M Nakamura

Summary

Affiliation: Tularik Inc
Country: USA

Publications

  1. ncbi Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa
    Biochim Biophys Acta 1328:83-9. 1997
  2. ncbi Functional coupling of adenosine A2a receptor to inhibition of the mitogen-activated protein kinase cascade in Chinese hamster ovary cells
    D Hirano
    Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
    Biochem J 316:81-6. 1996
  3. ncbi Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor
    M Nakamura
    Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
    Biochim Biophys Acta 1284:134-7. 1996
  4. ncbi KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa, Japan
    Receptors Channels 5:255-71. 1998
  5. ncbi Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors
    M Nakamura
    Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
    J Biol Chem 270:30102-10. 1995
  6. ncbi Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation
    T Izumi
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Biochem J 305:829-35. 1995
  7. ncbi A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages
    S Ishii
    Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Japan
    Biochem J 314:671-8. 1996
  8. ncbi Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
    M Yokoyama
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Inc, 13 2, Fukuura 1 chome, Kanazawa Ku, Yokohama, Kanagawa, 236, Japan
    Genomics 59:40-50. 1999
  9. ncbi A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping
    M Fujioka
    First Department of Internal Medicine, Mie University School of Medicine, Japan
    Genomics 49:59-68. 1998
  10. ncbi Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus
    J Miyagawa
    Institute for Protein Research, Osaka University, 3 2, Yamadaoka, Suita, Osaka, Japan
    Gene 240:289-95. 1999

Detail Information

Publications62

  1. ncbi Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa
    Biochim Biophys Acta 1328:83-9. 1997
    ..The mouse NPY-Y5 receptor gene can map about 10 kbp upstream of the transcriptional initiation sites of the NPY-Y1 receptor gene with an opposite orientation...
  2. ncbi Functional coupling of adenosine A2a receptor to inhibition of the mitogen-activated protein kinase cascade in Chinese hamster ovary cells
    D Hirano
    Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
    Biochem J 316:81-6. 1996
    ..These results suggest that cyclic AMP production through Ado A2a receptor inhibits thrombin-elicited MAPK activation by a Ca(2+)-independent/wortmannin-sensitive pathway in CHO cells...
  3. ncbi Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor
    M Nakamura
    Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
    Biochim Biophys Acta 1284:134-7. 1996
    ....
  4. ncbi KQT2, a new putative potassium channel family produced by alternative splicing. Isolation, genomic structure, and alternative splicing of the putative potassium channels
    M Nakamura
    Pharmaceutical Basic Research Laboratories Aobadai, Japan Tobacco Inc, Kanagawa, Japan
    Receptors Channels 5:255-71. 1998
    ..10 or mKQT2.11) were abundantly found on the 11th day after gestation. Although these mKQT2 isoforms had the characteristic structure of voltage-gated K+ channels, functional expression of K+ currents were not detected in Xenopus oocytes...
  5. ncbi Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors
    M Nakamura
    Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
    J Biol Chem 270:30102-10. 1995
    ..These results suggest that the Y1 beta receptor is an embryonic and a bone marrow form of the NPY-Y1 receptor, which decreases in the expression during development and differentiation...
  6. ncbi Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation
    T Izumi
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Biochem J 305:829-35. 1995
    ..These systems may provide a useful experimental model with which to investigate the relationship between eosinophilic differentiation and PAF receptor induction, and the role of eosinophils in allergic responses...
  7. ncbi A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages
    S Ishii
    Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Japan
    Biochem J 314:671-8. 1996
    ..These induction patterns were parallel to those of tumor necrosis factor-alpha mRNA. Thus the PAFR in macrophages is important in LPS-induced pathologies...
  8. ncbi Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
    M Yokoyama
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Inc, 13 2, Fukuura 1 chome, Kanazawa Ku, Yokohama, Kanagawa, 236, Japan
    Genomics 59:40-50. 1999
    ..These data suggest that this family of proteins may be involved in determining and maintaining a cell-specific phenotype through regulation of certain genes responsive to second messenger-mediated signals...
  9. ncbi A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping
    M Fujioka
    First Department of Internal Medicine, Mie University School of Medicine, Japan
    Genomics 49:59-68. 1998
    ..1, compared to the chromosomal location 12q15-q21-2 for MYPT1. It is suggested that the products of the two gene families of myosin phosphatase target subunit may be localized differently among various tissues...
  10. ncbi Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus
    J Miyagawa
    Institute for Protein Research, Osaka University, 3 2, Yamadaoka, Suita, Osaka, Japan
    Gene 240:289-95. 1999
    ..Overexpression of AZ2 inhibited TNF alpha mediated NFkappaB activation. AZ2 could be a component of a regulator of the NFkappaB activation cascade...
