Research Topics
| B N AmesSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Micronutrients prevent cancer and delay agingB N Ames
University of California, Berkeley 94720 3202, USA
Toxicol Lett 102:5-18. 1998....- DNA damage from micronutrient deficiencies is likely to be a major cause of cancerB N Ames
University of California, 94720 3202, Berkeley, CA, USA
Mutat Res 475:7-20. 2001..Remedying micronutrient deficiencies should lead to a major improvement in health and an increase in longevity at low cost... - The causes and prevention of cancer: gaining perspectiveB N Ames
Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720 3202, USA
Environ Health Perspect 105:865-73. 1997..Because default risk assessments use linear extrapolation, which ignores effects of the high dose itself, low-dose risks are often exaggerated... - Environmental pollution, pesticides, and the prevention of cancer: misconceptionsB N Ames
Department of Molecular and Cell Biology, University of California, 94720, USA
FASEB J 11:1041-52. 1997..A reexamination of priorities in cancer prevention, both public and private, seems called for... - Micronutrient deficiencies. A major cause of DNA damageB N Ames
University of California, Berkeley 94720 3202, USA
Ann N Y Acad Sci 889:87-106. 1999..Remedying micronutrient deficiencies is likely to lead to a major improvement in health and an increase in longevity at low cost... - Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detectionM K Shigenaga
Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720, USA
Proc Natl Acad Sci U S A 94:3211-6. 1997.... - DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanineH J Helbock
Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720 3202, USA
Proc Natl Acad Sci U S A 95:288-93. 1998..Lastly, we discuss remaining uncertainties inherent both in steady-state oxo8dG measurements and in estimates of endogenous oxidation ("hit rates") based on urinary excretion of oxo8dG and oxo8Gua... - Paracelsus to parascience: the environmental cancer distractionB N Ames
Division of Biochemistry and Molecular Biology and National Institutes of Environmental Health Sciences Center, University of California at Berkeley and Lawrence Berkeley National Laboratory Berkeley, Berkeley, CA 94720, USA
Mutat Res 447:3-13. 2000..d) Damage by distraction: regulating low hypothetical risks. Putting huge amounts of money into minuscule hypothetical risks damages public health by diverting resources and distracting the public from major risks... - Mitochondrial aging: open questionsK B Beckman
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202, USA
Ann N Y Acad Sci 854:118-27. 1998..mitochondria, apopotosis, and aging? and (9) How can mitochondrial function (ATP generation and the establishment of a membrane potential) and dysfunction (oxidant generation) be modulated and degenerative senescence thereby treated?.. - Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitroneT M Hagen
Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA
Ann N Y Acad Sci 854:214-23. 1998..Thus, dietary supplementation with ALCAR, particularly in combination with PBN, improves mitochondrial function without a significant increase in oxidative stress... - Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementationJ Lykkesfeldt
Department of Molecular and Cell Biology, University of California at Berkeley, 94720, USA
FASEB J 12:1183-9. 1998..These results provide further evidence for the potential of alpha-lipoic acid in treatment of diseases related to oxidative stress. Furthermore, the study extends the value of ascorbic acid as a biomarker of oxidative stress... - Sixth plot of the carcinogenic potency database: results of animal bioassays published in the General Literature 1989 to 1990 and by the National Toxicology Program 1990 to 1993L S Gold
Life Sciences Division, Lawrence Berkeley Laboratory, California, USA
Environ Health Perspect 103:3-122. 1995..A SAS database is also available... - N-t-Butyl hydroxylamine is an antioxidant that reverses age-related changes in mitochondria in vivo and in vitroH Atamna
Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, Oakland, California 94609, USA
FASEB J 15:2196-204. 2001..NtBHA is an antioxidant that is recycled by mitochondrial electron transport chain and prevents radical-induced toxicity to mitochondria... - Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLCI Girault
Division of Biochemistry and Molecular Biology, University of California, Berkeley CA, USA
Free Radic Biol Med 31:1375-87. 2001.... - Endogenous oxidative damage of mtDNAK B Beckman
Department of Molecular and Cell Biology, University of California, 401 Barker Hall, Berkeley, CA 94720 3202, USA
Mutat Res 424:51-8. 1999..We briefly describe methods being developed by a number of workers that are likely to surmount current obstacles and allow the hypothesis to be tested definitively... - gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attentionQ Jiang
University of California, the Department of Molecular and Cell Biology, Berkeley, USA
Am J Clin Nutr 74:714-22. 2001..We review current information on the bioavailability, metabolism, chemistry, and nonantioxidant activities of gamma-tocopherol and epidemiologic data concerning the relation between gamma-tocopherol and cardiovascular disease and cancer... - Oxidative damage increases with age in a canine model of human brain agingE Head
Institute for Brain Aging and Dementia, University of California, Irvine, California 92697 4540, USA
J Neurochem 82:375-81. 2002..This evidence of widespread oxidative damage and Abeta deposition is further justification for using the canine model for studying human brain aging and neurodegenerative diseases... - Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: revelance to agingH Atamna
Department of Molecular and Cell Biology, University of California, Berkeley, California 94609, USA
J Biol Chem 276:48410-6. 2001..The rate of removal and assembly of complex IV declines with age. These findings are relevant to worldwide iron deficiency in women and children and to an age-related decline in complex IV in Alzheimer's disease patients... - Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidationG Storz
Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720
Science 248:189-94. 1990..The results suggest that direct oxidation of the OxyR protein brings about a conformational change by which OxyR transduces an oxidative stress signal to RNA polymerase...