Research Topics
Genomes and Genes
| Maria Luisa AlegreSummaryAffiliation: University of Chicago Country: USA Publications
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Detail Information
Publications
Mechanisms of CTLA-4-Ig in tolerance inductionM L Alegre
Department of Medicine, Section of Rheumatology, University of Chicago, IL 60637, USA
Curr Pharm Des 12:149-60. 2006..In this review, we will focus on the current knowledge of the mechanisms of action of CTLA-4 and CTLA-4-Ig...- Toll-like receptor signaling in transplantationMaria Luisa Alegre
Department of Medicine, The University of Chicago, Chicago, Illinois, USA
Curr Opin Organ Transplant 13:358-65. 2008..This review summarizes recent advances in the role of endogenous and exogenous Toll-like receptor ligands in the activation and inhibition of immune responses in transplantation... - T-cell regulation by CD28 and CTLA-4M L Alegre
Department of Medicine, Section of Rheumatology and Committee in Immunology, Chicago, Illinois 60637, USA
Nat Rev Immunol 1:220-8. 2001.... - Expression and function of CTLA-4 in Th1 and Th2 cellsM L Alegre
Howard Hughes Medical Institute, University of Chicago, IL 60637, USA
J Immunol 161:3347-56. 1998..We conclude that CTLA-4 can function to suppress the production of cytokines produced by both Th1 and Th2 cells... - Costimulatory molecules as targets for the induction of transplantation toleranceMaria Luisa Alegre
Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Curr Mol Med 6:843-57. 2006..In this review, we will summarize the different reagents used to target costimulatory molecules, their effects, and the possible reasons limiting their efficacy in higher order mammals... - Toll-like receptors (TLRs) in transplantationMaria Luisa Alegre
Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL60637, USA
Front Biosci (Elite Ed) 1:36-43. 2009..In this review, we will summarize the results published to date on the role of TLRs in experimental and clinical transplantation... - Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation toleranceMaria Luisa Alegre
Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Transplantation 87:S77-9. 2009..Therefore, transiently targeting these innate, proinflammatory pathways may have therapeutic value to promote transplantation tolerance... - Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cellsKwang Woo Hwang
Department of Medicine and Committee in Immunology, University of Chicago, Chicago, IL 60637, USA
J Immunol 169:633-7. 2002..Furthermore, CTLA-4(+/+) T cells that had encountered 7M-expressing tumors in vivo acquired defects in cytokine production and cytotoxicity. Thus, deliberate ligation of CTLA-4 in vivo potently inhibits allogeneic T cell responses... - Overexpression of program death-1 in T cells has mild impact on allograft survivalLuqiu Chen
Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Transpl Int 21:21-9. 2008..We conclude that genetic engineering of T cells to express PD-1 constitutively has only a mild impact on allograft survival... - Secondary lymphoid organs are important but not absolutely required for allograft responsesPing Zhou
Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, USA
Am J Transplant 3:259-66. 2003..These results suggest that immunologic events capable of leading to allograft rejection can successfully occur at sites other than classical secondary lymphoid organs... - Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejectionSumit K Subudhi
Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
J Clin Invest 113:694-700. 2004..Ig fusion protein augmented naive T cell priming both in vitro and in vivo. Our results demonstrate that B7-H1 can provide positive costimulation for naive T cells to promote allograft rejection and autoimmune disease pathogenesis... - Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient miceKwang Woo Hwang
Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Immunol 173:5415-24. 2004..Thus, restoring CTLA-4 expression in T cells may be an attractive strategy to control clinical autoimmune diseases in which CTLA-4 expression is reduced... - Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulationDongdong Li
Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
J Immunol 173:7135-9. 2004..These observations indicate that CD28 and CTLA-4 tightly regulate Cbl-b expression which is critical for establishing the threshold for T cell activation... - TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanismHelena Harlin
Committee on Immunology and Department of Medicine, Section of Rheumatology, University of Chicago, IL 60637, USA
J Immunol 169:2451-9. 2002..Inasmuch as IL-13 can promote airway inflammation and cancer progression, production of IL-13 in a TCR-independent manner has important pathological implications in vivo... - Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xLPing Zhou
Department of Medicine, Section of Rheumatology, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
J Immunol 174:3447-53. 2005..Together, these results suggest that the death of alloreactive T cells may be partly responsible for the transplantation tolerance observed in mice with defective T cell-intrinsic NF-kappaB activation... - T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-bGuilin Qiao
Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 5100, Suite S 521, Chicago, IL 60637, USA
Mol Cell Biol 28:2470-80. 2008.... - Prevention of allograft tolerance by bacterial infection with Listeria monocytogenesTongmin Wang
Section of Transplantation, Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
J Immunol 180:5991-9. 2008..Our results indicate that bacterial exposure at the time of transplantation can antagonize tolerogenic regimens by enhancing alloantigen-specific immune responses independently of the generation of cross-reactive memory T cells... - Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated toleranceP Zhou
