Research Topics
| Natalia A TrayanovaSummaryAffiliation: Tulane University Country: USA Publications
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Detail Information
Publications
Defibrillation of the heart: insights into mechanisms from modelling studiesNatalia Trayanova
Department of Biomedical Engineering, 500 Lindy Boggs Center, Suite 500, Tulane University, New Orleans, LA 70118, USA
Exp Physiol 91:323-37. 2006..The article does this by reviewing the results of two studies, one on vulnerability to electric shocks and another on defibrillation. An overview of the modelling tools used in these studies is also provided...- Virtual electrode-induced positive and negative graded responses: new insights into fibrillation induction and defibrillationNatalia A Trayanova
Department of Biomedical Engineering, Tulane University, Boggs Center, Suite 500, New Orleans, LA 70118, USA
J Cardiovasc Electrophysiol 14:756-63. 2003 - Myocardial ischemia lowers precordial thump efficacy: an inquiry into mechanisms using three-dimensional simulationsWeihui Li
Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA
Heart Rhythm 3:179-86. 2006..Success rates vary and, according to clinical evidence, are significantly reduced under ischemic conditions... - Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarizationMary M Maleckar
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
Biophys J 97:2179-90. 2009..Our model provides mechanistic insight into the consequences of heterologous cell coupling on hAM electrophysiology, and can be extended to evaluate these implications at both tissue and organ levels... - Characterization of the relationship between preshock state and virtual electrode polarization-induced propagated graded responses resulting in arrhythmia inductionDavid W Bourn
Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA
Heart Rhythm 3:583-95. 2006..VEPiPGRs originate at the sites of maximum action potential abbreviation by the shock, always on the epicardium for the preparation used here... - Cell and tissue responses to electric shocksTakashi Ashihara
Department of Biomedical Engineering, Tulane University, Boggs Center, New Orleans, LA 70118, USA
Europace 7:155-65. 2005..CONCLUSIONS: The incorporation of electroporation and I(a) in a membrane model ensures match between simulation results and experimental data. The use of the aLRd model results in a lower threshold for shock-induced break excitation... - Tunnel propagation following defibrillation with ICD shocks: hidden postshock activations in the left ventricular wall underlie isoelectric windowJason Constantino
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
Heart Rhythm 7:953-61. 2010..The mechanisms underlying the IW remain incompletely understood... - Electromechanical models of the ventriclesNatalia A Trayanova
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
Am J Physiol Heart Circ Physiol 301:H279-86. 2011..Computational modeling of cardiac electromechanics will continue to complement basic science research and clinical cardiology and holds promise to become an important clinical tool aiding the diagnosis and treatment of cardiac disease... - Mechanistic inquiry into decrease in probability of defibrillation success with increase in complexity of preshock reentrant activityMatthew G Hillebrenner
Dept. of Biomedical Engineering, 500 Lindy Boggs Center, Suite 500, Tulane Univ, New Orleans, LA 70118, USA
Am J Physiol Heart Circ Physiol 286:H909-17. 2004.... - Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atriumMary M Maleckar
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
Prog Biophys Mol Biol 98:161-70. 2008..This study provides a basis for beginning to assess the utility of mathematical modeling in understanding detailed cell-cell interactions within the complex paracrine environment of the human atrial myocardium... - Mechanistic enquiry into the effect of increased pacing rate on the upper limit of vulnerabilityDavid W Bourn
Tulane University, Department of Biomedical Engineering 7001 Freret Street, New Orleans, LA 70118, USA
Philos Transact A Math Phys Eng Sci 364:1333-48. 2006..This explains why shocks of the same strength were more likely to result in arrhythmia induction when delivered to a preparation that was rapidly paced... - Asymmetry in membrane responses to electric shocks: insights from bidomain simulationsTakashi Ashihara
Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA
Biophys J 87:2271-82. 2004..Inclusion of Ia and electroporation is thus the bridge between experiment and simulation... - Postshock arrhythmogenesis in a slice of the canine heartMatthew G Hillebrenner
Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118, USA
J Cardiovasc Electrophysiol 14:S249-56. 2003..CONCLUSION: These results present new evidence regarding the mechanisms underlying failure of defibrillation shocks... - Models of cardiac electromechanics based on individual hearts imaging data: image-based electromechanical models of the heartViatcheslav Gurev
Institute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, 3400 N Charles St, CSEB Room 218, Baltimore, MD 21218, USA
