Michael Daly

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi Death by protein damage in irradiated cells
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences USUHS, School of Medicine, Bethesda, MD 20814, USA
    DNA Repair (Amst) 11:12-21. 2012
  2. ncbi Comparative genomics of Thermus thermophilus and Deinococcus radiodurans: divergent routes of adaptation to thermophily and radiation resistance
    Marina V Omelchenko
    Department of Pathology, F E Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    BMC Evol Biol 5:57. 2005
  3. ncbi Protein oxidation implicated as the primary determinant of bacterial radioresistance
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS Biol 5:e92. 2007
  4. ncbi Modulating radiation resistance: Insights based on defenses against reactive oxygen species in the radioresistant bacterium Deinococcus radiodurans
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 4799, USA
    Clin Lab Med 26:491-504, x. 2006
  5. ncbi Engineering radiation-resistant bacteria for environmental biotechnology
    M J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Curr Opin Biotechnol 11:280-5. 2000
  6. ncbi Accumulation of Mn(II) in Deinococcus radiodurans facilitates gamma-radiation resistance
    M J Daly
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Science 306:1025-8. 2004
  7. ncbi The emerging impact of genomics on the development of biological weapons. Threats and benefits posed by engineered extremophiles
    M J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Clin Lab Med 21:619-29, x. 2001
  8. ncbi Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics
    K S Makarova
    Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA
    Microbiol Mol Biol Rev 65:44-79. 2001
  9. ncbi Specific expansion of protein families in the radioresistant bacterium Deinococcus radiodurans
    K S Makarova
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Genetica 108:25-34. 2000
  10. ncbi How radiation kills cells: survival of Deinococcus radiodurans and Shewanella oneidensis under oxidative stress
    Debabrota Ghosal
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    FEMS Microbiol Rev 29:361-75. 2005

