Research Topics
| Susan G AmaraSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Neuroscience in recession?Susan G Amara
Department of Neurobiology, University of Pittsburgh School of Medicine, and the Center for Neuroscience at the University of Pittsburgh, Biomedical Science Tower 3, 6th Floor, Room 6057, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15260, USA
Nat Rev Neurosci 12:297-302. 2011..Their responses provide interesting and important insights into the regional impact of the global financial downturn, with some causes for optimism for the future of neuroscience research...- Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venomAndréia Cristina Karklin Fontana
Department of Neurobiology, University of Pittsburgh, 6068 BST3, 3501 Fifth Ave, Pittsburgh, PA 15260, USA
Mol Pharmacol 72:1228-37. 2007.... - Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transportersOle V Mortensen
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Neurochem 98:1531-40. 2006..Thus, these studies begin to identify residues that are important for the unique molecular interactions of benztropine and bupropion with the DAT, and that ultimately may contribute to the distinct behavioral actions of these drugs... - Dynamic regulation of the dopamine transporterOle V Mortensen
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Eur J Pharmacol 479:159-70. 2003..This review focuses on recent evidence for several distinct mechanisms which dynamically regulate dopamine transporter activity and thus have an important role in shaping the duration and amplitude of dopamine signals in the brain... - Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotoninAndreia C K Fontana
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Eur J Pharmacol 616:48-57. 2009.... - Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporterIndira H Shrivastava
Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 283:28680-90. 2008..The functional importance of Leu-303 or its counterpart Leu-391 in human EAAT1 (hEAAT1) is confirmed by site-directed mutagenesis and Na+ dependence assays conducted with hEAAT1 mutants L391C and L391A... - Genetic complementation screen identifies a mitogen-activated protein kinase phosphatase, MKP3, as a regulator of dopamine transporter traffickingOle Valente Mortensen
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Mol Biol Cell 19:2818-29. 2008..These results indicate that MKP3 can act to enhance DAT function and identifies MKP3 as a phosphatase involved in regulating dynamin-dependent endocytosis... - Close encounters of the oily kind: regulation of transporters by lipidsChristopher B Divito
University of Pittsburgh, Department of Neurobiology, Pittsburgh, PA 15260, USA
Mol Interv 9:252-62. 2009.... - Molecular simulations elucidate the substrate translocation pathway in a glutamate transporterYan Gu
Department of Computational Biology and Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 106:2589-94. 2009.... - Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptakeAndréia Cristina Karklin Fontana
Laboratory of Neurochemistry, Department of Biochemistry and Immunology, Ribeirao Preto School of Medicine, University of Sao Paulo, Brazil
Br J Pharmacol 139:1297-309. 2003..5) This active spider venom component may serve as a basis for designing therapeutic drugs that increase glutamate clearance and limit neurodegeneration... - The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporterAna M Carneiro
Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 22:7045-54. 2002.... - Effects of Tityus serrulatus scorpion venom and its toxin TsTX-V on neurotransmitter uptake in vitroAlessandra L Cecchini
, , Av. do Caf, s/n, 14040-903, , Brazil
Toxicol Appl Pharmacol 217:196-203. 2006..Thus, TsTX-V causes a reduction of (3)H-GABA and (3)H-DA uptake in a Ca(2+)-dependent manner, not directly affecting GABA transporters, but, in consequence of depolarization, involving voltage-gated Na(+) channels... - Dopamine transporter-mediated conductances increase excitability of midbrain dopamine neuronsSusan L Ingram
Vollum Institute and Howard Hughes Medical Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
Nat Neurosci 5:971-8. 2002..Thus, in addition to clearing extracellular DA, our results suggest that the currents associated with DAT modulate excitability and may regulate release of neurotransmitter from midbrain DA neurons... - Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1Barbara H Leighton
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
J Biol Chem 281:29788-96. 2006..Such behavior likely reflects rearrangements in the tertiary structure of the translocation pore during transport and thus provides constraints for modeling the structural dynamics associated with transport... - Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl terminiBala T S Susarla
Department of Pediatrics, University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
J Neurochem 91:1151-63. 2004.... - A hydrophobic domain in glutamate transporters forms an extracellular helix associated with the permeation pathway for substratesBarbara H Leighton
Vollum Institute, Howard Hughes Medical Institute, Oregon Health and Sciences University, Portland, Oregon 97201, USA
J Biol Chem 277:29847-55. 2002..Our data are consistent with a model in which domain 10 exists as an alpha-helix at an aqueous interface of the translocation pathway, which can be directly occluded by substrates and inhibitors at an early step in the transport cycle... - Chloride finds its place in the transport cycleSusan G Amara
Nat Struct Mol Biol 14:792-4. 2007 - Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transportersKeiko Shimamoto
Suntory Institute for Bioorganic Research, 1 1 1, Wakayamadai, Shimamoto cho, Mishima gun, Osaka 618 8503, Japan
Mol Pharmacol 65:1008-15. 2004..Taken together, these findings indicate that novel TBOA analogs, especially TFB-TBOA, should serve as useful tools for elucidating the physiological roles of the glutamate transporters... - A novel sorting motif in the glutamate transporter excitatory amino acid transporter 3 directs its targeting in Madin-Darby canine kidney cells and hippocampal neuronsChialin Cheng
Howard Hughes Medical Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurosci 22:10643-52. 2002....
Research Grants
- Molecular Studies of Human CNS Glutamate TransportersSusan G Amara; Fiscal Year: 2010....
- Molecular Studies of Human CNS Glutamate TransportersSusan Amara; Fiscal Year: 2007....
- Molecular Studies of Human CNS Glutamate TransportersSusan Amara; Fiscal Year: 2005..abstract_text> ..
- EXPRESSION PROFILING OF PSYCHOSTIMULANT-REGULATED GENESSusan Amara; Fiscal Year: 2002..Understanding the common and unique actions of drugs from a global, genomic perspective should enable us to characterize and understand the mechanisms that underlie their profound behavioral consequences. ..
- MOLECULAR STUDIES OF CNS GLUTAMATE TRANSPORTERSSusan Amara; Fiscal Year: 1999....
- MOLECULAR STUDIES OF CATECHOLAMINE TRANSPORTERSSusan G Amara; Fiscal Year: 2010..abstract_text> ..