Research Topics
| Vijay K SinghSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
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Detail Information
Publications
A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research InstituteVijay K Singh
Radiation Countermeasures Program, Scientific Research Department, Armed Forces Radiobiology Research Institute
Int J Radiat Biol 88:296-310. 2012..Here we review primarily the in vivo efficacy of selected countermeasures in animal models and clinical studies...- ?-Tocopherol succinate protects mice against radiation-induced gastrointestinal injuryPankaj K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
Radiat Res 177:133-45. 2012..Our data suggest that ?-TS protects mice from radiation-induced gastrointestinal damage by inhibiting apoptosis, promoting regeneration of crypt cells, and inhibiting translocation of gut bacteria... - Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factorVijay K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
Int J Radiat Biol 86:12-21. 2010..The purpose of this study was to further elucidate the role of granulocyte-colony stimulating factor (G-CSF)-induced in response to alpha-tocopherol succinate (TS) administration in protecting mice from total body irradiation (TBI)... - Immunomodulation by leadVijay K Singh
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Immunol Res 28:151-66. 2003.... - Effects of whole-body gamma irradiation and 5-androstenediol administration on serum G-CSFVijay K Singh
Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
Immunopharmacol Immunotoxicol 27:521-34. 2005.... - N-palmitoylation of the radioprotective domain of interleukin-1 affords inhibition of LPS-induced nitric oxide generationV K Singh
Radiation Casualty Management Team, Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
Immunopharmacol Immunotoxicol 26:193-202. 2004..These results indicate that N-palmitoylation of SRD may effectively ameliorate potentially fatal symptoms of LPS-induced endotoxemic hypotensive shock associated with IL-1 without inflammatory and pyrogenic toxic side effects... - Radioprotection by N-palmitoylated nonapeptide of human interleukin-1betaVijay K Singh
Radiation Casualty Management Team, Radiation Medicine Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
Peptides 26:413-8. 2005..These results suggest the importance of the derivatization of small peptides of radioprotective, but toxic cytokines in order to enhance radioprotective activity while reducing unwanted toxic side effects... - Role of cytokines and growth factors in radioprotectionVijay K Singh
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
Exp Mol Pathol 78:156-69. 2005..The information and insight gained about therapeutic potential of cytokine manipulation will allow for more rational design of treatment protocols... - Tocopherol succinate: modulation of antioxidant enzymes and oncogene expression, and hematopoietic recoveryVijay K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
Int J Radiat Oncol Biol Phys 79:571-8. 2011..We recently demonstrated that ?-tocopherol succinate (TS) is a potential radiation prophylactic agent. Our objective in this study was to further investigate the mechanism of action of TS in mice exposed to (60)Co ?-radiation... - Administration of 5-androstenediol to mice: pharmacokinetics and cytokine gene expressionV K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Exp Mol Pathol 84:178-88. 2008..The current results suggest that further studies are warranted to directly test the roles of cytokines in the radioprotective effects of 5-AED... - Induction of cytokines by radioprotective tocopherol analogsVijay K Singh
Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Exp Mol Pathol 81:55-61. 2006..These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy, where neutropenia is a serious problem with threatening infectious complications... - Mobilized progenitor cells as a bridging therapy for radiation casualties: a brief review of tocopherol succinate-based approachesVijay K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
Int Immunopharmacol 11:842-47. 2011.... - Gene therapy in ocular diseasesVijay K Singh
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Indian J Ophthalmol 50:173-81. 2002..Gene transfer into ocular tissues has been demonstrated with growing functional success and may develop into a new therapeutic tool for clinical ophthalmology in future... - Effects of genistein administration on cytokine induction in whole-body gamma irradiated miceVijay K Singh
Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
Int Immunopharmacol 9:1401-10. 2009.... - Tocopherol succinate: a promising radiation countermeasureVijay K Singh
Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
Int Immunopharmacol 9:1423-30. 2009..The stimulation of G-CSF by TS supports its effects on myeloid cell compartments. Our studies indicate that TS may be developed as a radioprotectant for humans against the potentially lethal effects of radiation exposure... - Preclinical development of a bridging therapy for radiation casualtiesVijay K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889 5603, USA
Exp Hematol 38:61-70. 2010..We report here preclinical development of a new bridging therapy that will allow the victim's immune system to recover from damage caused by ionizing radiation... - Immunomodulation by peptide analogs of retroviral envelope proteinShikhar Mehrotra
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
Peptides 24:979-85. 2003..7. Our observations suggests immunomodulatory potential of two retroviral peptide analogs... - ?-Tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in miceVijay K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Department of Radiation Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Exp Hematol 40:407-17. 2012.... - Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factorPankaj K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Cytokine 56:411-21. 2011..In conclusion, our current study suggests that induction of G-CSF resulting from TS administration is responsible for protection from 60Co ?-radiation injury... - Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasureVenkataraman Srinivasan
