Marvin A Konstam

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. ncbi Design of the heart failure endpoint evaluation of AII-antagonist losartan (HEAAL) study in patients intolerant to ACE-inhibitor
    Marvin A Konstam
    Tufts Medical Center, Boston, MA 02111, USA
    Eur J Heart Fail 10:899-906. 2008
  2. ncbi Transforming health care through the medical home: the example of heart failure
    Marvin A Konstam
    The Cardiovascular Center, Tufts Medical Center, and Tufts University, Boston, MA 02111, USA
    J Card Fail 15:736-8. 2009
  3. ncbi Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial
    Marvin A Konstam
    Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Lancet 374:1840-8. 2009
  4. ncbi Health-related quality of life in a multicenter randomized controlled comparison of telephonic disease management and automated home monitoring in patients recently hospitalized with heart failure: SPAN-CHF II trial
    Varda Konstam
    Department of Counseling and School Psychology, University of Massachusetts, 2 Avery Street, Boston, MA, USA
    J Card Fail 17:151-7. 2011
  5. ncbi Enalapril treatment and hospitalization with atrial tachyarrhythmias in patients with left ventricular dysfunction
    Alawi A Alsheikh-Ali
    Tufts-New England Medical Center, Department of Medicine, Division of Cardiolgy, Boston, Mass, USA
    Am Heart J 147:1061-5. 2004
  6. ncbi Hospital cost effect of a heart failure disease management program: the Specialized Primary and Networked Care in Heart Failure (SPAN-CHF) trial
    Douglas Gregory
    Cardiovascular Clinical Studies, Boston, MA 02111, USA
    Am Heart J 151:1013-8. 2006
  7. ncbi Acute hemodynamic effects of tolvaptan, a vasopressin V2 receptor blocker, in patients with symptomatic heart failure and systolic dysfunction: an international, multicenter, randomized, placebo-controlled trial
    James E Udelson
    Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 52:1540-5. 2008
  8. ncbi A multicenter, randomized, double-blind, placebo-controlled study of tolvaptan monotherapy compared to furosemide and the combination of tolvaptan and furosemide in patients with heart failure and systolic dysfunction
    James E Udelson
    Division of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, MA 02111, USA
    J Card Fail 17:973-81. 2011
  9. ncbi Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor
    Paul Bridgman
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Box 80, 750 Washington St, Boston, MA 02111, USA
    Am J Physiol Heart Circ Physiol 289:H586-92. 2005
  10. ncbi Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial
    Marvin A Konstam
    Division of Cardiology, Tufts New England Medical Center, Boston, Mass, USA
    JAMA 297:1319-31. 2007

Detail Information

Publications45

  1. ncbi Design of the heart failure endpoint evaluation of AII-antagonist losartan (HEAAL) study in patients intolerant to ACE-inhibitor
    Marvin A Konstam
    Tufts Medical Center, Boston, MA 02111, USA
    Eur J Heart Fail 10:899-906. 2008
    ....
  2. ncbi Transforming health care through the medical home: the example of heart failure
    Marvin A Konstam
    The Cardiovascular Center, Tufts Medical Center, and Tufts University, Boston, MA 02111, USA
    J Card Fail 15:736-8. 2009
    ....
  3. ncbi Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial
    Marvin A Konstam
    Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Lancet 374:1840-8. 2009
    ..We compared the effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure...
  4. ncbi Health-related quality of life in a multicenter randomized controlled comparison of telephonic disease management and automated home monitoring in patients recently hospitalized with heart failure: SPAN-CHF II trial
    Varda Konstam
    Department of Counseling and School Psychology, University of Massachusetts, 2 Avery Street, Boston, MA, USA
    J Card Fail 17:151-7. 2011
    ....
  5. ncbi Enalapril treatment and hospitalization with atrial tachyarrhythmias in patients with left ventricular dysfunction
    Alawi A Alsheikh-Ali
    Tufts-New England Medical Center, Department of Medicine, Division of Cardiolgy, Boston, Mass, USA
    Am Heart J 147:1061-5. 2004
    ..4 per 1000 patient-years in the placebo group (RR, 0.64; 95% CI, 0.48-0.85; P =.002). CONCLUSION: Enalapril is associated with a decreased incidence of hospitalization with atrial tachyarrhythmias in patients with LV dysfunction...