  11. ncbi Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain
    J Sun
    Department of Neurochemistry and Neuropharmacology, Biomedical Research Center, Osaka University Medical School, Suita, Japan
    FEBS Lett 437:304-8. 1998
    ..The PSD-Zip45 is, therefore, the first candidate as receptor anchoring proteins containing leucine zipper motifs in the central nervous system...
  12. ncbi The replicon of the cryptic Plasmid pSBO1 isolated from Streptococcus bovis JB1
    M Nakamura
    Rumen Microbiology Research Team, STAFF-Institute, 446-1 Ippaizuka, Kamiyokoba, Tsukuba, Ibaraki 305-0854, Japan
    Curr Microbiol 43:11-6. 2001
    ..bovis 12-U-1 and no8 strains. This result indicates that the putative rep encoded Rep and that the replicon of pSBO1 contained the DRs and the rep. Gel shift assays showed that the Rep of pSBO1 bound the 22-bp DRs...
  13. ncbi Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA
    H Bito
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 221:211-8. 1994
    ..Isolation of rat PAF-receptor cDNA should facilitate further analysis of PAF-receptor function and pharmacology in diverse pathophysiological processes...
  14. ncbi Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex
    H Nishitani
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Gene 272:25-33. 2001
    ..In this context, our previous notion that RanBPM is a centrosomal protein should be discarded. RanBPM is well conserved in the animal kingdom. It may play an important role in uncovering Ran-dependent nuclear events...
  15. ncbi Expression of Dax-1 during gonadal development of the frog
    J Sugita
    Department of Biology, School of Education, Waseda University, 1-6-1 Nishi-Waseda, Shinjuku-ku, Tokyo 169-8050, Japan
    Gene 280:67-74. 2001
    ..Taken together, the results suggest that the Dax-1 may be closely involved in testicular development of amphibians...
  16. ncbi Tobacco plants transformed with the O-acetylserine (thiol) lyase gene of wheat are resistant to toxic levels of hydrogen sulphide gas
    S Youssefian
    Laboratory of Molecular Genetics, Akita Prefectural College of Agriculture, Japan
    Plant J 4:759-69. 1993
    ..Fumigation experiments with toxic levels of hydrogen sulphide (H2S) gas showed that while sense transformants were highly resistant, control and antisense plants were severely damaged by the treatment...
  17. ncbi Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs
    Y Okazaki
    1] Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan
    Nature 420:563-73. 2002
    ..The present work, completely supported by physical clones, provides the most comprehensive survey of a mammalian transcriptome so far, and is a valuable resource for functional genomics...
  18. ncbi Cloning, gene structure and dietary regulation of the type-IIc Na/Pi cotransporter in the mouse kidney
    I Ohkido
    Department of Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, 770 850, Tokushima City, Japan
    Pflugers Arch 446:106-15. 2003
    ..The present study suggests that the type-IIc Na/Pi cotransporter is a functional of renal Pi transporter in adult mice fed a low-Pi diet...
  19. ncbi Lactoferrin Glu561Asp facilitates secondary amyloidosis in the cornea
    K Araki-Sasaki
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-0811, Japan
    Br J Ophthalmol 89:684-8. 2005
    ..CONCLUSION: Lactoferrin Glu561Asp is a key polymorphism related to facilitating amyloid formation in corneal amyloidosis with trichiasis...
  20. ncbi Plastidic RNA polymerase sigma factors in Arabidopsis
    K Kanamaru
    Laboratory of Molecular Genetics, University of Tokyo, Japan
    Plant Cell Physiol 40:832-42. 1999
    ..In addition, the two promoters were repeatedly activated in young seedlings under continuous light, possibly in an oscillated fashion...
  21. ncbi Stepwise progression of centrosome defects associated with local tumor growth and metastatic process of human pancreatic carcinoma cells transplanted orthotopically into nude mice
    M Shono
    Department of Surgery and OncologyGraduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lab Invest 81:945-52. 2001
    ....
  22. ncbi Functional assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-ORF3 gene cluster involved in the assembly of Fe-S clusters in Escherichia coli
    Y Takahashi
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560 0043, Japan
    J Biochem 126:917-26. 1999
    ..We propose a model in which the fdx gene product functions as an intermediate site for Fe-S cluster assembly...
