WILLIAM AREND

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Biological role of interleukin 1 receptor antagonist isoforms
    W P Arend
    Division of Rheumatology, University of Colorado Health Sciences Center, Denver, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Ann Rheum Dis 59:i60-4. 2000
  2. ncbi The development of anticytokine therapeutics for rheumatic diseases
    William P Arend
    University of Colorado School of Medicine, Denver, CO, USA
    Arthritis Rheum 58:S102-9. 2008
  3. ncbi Cytokines in the rheumatic diseases
    William P Arend
    Division of Rheumatology, University of Colorado Health Sciences Center B1115, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Rheum Dis Clin North Am 30:41-67, v-vi. 2004
  4. ncbi IL-1, IL-18, and IL-33 families of cytokines
    William P Arend
    Division of Rheumatology, University of Colorado Denver, School of Medicine, Denver, CO, USA
    Immunol Rev 223:20-38. 2008
  5. ncbi Physiologic role of interleukin-1 receptor antagonist
    W P Arend
    Division of Rheumatology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Arthritis Res 2:245-8. 2000
  6. ncbi The mode of action of cytokine inhibitors
    William P Arend
    University of Colorado Health Sciences Center, Denver 80262, USA
    J Rheumatol Suppl 65:16-21. 2002
  7. ncbi The balance between IL-1 and IL-1Ra in disease
    William P Arend
    B115 Division of Rheumatology, Health Sciences Centre, University of Colorado, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cytokine Growth Factor Rev 13:323-40. 2002
  8. ncbi Mechanisms of effects of complement inhibition in murine collagen-induced arthritis
    Nirmal K Banda
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arthritis Rheum 46:3065-75. 2002
  9. ncbi Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis
    Nirmal K Banda
    Divisions of Rheumatology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 177:1904-12. 2006
  10. ncbi Intracellular IL-1 receptor antagonist type 1 inhibits IL-1-induced cytokine production in keratinocytes through binding to the third component of the COP9 signalosome
    Nirmal K Banda
    Division of Rheumatology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 20262, USA
    J Immunol 174:3608-16. 2005

Research Grants

  1. ROLE OF INTERLEUKIN-1 INHIBITOR--INFLAMMATORY SYNOVITIS
    WILLIAM AREND; Fiscal Year: 1992
  2. IL1 RECEPTOR ANTAGONIST INTRACELLULAR VARIANTS
    WILLIAM AREND; Fiscal Year: 2003

