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Species | N M AmpelSummaryAffiliation: University of Arizona Country: USA Publications
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Publications
Combating opportunistic infections: coccidioidomycosisNeil M Ampel
University of Arizona, Southern Arizona Veterans Affairs Medical Center, Tucson, AZ 85723, USA
Expert Opin Pharmacother 5:255-61. 2004..Intrathecal amphotericin B is required for those cases that fail. Prevention of coccidioidomycosis by environmental control is difficult. In the future, immunisation or immune modulation may offer protection...- In vitro whole-blood analysis of cellular immunity in patients with active coccidioidomycosis by using the antigen preparation T27KNeil M Ampel
Medicine and Primary Care Service, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA
Clin Diagn Lab Immunol 9:1039-43. 2002..001), but not for IL-4, IL-5, or IL-10. These data indicate that in vitro assessment of CD69 expression on T lymphocytes by using T27K may be a useful measure of cellular immune response among subjects with active coccidioidomycosis... - Preliminary evaluation of whole-blood gamma interferon release for clinical assessment of cellular immunity in patients with active coccidioidomycosisNeil M Ampel
Medicine and Primary Care 1 111, Southern Arizona Veterans Affairs Health Care System, 3601 S Sixth Avenue, Tucson, AZ 85723, USA
Clin Diagn Lab Immunol 12:700-4. 2005..59; P < 0.01). These results suggest that the IFN-gamma release assay with T27K as the antigen may be a useful clinical test for assessing cellular immunity in patients with active coccidioidomycosis... - Assessment of the human cellular immune response to T27K, a coccidioidal antigen preparation, by flow cytometry of whole bloodN M Ampel
University of Arizona, Tucson, USA
Med Mycol 39:315-20. 2001..005). These data indicate that there is a specific human cellular immune response to T27K as a coccidioidal antigen and that this response can be categorized based on the clinical status of the coccidioidally infected patient... - Flow cytometric assessment of human peripheral blood mononuclear cells in response to a coccidioidal antigenN M Ampel
University of Arizona and the Medical and Research Services of the Tucson Veterans Affairs Medical Center, 85723, USA
Med Mycol 38:127-32. 2000..Addition of IL-12 leads to a significant recruitment of cells producing IFN-gamma among immune donors... - In vitro modulation of cytokine production by lymphocytes in human coccidioidomycosisNeil M Ampel
Medicine and Primary Care 1 111, Southern Arizona Veterans Affairs Medical Center, 3601 S Sixth Avenue, Tucson, AZ, USA
Cell Immunol 221:115-21. 2003..These data demonstrate a differential response to stimulation with the coccidioidal antigen T27K among donors with coccidioidomycosis that can be manipulated by cell type and cytokine environment... - Delayed-type hypersensitivity, in vitro T-cell responsiveness and risk of active coccidioidomycosis among HIV-infected patients living in the coccidioidal endemic areaN M Ampel
Medical and Research Services of the Tucson Veterans Affairs Medical Center, Department of Medicine of the University of Arizona College of Medicine 85723, USA
Med Mycol 37:245-50. 1999.... - In vitro modulation of proliferation and cytokine production by human peripheral blood mononuclear cells from subjects with various forms of coccidioidomycosisN M Ampel
Department of Medicine, University of Arizona College of Medicine, Tucson Veterans Affairs Medical Center, 85723, USA
Infect Immun 65:4483-7. 1997..On the other hand, PBMC from DTH-negative individuals do not respond in vitro to TSL and their response is not modulable, suggesting a lack of antigen response... - Measurement of cellular immunity in human coccidioidomycosisNeil M Ampel
University of Arizona, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA
Mycopathologia 156:247-62. 2003..Despite this, a study of a coccidioidal vaccine failed to demonstrate efficacy. Current and future studies are focused on modulating the coccidioidal immune response in vitro and in vivo and on developing an improved vaccine... - Coccidioidomycosis among persons with human immunodeficiency virus infection in the era of highly active antiretroviral therapy (HAART)N M Ampel