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland Wisconsin Avenue, Bethesda, MD 20889 5603, USA
Immunopharmacol Immunotoxicol 30:271-90. 2008..EUK-189 did not stimulate production of any cytokine or chemokine tested... - Human S-antigen: peptide determinant recognition in uveitis patientsParul Tripathi
Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow 226014, India
Exp Mol Pathol 76:122-8. 2004..In brief, our study suggests that a particular region of S-antigen plays an important role in idiopathic uveitis... - Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiolsK Sree Kumar
Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, Maryland 20889 5603, USA
Exp Mol Pathol 74:68-73. 2003.... - Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales diseaseSandeep Saxena
Department of Ophthalmology, King George s Medical University, Lucknow, India
Ocul Immunol Inflamm 17:201-6. 2009..The authors evaluated interleukin 1 beta (IL-1beta), interleukin-6 (IL-6), Interleukin-10 (IL-10), and tumor necrosis factor-alpha (TNF-alpha) in the serum of patients with Eales disease stages for the first time... - Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiationVijay K Singh
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA Department of Radiation Biology, F Edward Hebert School of Medicine, USUHS, Bethesda, MD, USA
Cytokine 58:406-14. 2012..Neutralizing antibody to G-CSF exacerbates the deleterious effects of radiation, indicating that G-CSF induced in response to irradiation plays an important role in recovery... - Immunomodulatory effects of curcuminV S Yadav
Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
Immunopharmacol Immunotoxicol 27:485-97. 2005..Our results suggest that curcumin most likely inhibits cell proliferation and cytokine production by inhibiting NF-kappaB target genes involved in the induction of these immune parameters... - Modulation of autoimmune diseases by nitric oxideV K Singh
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Immunol Res 22:1-19. 2000..This review will discuss the role of NO and nitric oxide synthase (NOS) in pathophysiologic and therapeutic implications in various autoimmune diseases with particular reference to T helper-1 (Th1) and T helper-2 (Th2) cytokines... - Inhibition of anti-CD3 and interleukin-2 stimulated T lymphocyte proliferation by peptidomimetic opioid compoundP Narayan
Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
Immunopharmacol Immunotoxicol 25:225-33. 2003..However, this peptidomimetic compound did not show any effect on LPS induced MAPK activation. These observations suggest that above peptidomimetic compound has potential to inhibit immune responses mediated by lymphocytes... - Immunomodulation by biphalin, dimeric synthetic opioid peptide, and its analogS Mehrotra
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Immunopharmacol Immunotoxicol 24:83-96. 2002..7. Our observations suggest immunomodulatory property of biphalin and its analog... - Immunomodulation by opioid peptidomimetic compoundP Narayan
Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
Neuroimmunomodulation 9:134-40. 2001..7, respectively. CONCLUSION: These observations suggest that compound 3 inhibits MLR through mu-opioid receptor present on cells... - Role of cytokines in experimental and clinical uveitisV K Singh
Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Indian J Ophthalmol 49:81-90. 2001..This article discusses in detail the uveitopathogenic and therapeutic potential of Th1 and Th2 cytokines in experimental and clinical uveitis... - Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizomeS Mehrotra
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226 014, India
Int Immunopharmacol 3:53-61. 2003..calamus extract but CD25 expression was down regulated. Our study demonstrates the antiproliferative and immunosuppressive potential of ethanolic extract of A. calamus rhizome in vitro... - Immunomodulation by ethanolic extract of Boerhaavia diffusa rootsS Mehrotra
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Int Immunopharmacol 2:987-96. 2002..Intracytoplasmic IFN-gamma and cell surface markers such as CD16, CD25, and HLA-DR did not get affected on treatment with B. diffusa extract. Our study demonstrates immunosuppressive potential of ethanolic extract of B. diffusa... - Inhibition of antigen specific lymphocyte proliferation and cytokine stimulation by peptidomimetic opioid compoundP Narayan
Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow, India
Int Immunopharmacol 2:751-7. 2002..Its immunosuppressive effect was further demonstrated by inhibition of interleukin-9 (IL-9), IL-10 but failed to influence IL-2, IL-15 and interferon-y (IFN-gamma) in PPD stimulated human PBMCs... - Cytokines in posterior uveitis: an updateV K Singh
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Immunol Res 23:59-74. 2001..This review evaluates various studies in which uveitopathogenic and therapeutic potentials of various Th1 and Th2 cytokines have been investigated... - The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergyV K Singh
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Immunol Res 20:147-61. 1999..In this review, we have discussed the paradigm of Th1 and Th2 cytokines in relation to autoimmunity and allergy... - Thymopentin and splenopentin as immunomodulators. Current statusV K Singh
Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Immunol Res 17:345-68. 1998..The immunomodulatory properties of TP, SP, TP-5, SP-5 and some of their synthetic analogs reported in the literature have been briefly reviewed...