Biomech Model Mechanobiol 10:295-306. 2011..The utility of the model is demonstrated in an example simulation of contraction during sinus rhythm using a model of the normal canine ventricles... - Action potential morphology heterogeneity in the atrium and its effect on atrial reentry: a two-dimensional and quasi-three-dimensional studySamuel R Kuo
Tulane University New Orleans, LA 70118, USA
Philos Transact A Math Phys Eng Sci 364:1349-66. 2006..The main effect of the continuous surface is the generation of secondary spiral waves which influences the primary rotors. The interaction of the primary and secondary spiral waves decreased as cylinder diameter increased... - Maintenance of ventricular fibrillation in heterogeneous ventricleHamenegild J Arevalo
Dept of Biomed Eng, Tulane Univ, New Orleans, LA 70118, USA
Conf Proc IEEE Eng Med Biol Soc 1:3950-3. 2006..The 3D computer simulations suggest that IK1 spatial heterogeneity alone can not lead to the formation of a stable rotor... - Cardiac defibrillation and the role of mechanoelectric feedback in postshock arrhythmogenesisViatcheslav Gurev
Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles Street, Clark Hall 201, Baltimore, MD 21218, USA
Ann N Y Acad Sci 1080:320-33. 2006..Stretch-induced deformation and changes in tissue conductivities resulted in a decrease in vulnerability to electric shocks... - Termination of reentry by a long-lasting AC shock in a slice of canine heart: a computational studyJason M Meunier
Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana 70118-5674, USA
J Cardiovasc Electrophysiol 13:1253-61. 2002..CONCLUSION: This study offers for the first time a mechanistic insight into cardioversion with long-lasting AC shocks... - Estimation of local orientations in fibrous structures with applications to the Purkinje systemHasan E Cetingül
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
IEEE Trans Biomed Eng 58:1762-72. 2011..Experiments on the free-running PS in an MR image also demonstrate the accuracy of our method in reconstructing such sparse fibrous structures... - Somato-dendritic mechanisms underlying the electrophysiological properties of hypothalamic magnocellular neuroendocrine cells: a multicompartmental model studyAlexander O Komendantov
Center for Computational Science, Tulane University, New Orleans, LA 70118, USA
J Comput Neurosci 23:143-68. 2007.... - Whole-heart modeling: applications to cardiac electrophysiology and electromechanicsNatalia A Trayanova
Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
Circ Res 108:113-28. 2011.... - The role of mechanoelectric feedback in vulnerability to electric shockWeihui Li
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
Prog Biophys Mol Biol 97:461-78. 2008.... - The role of photon scattering in optical signal distortion during arrhythmia and defibrillationMartin J Bishop
Oxford University Computing Laboratory, Oxford OX1 3QD, United Kingdom
Biophys J 93:3714-26. 2007..A shift of up to 4 mm in the phase singularity location was observed in V(opt) maps when compared to V(m). This combined experimental/simulation study provides an interpretation of optical recordings during VT and defibrillation... - Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heartMartin J Bishop
Computational Biology Group, University of Oxford Computing Laboratory, Oxford, UK
J Electrocardiol 40:S75-80. 2007..Computational models of the fluorescence recording are capable of assessing these distortion effects, providing important insight to assist experimental data interpretation... - Tunnel propagation of postshock activations as a hypothesis for fibrillation induction and isoelectric windowTakashi Ashihara
Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan
Circ Res 102:737-45. 2008..The tunnel propagation hypothesis could open a new avenue for interventions exploration to achieve significantly lower defibrillation threshold... - Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summaryYoram Rudy
Cardiac Bioelectricity and Arrhythmia Center, The Fred Saigh Distinguished Professor, Washington University, Campus Box 1097, Whitaker Hall Room 290B, One Brookings Dr, St Louis, MO 63130 4899, USA
Circulation 118:1202-11. 2008..The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm... - From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scalesGernot Plank
Institute of Biophysics, Medical University Graz, 8010 Graz, Austria
Philos Transact A Math Phys Eng Sci 366:3381-409. 2008.... - Computational techniques for solving the bidomain equations in three dimensionsEdward J Vigmond
Department of Electrical and Computer Engineering, University of Calgary, 2500 University Dr NW, Calgary, AB T2N 1N4, Canada
IEEE Trans Biomed Eng 49:1260-9. 2002..Parallelization over four processors was efficient only when the model comprised at least 500,000 nodes. Thus, it was possible to speed up solution of the bidomain equations by an order of magnitude with a slight decrease in accuracy... - The long and the short of long and short duration ventricular fibrillationNatalia A Trayanova
Circ Res 102:1151-2. 2008 - Are we closer to understanding defibrillation in the whole heart?Natalia A Trayanova
J Cardiovasc Electrophysiol 13:1128-30. 2002