Section of Transplantation, Departments of Surgery, Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Immunol 165:5580-7. 2000..These data suggest that the balance of type 1 and type 2 T lymphocyte differentiation is not critical for acute rejection but influences the robust tolerance induced by CD28/B7 blockade in this model... - TLR signals promote IL-6/IL-17-dependent transplant rejectionLuqiu Chen
Department of Medicine, Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
J Immunol 182:6217-25. 2009..Thus, proinflammatory signals at the time of transplantation can change the quality of the effector immune response and reveal a pathogenic function for IL-6 and IL-17 in wild-type recipients... - Cellular mechanisms underlying acute graft rejection: time for reassessmentMaria Luisa Alegre
Department of Medicine, Section of Rheumatology, University of Chicago, 5841 S Maryland Avenue, Room N005C, MC 0930, Chicago, IL 60637, USA
Curr Opin Immunol 19:563-8. 2007..The redundancy of rejection mechanisms explains the difficulty to induce transplantation tolerance and to develop reliable biomarkers for prediction of allograft outcome... - Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient miceG L Szot
Ben May Institute for Cancer Research, The University of Chicago, IL 60637, USA
Am J Transplant 1:38-46. 2001..These results may help to explain the failure to promote graft tolerance in some preclinical and clinical settings... - Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28H Lin
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
J Exp Med 188:199-204. 1998..Thus, the negative regulatory role of CTLA4 extends beyond its potential ability to prevent CD28 activation through ligand competition. Even in the absence of CD28, CTLA4 plays an inhibitory role in the regulation of allograft rejection... - High TCR stimuli prevent induced regulatory T cell differentiation in a NF-?B-dependent mannerLuciana L Molinero
Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Immunol 186:4609-17. 2011..Thus, NF-?B helps T cells control their differentiation fate in a cell-intrinsic manner and prevents peripheral iTreg development under conditions of high Ag load that may require more vigorous effector T cell responses... - Bacterial infections, alloimmunity, and transplantation toleranceEmily B Ahmed
Department of Surgery, The University of Chicago, Chicago, IL 60637, USA
Transplant Rev (Orlando) 25:27-35. 2011.... - The multiple facets of toll-like receptors in transplantation biologyMaria Luisa Alegre
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA
Transplantation 86:1-9. 2008..We then discuss the involvement of TLRs in the different phases of the rejection phenomenon and the impact of TLR-mediated events on regulatory circuits which dampen alloimmune responses... - Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndromeSangeeta M Bhorade
Section of Pulmonary, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
Transplantation 90:540-6. 2010..Studies in animal models suggest that intragraft T regulatory cells (Tregs) are important in maintaining transplantation tolerance, and FoxP3 is the protoypic Treg marker... - Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft modelT Wang
Department of Surgery, The University of Chicago, IL, USA
Am J Transplant 10:1524-33. 2010..In conclusion, these studies demonstrate that the proinflammatory effects of infections can induce the loss of tolerance and acute rejection of accepted allografts... - Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinasesE Chuang
Gwen Knapp Center for Lupus and Immunology Research, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Immunol 162:1270-7. 1999..The association of CTLA-4 with Src kinases and with SHP-2 results in the formation of a CTLA-4 complex with the potential to regulate T cell activation... - CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' diseaseT Kouki
Thyroid Study Unit, Department of Medicine, University of Chicago, Chicago, IL 60637 Fujita Health University, Aichi, Japan
J Immunol 165:6606-11. 2000..019). CTLA-4 polymorphism affects the inhibitory function of CTLA-4. The G allele is associated with reduced control of T cell proliferation and thus contributes to the pathogenesis of GD and presumably of other autoimmune diseases... - Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allograftsM L Alegre
Ben May Institute, Department of Pathology, Pritzker School of Medicine, University of Chicago, IL 60637
J Immunol 153:2738-49. 1994..Thus, this hu-Spl-SCID model may be useful for the study of immunosuppressive therapies in a preclinical in vivo setting... - Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissuesJames C Lo
Committee on Immunology and Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
Blood 107:1048-55. 2006.... - Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestationsNadera J Sweiss
Sarcoidosis and Scleroderma Clinic, Section of Rheumatology, University of Chicago, Chicago, Illinois, United States of America
PLoS ONE 5:e9088. 2010..The goal of this study was to evaluate lymphocyte subsets in peripheral blood in a cohort of sarcoidosis patients to determine the prevalence, severity, and clinical features associated with lymphopenia in major lymphocyte subsets... - Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signalingLuciana Lorena Molinero
Department of Medicine, Section of Rheumatology, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Transpl Int 22:845-52. 2009..These results indicate that T-cell inhibition of NF-kappaB results in cardiac allograft acceptance because of increased susceptibility to Fas-mediated cell death... - Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cellsMichael I Zimmer
