Research Topics
Species | H BagavantSummaryAffiliation: University of Virginia Country: USA Publications
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Publications
Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodesHarini Bagavant
Department of Internal Medicine, Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 177:8258-65. 2006..This T cell activation and infiltration are influenced by gender-dependent end-organ factors and may determine the progression of acute GN to chronic GN and renal failure...- Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitisHarini Bagavant
Department of Pathology and University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 175:944-50. 2005..After d3tx, the proliferative GN of female mice progressed to fatal GN, but largely regressed in the male, thereby revealing a checkpoint in lupus GN progression that depends on gender... - Novel therapeutic approaches to lupus glomerulonephritis: translating animal models to clinical practiceHarini Bagavant
Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
Am J Kidney Dis 57:498-507. 2011..This review describes recently developed targeted drug delivery technologies and potential targets that can regulate glomerular cell responses, offering a novel therapeutic approach for lupus nephritis... - Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal diseaseHarini Bagavant
Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
Am J Pathol 179:651-60. 2011..Our study shows that some of these factors are regulated by ID3. Thus, ID3 is a novel risk factor linking cardiovascular and renal disease... - Differential effect of neonatal thymectomy on systemic and organ-specific autoimmune diseaseHarini Bagavant
Health Sciences Center, Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
Int Immunol 14:1397-406. 2002..Therefore, d3tx paradoxically protects SNF1 mice from genetically prone lupus-like GN, yet promotes de novo organ-specific autoimmunity... - Induction and immunohistology of autoimmune ovarian disease in cynomolgus macaques (Macaca fascicularis)Harini Bagavant
Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
Am J Pathol 160:141-9. 2002..The results are discussed in the context of complications of ZP-based human immunocontraceptive vaccines and case reports of human autoimmune oophoritis... - Autoimmune ovarian inflammation triggered by proinflammatory (Th1) T cells is compatible with normal ovarian function in miceH Bagavant
Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
Biol Reprod 61:635-42. 1999..Despite these changes, fertility rates and gonadotropin-induced follicular development remained essentially normal. Therefore, normal ovarian function is compatible with severe ovarian inflammation mediated by autoreactive T cells... - Autoimmune ovarian disease: mechanism of induction and preventionK S Tung
Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
J Soc Gynecol Investig 8:S49-51. 2001..Future studies should determine the applicability of these findings to human ovarian autoimmunity... - Genetic complementation results in augmented autoantibody responses to lupus-associated antigensDavis L Sim
Department of Microbiology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
J Immunol 183:3505-11. 2009..In NZM/NOD F(1) mouse, genetic complementation between NZM and NOD genes leads to expression of phenotypes similar to those seen in certain lupus patients... - Autoimmune ovarian disease induced by immunization with zona pellucida (ZP3) peptideKenneth Tung
University of Virginia, Charlottesville, Virginia, USA
Curr Protoc Immunol . 2002..Surgical procedures are included for adult oophrectomy, neonatal ovariectomy, and implantation of ovarian grafts into mice without endogenous ovaries... - Immunogenicity and contraceptive potential of a human zona pellucida 3 peptide vaccineH Bagavant
Department of Pathology, University of Virginia, Charlottesville 22908, USA
Biol Reprod 56:764-70. 1997.... - Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigensChao Jiang
Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Immunol 184:1085-91. 2010..In addition, our findings provide insights into the origin of the anti-dsDNA Abs often detected in patients with systemic lupus erythematosus... - Pathogenesis of kidney disease in systemic lupus erythematosusHarini Bagavant
Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
Curr Opin Rheumatol 21:489-94. 2009..A combination of systemic autoimmunity and tissue response to immune injury underlie renal involvement in lupus erythematosus. In this review, we discuss recent literature investigating pathogenetic mechanisms of lupus glomerulonephritis... - Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland functionUmesh S Deshmukh
