Research Topics
Genomes and GenesSpecies | Bin ShanSummaryAffiliation: Tulane University Country: USA Publications
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Publications
Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transitionBin Shan
Department of Medicine and Tulane Cancer Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
J Biol Chem 283:21065-73. 2008..Our results identify HDAC6 as a critical regulator of EMT and a potential therapeutic target against pathological EMT, a key event for tumor progression and fibrogenesis...- Epstein - Barr virus Latent Membrane Protein 1 suppresses reporter activity through modulation of promyelocytic leukemia protein-nuclear bodiesMark D Sides
Department of Medicine, Section of Pulmonary Disease and Critical Care, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
Virol J 8:461. 2011..These data offer an explanation for previously conflicting data on LMP1 signaling and calls attention to the possibility of false-positives and false-negatives when using reporter assays as a research tool in cells expressing LMP1... - The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--?1 synergistically induce epithelial--mesenchymal transition in lung epithelial cellsMark D Sides
Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
Am J Respir Cell Mol Biol 44:852-62. 2011..Our in vitro data may help to explain the observation that patients with IPF demonstrating positive staining for LMP1 in lung epithelial cells have a more rapid demise than patients in whom LMP1 is not detected... - Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinaseBin Shan
Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
PLoS ONE 5:e11662. 2010..The current study provides a novel mechanistic insight to the distinct roles of fibroblast Thy-1 subsets in inflammation... - Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cellsMark D Sides
Department of Medicine, Section of Pulmonary Disease and Critical Care, Tulane University School of Medicine, New Orleans, LA, USA
Virology 416:86-97. 2011..This study introduces an effective modality to induce susceptibility to ganciclovir in epithelial cells with implications for the treatment of EBV associated pathologies... - Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibitionWeichao Guo
Biomedical Sciences Program, 1430 Tulane Ave SL 9, Tulane Medical School, New Orleans, LA 70112, USA
Am J Physiol Lung Cell Mol Physiol 297:L864-70. 2009..Together, these data demonstrate that the differentiation of NHLFs to myofibroblasts is HDAC4 dependent and requires phosphorylation of Akt... - Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activationYan Zhuang
Department of Medicine, Tulane School of Medicine, New Orleans, LA 70112, USA
Biochem Biophys Res Commun 392:608-13. 2010..Taken together, our results implicate that expression and function of hHDAC6p114 is differentially regulated when compared to hHDAC6p131... - Activation of proMMP-2 and Src by HHV8 vGPCR in human pulmonary arterial endothelial cellsBin Shan
Department of Medicine, Pulmonary Section, Department of Microbiology, Tulane Cancer Center and Program in Lung Biology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
J Mol Cell Cardiol 42:517-25. 2007..The current study implicates vGPCR as an etiological agent in iPAH and identifies Src and MMP-2 as potential therapeutic targets in HHV8 associated KS and iPAH... - Over-expression of PDGF-C using a lung specific promoter results in abnormal lung developmentYing Zhuo
Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
Transgenic Res 15:543-55. 2006..These results suggest that PDGF-C is activated during lung development and is a potent growth factor for mesenchymal cells in vivo... - Modulation of lung inflammation by the Epstein-Barr virus protein ZtaJames F Guenther
Dept of Pathology, Tulane Univ Health Sciences Center, New Orleans, LA 70112, USA
Am J Physiol Lung Cell Mol Physiol 299:L771-84. 2010..These observations indicate that the EBV lytic transactivator protein Zta displays activity consistent with a pathogenic role in pulmonary fibrosis associated with herpesvirus infection... - Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombinShigeki Saito
Department of Medicine, Tulane Medical School, New Orleans, LA, USA
Biochem Biophys Res Commun 408:630-4. 2011..Histone deacetylase 6 (HDAC6) deacetylates ?-tubulin, and thereby destabilizes microtubules. This study investigates a role for HDAC6 in EBD... - Binding sequence-dependent regulation of the human proliferating cell nuclear antigen promoter by p53Bin Shan
Program in Molecular and Cellular Biology, Department of Pathology, Tulane Cancer Center and Tulane Xavier Center for Bioenvironmental Research, Tulane University Health Sciences Center, SL 79, 1430 Tulane Avenue, New Orleans, LA 70112 2699, USA
Exp Cell Res 305:10-22. 2005..Limited activation of the PCNA promoter by p53 and its modified forms would restrict the amount of PCNA made available for DNA repair... - Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotypeChanghua Zhou
Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA
Breast Cancer Res 10:R105. 2008.... - Molecular recognition and enhancement of aqueous solubility and bioactivity of CD437 by ?-cyclodextrinRobert J Mishur
Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, United States
Bioorg Med Chem Lett 21:857-60. 2011.... - Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cellsBin Shan
Pulmonary and Critical Care Section, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
J Biol Chem 280:1103-11. 2005..Our findings indicate that CDK9 mediates TNF-alpha-induced MMP-9 transcription. Disruption of TNF-alpha signaling using CDK9 inhibitors could serve as a potential therapeutic strategy against tumor invasion and metastasis...