  6. ncbi Hospital cost effect of a heart failure disease management program: the Specialized Primary and Networked Care in Heart Failure (SPAN-CHF) trial
    Douglas Gregory
    Cardiovascular Clinical Studies, Boston, MA 02111, USA
    Am Heart J 151:1013-8. 2006
    ..Determine the effect on hospitalization cost of a heart failure disease management (HFDM) program delivered within a diverse provider network as demonstrated in the SPAN-CHF randomized controlled trial...
  7. ncbi Acute hemodynamic effects of tolvaptan, a vasopressin V2 receptor blocker, in patients with symptomatic heart failure and systolic dysfunction: an international, multicenter, randomized, placebo-controlled trial
    James E Udelson
    Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 52:1540-5. 2008
    ..This study sought to assess the acute hemodynamic effect of vasopressin V(2) receptor antagonism...
  8. ncbi A multicenter, randomized, double-blind, placebo-controlled study of tolvaptan monotherapy compared to furosemide and the combination of tolvaptan and furosemide in patients with heart failure and systolic dysfunction
    James E Udelson
    Division of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, MA 02111, USA
    J Card Fail 17:973-81. 2011
    ..The presence of background diuretic therapy may confound evaluations of vasopressin receptor antagonists (VRA)...
  9. ncbi Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor
    Paul Bridgman
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Box 80, 750 Washington St, Boston, MA 02111, USA
    Am J Physiol Heart Circ Physiol 289:H586-92. 2005
    ..Further work is necessary to explore the potential mechanisms underlying these gender-based differences...
  10. ncbi Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial
    Marvin A Konstam
    Division of Cardiology, Tufts New England Medical Center, Boston, Mass, USA
    JAMA 297:1319-31. 2007
    ..Vasopressin mediates fluid retention in heart failure. Tolvaptan, a vasopressin V2 receptor blocker, shows promise for management of heart failure...
  11. ncbi New concepts in post-infarction ventricular remodeling
    James E Udelson
    Division of Cardiology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Rev Cardiovasc Med 4:S3-12. 2003
    ..It is also demonstrated that drug therapies that slow or reverse the remodeling process appear to have favorable natural history effects in the short term as well as during long-term therapy...
  12. ncbi Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction
    James E Udelson
    Tufts Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Circ Heart Fail 3:347-53. 2010
    ..Few data are available on effects of aldosterone antagonism in patients with mild-to-moderate HF...
  13. ncbi The economic effect of a tertiary hospital-based heart failure program
    Douglas Gregory
    Cardiovascular Clinical Studies and Tufts University School of Medicine, Boston, Massachusetts, USA
    J Am Coll Cardiol 46:660-6. 2005
    ..This study was designed to determine the economic effect of a tertiary heart failure (HF) program at an academic medical center...
  14. ncbi Randomized, controlled evaluation of short- and long-term benefits of heart failure disease management within a diverse provider network: the SPAN-CHF trial
    Carey Kimmelstiel
    Division of Cardiology, Tufts-New England Medical Center, and Tufts University School of Medicine, Boston, Mass 02111, USA
    Circulation 110:1450-5. 2004
    ..Longer-term benefit likely requires more active chronic intervention, even among patients who appear clinically stable...
  15. ncbi Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach
    Daniel G Kramer
    Division of Cardiology and the CardioVascular Center, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 56:392-406. 2010
    ..The purpose of this study was to quantitatively assess the relationship between therapy-induced changes in left ventricular (LV) remodeling and longer-term outcomes in patients with left ventricular dysfunction (LVD)...
  16. ncbi Drug and device effects on peak oxygen consumption, 6-minute walk distance, and natriuretic peptides as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction
    Benjamin S Wessler
    Division of Cardiology, Cardiovascular Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA
    Circ Heart Fail 4:578-88. 2011
    ....
  17. ncbi A multicenter randomized controlled evaluation of automated home monitoring and telephonic disease management in patients recently hospitalized for congestive heart failure: the SPAN-CHF II trial
    Andrew Weintraub
    Division of Cardiology, Tufts Medical Center, Boston, MA, USA
    J Card Fail 16:285-92. 2010
    ..The AHM system measured and transmitted body weight, blood pressure, and heart rate data as well as subjective patient self-assessments via a standard telephone line to a central server...
  18. ncbi Comparison of losartan and captopril on heart failure-related outcomes and symptoms from the losartan heart failure survival study (ELITE II)
    Marvin A Konstam
    Division of Cardiology, Tufts New England Medical Center, Boston, MA 02111, USA
    Am Heart J 150:123-31. 2005
    ..We compared effects of losartan to captopril on mortality, morbidity, and functional status for patients in the ELITE II study...
