Research Topics
| K T BarnhartSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL)Kurt T Barnhart
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Contraception 72:65-70. 2005..Most linear spreading took place in the first 5 min after insertion, although lateral spreading continued to increase with time especially when ambulation took place. Leakage and gel was not a significant problem at either volume...- Participant characteristics associated with withdrawal from a large randomized trial of spermicide effectivenessElizabeth G Raymond
Family Health International, Research Triangle Park, NC, USA
BMC Med Res Methodol 4:23. 2004..The objective of this analysis was to explore characteristics of participants who failed to complete seven months of planned participation in a trial of spermicide efficacy... - Diagnostic accuracy of ultrasound above and below the beta-hCG discriminatory zoneK T Barnhart
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 10104, USA
Obstet Gynecol 94:583-7. 1999.... - Vaginal distribution of miconazole nitrate suspension from administration of a single vaginal insertKurt Barnhart
Reproductive Research Unit, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Reprod Med 49:83-8. 2004.... - Hormone pattern after misoprostol administration for a nonviable first-trimester gestationKurt T Barnhart
University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 5509, USA
Fertil Steril 81:1099-105. 2004..To evaluate serial hormone concentrations in subjects treated with vaginally administered misoprostol for early pregnancy failure... - Lesson learned and dispelled myths: three-dimensional imaging of the human vaginaKurt T Barnhart
Department of Obstetrics and Gynecology, and Senior Scholar, Center Clinical Epidemiology and Biostatistics, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Fertil Steril 81:1383-4. 2004..Three-dimensional imaging of the human vagina demonstrates that the cross section can be a "W," rather than an "H," and that intravaginal gel can ascend into the endocervix and presumably into the endometrium... - Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefinedKurt T Barnhart
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Obstet Gynecol 104:50-5. 2004..To analyze the change in serial human chorionic gonadotropin (hCG) levels in women symptomatic with pain or bleeding who presented with nondiagnostic ultrasonography but were ultimately confirmed to have a viable intrauterine pregnancy... - Microbiology of the endometrium and in vitro fertilization: do we yet understand the implications?Kurt T Barnhart
Penn Fertility Care and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Fertil Steril 82:797-8. 2004..The hypothesis that bacteria in the uterus may be detrimental to an embryo is very thought provoking. The data, however, do not yet support that this is a clinically relevant issue... - Decline of serum human chorionic gonadotropin and spontaneous complete abortion: defining the normal curveKurt Barnhart
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Obstet Gynecol 104:975-81. 2004..We sought to estimate a standard curve of serum human chorionic gonadotropin (hCG) decline that characterizes spontaneous abortion... - Distribution of a 3.5-mL (1.0%) C31G vaginal gel using magnetic resonance imagingKurt T Barnhart
Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Contraception 71:357-61. 2005..Repeat application of the gel may be necessary if intercourse has not occurred within the first few hours after initial insertion... - In vivo assessment of NuvaRing placementKurt T Barnhart
Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
Contraception 72:196-9. 2005..In vivo, NuvaRing is compressed laterally forming a gentle oval in the anterior-posterior direction (5-7 mm longer than wide), an effect that is seen more in nulliparous women... - The optimal analysis of MRI data to quantify the distribution of a microbicideKurt T Barnhart
Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, 19104, USA
Contraception 73:82-7. 2006..The objective of this study was to systematically review the use of MRI for the evaluation of deployment characteristics of vaginal microbicides and to understand the relationship of gel spread with potential influencing factors... - Baseline dimensions of the human vaginaKurt T Barnhart
Penn Fertility Care, Department of Obstetrics and Gynecology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
Hum Reprod 21:1618-22. 2006..Vaginal anatomy has been poorly studied. This study aimed to measure baseline dimensions of the undistended vagina of women of reproductive age... - Acute and chronic presentation of ectopic pregnancy may be two clinical entitiesKurt T Barnhart
Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 80:1345-51. 2003..The purpose of this study is to analyze whether these clinical presentations represent a spectrum of disease... - The medical management of ectopic pregnancy: a meta-analysis comparing "single dose" and "multidose" regimensKurt T Barnhart
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Obstet Gynecol 101:778-84. 2003..This analysis systematically compares the success and prevalence of side effects of these two regimens... - Risk factors for ectopic pregnancy in women with symptomatic first-trimester pregnanciesKurt T Barnhart
Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, USA
Fertil Steril 86:36-43. 2006..To evaluate the association between ectopic pregnancy (EP) and clinical and historical factors among women presenting with pain and/or bleeding in early pregnancy... - In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercourseKurt Thomas Barnhart
Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Contraception 70:498-505. 2004..Simulated intercourse greatly enhances gel spread. After simulated intercourse, the distribution of the gel at each volume was similar. Less leakage of gel was reported with the smaller volume... - Distribution of topical medication in the human vagina as imaged by magnetic resonance imagingK Barnhart
Department of Obstetrics and Gynecology, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania, USA
Fertil Steril 76:189-95. 2001..To assess the use of magnetic resonance imaging (MRI) to determine the varying distribution of a vaginally placed gel over time and with different levels of patient activity... - Distribution of a spermicide containing Nonoxynol-9 in the vaginal canal and the upper female reproductive tractK T Barnhart
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Hum Reprod 16:1151-4. 2001..This finding suggests that topical microbicides/spermicides may act both in the vaginal canal and in the upper female genital tract... - The truth is out there: a guide to the pitfalls of interpreting evidence-based medicine in studies of human reproductionKurt Barnhart
Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
Fertil Steril 77:223-8. 2002 - Effect of endometriosis on in vitro fertilizationKurt Barnhart
Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center and Health System, Philadelphia, Pennsylvania, USA
Fertil Steril 77:1148-55. 2002..To investigate the IVF outcome for patients with endometriosis... - The pharmacology of methotrexateK Barnhart
Division of Human Reproduction, Department of Obstetrics and Gynecology, 106 Dulles, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA
Expert Opin Pharmacother 2:409-17. 2001..As the efficacy of MTX therapy is not 100%, women must be followed clinically until there is compete resolution of human Chorionic Gonadotropin (hCG) titres from their serum... - Role of periovulatory luteinizing hormone concentrations during assisted reproductive technology cycles stimulated exclusively with recombinant follicle-stimulating hormoneM A Esposito
Center for Reproductive Medicine and Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, USA
Fertil Steril 75:519-24. 2001..It may be of clinical benefit, when exclusively using r-hFSH in ART cycles, to add LH in the late follicular phase or to further reduce the dose of GnRH agonist... - Diagnosing ectopic pregnancy: decision analysis comparing six strategiesC R Gracia
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 10104, USA
Obstet Gynecol 97:464-70. 2001..Ultrasound as the first step was the most efficient and accurate method of diagnosing ectopic pregnancies... - Hormone therapy and coronary heart disease in young womenMark G Weiner
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Menopause 15:86-93. 2008..Given the similarity between our UK General Practice Research Database (GPRD) study of older women and the WHI RCT, the GPRD methodology was used to study a cohort of younger women... - The effect of ambulation on vaginal distribution of miconazole nitrate (1200 mg)Seema Menon
Reproductive Research Unit, Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Womens Health (Larchmt) 16:703-6. 2007..To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis... - Does a prediction model for pregnancy of unknown location developed in the UK validate on a US population?K T Barnhart
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania, 3701 Market Street, Suite 800, Philadelphia, PA 19104, USA
Hum Reprod 25:2434-40. 2010..The purpose of this paper was to assess the utility of this model to predict the outcome for a woman (PUL) in a US population... - Race, socioeconomic status, and response to methotrexate treatment of ectopic pregnancy in an urban populationSamantha F Butts