University of Arizona College of Medicine, Tucson, AZ, USA
Semin Respir Infect 16:257-62. 2001..Future studies should indicate whether this is necessary if immune function has been reconstituted through appropriate therapy for the HIV infection... - Extraction of serologic and delayed hypersensitivity antigens from spherules of Coccidioides immitisJ N Galgiani
Medical Service, VA Medical Center, Tucson, AZ 85723
Diagn Microbiol Infect Dis 11:65-80. 1988.... - An archived lot of coccidioidin induces specific coccidioidal delayed-type hypersensitivity and correlates with in vitro assays of coccidioidal cellular immune responseNeil M Ampel
Department of Medicine, University of Arizona, Tucson, AZ, USA
Mycopathologia 161:67-72. 2006..01 for both). These data suggest that archived coccidioidin retains its potency and specificity and that in vitro test of coccidioidal immunity may have utility in the measurement of coccidioidal cellular immunity... - Dendritic cells pulsed with Coccidioides immitis lysate induce antigen-specific naive T cell activationJ O Richards
Department of Microbiology and Immunology, University of Arizona, Tucson, AZ 85724, USA
J Infect Dis 184:1220-4. 2001..immitis can specifically prime lymphocytes for coccidioidal antigens and that the response generated by the lymphocytes is characteristic of a cellular immune response... - Coccidioidomycosis in patients with HIV-1 infection in the era of potent antiretroviral therapyFares Y Masannat
Division of Infectious Diseases, Department of Medicine, and Valley Fever Center for Excellence, University of Arizona, and Southern Arizona Veterans Affairs Health Care System, Tucson, USA
Clin Infect Dis 50:1-7. 2010..However, there have been no studies on its incidence or clinical expression during the era of potent antiretroviral therapy... - Coccidioidomycosis in persons infected with HIV-1Neil M Ampel
Medical Service 1 111, SAVAHCS, 3601 S Sixth Avenue, Tucson, Arizona 85723, USA
Ann N Y Acad Sci 1111:336-42. 2007..The duration of treatment of coccidioidomycosis in those with HIV-1 infection is not established and in many patients it is either prolonged or life-long. Adherence to antiretroviral therapy is important in preventing recurrence... - The complex immunology of human coccidioidomycosisNeil M Ampel
Medical Service, 1 111, SAVAHCS, 3601 S Sixth Avenue, Tucson, AZ 85723, USA
Ann N Y Acad Sci 1111:245-58. 2007..These observations could be useful in the development of a human vaccine against coccidiodomycosis... - Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosisNeil M Ampel
Department of Medicine, Section of Infectious Diseases, University of Arizona, Tucson, AZ, USA
Clin Infect Dis 48:172-8. 2009..Studies that assess the value of initiating oral antifungal therapy to treat primary pulmonary coccidioidomycosis have not been published previously... - Mannose-binding lectin serum levels are low in persons with clinically active coccidioidomycosisNeil M Ampel
The Valley Fever Center for Excellence, The University of Arizona College of Medicine, Tucson, AZ 85723, USA
Mycopathologia 167:173-80. 2009..Mannose-binding lectin (MBL) is a circulating collectin that is part of the innate immune response. We explored the serum levels of MBL in persons with different forms of coccidioidomycosis... - Coccidioidomycosis: a review of recent advancesNeil M Ampel
College of Medicine, University of Arizona, Medical Service 1 111, SAVAHCS, Tucson, AZ 85723, USA
Clin Chest Med 30:241-51, v. 2009..With this increase in incidence have come new observations and insights and re-examination of past issues. This article explores some of these areas by focusing principally on recent publications that are of importance... - New perspectives on coccidioidomycosisNeil M Ampel
Division of Infectious Diseases, Department of Medicine, and the Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA
Proc Am Thorac Soc 7:181-5. 2010..However, a recent study suggests that, at least for those with primary pulmonary disease, antifungal therapy may lead to subsequent complications once this therapy is discontinued compared with those who receive no therapy at all... - CoccidioidomycosisJohn N Galgiani
Valley Fever Center for Excellence, Tucson, AZ 85723, USA
Clin Infect Dis 41:1217-23. 2005 - Coccidioidomycosis in persons infected with HIV type 1Neil M Ampel
