Research Topics
| James Melvin AndersonSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Setting up a selective barrier at the apical junction complexJames Melvin Anderson
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Curr Opin Cell Biol 16:140-5. 2004..Similarly, assembly of the barriers requires a conserved set of polarity-generating protein complexes, particularly the PAR protein complexes...
Claudin-2-dependent changes in noncharged solute flux are mediated by the extracellular domains and require attachment to the PDZ-scaffoldChristina M Van Itallie
Department Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Ann N Y Acad Sci 1165:82-7. 2009..4 A. They leave unanswered why both claudin-2 and -4 can influence electrical properties while only -2 can selectively increase permeability for small PEGs...
The molecular physiology of tight junction poresChristina M Van Itallie
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Physiology (Bethesda) 19:331-8. 2004..Study of inherited human claudin diseases and the outcome of the genetic manupulation of claudins in mice, Drosophila, and Caenorhabditis elegans are furthering our understanding of paracellular physiology...
Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1Alan S Fanning
Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, North Carolina 27599 7545, USA
FASEB J 16:1835-7. 2002..We conclude that direct interactions between ZO-1 and F-actin play a role in several different steps of junction assembly...
The life and work of Shoichiro TsukitaJames Melvin Anderson
School of Medicine, Cell and Molecular Physiology, University of North Carolina at Chapel Hill, North Carolina, USA
Ann N Y Acad Sci 1165:7-9. 2009..He was a pioneer in several areas of cell biology; most particularly he will be remembered as the founding father of the molecular study of tight junctions...
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architectureOscar R Colegio
Department of Cell Biology, Yale University, New Haven, Connecticut 06520, USA
Am J Physiol Cell Physiol 284:C1346-54. 2003..These results support a model in which the claudins create paracellular channels and the first extracellular domain is sufficient to determine both paracellular charge selectivity and TER...
Claudins create charge-selective channels in the paracellular pathway between epithelial cellsOscar R Colegio
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Physiol Cell Physiol 283:C142-7. 2002..These results support a model where claudins create charge-selective channels in the paracellular space...
Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin-4Laura L Mitic
Department of Internal Medicine and Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Protein Sci 12:218-27. 2003..In contrast to proteins of similar topology, such as gap junction family connexins, the oligomeric state of claudins appears more dynamic. These data suggest the structural organization of claudins in tight junction pores is unique...