Division of Rheumatology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Oral Pathol Med 38:42-7. 2009..As viral infections are considered to be a trigger for SS, in this study we investigated whether in vivo engagement of TLR3 affects salivary gland function... - A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreadingUmesh S Deshmukh
Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 178:2565-71. 2007..Thus caution must be taken in the identification of Ags responsible for initiating autoimmune responses based solely on serological analysis of patients and animals with systemic autoimmune disorders... - Role of anti-DNA antibodies in the pathogenesis of lupus nephritisUmesh S Deshmukh
Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
Autoimmun Rev 5:414-8. 2006..Thus, reactivity to dsDNA should be considered as one of the characteristic of polyreactive autoantibodies and not a primary requisite for the pathogenesis of lupus nephritis... - Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritisSamuel T Waters
The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Exp Med 199:255-64. 2004..These results reaffirm that anti-dsDNA and related Ab production and chronic glomerulonephritis are under independent genetic control. These findings have significant implications in the pathogenesis of systemic lupus erythematosus... - Epitope spreading within lupus-associated ribonucleoprotein antigensUmesh S Deshmukh
Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, Department of Internal Medicine, HSC Box 800412, University of Virginia, Charlottesville, VA 22908, USA
Clin Immunol 117:112-20. 2005..This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis... - Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren's syndrome-like diseaseS R Nandula
Division of Nephrology, Center for Immunity Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
Oral Dis 17:801-7. 2011..This study was undertaken to investigate the effects of innate immunity activation on sialoadenitis in a mouse strain genetically susceptible for development of SS-like disease... - Lupus glomerulonephritis revisited 2004: autoimmunity and end-organ damageH Bagavant
The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Scand J Immunol 60:52-63. 2004..The data discussed in this review call for a re-evaluation of the current paradigms for pathogenesis of SLE. An interactive model separating autoimmunity from end-organ susceptibility for the pathogenesis of SLE is proposed... - Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cellsYulius Y Setiady
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
Blood 107:1056-62. 2006..We conclude that the physiologic autoAg quickly and continuously enhances disease-specific polyclonal Treg function to maintain self-tolerance... - Anti-alpha8 integrin immunoliposomes in glomeruli of lupus-susceptible mice: a novel system for delivery of therapeutic agents to the renal glomerulus in systemic lupus erythematosusYogesh Scindia
University of Virginia, Charlottesville, VA 22908, USA
Arthritis Rheum 58:3884-91. 2008..This study was undertaken in a mouse model of lupus GN to identify mesangial markers and to develop a system for targeted drug delivery to the glomerulus... - The role of Fas in the immune system biology of IL-2R alpha knockout mice: interplay among regulatory T cells, inflammation, hemopoiesis, and apoptosisRahul Sharma
Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 0412, USA
J Immunol 175:1965-73. 2005.... - Inflammatory stimuli accelerate Sjögren's syndrome-like disease in (NZB x NZW)F1 miceUmesh S Deshmukh
University of Virginia, Charlottesville, VA 22908, USA
Arthritis Rheum 58:1318-23. 2008..This study was undertaken to determine whether induction of systemic inflammation accelerates the development of Sjögren's syndrome (SS) in genetically susceptible mice... - New insights from murine lupus: disassociation of autoimmunity and end organ damage and the role of T cellsHarini Bagavant
Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, 22908, USA
Curr Opin Rheumatol 17:523-8. 2005..Thus, murine models provide new insights into the pathogenesis of systemic lupus erythematosus...
Research Grants
- Regulatory T cells in Systemic Lupus ErythematosusHarini Bagavant; Fiscal Year: 2007..This award will help to overcome the lag period in my career induced by my leave of absence and return to a new field of study, and will facilitate my aim of becoming an independent scientist. ..
- Autoimmunity and Pathogenesis of GlomerulonephritisHarini Bagavant; Fiscal Year: 2010..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
- Autoimmunity and Pathogenesis of GlomerulonephritisHarini Bagavant; Fiscal Year: 2009..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..