Department of Medicine, University of Arizona College of Medicine and Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA
Clin Infect Dis 41:1174-8. 2005..Other manifestations of coccidioidomycosis require prolonged therapy, and life-long treatment is recommended for persons with meningitis... - Reversal of coccidioidal anergy in vitro by dendritic cells from patients with disseminated coccidioidomycosisJohn O Richards
Department of Microbiology and Immunology, Arizona Health Sciences Center, Tucson, AZ 85724, USA
J Immunol 169:2020-5. 2002.... - What's Behind the Increasing Rates of Coccidioidomycosis in Arizona and California?Neil M Ampel
Medical Service 1 111, Southern Arizona Veterans Affairs Health Care System, 3601 South Sixth Avenue, Tucson, AZ, 85723, USA
Curr Infect Dis Rep 12:211-6. 2010..None of these factors are mutually exclusive and none has been clearly established as the etiology for the increase... - Increased risk of coccidioidomycosis in patients treated with tumor necrosis factor alpha antagonistsLaurie Bergstrom
University of Arizona, Tucson, 85724, USA
Arthritis Rheum 50:1959-66. 2004.... - The mannose receptor mediates the cellular immune response in human coccidioidomycosisNeil M Ampel
Department of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona, USA
Infect Immun 73:2554-5. 2005..These data suggest that MR mediates IL-2 release by T27K... - Barriers to use of electronic adherence monitoring in an HIV clinicC S Wendel
Health Services Research Center, Southern Arizona Veterans Affairs Health Care System, Tucson, 85723 0001, USA
Ann Pharmacother 35:1010-5. 2001..To evaluate barriers to Medication Event Monitoring System (MEMS) measurement of adherence to combination antiretroviral therapy in an HIV clinic... - Practice guideline for the treatment of coccidioidomycosis. Infectious Diseases Society of AmericaJ N Galgiani
Valley Fever Center for Excellence, Southern Arizona Veterans Affairs Health Care System, and University of Arizona, Tucson, 85723, USA
Clin Infect Dis 30:658-61. 2000..Duration of therapy often ranges from many months to years, and, for some patients, chronic suppressive therapy is needed to prevent relapses... - Coccidioidomycosis as a common cause of community-acquired pneumoniaLisa Valdivia
University of Arizona College of Medicine, Tucson, Arizona 85723, USA
Emerg Infect Dis 12:958-62. 2006..If CAP develops in persons who travel or reside in Coccidioides-endemic regions, diagnostic evaluation should routinely include laboratory evaluation for this organism... - Polyfunctional T lymphocytes are in the peripheral blood of donors naturally immune to coccidioidomycosis and are not induced by dendritic cellsLance Nesbit
Department of Immunobiology, University of Arizona, Tucson, Arizona, USA
Infect Immun 78:309-15. 2010..03). These data demonstrate the presence of polyfunctional T lymphocytes in the peripheral blood of individuals with coccidioidal immunity and suggest a model for the in vitro testing of vaccine candidates for coccidioidomycosis... - Emerging disease issues and fungal pathogens associated with HIV infectionN M Ampel
University of Arizona College of Medicine, Tuscon Veterans Affairs Medical Center, Tucson, Arizona 85713, USA
Emerg Infect Dis 2:109-16. 1996.... - Fatigue in coccidioidomycosis. Quantification and correlation with clinical, immunological, and nutritional factorsJennifer Muir Bowers
Valley Fever Center for Excellence and the Department of Medicine of the University of Arizona, and the Southern Arizona Veterans Affairs Health Center System, Tucson, Arizona, USA
Med Mycol 44:585-90. 2006..078, P=0.261) or serum TNF-alpha (r2=0.028, P=0.504) concentrations. Severe fatigue is a common condition among patients with active coccidioidomycosis and is associated with a declining BMI... - Spherules derived from Coccidioides posadasii promote human dendritic cell maturation and activationSara O Dionne
Valley Fever Center for Excellence, Tuscon, AZ, USA
Infect Immun 74:2415-22. 2006.... - Cellular immune suppressor activity resides in lymphocyte cell clusters adjacent to granulomata in human coccidioidomycosisLijin Li
Department of Microbiology and Immunology, University of Arizona, Tucson, Arizona, USA
Infect Immun 73:3923-8. 2005.... - The solitary pulmonary noduleNeil M Ampel
N Engl J Med 349:1575; author reply 1575. 2003