James Joseph

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model
    J A Joseph
    USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Neurosci 6:153-62. 2003
  2. ncbi Oxidative stress and inflammation in brain aging: nutritional considerations
    J A Joseph
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Neurochem Res 30:927-35. 2005
  3. ncbi Nutrition, brain aging, and neurodegeneration
    James Joseph
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Neurosci 29:12795-801. 2009
  4. ncbi Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes
    J A Joseph
    USDA HNRC at Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 9:35-42. 2006
  5. ncbi Fruit extracts antagonize Abeta- or DA-induced deficits in Ca2+ flux in M1-transfected COS-7 cells
    James A Joseph
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 6:403-11; discussion 443-9. 2004
  6. ncbi Muscarinic receptor subtype determines vulnerability to amyloid beta toxicity in transfected cos-7 cells
    J A Joseph
    USDA Human Nutrition Research Center on Aging at Tufts University Boston, MA 02111, USA
    J Alzheimers Dis 5:197-208. 2003
  7. ncbi Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract
    J A Joseph
    USDA HNRCA at Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 10:423-37. 2006
  8. ncbi The M3 muscarinic receptor i3 domain confers oxidative stress protection on calcium regulation in transfected COS-7 cells
    James A Joseph
    USDA HNRC, Tufts University, Boston, MA 02111, USA
    Aging Cell 3:263-71. 2004
  9. ncbi Fruit polyphenols and their effects on neuronal signaling and behavior in senescence
    James A Joseph
    Tufts University, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
    Ann N Y Acad Sci 1100:470-85. 2007
  10. ncbi Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds
    James A Joseph
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, and the Institute of Pathology, Case Western Reserve University, Cleveland, USA
    Am J Clin Nutr 81:313S-316S. 2005