  19. ncbi Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart
    Richard D Patten
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 45:1419-24. 2005
    ..We examined the effect of mechanical unloading with ventricular assist device (VAD) therapy on myocardial inducible nitric oxide synthase (iNOS) expression and cardiomyocyte apoptosis in patients with end-stage heart failure (HF)...
  20. ncbi Multicenter, randomized, double-blind, placebo-controlled study on the effect of oral tolvaptan on left ventricular dilation and function in patients with heart failure and systolic dysfunction
    James E Udelson
    Division of Cardiology, Tufts New England Medical Center Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 49:2151-9. 2007
    ..This study sought to examine the effects of vasopressin V2 receptor antagonism with tolvaptan on the changes in left ventricular (LV) volumes over time...
  21. ncbi Advanced heart failure and transplant cardiology: a subspecialty is born
    Marvin A Konstam
    Cardiovascular Center, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Card Fail 15:98-100. 2009
    ..In the years to come, the specialty must adapt to the ongoing rapid expansion of evidence-based knowledge in this field to continue to provide the highest level of care and the best outcomes to patients with heart failure...
  22. ncbi Emerging ventricular assist devices for long-term cardiac support
    Rajan Krishnamani
    The Cardiovascular Center, Tufts Medical Center, Boston, MA 02111, USA
    Nat Rev Cardiol 7:71-6. 2010
    ..These devices are at various stages of development and clinical investigation. One or more of these newer devices is likely to emerge as an important development in the treatment of patients with advanced heart failure...
  23. ncbi A cost-saving strategy for inpatient management of advanced decompensated heart failure patients: the Cardiomyopathy Unit
    Douglas Gregory
    Cardiovascular Clinical Studies, Boston, MA 02111, USA
    J Card Fail 15:428-34. 2009
    ..This article analyzes the relative costs and revenues of the Tufts Medical Center Cardiomyopathy Unit (CMU), a recent innovation for grouping and managing advanced decompensated heart failure patients...
  24. ncbi Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment
    Marvin A Konstam
    Cardiovascular Center, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 4:98-108. 2011
    ....
  25. ncbi Novel neurohormonal antagonist strategies: vasopressin antagonism, anticytokine therapy, and endothelin antagonism in patients who have heart failure
    Olaf Hedrich
    Tufts-New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    Heart Fail Clin 1:103-27. 2005
  26. ncbi Advanced heart failure and transplant cardiology: a subspecialty is born
    Marvin A Konstam
    Cardiovascular Center, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 53:834-6. 2009
    ..In the years to come, the specialty must adapt to the ongoing rapid expansion of evidence-based knowledge in this field to continue to provide the highest level of care and the best outcomes to patients with heart failure...
  27. ncbi Fatty infiltration of right ventricle (adipositas cordis): an unrecognized cause of early graft failure after cardiac transplantation
    Rajan Krishnamani
    Department of Medicine, Division of Cardiology, Tufts-New England Medical Center, Boston, MA 02111, USA
    J Heart Lung Transplant 24:1143-5. 2005
    ..If the diagnosis of fatty infiltration is suspected at time of donor harvest, the relative risks and benefits of proceeding with transplantation should be carefully assessed...
  28. ncbi Prevention and reversal of left ventricular remodeling: summation
    Marvin A Konstam
    Department of Medicine, Division of Cardiology, Tufts-New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Card Fail 8:S506-11. 2002
  29. ncbi Comparison of survival and other complications after heart transplantation in patients taking amiodarone before surgery versus those not taking amiodarone
    Patrick J Blomberg
    Division of Cardiology, Tufts University Medical School, Tufts-New England Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 93:379-81. 2004
    ..These findings raise further concern about the use of amiodarone treatment in patients with heart failure before undergoing HT...
  30. ncbi Endothelin expression and the progression of heart failure: exemplifying the vagaries of therapeutic development
    Marvin A Konstam
    Division of Cardiology, Department of Medicine, Tufts-New England Medical Center and Tufts University School of Medicine, Boston, Mass, USA
    Circulation 109:143-5. 2004
  31. ncbi Impact of chronic kidney disease and anemia on hospitalization expense in patients with left ventricular dysfunction
    Douglas D Gregory
    Division of Clinical Decision Making, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Cardiol 92:1300-5. 2003
    ....