  23. ncbi Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC
    F Hamada
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita 565 0871, Japan and
    Genes Cells 4:465-74. 1999
    ..The product of the APC gene forms a complex with beta-catenin, glycogen synthase kinase 3beta (GSK-3beta) and Axin/conductin, and induces the degradation of beta-catenin...
  24. ncbi Transfection of antisense core 2 beta1,6-N-acetylglucosaminyltransferase-1 cDNA suppresses selectin ligand expression and tissue infiltration of B-cell precursor leukemia cells
    J Kikuchi
    Cell Regulation Analysis Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    Leukemia 19:1934-40. 2005
    ..Downregulation of the selectin ligand expression level inhibits tissue infiltration of BCP-leukemia cells. C2GnT-1 may be a candidate of therapeutic target for the inhibition of infiltration of leukemia cells...
  25. ncbi Molecular cloning of a human neuroD from a neuroblastoma cell line specifically expressed in the fetal brain and adult cerebellum
    M Yokoyama
    Life Science Research Laboratory, Japan Tobaco, Inc, Kanagawa, Japan
    Brain Res Mol Brain Res 42:135-9. 1996
    ..The results suggest that the human as well as the mouse neuroD may play some important functions not only in the fetal brain but also in the fetal brain but also in the matured neurons of the cerebellum...
  26. ncbi Cloning, expression, and fatty acid regulation of the human delta-5 desaturase
    H P Cho
    Program of Nutritional Sciences and the Institute for Cellular and Molecular Biology, The University of Texas Austin, Austin, Texas 78712, USA
    J Biol Chem 274:37335-9. 1999
    ..Finally, a BLAST and Genemap search of the human genome revealed that the Delta-5 and Delta-6 desaturase genes reside in reverse orientation on chromosome 11 and that they are separated by <11,000 base pairs...
  27. ncbi Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis
    J Kikuchi
    Division of Molecular Hemopoiesis, Center for Molecular Medicine, Jichi Medical School, Tochigi, Japan
    Arterioscler Thromb Vasc Biol 20:128-34. 2000
    ..These results suggest that LIG contributes to foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequent degradation of p53...
  28. ncbi Diet-dependent shifts in the bacterial population of the rumen revealed with real-time PCR
    K Tajima
    Laboratory of Rumen Microbiology, STAFF-Institute, Tsukuba, Ibaraki 305-0854, Japan
    Appl Environ Microbiol 67:2766-74. 2001
    ..This observation may explain why some predominant rumen bacteria have not been detected in PCR-generated 16S ribosomal DNA libraries...
  29. ncbi Defect of lck in a patient with common variable immunodeficiency
    T Sawabe
    First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    Int J Mol Med 7:609-14. 2001
    ..Considering these findings, the aberrant splicing of lck gene is suggested to be correlated, at least with a subset of congenital immunodeficiency plus CD4 lymphopenia...
  30. ncbi A novel serum protein that is selectively produced by cytotoxic lymphocytes
    K Ogawa
    R and D Center and Laboratory Headquarters, BML, Saitama, Japan
    J Immunol 166:6404-12. 2001
    ..These results suggest that Ksp37 may be involved in an essential process of cytotoxic lymphocyte-mediated immunity and that Ksp37 may also have clinical value as a new type of serum indicator for monitoring cytotoxic lymphocytes in vivo...
  31. ncbi Mutations affecting nerve attachment of Caenorhabditis elegans
    G Shioi
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Genetics 157:1611-22. 2001
    ..The pleiotropic nature of the defects indicates that ven and mua/mup genes are required generally for the maintenance of attachment of tissues to the body wall in C. elegans...
  32. ncbi Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
    S Vidal
    Centre de Genetique Moleculaire, CNRS, 91198 Gif sur Yvette, France
    Genes Dev 15:1900-12. 2001
    ..Our genetic demonstration of dTAK1's role in the regulation of Drosophila antimicrobial peptide gene expression suggests an evolutionary conserved role for TAK1 in the activation of Rel/NF-kappaB-mediated host defense reactions...
  33. ncbi Nuclear factor 1 is a negative regulator of gadd153 gene expression in vascular smooth muscle cells
    M Nakamura
    Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
    Hypertension 37:419-24. 2001
    ..These results suggest that gadd153 gene expression in VSMCs is negatively regulated by an NF1-binding motif, and NF1 may act as an antiapoptotic factor by continuously suppressing gadd153 gene expression in growing VSMCs...
  34. ncbi Interleukin-10 relieves the inhibitory effects of interferon-gamma on normal human lung fibroblasts
    T Hashimoto
    Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
    Int J Mol Med 7:149-54. 2001
    ..The relief of the suppressive function of IFN-gamma by IL-10 suggested that IL-10 is indirectly involved in the remodeling process in the lung interstitium...