Department of Pathology, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 106:1909-14. 2009..Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells... - Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expressionE Chuang
Gwen Knapp Center for Lupus and Immunology Research, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
J Immunol 159:144-51. 1997..Together these data suggest that the interaction of CTLA-4 with AP50 plays an important role in regulating the cell surface expression of CTLA-4... - Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cellsL L Molinero
Department of Medicine, University of Chicago, Chicago, IL, USA
Am J Transplant 8:21-31. 2008..The combined blockade of T-cell-NF-kappaB with that of alternative pathways allowing activation of NF-kappaB-impaired T cells may be an effective strategy for tolerance induction to highly immunogenic organs... - Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphataseT F Gajewski
Department of Pathology, University of Chicago, Chicago, IL 60637, USA
J Immunol 166:3900-7. 2001..Thus, the biochemical mechanism explaining the differential inhibitory effect of CTLA-4 on naive and primed CD8(+) T cells remains unclear... - Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemiaTomas Vilimas
Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue Chicago, Illinois 60637, USA
Nat Med 13:70-7. 2007..These findings identify NF-kappaB as one of the major mediators of Notch1-induced transformation and suggest that the NF-kappaB pathway is a potential target of future therapies of T-ALL... - Impaired negative selection in CD28-deficient miceP J Noel
Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA
Cell Immunol 187:131-8. 1998..In contrast to its role in T cell activation and survival in the peripheral immune system, the CD28 receptor appears to participate in the intracellular signaling events that result in negative selection in the thymus... - CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathwayZ Guo
Department of Surgery, University of Chicago, Illinois 60637, USA
Transplantation 71:1351-4. 2001..Disruption of the CD40/CD154 pathway inhibits rejection in numerous models. The importance of this pathway on intestinal allograft rejection was examined in this study... - CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cellsLuciana L Molinero
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Immunol 182:6736-43. 2009..These data suggest a modified model of nTreg development in which TCR-CBM-dependent signals are essential to commit immature thymocytes to the nTreg lineage... - Tissue distribution, regulation and intracellular localization of murine CD1 moleculesM Mandal
Gwen Knapp Center for Lupus and Immunology Research, Department of Pathology, University of Chicago, IL 60637, USA
Mol Immunol 35:525-36. 1998..Localization in endocytic compartments indicates that murine CD1 may be capable of binding endocytosed antigens... - Role of bacterial infections in allograft rejectionEmily B Ahmed
Department of Surgery, University of Chicago, Chicago, IL 60637, USA
Expert Rev Clin Immunol 4:281-93. 2008..This review seeks to explore the clinical and scientific literature examining the role of bacterial infections in transplant rejection... - Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cellsShannon K O'Neill
Department of Medicine, Section of Rheumatology, and The Knapp Center for Lupus Research, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 106:6262-7. 2009..These results indicate that B cell anergy is reinforced by the exclusion of both TLRs and their BCR captured ligands from subcellular environments necessary for TLR activation... - Modulation of tryptophan catabolism by regulatory T cellsFrancesca Fallarino
Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
Nat Immunol 4:1206-12. 2003..Thus, regulation of immunosuppressive tryptophan catabolism in dendritic cells might represent a major mechanism of action of T(R) cells... - Actin cytoskeleton regulates calcium dynamics and NFAT nuclear durationFabiola V Rivas
Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
Mol Cell Biol 24:1628-39. 2004..Our results imply a novel role for the actin cytoskeleton in modulating the duration of Ca(2+)-NFAT signaling and indicate that actin dynamics regulate features of T-cell activation downstream of receptor clustering... - CTLA-4 engagement regulates NF-kappaB activation in vivoHelena Harlin
Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, Ill 60637 USA
Eur J Immunol 32:2095-104. 2002..Thus, impaired NF-kappaB activity in T cells prevents specific aspects of the CTLA-4(-/-) phenotype, suggesting that inhibition of NF-kappaB activation is one of the key biochemical events regulated by CTLA-4 ligation in vivo... - CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivoQizhi Tang
Diabetes Center and Department of Medicine, University of California, San Francisco, CA 94143, USA
J Immunol 170:1510-6. 2003.... - Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin graftsPing Zhou
Department of Medicine, University of Chicago, Chicago, IL, USA
Am J Transplant 3:139-47. 2003.... - Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cellsKelly Blaine
Committee on Cancer Biology and Department of Pathology, University of Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 101:9351-6. 2004.... - The balance of immune responses: costimulation verse coinhibitionSumit K Subudhi
Department of Pathology, University of Chicago, 5841 S. Maryland, Chicago, IL 60637, USA
J Mol Med 83:193-202. 2005..This cautions against using clinical immunotherapeutic reagents targeted against these molecules until we gain a better understanding of the circumstances that regulate the outcomes of the T cell response...