  32. ncbi Outcomes in patients with symptomatic cerebrovascular disease undergoing heart transplantation
    Vishnu Patlolla
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Am Coll Cardiol 58:1036-41. 2011
    ..Second, we sought to determine factors associated with stroke in the perioperative period after heart transplantation...
  33. ncbi Relation between left ventricular remodeling and clinical outcomes in heart failure patients with left ventricular systolic dysfunction
    James E Udelson
    Division of Cardiology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    J Card Fail 8:S465-71. 2002
    ....
  34. ncbi Effects of angiotensin II receptor blockade versus angiotensin-converting-enzyme inhibition on ventricular remodelling following myocardial infarction in the mouse
    Richard D Patten
    Molecular Cardiology Research Institute, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    Clin Sci (Lond) 104:109-18. 2003
    ..These results serve as an important basis for planned investigations to evaluate the anti-remodelling effects of these agents on mice in which genetic manipulations are used to disrupt components of the Ang II signalling system...
  35. ncbi Peripheral vascular endothelial function correlates with exercise capacity in cardiac transplant recipients
    Ayan R Patel
    Division of Cardiology/Department of Medicine, Molecular Cardiology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Cardiol 91:897-9. 2003
  36. ncbi Improving clinical outcomes with drug treatment in heart failure: what have trials taught?
    Marvin A Konstam
    Department of Medicine, Division of Cardiology, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 91:9D-14D. 2003
    ..Clinical trials have provided significant treatment advances; ongoing and future trials will demonstrate the degree to which we can improve on what we have achieved to date with pharmacologic treatments...
  37. ncbi Should beta-blockers be given to patients with heart disease and peanut-induced anaphylaxis? A decision analysis
    John A TenBrook
    Division of Clinical Decision Making, Informatics, and Telemedicine, Department of Medicine, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, USA
    J Allergy Clin Immunol 113:977-82. 2004
    ..However, the epidemiology of anaphylaxis and effects of beta-blocker therapy on anaphylaxis incidence and mortality require further study...
  38. ncbi Heart failure training: a call for an integrative, patient-focused approach to an emerging cardiology subspecialty
    Marvin A Konstam
    Division of Cardiology, Department of Medicine, Tufts New England Medical Center, 750 Washington Street, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 44:1361-2. 2004
    ....
  39. ncbi Arginine vasopressin antagonists for the treatment of heart failure and hyponatremia
    John J Finley
    Division of Cardiology and Department of Medicine, Tufts Medical Center, Boston, Mass. 02111, USA
    Circulation 118:410-21. 2008
  40. ncbi Reversal of left ventricular remodeling by pericardial tamponade
    Prem Soman
    Division of Cardiology, Tufts-New England Medical Center, Boston, MA 02451, USA
    J Card Fail 11:131-3. 2005
  41. ncbi Continuous aortic flow augmentation: a pilot study of hemodynamic and renal responses to a novel percutaneous intervention in decompensated heart failure
    Marvin A Konstam
    Tufts New England Medical Center, Tufts University, Boston, MA, USA
    Circulation 112:3107-14. 2005
    ....
  42. ncbi Heart Failure Society of America: a society with a mission
    Marvin A Konstam
    President, Heart Failure Society Of America, Boston, Massachusetts, USA
    J Card Fail 8:275-8. 2002
  43. ncbi Contemporary medical options for treating patients with heart failure
    Marvin A Konstam
    Department of Medicine, Division of Cardiology, Tufts-New England Medical Center, and Tufts University School of Medicine, Boston, Mass 02111, USA
    Circulation 105:2244-6. 2002
  44. ncbi Recent advances in the treatment of heart failure
    Ayan R Patel
    Division of Cardiology, New England Medical Center and Tufts University, Boston, Massachusetts 02111, USA
    Circ J 66:117-21. 2002
    ..As the importance of neurohormonal activation in the progression of heart failure becomes increasingly apparent, new therapeutic strategies targeting these neurohormonal systems are being investigated...
  45. ncbi Current perspective on the cardiovascular effects of coxibs
    Marvin A Konstam
    Tufts University School of Medicine and the New England Medical Center, Boston, MA 02111, USA
    Cleve Clin J Med 69:SI47-52. 2002
    ..Additional placebo-controlled data, from patients at both high and low risk for cardiovascular events, are warranted to clarify the cardiovascular effects of this class of agents...