Research Topics
| Abeer M Al-GhananeemSummaryAffiliation: University of Kentucky Country: USA Publications
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Detail Information
Publications
Gamma scintigraphy for testing bioequivalence: a case study on two cromolyn sodium nasal spray preparationsAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 927 Rose Street, Lexington, KY 40536, USA
Int J Pharm 357:70-6. 2008....- Bioavailability of ??-tetrahydrocannabinol following intranasal administration of a mucoadhesive gel spray delivery system in conscious rabbitsAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, 40536 0082, USA
Drug Dev Ind Pharm 37:329-34. 2011..A further aim was to investigate the effect of nasally administered chitosan-based nasal bioadhesive gel on THC bioavailability as a formulation strategy to decrease normal mucociliary drug clearance... - Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and deliveryAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
Molecules 12:373-88. 2007..This present article reviews the progress in ocular prodrug and codrug design and delivery in light of ocular metabolic activities... - Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sicknessAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
Drug Dev Ind Pharm 33:577-82. 2007.... - Pharmacokinetics of lofexidine hydrochloride in healthy volunteersAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536 0082, USA
J Pharm Sci 98:319-26. 2009.... - Intratumoral delivery of Paclitaxel in solid tumor from biodegradable hyaluronan nanoparticle formulationsAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 927 Rose Street, Lexington, Kentucky 40536 0082, USA
AAPS PharmSciTech 10:410-7. 2009..9-fold larger than the baseline volume at 57 days post-drug administration. Intratumoral administration of paclitaxel-loaded hyaluronan nanoparticles could be a promising treatment modality for solid mammary tumors... - Urine and plasma pharmacokinetics of lofexidine after oral delivery in opiate-dependent patientsAbeer M Al Ghananeem
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, 40536 0082, USA
Am J Drug Alcohol Abuse 35:311-5. 2009..To date, there have been no published studies on lofexidine appearance and excretion in urine of opioid dependent subjects... - Formulation-based approach to support early drug discovery and development efforts: a case study with enteric microencapsulation dosage form development for a triarylmethane derivative TRAM-34; a novel potential immunosuppressantAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
Drug Dev Ind Pharm 36:563-9. 2010..Enteric microencapsulation of the potential immunosuppressant TRAM-34 was investigated as a means of enhancing oral drug delivery and minimizing or eliminating hydrolysis of pyrazole-substituted triarylmethane to the respective alcohol... - Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS virusesAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
J Drug Target 18:381-8. 2010..n. dosing was 2.1 and 1.9 in CSF and brain, respectively. Thus, both the i.n. route of administration and formulation of ddI in chitosan nanoparticles increased delivery of ddI to CSF and brain... - A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrugMichelle Howard Sparks
College of Pharmacy, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0082, USA
Drug Dev Ind Pharm 33:677-82. 2007.... - Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray deliveryAhmad H Malkawi
College of Pharmacy, University of Kentucky, Lexington, Kentucky, 40536-0082, USA
AAPS J 10:261-7. 2008 - Effect of pH on sublingual absorption of oxycodone hydrochlorideAbeer M Al-Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA
AAPS PharmSciTech 7:E23. 2006..The formulation pH had no significant influence on oxycodone bioavailability (P < .05). A sublingual spray dosage form of oxycodone hydrochloride would be a good alternative for fast onset pain management, especially in children... - A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agentAbeer M Al Ghananeem
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
Cancer Chemother Pharmacol 60:915-9. 2007..2.2]octane-3-ol (BMABO), a novel radio-sensitization agent, after oral delivery... - Nicotine exposure can be detected in cerebrospinal fluid of active and passive smokersAhmad H Malkawi
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
J Pharm Biomed Anal 49:129-32. 2009..6-81.1 ng/ml). The concentrations of cotinine in CSF samples suggests that nicotine easily passes into the CSF, which makes it an excellent CSF marker for tobacco-smoke exposure... - An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasmaAhmad H Malkawi
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
J Pharm Biomed Anal 45:120-4. 2007.... - Neonatal exposure to drugs in breast milkPatrick J McNamara
College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA
Pharm Res 21:555-66. 2004..g., colostrum vs. mature milk, fore vs. hind milk) and infant clearance (e.g., ontogeny of elimination pathways, pharmacogenetics) and their role in modulating exposure are also discussed... - Synthesis and stability of two indomethacin prodrugsShyamala Chandrasekaran
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA
Bioorg Med Chem Lett 16:1874-9. 2006..2h in 80% buffered plasma. In contrast, the amide conjugate 12 appeared to be stable over the entire pH range studied with the only observed degradation being cleavage of the indolic N-4-chlorobenzoyl moiety... - Evaluation of O(3alpha)-, O(21)-di-(N(1)-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17alpha-hydroxy-5beta-pregnan-20-one as a novel potential antiangiogenic codrugMichelle Howard-Sparks
College of Pharmacy, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536, USA
J Enzyme Inhib Med Chem 20:417-28. 2005..In the hydrolysis studies 5FU was released at a faster rate than THS with an unknown intermediate observed by HPLC, a rationale and proposed structure and mechanism of the unknown THS derivative is provided... - Targeted brain delivery of 17 beta-estradiol via nasally administered water soluble prodrugsAbeer M Al-Ghananeem
Division of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
AAPS PharmSciTech 3:E5. 2002..These prodrugs are capable of producing high levels of estradiol in the CSF and as a result may have a significant value in the treatment of Alzheimer's disease... - Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congenersPeter A Crooks
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, 40536 0082, USA
Bioorg Med Chem Lett 16:4291-5. 2006..Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphine at the mu-opiate receptor and was the most selective compound at this receptor subtype... - Novel antiglaucoma prodrugs and codrugs of ethacrynic acidGrazyna Cynkowska
New England Eye Center, Boston, MA 02111, USA
Bioorg Med Chem Lett 15:3524-7. 2005....