, USA
Am J Physiol Lung Cell Mol Physiol 297:L401-10. 2009.... - A breath biofeedback computer game for children with cystic fibrosisPeter M Bingham
University of Vermont, Burlington, USA
Clin Pediatr (Phila) 49:337-42. 2010..026). It was concluded that an electronic breath game is safe and can improve breath awareness among children with CF. This technology could also contribute to awareness of respiratory symptoms and foster social ties among CF patients... - Assessment of peripheral lung mechanicsJason H T Bates
Department of Medicine, University of Vermont College of Medicine, HSRF 228, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
Respir Physiol Neurobiol 163:54-63. 2008..We are now beginning to decipher the relative contributions of these various factors to pathological alterations in peripheral lung mechanics, which may eventually lead to the development and assessment of novel therapies... - A recruitment model of quasi-linear power-law stress adaptation in lung tissueJason H T Bates
Department of Medicine, University of Vermont College of Medicine, HSRF 228, 149 Beaumont Avenue, Burlington, Vermont 05405 0075, USA
Ann Biomed Eng 35:1165-74. 2007..The model suggests that stress relaxation in lung tissue could occur via a sequence of micro-rips that cause stresses to be passed from one local stress bearing region to another... - Physiologic dysfunction of the asthmatic lung: what's going on down there, anyway?Charles G Irvin
Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, VT 05405 0075, USA
Proc Am Thorac Soc 6:306-11. 2009..Together, these recent findings provide a better understanding of the causes of airflow obstruction and AHR, suggesting new avenues for the development of more effective asthma therapies... - Modeling the oscillation dynamics of activated airway smooth muscle stripsJason H T Bates
Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, USA
Am J Physiol Lung Cell Mol Physiol 289:L849-55. 2005..We conclude that the dynamic behavior of airway smooth muscle can be ascribed in large part to an interaction between connective tissue rheology and the force-velocity behavior of contractile proteins... - Effects of electrode size and spacing on the resolution of intracardiac electrogramsJustin M Stinnett-Donnelly
Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA
Coron Artery Dis 23:126-32. 2012..The spatial resolution of an electrode thus plays an important role in mapping complex rhythms... - Measuring lung function in mice: the phenotyping uncertainty principleJason H T Bates
Vermont Lung Center and College of Medicine, University of Vermont, Burlington, Vermont 05405, USA
J Appl Physiol 94:1297-306. 2003..No method is optimal in all regards; therefore, the appropriate technique to use depends on the application... - Quantifying the roles of tidal volume and PEEP in the pathogenesis of ventilator-induced lung injuryAdrian S Seah
Department of Surgery, Fletcher Allen Health Care, Burlington, VT 05405, USA
Ann Biomed Eng 39:1505-16. 2011..Within this plane, non-injurious combinations of Vt and PEEP lie within a "safe region", the boundaries of which shrink as VILI develops... - Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsivenessScott S Wagers
Vermont Lung Center, Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405 0075, USA
J Clin Invest 114:104-11. 2004..These results are consistent with the hypothesis that leakage of fibrinogen and thrombin and their accumulation on the airway surface can contribute to the pathogenesis of airway hyperresponsiveness... - Effects of recruitment/derecruitment dynamics on the efficacy of variable ventilationBaoshun Ma
Vermont Lung Center, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
J Appl Physiol 110:1319-26. 2011..We conclude that the dynamics of recruitment and derecruitment in the lung may be important factors responsible for the benefits of VV compared with CV... - A reevaluation of the validity of unrestrained plethysmography in miceLennart K A Lundblad
Vermont Lung Center, University of Vermont, Burlington, Vermont 05405, USA
J Appl Physiol 93:1198-207. 2002.... - Pulmonary impedance and alveolar instability during injurious ventilation in ratsGilman B Allen
Department of Medicine, Vermont Lung Center, 149 Beaumont Avenue, Burlington, VT 05405 0075, USA
J Appl Physiol 99:723-30. 2005..We conclude that simultaneous increases in both H and eta are reflective of lung injury in the form of alveolar instability, whereas an isolated and reversible increase in H during low Vt reflects merely derecruitment of alveoli... - The estimation of lung mechanics parameters in the presence of pathology: a theoretical analysisJason H T Bates
Vermont Lung Center Departments of Medicine and Molecular Physiology and Biophysics, University of Vermont Burlington, Burlington, VT 05405 0075, USA
Ann Biomed Eng 34:384-92. 2006..We also show that recruitment of closed lung units during lung inflation may lead to variables responses in both eta and E (L)... - Multi-scale lung modelingMerryn H Tawhai
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
J Appl Physiol 110:1466-72. 2011..The art of multi-scale lung modeling thus reduces not to being limitlessly inclusive, but rather to knowing what biological details to leave out... - Lung tissue mechanics as an emergent phenomenonBela Suki
