Research Topics
| Cristian ApetreiSummaryAffiliation: Tulane University Country: USA Publications
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Publications
Kuru experiments triggered the emergence of pathogenic SIVmacCristian Apetrei
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
AIDS 20:317-21. 2006- Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstmCristian Apetrei
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 79:8991-9005. 2005..The genetic variability of SIVsm strains among PCs may influence the diagnosis and monitoring of SIVsm infection and, consequently, may bias the results of pathogenesis studies... - Detection and partial characterization of simian immunodeficiency virus SIVsm strains from bush meat samples from rural Sierra LeoneCristian Apetrei
Microbiology Division, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
J Virol 79:2631-6. 2005..In spite of the fact that our study doubles the number of known SIVsm strains from wild SMs, none of the simian strains were close to the groups in which HIV-2 was epidemic (groups A and B)... - Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeysCristian Apetrei
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 81:7913-23. 2007..Taken together, this systematic analysis of the subtype-specific features of SIV(smm) infection in natural SM hosts identifies subtype-specific differences in the pathogenicity of SIV(smm) infection... - Effect of B-cell depletion on viral replication and clinical outcome of simian immunodeficiency virus infection in a natural hostThaidra Gaufin
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
J Virol 83:10347-57. 2009..Our results, although obtained with a limited number of animals, suggest that humoral immune responses play only a minor role in the control of SIV viral replication during acute and chronic SIV infection in natural hosts... - Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strainThaidra Gaufin
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
Blood 113:4250-61. 2009..Our data suggest that a deficiency of Ab responses did not markedly affect viral replication or disease progression and that they may be compensated by more robust cellular responses... - In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaquesRajeev Gautam
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
Virology 362:257-70. 2007..In vivo, SIVsmm isolates replicated at high levels in all SIVsmm-infected Rh. The poor in vitro replication of primary SIVsmm isolates in Rh cells did not correlate with in vivo replication, emphasizing the value of in vivo studies... - Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletionIvona Pandrea
Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
J Immunol 181:6687-91. 2008.... - Simian immunodeficiency virus SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through expanded coreceptor usage in vivoRajeev Gautam
Tulane National Primate Research Center, Covington, LA 70433, USA
J Virol 83:7894-908. 2009..Taken together, these findings emphasize the importance of understanding the selective forces driving viral adaptation to a new host... - Experimental depletion of CD8+ cells in acutely SIVagm-infected African Green Monkeys results in increased viral replicationThaidra Gaufin
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
Retrovirology 7:42. 2010..To assess the role of cellular immune responses in the control of SIV replication in natural hosts, we investigated the impact of CD8+ cell depletion during acute SIV infection in AGMs... - Simian immunodeficiency virus SIVagm dynamics in African green monkeysIvona Pandrea
Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 82:3713-24. 2008.... - Functional cure of SIVagm infection in rhesus macaques results in complete recovery of CD4+ T cells and is reverted by CD8+ cell depletionIvona Pandrea
Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
PLoS Pathog 7:e1002170. 2011.... - Classic AIDS in a sooty mangabey after an 18-year natural infectionBinhua Ling
Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
J Virol 78:8902-8. 2004..Therefore, the results also suggest that SMs have a special mechanism for resisting AIDS development... - Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hostsIvona Pandrea
Tulane National Primate Research Center, Covington, LA 70433, USA
Blood 109:1069-76. 2007..Beneficial effects of low CCR5 expression on CD4+ T cells may include the reduction of target cells for viral replication and a decreased homing of activated CD4+ T cells to inflamed tissue... - Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulenceIvona V Pandrea
Divisions of Comparative Pathology and Microbiology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Immunol 179:3035-46. 2007.... - Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinctionCristian Apetrei
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA
J Infect Dis 202:S371-6. 2010..Thus, down?regulation of CD4 and CCR5 expression on CD4+ T cells may effectively control human immunodeficiency virus acquisition and result in SIV extinction... - Direct inoculation of simian immunodeficiency virus from sooty mangabeys in black mangabeys (Lophocebus aterrimus): first evidence of AIDS in a heterologous African species and different pathologic outcomes of experimental infectionCristian Apetrei
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
J Virol 78:11506-18. 2004..Finally, this case of AIDS in an African monkey suggests that the dogma of SIV nonpathogenicity in African NHP hosts should be reconsidered... - Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differencesIvona Pandrea