Research Grants

  1. Nutritional Modulation of Aging and Age-Related Diseases
    James Joseph; Fiscal Year: 2003

Collaborators

Detail Information

Publications42

  1. ncbi Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model
    J A Joseph
    USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Neurosci 6:153-62. 2003
    ..Thus, our data indicate for the first time that it may be possible to overcome genetic predispositions to Alzheimer disease through diet...
  2. ncbi Oxidative stress and inflammation in brain aging: nutritional considerations
    J A Joseph
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Neurochem Res 30:927-35. 2005
    ..Importantly, using muscarinic receptors as examples, we will also try to show that the sensitivity to these insults may be differentially expressed among neurotransmitter receptor subtypes...
  3. ncbi Nutrition, brain aging, and neurodegeneration
    James Joseph
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Neurosci 29:12795-801. 2009
    ....
  4. ncbi Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes
    J A Joseph
    USDA HNRC at Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 9:35-42. 2006
    ..These findings also suggest that BB may antagonize oxidative stress effects induced by DA in M1-transfected cells by lowering activation of pCREB, and possibly pPKCgamma...
  5. ncbi Fruit extracts antagonize Abeta- or DA-induced deficits in Ca2+ flux in M1-transfected COS-7 cells
    James A Joseph
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 6:403-11; discussion 443-9. 2004
    ..Interestingly, assessments of DA-induced decrements in viability revealed that all of the extracts had some protective effects. These findings suggest that the putative toxic effects of Abeta or DA might be reduced by HA fruit extracts...
  6. ncbi Muscarinic receptor subtype determines vulnerability to amyloid beta toxicity in transfected cos-7 cells
    J A Joseph
    USDA Human Nutrition Research Center on Aging at Tufts University Boston, MA 02111, USA
    J Alzheimers Dis 5:197-208. 2003
    ..Results are discussed in terms of differences in MAChR structure that could lead to selective Abeta effects and the possible implications on memory and AbetaPP processing...
  7. ncbi Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract
    J A Joseph
    USDA HNRCA at Tufts University, Boston, MA 02111, USA
    J Alzheimers Dis 10:423-37. 2006
    ..A similar partial effect of BBs was seen in the M3(M1i3) chimerics which showed increased OSS in response to DA. It appears that antioxidants found in BBs might be targeting additional sites on these chimerics to decrease OSS...
  8. ncbi The M3 muscarinic receptor i3 domain confers oxidative stress protection on calcium regulation in transfected COS-7 cells
    James A Joseph
    USDA HNRC, Tufts University, Boston, MA 02111, USA
    Aging Cell 3:263-71. 2004
    ..Results suggest that the longer i3 loop of the M3 may decrease OSS, possibly playing a role in targeting antioxidants to specific receptor sites that impart OSS...
  9. ncbi Fruit polyphenols and their effects on neuronal signaling and behavior in senescence
    James A Joseph
    Tufts University, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
    Ann N Y Acad Sci 1100:470-85. 2007
    ..The purpose of this article is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits...
  10. ncbi Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds
    James A Joseph
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, and the Institute of Pathology, Case Western Reserve University, Cleveland, USA
    Am J Clin Nutr 81:313S-316S. 2005
    ....
  11. ncbi Roles of vitamins E and C on neurodegenerative diseases and cognitive performance
    Antonio Martin
    Neuroscience Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Nutr Rev 60:308-26. 2002
    ..Several studies reveal a link between diets rich in fruits and vegetables containing generous amounts of vitamins E and C and lower incidence of certain chronic diseases...
  12. ncbi Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory
    Cristina Andres-Lacueva
    Nutrition and Food Science Department-CeRTA, Pharmacy Faculty, University of Barcelona, Barcelona, Spain
    Nutr Neurosci 8:111-20. 2005
    ..These findings suggest that these compounds may deliver their antioxidant and signaling modifying capabilities centrally...
  13. ncbi Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammation
    Natalia A Crivello
    Nutrition and Neurocognition Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Neurochem Int 47:573-9. 2005
    ..1.4.12; N-Sase), a key enzyme of sphingolipid metabolism and sphingolipid-induced signaling...
  14. ncbi Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection
    Rachel L Galli
    Neuroscience Laboratory, USDA-ARS Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Neurobiol Aging 27:344-50. 2006
    ..Results are discussed in terms of the multiplicity of the effects of the BB supplementation which appear to range from antioxidant/anti-inflammatory activity to signaling...
  15. ncbi The beneficial effects of fruit polyphenols on brain aging
    Francis C Lau
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Neurobiol Aging 26:128-32. 2005
    ..Furthermore, we have shown that short-term blueberry (BB) supplementation increases hippocampal plasticity. These findings are briefly reviewed in this paper...
  16. ncbi Effects of Concord grape juice on cognitive and motor deficits in aging
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Nutrition 22:295-302. 2006
    ....
  17. ncbi Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
    Mark A Wilson
    Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA
    Aging Cell 5:59-68. 2006
    ..In conclusion, polyphenolic compounds in blueberries had robust and reproducible benefits during aging that were separable from antioxidant effects...
  18. ncbi Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Neurobiol Aging 28:1187-94. 2007
    ..These data suggest that (56)Fe particle irradiation causes deficits in behavior and signaling in rats which were ameliorated by an antioxidant diet and that the polyphenols in these fruits might be acting in different brain regions...
  19. ncbi Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons
    Susan O McGuire
    Department of Pathology, Loyola University Medical School, Loyola University Chicago, Maywood, IL 60153, USA
    Nutr Neurosci 9:251-8. 2006
    ..These findings provide support for the potential of dietary phytochemicals as an easily administered and well-tolerated therapy that can be used to improve the effectiveness of DA neuron replacement...
  20. ncbi Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia
    Francis C Lau
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Neurosci Res 85:1010-7. 2007
    ..The results suggest that blueberry polyphenols attenuate inflammatory responses of brain microglia and could be potentially useful in modulation of inflammatory conditions in the CNS...
  21. ncbi Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress
    Francis C Lau
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Subcell Biochem 42:299-318. 2007
    ..Thus, nutritional intervention may exert therapeutic protection against age-related deficits and neurodegenerative diseases...
  22. ncbi Berry fruit supplementation and the aging brain
    Barbara Shukitt-Hale
    USDA ARS Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Agric Food Chem 56:636-41. 2008
    ..The purpose of this paper is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits...
  23. ncbi Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats
    Gemma Casadesus
    VSDA, HNRC on Aging, Tufts University, Boston, MA, USA
    Exp Gerontol 40:249-54. 2005
    ..Additionally, irradiated subjects show decreased levels of PSA-NCAM expression. These changes are consistent with those found in aged subjects indicating that heavy-particle irradiation is an adequate model for the study of aging...
  24. ncbi Effects of age and diet on the heavy particle-induced disruption of operant responding produced by a ground-based model for exposure to cosmic rays
    Bernard M Rabin
    Department of Psychology, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Brain Res 1036:122-9. 2005
    ..The results indicate that diets containing strawberry extract may provide a significant level of radiation protection on exploratory class missions...
  25. ncbi Fruit polyphenolics and brain aging: nutritional interventions targeting age-related neuronal and behavioral deficits
    Rachel L Galli
    USDA ARS, HNRCA at Tufts University, Boston, Massachusetts 02111, USA
    Ann N Y Acad Sci 959:128-32. 2002
    ....
  26. ncbi Ill-fated amyloid-beta vaccine
    Mark A Smith
    J Neurosci Res 69:285. 2002
  27. ncbi The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease
    Catherine A Rottkamp
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Peptides 23:1333-41. 2002
    ..Below, we present a brief synopsis of the trial for you, the jury, to decide the verdict. Amyloid-beta: guilty or not-guilty?..
  28. ncbi Effects of heavy particle irradiation and diet on amphetamine- and lithium chloride-induced taste avoidance learning in rats
    Bernard M Rabin
    Department of Psychology, UMBC, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Brain Res 953:31-6. 2002
    ..The failure of either irradiation or diet to influence LiCl-induced responding suggests that oxidative stress may not be involved in CTA learning following injection of LiCl...
  29. ncbi Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging?
    Gemma Casadesus
    USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Rm 919, Boston, MA 02111, USA
    Neurobiol Aging 23:747-69. 2002
    ..The two interventions will be compared and contrasted in terms of their effectiveness, safety, and generalization capacity for human treatment...
  30. ncbi Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain
    Mark A Smith
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Free Radic Biol Med 33:1194-9. 2002
    ..The notion that amyloid-beta and tau function as protective components brings into serious question the rationale of current therapeutic efforts targeted toward lesion removal...
  31. ncbi Dopamine neurotoxicity: age-dependent behavioral and histological effects
    Ippolita Cantuti-Castelvetri
    USDA Human Nutrition Research Center on Aging at Tufts University, Room 919, 711 Washington Street, Boston, MA 02111, USA
    Neurobiol Aging 24:697-706. 2003
    ..These results suggest that a neurochemical deficit and not cell loss per se within the nigrostriatal system underlies the motor behavioral deficits observed in the middle-aged rats...
  32. ncbi Amyloid-beta: a (life) preserver for the brain
    Mark E Obrenovich
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Neurobiol Aging 23:1097-9. 2002
  33. ncbi Effect of age on the radial arm water maze-a test of spatial learning and memory
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Neurobiol Aging 25:223-9. 2004
    ..The RAWM is a reliable, sensitive, and powerful additional test to assess age-related spatial learning and memory deficits, combining the advantages of the Morris water maze and the radial arm maze while minimizing the disadvantages...
  34. ncbi Perspectives on the amyloid-beta cascade hypothesis
    Hyoung-Gon Lee
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Alzheimers Dis 6:137-45. 2004
    ..These findings bring into serious doubt the validity of the Amyloid Cascade Hypothesis as the central cause of Alzheimer disease and, consequently, the potential usefulness of therapeutic targets against amyloid-beta...
  35. ncbi Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats
    Pilar Goyarzu
    National Autonomous University of Mexico, Mexico City, Mexico
    Nutr Neurosci 7:75-83. 2004
    ..Normalized NF-kappaB levels (averaged across regions and in several individual regions) correlated negatively and significantly with the object memory scores...
  36. ncbi Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats
    Gemma Casadesus
    USDA, HNRC on Aging at Tufts University, Boston, MA, USA
    Nutr Neurosci 7:309-16. 2004
    ..Therefore, cognitive improvements afforded by polyphenolic-rich fruits such as blueberries appear, in part, to be mediated by their effects on hippocampal plasticity...
  37. ncbi Nutritional interventions in aging and age-associated diseases
    George S Roth
    GeroScience, Inc Pylesville, Maryland 21132, USA
    Ann N Y Acad Sci 1114:369-71. 2007
    ..This brief report covers both, providing selected examples of the most recent research into both these types of interventions and their mechanisms of action...
  38. ncbi Predicting the failure of amyloid-beta vaccine
    Mark A Smith
    Lancet 359:1864-5. 2002
  39. ncbi Dangers of the amyloid-beta vaccination
    Mark A Smith
    Acta Neuropathol 104:110. 2002
  40. ncbi What is aging? What is its role in Alzheimer's disease? What can we do about it?
    J Wesson Ashford
    Stanford/VA Alzheimer Center, Palo Alto, CA 94304-1207, USA
    J Alzheimers Dis 7:247-53; discussion 255-62. 2005
  41. ncbi Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system
    Kuresh A Youdim
    Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, Guy's King's and St. Thomas's School of Biomedical Sciences, King's College, London SE1 9RT, UK
    Free Radic Biol Med 37:1683-93. 2004
    ..Therefore cognitive aging, according to this hypothesis, should be slowed, and possibly even reversed, by appropriately increasing levels of antioxidants or decreasing overproduction of free radicals in the body...
  42. ncbi The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathway
    Waleed N Hassan
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Free Radic Biol Med 32:551-61. 2002
    ..These data suggest a model in which PBN attenuates H(2)O(2)-induced Ca(+2) entry, yet magnifies or alters Ca(+2) action, resulting in the activation of the EGF receptor/ERK pathway...

Research Grants1

  1. Nutritional Modulation of Aging and Age-Related Diseases
    James Joseph; Fiscal Year: 2003
    ....