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA
J Appl Physiol 110:1111-8. 2011..Finally, we discuss the inevitability of why lung tissue mechanics need to be complex... - The interface between measurement and modeling of peripheral lung mechanicsJason H T Bates
Vermont Lung Center, University of Vermont College of Medicine, HSRF 228, 149 Beaumont Avenue, Burlington, VT 05405, USA
Respir Physiol Neurobiol 148:153-64. 2005..An increasing body of evidence indicates that constriction in this part of the lung is a crucial determinant of the severity of asthma... - Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammationScott Wagers
Vermont Lung Center, Department of Medicine, University of Vermont, Burlington 05405, USA
J Appl Physiol 92:1802-7. 2002..We speculate that airway closure in the constricted ova/ova mice accentuated the volume-dependent nonlinearity by decreasing lung volume and overdistending the remaining lung... - Modeling the complex dynamics of derecruitment in the lungBaoshun Ma
Vermont Lung Center, Department of Medicine, University of Vermont College of Medicine, 149 Beaumont Ave, HSRF 228, Burlington, VT 05405, USA
Ann Biomed Eng 38:3466-77. 2010.... - On the ill-conditioned nature of the intracardiac inverse problemJason H T Bates
Department of Medicine, University of Vermont and Fletcher Allen Health Care, Burlington, VT 05405, USA
Conf Proc IEEE Eng Med Biol Soc 2009:3929-31. 2009..We discuss ways in which the conditioning of the problem might be improved through the application of constraints on the solution... - Mechanical properties of the lung and upper airways in patients with sleep-disordered breathingEve L Bijaoui
Meakins-Christie Laboratories, McGill University, Montreal, Canada
Am J Respir Crit Care Med 165:1055-61. 2002..Our results suggest that OSAHS may lead to transient abnormalities in the recruitment of lung units and the gas exchanging capacity of the lungs... - Geometric determinants of airway resistance in two isomorphic rodent speciesRute F M Gomes
Meakins-Christie Laboratories, McGill University, 3626 St. Urbain Street, Montreal, Que, H2X 2P2, Canada
Respir Physiol Neurobiol 130:317-25. 2002..We also showed that these differences are due to a combination of differences both in relative airway diameters and in the degree of asymmetry of the airway trees... - Dependence of intrapulmonary pressure amplitudes on respiratory mechanics during high-frequency oscillatory ventilation in preterm lambsJ Jane Pillow
Clinical Sciences Division, Centre for Child Health Research, Subiaco, West Perth, Western Australia
Pediatr Res 52:538-44. 2002.... - Airway hyperresponsiveness induced by cationic proteins in vivo: site of actionToshiaki Homma
Division of Respiratory Disease, University of Tsukuba, Japan
Am J Physiol Lung Cell Mol Physiol 289:L413-8. 2005..Together, these findings suggest that cationic proteins alter airway responsiveness in vivo by an effect that is apparently limited to the bronchial epithelium... - How should airway smooth muscle be punished for causing asthma?Jason H T Bates
J Appl Physiol 104:575-6. 2008 - Point:Counterpoint: lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary diseaseJason H T Bates
J Appl Physiol 103:1900-1; discussion 1904. 2007 - The "Goldilocks effect" in cystic fibrosis: identification of a lung phenotype in the cftr knockout and heterozygous mouseJ Craig Cohen
Departments of Medicine and Physiology, Louisiana State University, School of Medicine, New Orleans, LA, 70112 USA
BMC Genet 5:21. 2004..However, knockout in the mouse of cftr, the gene whose mutant alleles are responsible for cystic fibrosis, has previously failed to produce a readily, quantifiable lung phenotype... - Time course of airway mechanics of the (+)insert myosin isoform knockout mouseStephanie A Tuck
Meakins Christie Laboratories, Department of Medicine, McGill University, 3626 St Urbain St, Montreal, PQ, H2X 2P2 Canada
Am J Respir Cell Mol Biol 30:326-32. 2004..8 +/- 5.6%. We conclude that the presence of the (+)insert myosin isoform in the airways increases the rate of bronchoconstriction... - Mechanical properties of mouse distal lung: in vivo versus in vitro comparisonAnita Fust
Meakins Christie Laboratories, McGill University, 3626 St. Urbain Street, Montreal, Que, Canada H2X 2P2
Respir Physiol Neurobiol 143:77-86. 2004..003). The higher values of eta in vivo may represent the effects of airway heterogeneities, surfactant, or changes in alveolar geometry. Measurement of mechanics in the tissue strip offers a better assessment of pure tissue properties... - On the terminology for describing the length-force relationship and its changes in airway smooth muscleTony R Bai
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
J Appl Physiol 97:2029-34. 2004..We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously... - Alpha1-antitrypsin determines the pattern of emphysema and function in tobacco smoke-exposed mice: parallels with human diseaseYasutaka Takubo
Respiratory Division, Royal Victoria Hospital, Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada
Am J Respir Crit Care Med 166:1596-603. 2002.... - Emergency medicineJason H T Bates
J Appl Physiol 104:1849; author reply 1851. 2008