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 94:2789-92. 2010..In this retrospective cohort study, a racial disparity in methotrexate effectiveness was not found, but a significant relationship between low socioeconomic status and methotrexate failure was demonstrated... - Estrogen affects post-menopausal women differently than estrogen plus progestin replacement therapyRichard L Tannen
Department of Medicine, University of Pennsylvaniua School of Medicine, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
Hum Reprod 22:1769-77. 2007..Since we previously reasonably replicated the combined estrogen-progestin WHI RCT using the UK General Practice Research Database (GPRD), estrogen-only treatment was investigated using a similar methodology... - Correlation of telomere length and telomerase activity with occult ovarian insufficiencySamantha Butts
Division of Infertility and Reproductive Endocrinology, University of Pennsylvania Medical School, 3701 Market Street, Suite 800, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 94:4835-43. 2009..Abnormalities in telomere length and telomerase activity in human granulosa cells may serve as molecular markers for this condition... - A randomized trial to determine the distribution of four topical gel formulations in the human vaginaKurt Barnhart
Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
Contraception 79:297-303. 2009..We compared distribution and acceptability of four different gel formulations to be used as a vehicle for a microbicide... - Return to fertility after cessation of a continuous oral contraceptiveKurt Barnhart
Department of Obstetrics and Gynecology, Penn Fertility Care, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Fertil Steril 91:1654-6. 2009..To evaluate the return to fertility among women planning to become pregnant after the use of a continuous regimen of levonorgestrel 90 microg and ethinyl E(2) 20 microg... - Patient acceptability of manual versus electric vacuum aspiration for early pregnancy lossScott Edwards
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Womens Health (Larchmt) 16:1429-36. 2007.... - Use of "2-dose" regimen of methotrexate to treat ectopic pregnancyKurt Barnhart
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 87:250-6. 2007..To evaluate the safety and acceptability of a novel dosing regimen of methotrexate to treat ectopic pregnancy... - The clinical rationale for menses-free contraceptionKat Lin
Reproductive Research Unit, Center for Reproductive Medicine and Surgery, University of Pennsylvania, Philadelphia, PA 19107, USA
J Womens Health (Larchmt) 16:1171-80. 2007.... - Safety and efficacy of bedtime versus daytime administration of the miconazole nitrate 1200 mg vaginal ovule insert to treat vulvovaginal candidiasisKurt Barnhart
Reproductive Research Unit, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Curr Med Res Opin 21:127-34. 2005..Safety, efficacy, and ' therapeutic cure with bedtime versus daytime treatment of vulvovaginal candidiasis (VVC) were assessed to potentially improve compliance and convenience with vaginal antifungal treatment... - A simulation using data from a primary care practice database closely replicated the women's health initiative trialRichard L Tannen
Department of Medicine, University of Pennsylvania School of Medicine, 295 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
J Clin Epidemiol 60:686-95. 2007..To assess the validity of a novel observational study design, we compared the WHI RCT with a simulation using data from the United Kingdom General Practice Research Database (GPRD)... - Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourseE Scott Pretorius
Departments of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Contraception 66:443-51. 2002..simulated intercourse, or on post-intercourse scans of 3 mL versus 5 mL. MRI is a sensitive, reproducible means of tracking the spread of intravaginal medications... - Use of MRI to determine the in vivo position of a silicone vaginal barrier contraceptive deviceE Scott Pretorius
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Contraception 65:343-6. 2002..After insertion, the Lea's Shield occupies the upper vagina and completely covers the cervix... - A moderately elevated day 3 FSH concentration has limited predictive value, especially in younger womenM A Esposito
Division of Human Reproduction, Center for Reproductive Medicine and Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA
Hum Reprod 17:118-23. 2002..CONCLUSIONS: Much of the predictive value of an elevated FSH is confounded by poor response to gonadotrophin stimulation, which may be overcome in younger women... - Prophylactic methotrexate after linear salpingostomy: a decision analysisC R Gracia
Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Fertil Steril 76:1191-5. 2001..3%. CONCLUSION(S): Prophylactic methotrexate at the time of linear salpingostomy for the treatment of ectopic pregnancy is preferable to observation as long as certain conditions exist... - Defining the curve when initial levels of human chorionic gonadotropin in patients with spontaneous abortions are lowKarine Chung
Penn Fertility Care, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Fertil Steril 85:508-10. 2006..When initial levels lie between 50 and 500 mIU/mL, the slowest expected percentage decline ranges from 12% to 24% in 2 days and from 34% to 68% in 7 days... - Is factor V Leiden mutation a cause of in vitro fertilization failure?Briana Rudick
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California, USA
Fertil Steril 92:1256-9. 2009..6%) and had a preliminarily positive association with pregnancy, suggesting that routine testing in a general IVF population for FVL mutation as a cause of IVF failure and infertility is not indicated... - Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthoodB L Strom
University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics, 824 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
JAMA 286:807-14. 2001..However, a paucity of data exists on the long-term effects of infant soy formulas... - Safety analysis of the diaphragm in combination with lubricant or acidifying microbicide gels: effects on markers of inflammation and innate immunity in cervicovaginal fluidDeborah J Anderson
Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany St, Suite 516, Boston, MA 02118, USA
Am J Reprod Immunol 61:121-9. 2009..The purpose of this study was to determine whether use of a diaphragm with microbicide or placebo gel causes cervicovaginal inflammation or perturbations in cervicovaginal immune defense... - Reliability of clinicians versus radiologists for detecting abnormalities on hysterosalpingogram filmsLinda Renbaum
Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19104, USA
Fertil Steril 78:614-8. 2002..Clinicians more reliably diagnose hydrosalpinx and tubal obstruction, while radiologists more reliably detect the more subtle findings of salpingitis isthmica nodosa or uterine adhesions... - Misoprostol for treatment of early pregnancy failure in women with previous uterine surgeryBeatrice A Chen
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, and Magee Womens Research Institute, Pittsburgh, PA, USA
Am J Obstet Gynecol 198:626.e1-5. 2008..Misoprostol use in early pregnancy may incur a risk of uterine rupture in women with previous uterine surgery... - Risk factors and clinical features of recurrent ectopic pregnancy: a case control studySamantha Butts
Center for Reproductive Medicine and Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 80:1340-4. 2003..Clinicians' ability to both diagnose and counsel patients at risk for recurrent ectopic pregnancy can be optimized by awareness of the clinical features of this condition... - Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile womenEvan R Myers
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710, USA
Fertil Steril 82:1278-82. 2004..To assess effects of biopsy timing and fertility status on inter- and intraobserver variability in dating of the endometrium... - Human chorionic gonadotropin profile for women with ectopic pregnancyCelso Silva
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Obstet Gynecol 107:605-10. 2006..The hCG profile in women with ectopic pregnancy can mimic that of an intrauterine pregnancy or a completed spontaneous abortion in approximately 29% of cases. LEVEL OF EVIDENCE: II-2... - Cost-effectiveness of inhaled nitric oxide for the management of persistent pulmonary hypertension of the newbornScott A Lorch
Department of Pediatrics, Center for Outcomes Research, Children s Hospital of Philadelphia, 3535 Market St, Ste 1029, Philadelphia, Pennsylvania 19104, USA
Pediatrics 114:417-26. 2004..The objective of this study was to evaluate the economic impact of adding iNO to the treatment protocol of PPHN for term infants from birth to the time of discharge from their initial hospitalization... - Bleeding patterns after misoprostol vs surgical treatment of early pregnancy failure: results from a randomized trialAnne R Davis
Columbia University, Department of Obstetrics and Gynecology, 622 West 168th St, PH 16 Room 80, New York, NY 10032, USA
Am J Obstet Gynecol 196:31.e1-7. 2007..The purpose of this study was to describe bleeding patterns after misoprostol or curettage for early pregnancy failure (EPF)... - Comparative crossover study of the PATH Woman's Condom and the FC Female CondomJill L Schwartz
Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Contraception 78:465-73. 2008..The Program for Appropriate Technology in Health (PATH) Woman's Condom (WC) was developed in an effort to overcome these obstacles...