  35. ncbi Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes
    S Colella
    International Agency for Research on Cancer (IARC, Lyon, France
    Int J Cancer 93:798-804. 2001
    ..By comparison, the levels of the Balpha and Calpha subunits were mostly normal. Our data indicate that these tumors contain very low levels of core and holoenzyme and high amounts of unregulated catalytic C subunit...
  36. ncbi Green fluorescent protein-transgenic rat: a tool for organ transplantation research
    Y Hakamata
    Center for Molecular Medicine, Jichi Medical School, Kawachi, Tochigi, Japan
    Biochem Biophys Res Commun 286:779-85. 2001
    ..These results showed that GFP transgenic rat is a useful tool for organ transplantation research such as cell migration study after organ transplantation without donor cell staining...
  37. ncbi Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
    F Hamada
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita 565 0871, Japan
    Science 283:1739-42. 1999
    ..Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila...
  38. ncbi Selective expression of a novel surface molecule by human Th2 cells in vivo
    K Nagata
    R and D Center, BioMedical Laboratories, Kawagoe, Saitama, Japan
    J Immunol 162:1278-86. 1999
    ..Together, these results indicate that CRTH2 is selectively expressed in vivo in an activated state of Th2 cells including allergen-responsive Th2 cells, suggesting its pivotal roles in ongoing Th2-type immune reactions...
  39. ncbi Isolation and properties of platelet-activating factor receptor cDNAs
    M Nakamura
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    J Lipid Mediat 6:163-8. 1993
    ....
  40. ncbi Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor
    H Mutoh
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    FEBS Lett 322:129-34. 1993
    ..Existence of distinct promoters was thus suggested to play a role in the regulatory control of PAF receptor gene expression in different human tissues and cells...
  41. ncbi A novel transcript from a pseudogene for human glucocerebrosidase in non-Gaucher disease cells
    K Imai
    Department of Biochemistry, Shimane Medical University, Izumo, Japan
    Gene 136:365-8. 1993
    ..In vitro translation of RNA synthesized by transcription of the pseudogene cDNA produced a polypeptide of approximately 30 kDa...
  42. ncbi Arachidonate 12-lipoxygenase of rat pineal glands: catalytic properties and primary structure deduced from its cDNA
    T Hada
    Department of Biochemistry, Tokushima University, School of Medicine, Japan
    Biochim Biophys Acta 1211:221-8. 1994
    ..The predominant presence of 12-lipoxygenase mRNA in pineal gland was confirmed by in situ hybridization of rat brain. Significant amounts of 12-lipoxygenase mRNA were also detected in rat spleen, aorta, lung and leukocytes...
  43. ncbi Molecular cloning and characterization of the inositol 1,4,5-trisphosphate receptor in Drosophila melanogaster
    S Yoshikawa
    Division of Behavior and Neurobiology, National Institute for Basic Biology, Okazaki, Japan
    J Biol Chem 267:16613-9. 1992
    ..The present study points to the likely functional importance of the InsP3/Ca2+ signaling system in Drosophila...
  44. ncbi Molecular cloning and characterization of a cDNA encoding monoclonal nonspecific suppressor factor
    M Nakamura
    Department of Biochemistry, Shimane Medical University, Izumo, Japan
    Proc Natl Acad Sci U S A 92:3463-7. 1995
    ..Recombinant MNSF beta also showed a similar biologic activity. Thus, ubiquitin-like protein(s) may be involved in the regulation of the immune responses...
  45. ncbi Studies of cloned DNA encoding the structure for the bovine corticotropin-beta-lipotropin precursor protein
    S N Cohen
    Ann N Y Acad Sci 343:415-24. 1980
  46. ncbi Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax
    S Miura
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Mol Cell Biol 11:1313-25. 1991
    ....
  47. ncbi Cloning of the gamma chain of the human IL-2 receptor
    T Takeshita
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Science 257:379-82. 1992
    ..Thus, the gamma chain is an indispensable component of the functional IL-2R...
  48. ncbi Novel variant transthyretin gene (Ser50 to Ile) in familial cardiac amyloidosis
    H Nishi
    Department of Genetics, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 187:460-6. 1992
    ..Subsequent sequencing analysis revealed a T to A transversion and led to a replacement of Ser by Ile at codon 50 of the TTR gene...