Tulane National Primate Research Center, Covington, LA 70433, USA
J Med Primatol 35:194-201. 2006.... - Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feedingIvona Pandrea
Departement de Virologie, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, Louisiana 70433, USA
J Virol 82:5501-9. 2008.... - Potential for HIV transmission through unsafe injectionsCristian Apetrei
Tulane National Primate Research Center, Covington, LA 70433, USA
AIDS 20:1074-6. 2006..All 36 strains were HIV-1 group M. The majority belonged to the circulating recombinant form CRF02 (IbNg). Our data support a role for unsafe injections in the spread of HIV-1 in Africa, in contrast to recent studies... - Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hostsIvona Pandrea
Tulane National Primate Research Center, Covington, LA 70433, USA
J Virol 80:4858-67. 2006..sab92018). Due to these similarities, we conclude that Caribbean AGMs are a useful alternative to AGMs of African origin as a model for the study of SIV infection in natural African hosts... - AIDS in african nonhuman primate hosts of SIVs: a new paradigm of SIV infectionIvona Pandrea
Divisions of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA
Curr HIV Res 7:57-72. 2009.... - Molecular epidemiology of simian T-cell lymphotropic virus type 1 in wild and captive sooty mangabeysVicki L Traina-Dorge
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
J Virol 79:2541-8. 2005.... - Into the wild: simian immunodeficiency virus (SIV) infection in natural hostsIvona Pandrea
Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
Trends Immunol 29:419-28. 2008..Immunologic features observed during natural SIV infections suggest approaches for designing new strategies for producing novel second-generation vaccines and therapeutic approaches to inhibit disease progression in HIV-infected humans... - HIV genetic diversity: biological and public health consequencesIsolde F Butler
Tulane National Primate Research Center, Covington, LA 70433, USA
Curr HIV Res 5:23-45. 2007..Here we discuss the distribution of these divergent viral forms worldwide and the potential consequences of such a tremendous viral diversity for diagnostic, monitoring, treatment and the development of an effective vaccine... - AIDS as a zoonosis? Confusion over the origin of the virus and the origin of the epidemicsPreston A Marx
Tulane National Primate Research Center, Covington, LA, USA
J Med Primatol 33:220-6. 2004..Much is known about emerging viruses, but almost nothing is known about emerging viral diseases... - African lentiviruses related to HIVCristian Apetrei
Tulane National Primate Research Center, Covington, LA 70433, USA
J Neurovirol 11:33-49. 2005 - Impact of viral factors on very early in vivo replication profiles in simian immunodeficiency virus SIVagm-infected African green monkeysIvona Pandrea
Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 79:6249-59. 2005..sab92018 and for SIVagm.ver644. In conclusion, our study showed that the extent of virus replication during the primary infection is primarily dependent on viral determinants... - Vesicular stomatitis virus-simian retrovirus type 2 vaccine protects macaques from detectable infection and B-cell destructionRajeev Gautam
Division of Microbiology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 85:5889-96. 2011..B-cell protection was the strongest correlate of the long-term survival of all vaccinated and control RMs... - The evolution of HIV and its consequencesCristian Apetrei
Tulane National Primate Research Center and Department of Tropical Medicine, Tulane University Health Sciences Center, Covington, LA 70433, USA
Infect Dis Clin North Am 18:369-94. 2004..The potential impact of this viral diversity on treatment, monitoring,and vaccine development is discussed... - The history of SIVS and AIDS: epidemiology, phylogeny and biology of isolates from naturally SIV infected non-human primates (NHP) in AfricaCristian Apetrei
Microbiology Division, Tulane National Primate Research Center, Covington, LA 40433, USA
Front Biosci 9:225-54. 2004.... - HIV type 1 diversity in northeastern Romania in 200-2001 based on phylogenic analysis of pol sequences from patient failing antiretroviral therapyCristian Apetrei
Virology Laboratory, Pathology Laboratory and Infectious diseases Clinic, School of Medicine, Gr T Popa University of Iasi, Romania
AIDS Res Hum Retroviruses 19:1155-1161. 2003..The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe.... - Mucosal simian immunodeficiency virus transmission in African green monkeys: susceptibility to infection is proportional to target cell availability at mucosal sitesIvona Pandrea
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA
J Virol 86:4158-68. 2012.... - Simian retroviral infections in human beingsCristian Apetrei
Lancet 364:137-8; author reply 139-40. 2004 - Reliability of rapid diagnostic tests for HIV variant infectionMaria Makuwa
Centre International de Recherches Medicales, Franceville, Gabon
J Virol Methods 103:183-90. 2002..These results stress the need for better screening tools and specific local evaluations... - The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virusRichard Dunham
Emory University, Emory Vaccine Center, Yerkes Primate Research Center, and the School of Public Health, Atlanta, GA, USA