Collaborators

Detail Information

Publications19

  1. ncbi Biological role of interleukin 1 receptor antagonist isoforms
    W P Arend
    Division of Rheumatology, University of Colorado Health Sciences Center, Denver, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Ann Rheum Dis 59:i60-4. 2000
    ..Restoration of the balance between IL1Ra and IL1 through a variety of approaches is a therapeutic goal in specific chronic inflammatory diseases...
  2. ncbi The development of anticytokine therapeutics for rheumatic diseases
    William P Arend
    University of Colorado School of Medicine, Denver, CO, USA
    Arthritis Rheum 58:S102-9. 2008
  3. ncbi Cytokines in the rheumatic diseases
    William P Arend
    Division of Rheumatology, University of Colorado Health Sciences Center B1115, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Rheum Dis Clin North Am 30:41-67, v-vi. 2004
    ..This article summarizes the role of cytokines in rheumatic diseases by focusing on each disease and the involved pathways of pathophysiology...
  4. ncbi IL-1, IL-18, and IL-33 families of cytokines
    William P Arend
    Division of Rheumatology, University of Colorado Denver, School of Medicine, Denver, CO, USA
    Immunol Rev 223:20-38. 2008
    ..IL-18 provides an important link between the innate and adaptive immune responses. Newly described IL-33 binds to the orphan IL-1 family receptor T1/ST2 and stimulates T-helper 2 responses as well as mast cells...
  5. ncbi Physiologic role of interleukin-1 receptor antagonist
    W P Arend
    Division of Rheumatology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Arthritis Res 2:245-8. 2000
    ..Thus, an imbalance between IL-1 and IL-1Ra may predispose to local inflammatory disease in particular tissues in the presence of other as yet unknown genetically influenced factors...
  6. ncbi The mode of action of cytokine inhibitors
    William P Arend
    University of Colorado Health Sciences Center, Denver 80262, USA
    J Rheumatol Suppl 65:16-21. 2002
    ..However, these differential actions have not been borne out in clinical trials, where TNF-alpha blockers and anakinra similarly reduce clinical signs and symptoms of RA as well as slow radiographic evidence of disease progression...
  7. ncbi The balance between IL-1 and IL-1Ra in disease
    William P Arend
    B115 Division of Rheumatology, Health Sciences Centre, University of Colorado, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cytokine Growth Factor Rev 13:323-40. 2002
    ..Treatment of RA with daily subcutaneous injections of recombinant IL-1Ra protein has been shown to be efficacious. Gene therapy approaches with IL-1Ra are being evaluated for the treatment of RA and other human diseases...
  8. ncbi Mechanisms of effects of complement inhibition in murine collagen-induced arthritis
    Nirmal K Banda
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Arthritis Rheum 46:3065-75. 2002
    ..The greater inhibitory effects on CIA of anti-C5 antibody in comparison with Crry-Ig may be attributable primarily to decreased levels of IL-1beta and TNFalpha mRNA in the joints...
  9. ncbi Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis
    Nirmal K Banda
    Divisions of Rheumatology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 177:1904-12. 2006
    ..The mechanisms by which these target organ-specific mAbs bypass the requirements for engagement of the classical pathway remain to be defined but do not appear to involve a lack of alternative pathway regulatory proteins...
  10. ncbi Intracellular IL-1 receptor antagonist type 1 inhibits IL-1-induced cytokine production in keratinocytes through binding to the third component of the COP9 signalosome
    Nirmal K Banda
    Division of Rheumatology, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 20262, USA
    J Immunol 174:3608-16. 2005
    ..Thus, icIL-1Ra1 exhibits unique anti-inflammatory properties inside cells through binding to CSN3 with subsequent inhibition of the p38 MAPK signal transduction pathway...
  11. ncbi Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase
    Aron D Ross
    National Jewish Medical and Research Center, Denver, Colorado, USA
    Arthritis Rheum 50:3702-11. 2004
    ..To examine the influence of superoxide on the severity of collagen-induced arthritis (CIA) in mice...
  12. ncbi Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y
    Nirmal K Banda
    Division of Rheumatology, University of Colorado Health Sciences Center, Denver, CO 80262 BolderPATH, Boulder, CO 80309, USA
    J Immunol 171:2109-15. 2003
    ..These results suggest that suppression of CIA in Crry-Tg mice may be due to enhanced synthesis of Crry locally in the joint with decreased production of proinflammatory cytokines...
  13. ncbi Mice transgenic for intracellular interleukin-1 receptor antagonist type 1 are protected from collagen-induced arthritis
    Gaby Palmer
    Division of Rheumatology, University Hospital, Geneva, Switzerland
    Eur J Immunol 33:434-40. 2003
    ..In conclusion, icIL-1Ra1, which is released into the extracellular space when produced in high amounts, has a similar anti-arthritic effect as sIL-1Ra...
  14. ncbi Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein
    Nirmal K Banda
    Division of Rheumatology, Health Sciences Center, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 170:2100-5. 2003
    ..The mechanisms of mIL-18BP inhibition of CIA include reductions in cell-mediated and humoral immunity to collagen as well as decreases in production of proinflammatory cytokines in the spleen and joints...
  15. ncbi Generation and characterization of mice transgenic for human IL-18-binding protein isoform a
    Giamila Fantuzzi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 74:889-96. 2003
    ..These results indicate that high endogenous levels of IL-18BP in trangenic mice effectively neutralize IL-18 and are protective in response to different inflammatory stimuli...
  16. ncbi Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways
    Chrystelle Garat
    Division of Rheumatology, Department of Medicine, University of Colorado Health Sciences Center B115, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cytokine 23:31-40. 2003
    ..This intracellular anti-inflammatory activity of icIL-1Ra1 was mediated through inhibition of p38 MAP kinase and NF-kappaB signal transduction pathways...
  17. ncbi Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
    Kristine A Kuhn
    Department of Immunology and Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 116:961-73. 2006
    ..These results demonstrate that antibodies against citrullinated proteins are centrally involved in the pathogenesis of autoimmune arthritis...
  18. ncbi Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis
    Shailaja S Bhatia
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, 4200 East Ninth Avenue, Box B119, Denver, CO 80262, USA
    Ann Rheum Dis 66:267-9. 2007
    ..To examine whether oral contraceptive use is associated with the presence of serum rheumatoid factor in women of reproductive age without rheumatoid arthritis...
  19. ncbi Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway
    Nirmal K Banda
    Division of Rheumatology B115, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Immunol 179:4101-9. 2007
    ..These results indicate that the alternative pathway amplification loop, with its ability to greatly enhance C3 activation, is necessary to mediate inflammatory arthritis induced by adherent immune complexes...

Research Grants13

  1. ROLE OF INTERLEUKIN-1 INHIBITOR--INFLAMMATORY SYNOVITIS
    WILLIAM AREND; Fiscal Year: 1992
    ..These proposed studies should provide important information on the mechanisms of regulation of production of an IL 1 inhibitor by human monocytes and synovial macrophages...
  2. IL1 RECEPTOR ANTAGONIST INTRACELLULAR VARIANTS
    WILLIAM AREND; Fiscal Year: 2003
    ..Not only does sIL-1Ra inhibit the binding of IL-1 to cell surface receptors, but they hypothesize that the intracellular isoforms of IL-1Ra will exhibit additional antiinflammatory effect inside cells. ..