  49. ncbi Molecular mechanism of the regulation of expression of plasmid-encoded mouse bacteremia (mba) genes in Salmonella serovar Choleraesuis
    H Matsui
    Department of Bacteriology, Kitasato Institute, Tokyo, Japan
    Mol Gen Genet 236:219-26. 1993
    ..The present study provides clear evidence to show that the Mba1 protein binds to the promoter region of mba2, and positively regulates the expression of mba2, mba3, and mba4 genes...
  50. ncbi The primary structures and properties of non-stomach lysozymes of sheep and cow, and implication for functional divergence of lysozyme
    Y Ito
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Biochem 213:649-58. 1993
    ..The decreased net positive charge observed in cow and sheep kidney lysozymes may suggest that the ruminant kidney lysozyme had functioned once as a digestive enzyme in the stomach of an ancestral ruminant...
  51. ncbi Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors
    S Kumaki
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 193:356-63. 1993
    ..These results indicate that the mouse functional IL-2 receptor is a complex comprising three distinct subunits, alpha, beta and gamma chains, but the beta gamma heterodimer is not functional and different from the human heterodimer...
  52. ncbi Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice
    A Kushi
    Central Pharmaceutical Research Institute, Pharmaceutical Frontiers Research Laboratory, Japan Tobacco Inc, 1 13 2, Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236, Japan
    Proc Natl Acad Sci U S A 95:15659-64. 1998
    ..This model will be useful for studying the mechanism of mild obesity and abnormal insulin metabolism in noninsulin-dependent diabetes mellitus...
  53. ncbi Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase
    A Ishii
    Virology and Glycobiology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 273:31652-5. 1998
    ..4-kilobase transcript of the gene was found in a tissue-specific manner, with predominant expression in brain, skeletal muscle, and testis, and very low expression in liver...
  54. ncbi When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin
    M Nakamura
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 82, Japan
    J Cell Biol 143:1041-52. 1998
    ..These results provide evidence that the Ran-binding protein, RanBPM, is involved in microtubule nucleation, thereby suggesting that Ran regulates the centrosome through RanBPM...
  55. ncbi Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain
    M Watanabe
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Eur J Neurosci 10:2016-25. 1998
    ....
  56. ncbi Molecular mechanisms of promoter regulation of the gp34 gene that is trans-activated by an oncoprotein Tax of human T cell leukemia virus type I
    K Ohtani
    Human Gene Sciences Center, Japan
    J Biol Chem 273:14119-29. 1998
    ..Our results imply complex regulation of expression of the gp34 gene and suggest implication of gp34 in proliferation of HTLV-I infected T cells...
  57. ncbi Cloning and recombinant expression of rat and human kynureninase
    S Toma
    BioScience Center, Pharmacia and Upjohn, Nerviano, Italy
    FEBS Lett 408:5-10. 1997
    ..Interestingly, COS-1 cells transfected with the cDNA coding for rat kynureninase also display cysteine-conjugate beta-lyase activity...
  58. ncbi Genomic organization of the mouse AZ1 gene that encodes the protein localized to preacrosomes of spermatids
    H Aoto
    Institute for Protein Research, Osaka University, Japan
    Genomics 40:138-41. 1997
    ..Exon 1 and a part of intron 1 of the AZ1 gene constituted a typical CpG island, and an about 0.2-kb sequence of the 5'-proximal region exhibited a G + C content and CpG ratio higher than the averages for the mammalian genomic sequence...
  59. ncbi Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1
    E Noguchi
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    EMBO J 15:5595-605. 1996
    ..pombe homologues of Ran and RCC1, respectively. Although the biological function of the heterotrimeric oligomer consisting of Dis3, Spi1 and Pim1 is unknown, our results indicate that Dis3 is a component of the RCC1-Ran pathway...
  60. ncbi The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development
    K Ohta
    Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Japan
    Mech Dev 54:59-69. 1996
    ..The unique expression of Cek8 suggests its involvement in cellular survival or cell-cell interactions for specific subpopulations of developing motoneurons...
  61. ncbi A novel human tyrosine kinase gene inducible in T cells by interleukin 2
    N Tanaka
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    FEBS Lett 324:1-5. 1993
    ..This gene was transcriptionally induced in normal T cells by interleukin 2 stimulation. These results suggest the crucial roles of this gene in T cell proliferation and differentiation...
  62. ncbi Cloning and sequencing of a rat type II activin receptor
    H Shinozaki
    Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan
    FEBS Lett 312:53-6. 1992
    ..We examined the effect of PMSG-hCG on the mRNA level of type II activin receptor in immature rat ovaries. Northern blot analysis of ovarian RNA revealed two mRNAs (3.0 kb and 6.0 kb)...