Justin Ashworth

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Computational redesign of endonuclease DNA binding and cleavage specificity
    Justin Ashworth
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Nature 441:656-9. 2006
  2. ncbi Assessment of the optimization of affinity and specificity at protein-DNA interfaces
    Justin Ashworth
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 37:e73. 2009
  3. ncbi Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
    Justin Ashworth
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 38:5601-8. 2010
  4. ncbi Exploitation of binding energy for catalysis and design
    Summer B Thyme
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Nature 461:1300-4. 2009
  5. ncbi RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite
    Sarel J Fleishman
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e20161. 2011
  6. ncbi Thermodynamics of DNA target site recognition by homing endonucleases
    Jennifer H Eastberg
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, A3 025 Seattle, WA 98109, USA
    Nucleic Acids Res 35:7209-21. 2007
  7. ncbi Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics
    Raynard L Bateman
    Arthur F Scott Laboratory of Chemistry, Reed College, 3203 SE Woodstock Blvd, Portland, OR 97202, USA
    Biochem J 402:251-60. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Computational redesign of endonuclease DNA binding and cleavage specificity
    Justin Ashworth
    Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Nature 441:656-9. 2006
    ..These results suggest that computational protein design methods can have an important role in the creation of novel highly specific endonucleases for gene therapy and other applications...
  2. ncbi Assessment of the optimization of affinity and specificity at protein-DNA interfaces
    Justin Ashworth
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 37:e73. 2009
    ..The approach provides a complement to traditional methods of mutational analysis, and should be useful for rapidly formulating hypotheses about the roles of amino acid residues in protein-DNA interfaces...
  3. ncbi Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
    Justin Ashworth
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Nucleic Acids Res 38:5601-8. 2010
    ....
  4. ncbi Exploitation of binding energy for catalysis and design
    Summer B Thyme
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Nature 461:1300-4. 2009
    ..Our results illustrate how classical enzymology and modern protein design can each inform the other...
  5. ncbi RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite
    Sarel J Fleishman
    Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e20161. 2011
    ....
  6. ncbi Thermodynamics of DNA target site recognition by homing endonucleases
    Jennifer H Eastberg
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, A3 025 Seattle, WA 98109, USA
    Nucleic Acids Res 35:7209-21. 2007
    ....
  7. ncbi Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics
    Raynard L Bateman
    Arthur F Scott Laboratory of Chemistry, Reed College, 3203 SE Woodstock Blvd, Portland, OR 97202, USA
    Biochem J 402:251-60. 2007
    ..These potent inhibitors provide a means to chemically phenocopy the metabolic defects of either HT1 or FAH knockout mice and promise future pharmacological utility for hepatocyte transplantation...