Research Grants

  1. RADIOBIOLOGY OF D RADIODURANS--GENETIC APPROACH
    Michael Daly; Fiscal Year: 2001

Collaborators

Detail Information

Publications20

  1. ncbi Death by protein damage in irradiated cells
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences USUHS, School of Medicine, Bethesda, MD 20814, USA
    DNA Repair (Amst) 11:12-21. 2012
    ....
  2. ncbi Comparative genomics of Thermus thermophilus and Deinococcus radiodurans: divergent routes of adaptation to thermophily and radiation resistance
    Marina V Omelchenko
    Department of Pathology, F E Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    BMC Evol Biol 5:57. 2005
    ..radiodurans is a mesophile, which is highly radiation- and desiccation-resistant. Here we present an in-depth comparison of the genomes of these two related but differently adapted bacteria...
  3. ncbi Protein oxidation implicated as the primary determinant of bacterial radioresistance
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS Biol 5:e92. 2007
    ..We present the case that protein, rather than DNA, is the principal target of the biological action of IR in sensitive bacteria, and extreme resistance in Mn-accumulating bacteria is based on protein protection...
  4. ncbi Modulating radiation resistance: Insights based on defenses against reactive oxygen species in the radioresistant bacterium Deinococcus radiodurans
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 4799, USA
    Clin Lab Med 26:491-504, x. 2006
    ....
  5. ncbi Engineering radiation-resistant bacteria for environmental biotechnology
    M J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Curr Opin Biotechnol 11:280-5. 2000
    ..A cleanup technology is being developed based on the radiation-resistant bacterium Deinococcus radiodurans, which is being engineered to express bioremediating functions...
  6. ncbi Accumulation of Mn(II) in Deinococcus radiodurans facilitates gamma-radiation resistance
    M J Daly
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Science 306:1025-8. 2004
    ..In contrast, Shewanella oneidensis and Pseudomonas putida have high iron but low intracellular manganese concentrations and are very sensitive. We propose that Mn(II) accumulation facilitates recovery from radiation injury...
  7. ncbi The emerging impact of genomics on the development of biological weapons. Threats and benefits posed by engineered extremophiles
    M J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Clin Lab Med 21:619-29, x. 2001
    ..Using a generally applicable combination of conventional genetic engineering and genomic informatics, this extremely radiation-resistant and environmentally robust bacterium is being developed for biotechnology...
  8. ncbi Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics
    K S Makarova
    Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA
    Microbiol Mol Biol Rev 65:44-79. 2001
    ..In combination, these observations suggest that several different biological mechanisms contribute to the multiple DNA repair-dependent phenotypes of this organism...
  9. ncbi Specific expansion of protein families in the radioresistant bacterium Deinococcus radiodurans
    K S Makarova
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Genetica 108:25-34. 2000
    ..Such unique proteins are good targets for knock-out and gene expression studies, which are aimed to shed light on the unusual features of this interesting bacterium...
  10. ncbi How radiation kills cells: survival of Deinococcus radiodurans and Shewanella oneidensis under oxidative stress
    Debabrota Ghosal
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    FEMS Microbiol Rev 29:361-75. 2005
    ....
  11. ncbi Protein oxidation: key to bacterial desiccation resistance?
    James K Fredrickson
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    ISME J 2:393-403. 2008
    ..We present the case that survival of bacteria that inhabit dry-climate soils are highly dependent on mechanisms, which limit protein oxidation during dehydration...
  12. ncbi Hg(II) sequestration and protection by the MerR metal-binding domain (MBD)
    Jie Qin
    Department of Microbiology and the Center for Metalloenzyme Studies, University of Georgia, Athens, GA 30602 2605, USA
    Microbiology 152:709-19. 2006
    ..MBD expressed in the cystosol also afforded improved survival from Hg(II) exposure for E. coli and for the completely unrelated bacterium Deinococcus radiodurans...
  13. ncbi Transcriptome analysis applied to survival of Shewanella oneidensis MR-1 exposed to ionizing radiation
    Xiaoyun Qiu
    Center for Microbial Ecology, PSSB 540, Michigan State University, East Lansing, MI 48824, USA
    J Bacteriol 188:1199-204. 2006
    ..Instead, a combination of oxidative stress, protein damage, and prophage-mediated cell lysis during irradiation and recovery might underlie this organism's great sensitivity to IR...
  14. ncbi The structure of D. radiodurans
    John R Battista
    Science 302:567-8; author reply 567-8. 2003
  15. ncbi Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags
    Mary S Lipton
    Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999, MSIN: K8-98, Richland, WA 99352, USA
    Proc Natl Acad Sci U S A 99:11049-54. 2002
    ..This fraction represents the broadest proteome coverage for any organism to date and includes 715 proteins previously annotated as either hypothetical or conserved hypothetical...
  16. ncbi Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation
    Yongqing Liu
    Environmental Sciences and Life Sciences Divisions, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Proc Natl Acad Sci U S A 100:4191-6. 2003
    ..Components of this network include a predicted distinct ATP-dependent DNA ligase and metabolic pathway switching that could prevent additional genomic damage elicited by metabolism-induced free radicals...
  17. ncbi Deinococcus radiodurans engineered for complete toluene degradation facilitates Cr(VI) reduction
    Hassan Brim
    Department of Microbiology and Cancer Center, Howard University, 2041 Georgia Avenue N W, Washington, DC 20060, USA
    Microbiology 152:2469-77. 2006
    ..As such, the Tod/Xyl strain could provide a model for examining the reduction of metals coupled to organic contaminant oxidation in aerobic radionuclide-contaminated sediments...
  18. ncbi Multiple uracil-DNA glycosylase activities in Deinococcus radiodurans
    Margarita Sandigursky
    Department of Radiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    DNA Repair (Amst) 3:163-9. 2004
    ..radiodurans crude cell extracts utilizing the Ugi peptide. The implications for D. radiodurans having multiple uracil-DNA glycosylase activities and other possible roles for these enzymes are discussed...
  19. ncbi Deinococcus geothermalis: the pool of extreme radiation resistance genes shrinks
    Kira S Makarova
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 2:e955. 2007
    ....
  20. ncbi Engineering Deinococcus geothermalis for bioremediation of high-temperature radioactive waste environments
    Hassan Brim
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Appl Environ Microbiol 69:4575-82. 2003
    ..These characteristics support the prospective development of this thermophilic radiophile for bioremediation of radioactive mixed waste environments with temperatures as high as 55 degrees C...

Research Grants3

  1. RADIOBIOLOGY OF D RADIODURANS--GENETIC APPROACH
    Michael Daly; Fiscal Year: 2001
    ..These studies will delineate the genetics and biochemistry of radioresistance in D. radiodurans. Insight into its strategies may have broad implications for understanding radioresistance and DSB-metabolism throughout nature. ..