Blood 108:209-17. 2006..These findings indicate that the absence of AIDS in naturally SIV-infected sooty mangabeys is independent of a strong cellular immune response to the virus... - High levels of viral replication contrast with only transient changes in CD4(+) and CD8(+) cell numbers during the early phase of experimental infection with simian immunodeficiency virus SIVmnd-1 in Mandrillus sphinxRichard Onanga
, Centre de Primatologie, , Franceville BP 769, Gabon
J Virol 76:10256-63. 2002.... - Analysis of partial pol and env sequences indicates a high prevalence of HIV type 1 recombinant strains circulating in GabonIvona Pandrea
Laboratoire de Retroviologie, Centre International de Recherches Medicales, Franceville, Gabon
AIDS Res Hum Retroviruses 18:1103-16. 2002..The main advantage of this approach is that it also allows for evaluation of genotypic susceptibility to antiretroviral drugs without the need for supplementary analyses... - Noninvasive detection of new simian immunodeficiency virus lineages in captive sooty mangabeys: ability to amplify virion RNA from fecal samples correlates with viral load in plasmaBinhua Ling
Aaron Diamond AIDS Research Center, New York, New York 10016, USA
J Virol 77:2214-26. 2003..These assays will be useful for studying the phylogeny and epidemiology of SIVsm infections in the wild, and they hold promise as tools for investigating natural SIV infections in endangered nonhuman primates... - Primary simian immunodeficiency virus SIVmnd-2 infection in mandrills (Mandrillus sphinx)Richard Onanga
Departement de Virologie, Centre International de Recherche Médicales, Gabon
J Virol 80:3301-9. 2006..The dynamics of SIVmnd-2 infection in mandrills showed a pattern similar to that of SIVmnd-1 infection. This might be a general feature of nonpathogenic SIV natural African NHP models... - High levels of SIVmnd-1 replication in chronically infected Mandrillus sphinxIvona Pandrea
Laboratoire de Virologie, UGENET, SEGC, , Centre de Primatologie, , BP769, Franceville, Gabon, France
Virology 317:119-27. 2003..Similar to other nonpathogenic models of lentiviral infection, these results show a persistent high level of SIVmnd-1 replication during chronic infection of mandrills, with minimal effects on T cell subpopulations... - Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDSChristopher Kornfeld
, Institut Pasteur, Paris, France
J Clin Invest 115:1082-91. 2005.... - Sequence analysis of the GP, NP, VP40 and VP24 genes of Ebola virus isolated from deceased, surviving and asymptomatically infected individuals during the 1996 outbreak in Gabon: comparative studies and phylogenetic characterizationEric M Leroy
Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
J Gen Virol 83:67-73. 2002..In contrast, nonsynonymous substitutions predominated over synonymous substitutions in the NP gene of the two Gabon strains, pointing to divergent evolution of these strains and to selective pressures on this gene... - Mucosal immune dysfunction in AIDS pathogenesisMirko Paiardini
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
AIDS Rev 10:36-46. 2008..Further studies of mucosal immunity during primate lentiviral infections will be needed to better understand, and ultimately prevent and treat, the mechanisms underlying the AIDS-associated mucosal immune dysfunction... - Identification of hepatitis B virus subgenotype A3 in rural GabonMaria Makuwa
Laboratoire de Retrovirologie, Centre International de Recherches Medicales, CIRMF, Franceville, Gabon
J Med Virol 78:1175-84. 2006..Two full genome sequences of two new Gabonese HBV isolates are also presented and confirm the distinctive HBV-Gab-A3 cluster... - Phylogenetic characteristics of three new HIV-1 N strains and implications for the origin of group NPierre Roques
International Centre for Medical Research, Franceville, Gabon, France
AIDS 18:1371-81. 2004..However, continuous monitoring of HIV-1 diversity will be important to survey the potential of unusual HIV infections, such as group N, to contribute to the HIV/AIDS pandemic... - Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesisShari N Gordon
University of Pennsylvania School of Medicine, 705 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19143, USA
J Virol 82:3725-35. 2008.... - Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeysShari N Gordon
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 179:3026-34. 2007.... - Sequence diversity among chimpanzee simian immunodeficiency viruses (SIVcpz) suggests that SIVcpzPts was derived from SIVcpzPtt through additional recombination eventsThomas Leitner
Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA
AIDS Res Hum Retroviruses 23:1114-8. 2007..t.t. and P.t.s. split, SIV superinfection led to further recombination resulting in the emergence of SIVcpzPts. This shows that there have been multiple SIV transfers to chimpanzees at different times in their evolution... - Going wild: lessons from naturally occurring T-lymphotropic lentivirusesSue Vandewoude
Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO 80538-1619, USA
Clin Microbiol Rev 19:728-62. 2006..This comparison of consistent patterns in lentivirus biology will expose new directions for scientific inquiry for understanding the basis for virulence versus avirulence... - T regulatory cells: aid or hindrance in the clearance of disease?Clint A Coleman
Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA, USA
J Cell Mol Med 11:1291-325. 2007..Ultimately, an overall understanding of the exact mechanism which CD4+ CD25+ Tregs implement during disease progression will enhance our ability to manipulate CD4+ CD25+ Tregs in a clinically beneficial manner...